LOCUS       NM_001024761            1836 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus LRR binding FLII interacting protein 2 (Lrrfip2),
            transcript variant 1, mRNA.
ACCESSION   NM_001024761 XM_217271
VERSION     NM_001024761.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Dai P, Jeong SY, Yu Y, Leng T, Wu W, Xie L and Chen X.
  TITLE     Modulation of TLR signaling by multiple MyD88-interacting partners
            including leucine-rich repeat Fli-I-interacting proteins
  JOURNAL   J Immunol 182 (6), 3450-3460 (2009)
   PUBMED   19265123
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Fong KS and de Couet HG.
  TITLE     Novel proteins interacting with the leucine-rich repeat domain of
            human flightless-I identified by the yeast two-hybrid system
  JOURNAL   Genomics 58 (2), 146-157 (1999)
   PUBMED   10366446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC097955.1.
            
            On Jun 10, 2005 this sequence version replaced XM_217271.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1836
                     /gene="Lrrfip2"
                     /note="LRR binding FLII interacting protein 2"
                     /db_xref="GeneID:301035"
                     /db_xref="RGD:1306234"
     exon            1..212
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..284
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..428
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    327..329
                     /gene="Lrrfip2"
                     /note="upstream in-frame stop codon"
     CDS             339..1652
                     /gene="Lrrfip2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat flightless-interacting protein 2; LRR
                     FLII-interacting protein 2; leucine rich repeat (in FLII)
                     interacting protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat flightless-interacting
                     protein 2 isoform 1"
                     /protein_id="NP_001019932.1"
                     /db_xref="GeneID:301035"
                     /db_xref="RGD:1306234"
                     /translation="

MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQRESSSKDITGTHWSRASTPKRRDMMYDSIKDRSSRVSSLLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPESTPNGDVNHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAEEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAEKRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ"

     misc_feature    390..392
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    435..794
                     /gene="Lrrfip2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V7E8.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    477..1424
                     /gene="Lrrfip2"
                     /note="LRRFIP family; Region: LRRFIP; pfam09738"
                     /db_xref="CDD:430789"
     misc_feature    678..680
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y608; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    687..689
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y608; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    711..713
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    723..725
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y608; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    735..737
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    744..746
                     /gene="Lrrfip2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q91WK0; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    747..749
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91WK0; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     misc_feature    750..752
                     /gene="Lrrfip2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91WK0; propagated from
                     UniProtKB/Swiss-Prot (Q4V7E8.1); phosphorylation site"
     exon            429..515
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..584
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..626
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..671
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..788
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..959
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1052
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1185
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1235
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1356
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1436
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1541
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1812
                     /gene="Lrrfip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggctggggttgcctggagggtctccggctagcttctcccgccccccgcgggggaaaaaagggttacgccccttggaccgggcatcacttgggacagctgggtgctccagctcccgttgctcccggcgccacactctctcagactctttcccctgtcccgggaggagccgccccgggaacggtgtcaggccggtggagggcgtagctttttaaatgtgggaagacaaatgaagggatttagaaaccaaataaatgccagtggaaaggagagctaccatcactaagtgctgaacacgagtaaactcattttcagagttaaaaaattattaaaaaaacaagatggggactcctggttctggaaggaaaagaacaccagtgaaagatcgattttctgcagaagatgaagctttgagtaacatcgccagagaggctgaagcaaggctagcagcaaagcgggccgccagggcagaagcaagagacatccgcatgagggaactggaacgacagcagagagagagttcatcgaaggatattactggaacacactggagcagagccagtacgcccaagaggagagacatgatgtatgattccatcaaggacagatcatcaagagtttcatcattattggatgaaaaatctgacaaacagtatgctgaaaattacacaagaccctcatctcgaaattctgcgtcagcaacaacacctctaagcggaaactcatccagacggggtagtggggacaccagtagtttaatagacccagacacctcgttaagtgaactgcgggagtctttgtctgaagtagaagagaagtacaagaaagccatggtgtccaatgcacaactagacaacgagaagaacaatctgatctaccaggtggacaccctcaaggacgtcatcgaggagcaggaggagcagatggcagagttctatagagaaaacgaagagaaatcaaaggagttggaacggcagaaacatatgtgcagtgtgctgcagcataagatggatgaactgaaagagggccttcggcagagggacgagctcatcgagaagcacggcttagttataatcccagagagtactcccaatggcgacgtcaatcatgagcctgtggttggagccattactgctgtgtctcaggaagctgctcaggtcttggagtcagcaggagaagggccactagatgtgaggctgcggaagcttgctgaggaaaaggacgagctcctgtcacagattagaaaactgaagctccagttagaggaagaacggcagaagtgttccaggaatgatggcatgtccggggacctggcagggctgcagaacggctccgacttgcagttcatcgagatgcagagagacgccaatagacaaattagtgaatacaaattcaagctttcgaaagcagaacaagacatagctaccttggaacaaagtatcagccggcttgaggggcaggtgctgaggtacaagactgccgctgagaacgctgagaagattgaagacgagctgaaagcagagaagaggaagctacagcgagagctacggacagcacaggacaagatcgaggagatggagatgaccaacagccacctggcaaagcggctagagaagatgaaggccaacaggacagcccttctagcccagcagtaggaggcagcccctccacctgggtgctgctctgagggctttgctgggagatactgactcttgtacattgacacagccccttccagtactgttttgagtcttgtcattaaacagccacctttgtattttataatttatgagaatgaagcaggtttaatcgttaaaaaaaaaaaaaaaaaaaaaaaaa

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