LOCUS       NM_001047097            9002 bp    mRNA    linear   ROD 14-JUL-2023
DEFINITION  Rattus norvegicus zinc fingers and homeoboxes 3 (Zhx3), mRNA.
ACCESSION   NM_001047097 XM_001057189 XM_001068695 XM_001068743 XM_230811
VERSION     NM_001047097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9002)
  AUTHORS   Suehiro F, Nishimura M, Kawamoto T, Kanawa M, Yoshizawa Y, Murata H
            and Kato Y.
  TITLE     Impact of zinc fingers and homeoboxes 3 on the regulation of
            mesenchymal stem cell osteogenic differentiation
  JOURNAL   Stem Cells Dev 20 (9), 1539-1547 (2011)
   PUBMED   21174497
REFERENCE   2  (bases 1 to 9002)
  AUTHORS   Liu G, Clement LC, Kanwar YS, Avila-Casado C and Chugh SS.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   3  (bases 1 to 9002)
  AUTHORS   Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T,
            Sekiguchi T, Yoshino M, Kajitani T and Miyamoto K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem J 373 (Pt 1), 167-178 (2003)
   PUBMED   12659632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000120.1.
            
            On May 18, 2021 this sequence version replaced NM_001047097.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ017884.1, CB694730.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JACYVU010000120.1  4087893-4088059     c
            168-283             JACYVU010000120.1  4051781-4051896     c
            284-3265            JACYVU010000120.1  4005980-4008961     c
            3266-9002           JACYVU010000120.1  3990022-3995758     c
FEATURES             Location/Qualifiers
     source          1..9002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..9002
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="zinc fingers and homeoboxes 3"
                     /db_xref="GeneID:311604"
                     /db_xref="RGD:631431"
     exon            1..167
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..283
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..3265
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    400..402
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="upstream in-frame stop codon"
     CDS             421..3276
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="zinc finger and homeodomain protein 3; triple
                     homeobox 1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 3"
                     /protein_id="NP_001040562.1"
                     /db_xref="GeneID:311604"
                     /db_xref="RGD:631431"
                     /translation="

MASKRKSTTPCMIPVKTMVLPGASTEAQPVEPLPEGPQQDLPSEAPEASSEAAPNPSSTDGSALANGHRGTLDGYVYSCKECDFRSQDVTHFVGHMTSEHTDFNKDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPENASSSVLAGESTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPTQPGGEALPKPLAGETEGKEGDHTFINGATPVSQASANSTKPPHTANGPLIGTVPVLPAGIAQFLSLQQPTVHPQHHPHQPLPTSKALPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPTAAPINTVCSNTTSAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGTRAMVPGEHGSVLIDSVPEVPFPLSSKVPEVPCVPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKRVNAEETKKADGHAPQEEAEGAEEEGRDEELASELRAPGENGSSEMFLSHTLAERKVSPIKINLKNLRVTEASGKSELPGMGMGVCEPEEDGLNKAVEQPPSRVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEKMGEETRAVADTSSEDQGPGHGEPVAVDKVLGDACAALSENSEAWEPSAPEAGSEPFDTSSPQSGRQLETD"

     misc_feature    421..618
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    733..891
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Zinc-fingers and homeoboxes C2H2 finger domain;
                     Region: zf_C2H2_ZHX; pfam18387"
                     /db_xref="CDD:436457"
     misc_feature    1012..1167
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1129..1863
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Required for homodimerization and interaction with
                     NFYA. /evidence=ECO:0000250|UniProtKB:Q9H4I2"
     misc_feature    1309..1905
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Required for repressor activity.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2"
     misc_feature    1339..1491
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    1888..2064
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Required for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2"
     misc_feature    1897..2058
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1897..1899,2017..2019,2026..2031,2038..2040)
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    2209..2211
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z36.2); phosphorylation site"
     misc_feature    2260..2397
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    2281..2346
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2401..2526
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2521..2523
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C0Q2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z36.2); phosphorylation site"
     misc_feature    2566..2568
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z36.2); phosphorylation site"
     misc_feature    2701..2874
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(2701..2712,2716..2718,2767..2769,2785..2787,
                     2824..2826,2830..2835,2842..2847,2851..2859,2863..2868)
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(2704..2706,2713..2715,2833..2835,2842..2847,
                     2854..2856)
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    <2953..3084
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Homeodomain leucine-zipper encoding, Homez; Region:
                     Homez; pfam11569"
                     /db_xref="CDD:431938"
     misc_feature    3073..3273
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z36.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3184..3186
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z36.2); phosphorylation site"
     misc_feature    3241..3243
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4I2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z36.2); phosphorylation site"
     exon            3266..9002
                     /gene="Zhx3"
                     /gene_synonym="Tix1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaattgtgttagctgtggaaagcagcgaacaggctggatgaaagatgagcttcttccttttctgtccttgtctcctgccaacccgccgctcattgtggagagggaaagagaggagatgagcagagccggtgccctgtcatttagtgttcagacccaagatttgcaaggcctgaattgcaactagagaggcaacaagtgactccttaaagatgccacagggctgcagaaggggaccttgaagaggttgatgaagtgagaagaatgtttctcccaacgacgagaagcttaataaggaaaagtggctttctgcgaataactgataaaactacccttagaagcgcctcctgggccctcatggaatagctgggatttgtactgcaaggctttcttgcctgctgctgacccgaagtgattgtcaccatggccagcaagaggaagtccactaccccatgcatgatcccggttaagaccatggtgctgccgggtgccagcacagaggctcagcctgtggaacctctacctgaaggtccccagcaggaccttccctcagaggcccctgaagccagcagtgaggcagccccaaaccccagcagcactgatggctctgccctggcaaatgggcaccggggcactttggacggctacgtatattcctgtaaggagtgtgacttcaggtcccaggatgtgacccactttgtaggacacatgacttcagaacacacggactttaataaagacccacattttgtatgtacagggtgcagtttcctggcaaaaacccctgaagggctgtccctgcataatgccaagtgtcactcaggggaagccagctttctgtggaatgtgaccaagccagacaatcatgtggtggtggagcagagtgtccctgagaatgctagctcatctgtcctagcaggtgagtctactgaagggactgaaatcatcattaccaagactccaatcatgaagataatgaaaggcaaagctgaagccaagaaaatccatatgcttaaagagaacgctcctactcagcctggcggggaggccttgcctaagccattggccggggagacagagggtaaagagggggaccacactttcatcaatggggccactccagtcagtcaggcatctgctaattccacaaaaccccctcatactgccaatgggcccctgataggaacagtgcccgtattgccagctggcatagcacagttcctctccctccagcagcccacagtacatccccagcaccatccccaccaacccctgcccacatccaaggcccttccaaaagtcatgatccccctgagcagcatcccgacatacaatgcagccatggactccaacagttttctgaagaactccttccacaaattcccctacccaaccaaagctgagctctgctacttgactgtggtgaccaagtatccagaagaacagcttaaaatctggttcacagcccagagactgaagcagggaatcagctggtctcctgaggagatcgaagatgccaggaaaaagatgttcaatacagtcatccagtctgtgcctcagcccacaatcacagttctaaacacaccacttgttgccagtgctggcaatgtccagcacctcatccaggctgctctcccaggtcatgctgtgggacagcctgagggcacagcagggggcctgttggtcactcaaccattgatggccaatgggctacaagcatcaagctcatctctccccctgacaactgcatctgttcccaagccaactgcggcacccattaacactgtgtgttcaaatacaacatccgctgtgaaggttgtcaatgcagcccagtcactcctcacagcatgccccagcataacttcccaagctttccttgatgcaaacatctacaaaaataagaagtctcatgaacagctgtcggctctgaaaggaagcttctgccggaaccagtttcccgggcagagtgaagtagagcacctgaccaaagtcacaggcctcagcaccagagaggtccggaagtggttcagtgaccggagatatcactgccggaacctgaagggcaccagggccatggtgcctggagagcatggctctgttctcattgactctgtgccagaggtgccctttcccctgtcatctaaagttccagaggtgccctgtgtcccaacagcaacctcactagtgagtcaccctgccaccaaacgacagtcttggcaccagaccccagacttcacgccaaccaaatacaaagagagagccccagagcagctgcgagtgctagagagcagctttgcacaaaacccacttccccccgaggaggagctggaccgcctaagaagtgaaacaaaaatgacccggagggaaattgatggctggttctcagagaggcggaaaagggtgaatgcggaggagacaaagaaggctgatgggcatgcgcctcaggaggaggcagagggtgcggaggaggagggtagagatgaagagctggccagtgagctgagggctcctggtgaaaatggctcttcggaaatgtttcttagccataccttggcagaacggaaggttagccccatcaaaatcaacctcaagaacctgcgggtcactgaagccagtggcaagagtgagcttccggggatggggatgggtgtctgtgagcctgaggaagatggcttgaacaaggcggtagagcagccgcccagcagagtaagctacaagaagactgcacagcagcgccacttgctgcggcagctctttgtccagacacagtggcccagcaaccaggactacgactccatcatggcccaaacagggctgccccggccggaggtggttcgctggtttggtgatagcaggtatgcccttaagaacggccagctcaagtggtacgaagactataagaggggcaacttcccaccaggtttgctggtcatagcccctggcaaccgagagctgctgcaagattattacatgacacacaagatgctgtgtgaggaggacctgcagaccctctgcgagaagacccagatgagtgcccagcaggtcaagcagtggtttgctgagaaaatgggtgaagagacccgggctgtggcagatacaagcagtgaggatcagggccctggacacggagagcctgtggcagttgacaaggtgctgggcgatgcctgtgcagcgctgtctgagaacagtgaagcatgggagccaagtgctcctgaggccggctcagagccctttgacacttcaagtccccagtccggacgtcagctcgaaacagactgaatttgatctgattactgtgaaggaccggccagtctgggatgctgtctgccatgtggaaaggccaaacctgccacacatcatcttgatggccagctgccaggcaccaggagagcctctggagcctcgctgagcccagaacctgccgccaccccaaccaccctctgcctgacacttctaagcaagtagctatggtttctcatcagcctatcctcccacagtgcgggacctttccttggcctcccaaggacaaaccgttcagattgcatatacctagactcagaatcacgttgttagcatacacagttaataaagcatcctaccacagacattctcaatacataggaactcagctaccaaagcagtacaactctgacaatgccatgtctgttctctgggaagctgaggccacagggaccctcatcctctgcgcagtgggagtcgcaggcatgctcagaactgcatcaggcctgaccctacttgtcttctcaagggaacagactgttggaagagatctctgcgtcactgagtggaggcaagccacactttgtgccaggcttgtcttgtgttctgattgacacagaacccaccgttaccctaggttctgaacacagccaagctgtggcatcaccattggatgctaacctctctctagttaactgtaactctgctttttatggagtttgaatcatggaccaacttctccattatcagatcaactaaagaaaccattgtaaagcccaatctactggcctgtatgctcccttcaagtcaaactccgttagaacaaaaggaaagcggtcaaagtagagccagttgctgtggttttggccaccacagtgctcaatgcctcctgcaggtcagaaggaagtacatggtggctggtaggaagaatgaggctgaagggcttcggagagttgaagtgactagagctctcagtggtcttgagcacaaaggcctgcaggtgacagttctggcaaaatgcctttgtcacacaccaagggcctggccagctactggtttcaggatccagaggtgctgggcatccctggacagaaccccctgaggacatttttaaagttccacatgtatattcccagcctgagaaacaagtactctatctactttgcctaagcctcgtgtctttttaattaaaatcacaagaaatggtgcctttgaaacaatggaaaacttgcttagggagctgtactaaaccttaaagccccaggctctcctagactggcttctctgagagcagtaggcaaagcagggcaggggaaggaaaggacaaacaggctgtgtcacccatggccccacttaccttttggagactccatcaggaggatgagagctttgactaagaaggcagaggtcaacttctaggtgttctccctccccctcccacgggaggggaatagtttaaggatgatggaggccttcagccttttaggaaagagggctttctttgtaacccagggtcctggaactattatgtttctcctgctcttcctgtccccatagggatggcctcacatttgtcttagattgaggtgttgttttgtttttttgactacttggcaagttttgcagcctatttttgtatcctttctgtttggggagggaagctatttggccccaaaccttgaggagttggaaagaatgaatggtgagtgattgttttccttcagagaacagatgcctgaaaattttcctttagtgtttgtgta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