LOCUS       NM_001024772            2170 bp    mRNA    linear   ROD 15-JUL-2023
DEFINITION  Rattus norvegicus nuclear assembly factor 1 ribonucleoprotein
            (Naf1), mRNA.
ACCESSION   NM_001024772
VERSION     NM_001024772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Stanley SE, Gable DL, Wagner CL, Carlile TM, Hanumanthu VS,
            Podlevsky JD, Khalil SE, DeZern AE, Rojas-Duran MF, Applegate CD,
            Alder JK, Parry EM, Gilbert WV and Armanios M.
  TITLE     Loss-of-function mutations in the RNA biogenesis factor NAF1
            predispose to pulmonary fibrosis-emphysema
  JOURNAL   Sci Transl Med 8 (351), 351ra107 (2016)
   PUBMED   27510903
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J
            and Artandi SE.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Iles MM, Bishop DT, Taylor JC, Hayward NK, Brossard M, Cust AE,
            Dunning AM, Lee JE, Moses EK, Akslen LA, Andresen PA, Avril MF,
            Azizi E, Scarra GB, Brown KM, Debniak T, Elder DE, Friedman E,
            Ghiorzo P, Gillanders EM, Goldstein AM, Gruis NA, Hansson J,
            Harland M, Helsing P, Hocevar M, Hoiom V, Ingvar C, Kanetsky PA,
            Landi MT, Lang J, Lathrop GM, Lubinski J, Mackie RM, Martin NG,
            Molven A, Montgomery GW, Novakovic S, Olsson H, Puig S,
            Puig-Butille JA, Radford-Smith GL, Randerson-Moor J, van der Stoep
            N, van Doorn R, Whiteman DC, MacGregor S, Pooley KA, Ward SV, Mann
            GJ, Amos CI, Pharoah PD, Demenais F, Law MH, Newton Bishop JA and
            Barrett JH.
  CONSRTM   AMFS Investigators; IBD investigators; QMEGA and QTWIN
            Investigators; SDH Study Group; GenoMEL Consortium
  TITLE     The effect on melanoma risk of genes previously associated with
            telomere length
  JOURNAL   J Natl Cancer Inst 106 (10) (2014)
   PUBMED   25231748
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Egan ED and Collins K.
  TITLE     An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
  JOURNAL   Mol Cell Biol 32 (13), 2428-2439 (2012)
   PUBMED   22527283
REFERENCE   5  (bases 1 to 2170)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2170)
  AUTHORS   Fu D and Collins K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   7  (bases 1 to 2170)
  AUTHORS   Kittur N, Darzacq X, Roy S, Singer RH and Meier UT.
  TITLE     Dynamic association and localization of human H/ACA RNP proteins
  JOURNAL   RNA 12 (12), 2057-2062 (2006)
   PUBMED   17135485
REFERENCE   8  (bases 1 to 2170)
  AUTHORS   Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M and Henry Y.
  TITLE     hNaf1 is required for accumulation of human box H/ACA snoRNPs,
            scaRNPs, and telomerase
  JOURNAL   RNA 12 (5), 832-840 (2006)
   PUBMED   16601202
REFERENCE   9  (bases 1 to 2170)
  AUTHORS   Darzacq X, Kittur N, Roy S, Shav-Tal Y, Singer RH and Meier UT.
  TITLE     Stepwise RNP assembly at the site of H/ACA RNA transcription in
            human cells
  JOURNAL   J Cell Biol 173 (2), 207-218 (2006)
   PUBMED   16618814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000279.1.
            
            On Apr 23, 2021 this sequence version replaced NM_001024772.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094302.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               JACYVU010000279.1  2772109-2772485     c
            378-540             JACYVU010000279.1  2768335-2768497     c
            541-634             JACYVU010000279.1  2754704-2754797     c
            635-717             JACYVU010000279.1  2752470-2752552     c
            718-878             JACYVU010000279.1  2748158-2748318     c
            879-930             JACYVU010000279.1  2746031-2746082     c
            931-1033            JACYVU010000279.1  2744025-2744127     c
            1034-2170           JACYVU010000279.1  2741748-2742884     c
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2170
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="nuclear assembly factor 1 ribonucleoprotein"
                     /db_xref="GeneID:306387"
                     /db_xref="RGD:1306802"
     exon            1..377
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    67..69
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="upstream in-frame stop codon"
     CDS             106..1479
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="nuclear assembly factor 1 homolog"
                     /codon_start=1
                     /product="H/ACA ribonucleoprotein complex non-core subunit
                     NAF1"
                     /protein_id="NP_001019943.1"
                     /db_xref="GeneID:306387"
                     /db_xref="RGD:1306802"
                     /translation="

MEVVEAAAQLQTLKFGGSGPGSAASPPPEERPDAEQAEQAPPAGEQPPPAPSSDAGENPPPPSGPCATAPDAAEPLPELQDSDSSDSDSDSETDSDSSSSSSSSSSSSSSCGSLPPVLSDGEEDVQVEKENKNFPLKTKDELLLNELPSVEELTVTLPEDIALKPLGKVSSIIEQLVIIESMTNIPPVNEDTVIFKSDRQAAGKIFEIFGPVAHPFYVLRFNSSEHIESKGIKIKDTMYFAPSMKDFTQYIFTEKLKQDRGSDASWKNDQEPPPEALDFSDDEKEKEAKQRKKSQIQGRKKLKSELNESGEDFGEVHQNWNANSSSEHSKGYHNREFTRGFPRGRYSRGSHGRPPPQQYYNSDPMASQESLGFPPQRQDNPVMPHYPFPPPMFDMHNFPLPPPPPPPPTVSMGWAAPSMTSHPVLNLPYSLPPPPLPPPPPPPSPGESNSSHFGSYY"

     misc_feature    106..501
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="propagated from UniProtKB/Swiss-Prot (Q52KK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    106..108
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q96HR8; propagated from
                     UniProtKB/Swiss-Prot (Q52KK4.1); acetylation site"
     misc_feature    <151..>339
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated; Region: PRK07764"
                     /db_xref="CDD:236090"
     misc_feature    592..858
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="Gar1/Naf1 RNA binding region; Region: Gar1;
                     pfam04410"
                     /db_xref="CDD:427931"
     misc_feature    886..1014
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="propagated from UniProtKB/Swiss-Prot (Q52KK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    943..945
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q52KK4.1); phosphorylation site"
     misc_feature    1051..1269
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="propagated from UniProtKB/Swiss-Prot (Q52KK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1372..1476
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /note="propagated from UniProtKB/Swiss-Prot (Q52KK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            378..540
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            541..634
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            635..717
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            718..878
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            879..930
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1033
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..2170
                     /gene="Naf1"
                     /gene_synonym="RGD1306802"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgacgccgtgcggttacctgagagacgcgcgagttttagtgcggcgtgaaggcgtgcgcgtcttcttaggagaacctcgagctcgtcttaggcccgtgcggcgccatggaggtggtggaggctgccgcgcagctgcagacgctcaagttcggcggctccggcccgggatccgcagcatcgccgccacctgaggagcgcccggacgccgagcaggcggagcaggccccgccggcaggggagcagccgccgccagccccgagctcggatgctggtgaaaacccaccgccgccgagcgggccctgcgccaccgcaccggacgccgcggagccgctgccagagctgcaggactcggactcatcggactcggattcggacagtgaaacggattcggatagctcaagctcttcctcttcctcatcttcatcatcttcctcctgtggatcgcttcctcctgtgttgtcagacggagaggaggatgtccaagttgagaaagaaaataagaattttcctcttaaaacaaaagatgaattgcttcttaatgaactaccttctgtggaagaactcactgttactctgcctgaagacattgcactaaagcctcttgggaaggtttcgagcattattgaacagttagtgataattgagtctatgactaacatacctccagttaatgaggatactgtcattttcaaaagtgatcgacaagcagcagggaagatatttgagatctttggacctgttgcccatccattttatgtgttacggttcaattcttcagagcacattgagagtaaaggtatcaaaataaaggatactatgtattttgctccatcaatgaaagacttcactcagtatatattcacagaaaaactcaaacaggacagaggatctgatgcttcttggaagaatgatcaggaaccacctccagaagccttggatttcagtgatgatgagaaagaaaaagaagccaaacagaggaaaaagtctcagattcaaggccgcaaaaaactcaagtctgaattgaatgagtcaggtgaagattttggtgaagtgcatcagaattggaatgccaatagctcttcagaacattcgaaaggatatcacaacagggaattcacgagaggctttccgaggggcagatactctcgaggaagccatggcagacctccgccacagcagtactataactcagatcctatggcatctcaagagagcttgggatttccacctcagagacaagataatcctgtcatgccccactatccttttcccccacccatgtttgatatgcataactttccactgccgcccccgcccccacccccaccaacggttagcatggggtgggctgcacctagcatgacctctcatcctgttcttaacttaccatactccctaccccctcctccacttcctcctccccctcctcctccctctcctggggaaagtaattcttctcattttggatcttactattagttctatgcttgtatttcagagaaatatggtaaaaaaaatttaaacaaaaatatattatagaactagatttaaaaaaaaaccactgtaaaatactaaatcaaatgattcagttgtacgttcatatatattttaagtaactcagttgtgagttcatatatgtttgtaacctttatgaaggtattcatagggacagttcatctcattcttagaaaacatgtaatatttaaatattgactcatgtcctccattacccacagctggttaacaatgtgtacagtagtggttatgaagcgggtttcatcacagcctctaatatgctgaccactgaattgtctttttagtataatcttaaaatgttgaagtcctactaagagtctttaaaataaagtatttttataaacttgacacctttgaaattgattgtaaatgcaagaattctttaaacttgatttccttaagcgagttaggagtgtgaaggaggaagacactattggccgaagctctcactagctggttagtattagctatgtattggcagacatccgttttctgtgtagctgtccgttattgggaaagctttactgtctgctgcttccattaaggcgtgtatatatgtgtattctgtgtctgttcccaggctctccagtgtctgacatggatgacatgcataataaaggcattgaatgactga

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