LOCUS       NM_001013074            4393 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Rattus norvegicus PBX/knotted 1 homeobox 1 (Pknox1), transcript
            variant 1, mRNA.
ACCESSION   NM_001013074 XM_039098545 XM_215364
VERSION     NM_001013074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4393)
  AUTHORS   Ye,D., Lou,G., Zhang,T., Dong,F. and Liu,Y.
  TITLE     MiR-17 family-mediated regulation of Pknox1 influences hepatic
            steatosis and insulin signaling
  JOURNAL   J Cell Mol Med 22 (12), 6167-6175 (2018)
   PUBMED   30338914
  REMARK    GeneRIF: These data implicate the upregulated hepatic expression of
            Pknox1 in type 2 diabetes mellitus (T2DM) complicated with
            nonalcoholic fatty liver disease (NAFLD) may be caused by the
            reduced expression of miR-17 family, indicating that developing
            miRNA-mediated regulation strategies on Pknox1 may provide new
            therapeutic options for metabolic disease
REFERENCE   2  (bases 1 to 4393)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   3  (bases 1 to 4393)
  AUTHORS   Di Rosa,P., Villaescusa,J.C., Longobardi,E., Iotti,G., Ferretti,E.,
            Diaz,V.M., Miccio,A., Ferrari,G. and Blasi,F.
  TITLE     The homeodomain transcription factor Prep1 (pKnox1) is required for
            hematopoietic stem and progenitor cell activity
  JOURNAL   Dev Biol 311 (2), 324-334 (2007)
   PUBMED   17904118
REFERENCE   4  (bases 1 to 4393)
  AUTHORS   Yoshioka,H., Geyer,C.B., Hornecker,J.L., Patel,K.T. and
            McCarrey,J.R.
  TITLE     In vivo analysis of developmentally and evolutionarily dynamic
            protein-DNA interactions regulating transcription of the Pgk2 gene
            during mammalian spermatogenesis
  JOURNAL   Mol Cell Biol 27 (22), 7871-7885 (2007)
   PUBMED   17875925
REFERENCE   5  (bases 1 to 4393)
  AUTHORS   Zhang,X., Rowan,S., Yue,Y., Heaney,S., Pan,Y., Brendolan,A.,
            Selleri,L. and Maas,R.L.
  TITLE     Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic
            development
  JOURNAL   Dev Biol 300 (2), 748-757 (2006)
   PUBMED   17049510
REFERENCE   6  (bases 1 to 4393)
  AUTHORS   Bailey,J.S., Rave-Harel,N., McGillivray,S.M., Coss,D. and
            Mellon,P.L.
  TITLE     Activin regulation of the follicle-stimulating hormone beta-subunit
            gene involves Smads and the TALE homeodomain proteins Pbx1 and
            Prep1
  JOURNAL   Mol Endocrinol 18 (5), 1158-1170 (2004)
   PUBMED   14764653
REFERENCE   7  (bases 1 to 4393)
  AUTHORS   Villaescusa,J.C., Verrotti,A.C., Ferretti,E., Farookhi,R. and
            Blasi,F.
  TITLE     Expression of Hox cofactor genes during mouse ovarian follicular
            development and oocyte maturation
  JOURNAL   Gene 330, 1-7 (2004)
   PUBMED   15087118
REFERENCE   8  (bases 1 to 4393)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   9  (bases 1 to 4393)
  AUTHORS   Ferretti,E., Schulz,H., Talarico,D., Blasi,F. and Berthelsen,J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
REFERENCE   10 (bases 1 to 4393)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Nov 15, 2024 this sequence version replaced
            XM_039098545.2, NM_001013074.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.60938.1,
                                           SRR26643289.43669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000020.1  9664212-9664335
            125-232             JAXUCZ010000020.1  9681691-9681798
            233-360             JAXUCZ010000020.1  9685888-9686015
            361-532             JAXUCZ010000020.1  9687927-9688098
            533-703             JAXUCZ010000020.1  9689376-9689546
            704-803             JAXUCZ010000020.1  9692503-9692602
            804-901             JAXUCZ010000020.1  9693257-9693354
            902-1030            JAXUCZ010000020.1  9696043-9696171
            1031-1107           JAXUCZ010000020.1  9698893-9698969
            1108-1280           JAXUCZ010000020.1  9701776-9701948
            1281-4393           JAXUCZ010000020.1  9703216-9706328
FEATURES             Location/Qualifiers
     source          1..4393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4393
                     /gene="Pknox1"
                     /note="PBX/knotted 1 homeobox 1"
                     /db_xref="GeneID:294322"
                     /db_xref="RGD:1305003"
     exon            1..124
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            125..232
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    161..163
                     /gene="Pknox1"
                     /note="upstream in-frame stop codon"
     CDS             182..1492
                     /gene="Pknox1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein PKNOX1"
                     /codon_start=1
                     /product="homeobox protein PKNOX1 isoform 1"
                     /protein_id="NP_001013092.1"
                     /db_xref="GeneID:294322"
                     /db_xref="RGD:1305003"
                     /translation="

MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSDPDAEGVSPPPIESQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKDGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQEDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKPAQNRPVQRFWPDSLASGVAQATPGELAMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEDEGGALAPTHISGLVLENSDSLQ"

     misc_feature    419..676
                     /gene="Pknox1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(959..973,977..979,1037..1039,1055..1057,1094..1096,
                     1100..1105,1112..1117,1121..1129)
                     /gene="Pknox1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(965..967,974..976,1103..1105,1112..1117,1124..1126)
                     /gene="Pknox1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1013..1129
                     /gene="Pknox1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            233..360
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..532
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..703
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..803
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..901
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1030
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1107
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1280
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..4393
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcctcccattgagcgaggctgtgtcgcgtggcccggcgtcggcgtgacggttggacgcgggcgcggcactgcgggtcccgattgctgcagccgcttgtcagtgtgatgaagattggcacccagacaccattcgcttctcactcaagatgatctgatgtctgaagtgaactctcatcaaccatgatggctacacagacgctaagtatagacagctatcaagatggacaacaaatgcaggtggtcactgagttgaaaacagagcaggatcccaactgctctgacccggatgcagaaggagtgagtcctcctcccatcgagtctcagaccccgatggatgccgacaagcaggccatttataggcacccgctatttccattgctagctttgctgtttgagaaatgtgagcagtccacacagggatcagaaggcacgacgtccgccagcttcgatgtggacattgagaactttgtcaggaagcaagaaaaggacgggaagcccttcttctgtgaagatccggaaacagacaacttaatggtgaaagcaatccaggtcctgcgtattcatcttcttgaactggagaaggtgaacgagctctgtaaagacttctgtagtcggtacattgcctgtctgaagacaaaaatgaacagcgagaccctgctgagtggggagcctggaagtccgtactccccagtgcagtcccagcagattcaaagcgccatcacaggcactctcagcccccagggaatcgtggtgccagcatcagccctgcaacaggggaatgtaaccatggcaacagtggcaggtggcacagtgtaccagcctgtcaccgtcgtcactccacaaggccaagtggtcacgcaggcattatctcctgggacaattaggatccagaactcgcagcttcaattgcagttgaaccaggatctcagcatcttgcatcaagaggacggctcctccaagaacaagaggggcgtcctgccgaagcacgccaccaacgtgatgcgttcctggctcttccagcacatagggcatccctaccccaccgaggatgagaagaagcagattgctgctcagacaaacttgacactgcttcaagtcaacaactggttcatcaatgcccgaagacggattctccagccaatgttggattccagctgttcagagactccaaaaacaaagaaaaagcctgctcagaacaggccagttcagaggttttggccggattctcttgcatcaggagtggcacaagcaacacccggagagctcgccatgtcggaaggtgccgttgtgaccatcaccacacctgtaaacatgaatgtggacagccttcagtccctgtcctcagacggggccaccctggcggtacagcaggtcatgatggcggggcagagtgaggacgagtcggtggatagcacagaagatgagggtggcgccctggcacccacacacatcagcgggctggtgctggagaacagcgactcccttcagtaggaacggagtggaacggccagtgtggagcctggacgccggactctttactgtttgcacagcaaacattttacagttttctttgtaacatgttttatatgtagatatagaagagtgcacttttgtatctcacagcttcaagacgtcttcgctggtgcagcagcttccttcagatgtgcgtgtatgggtttttaatgctagaaacgtgatgagtggcccctgccccttgagtccctgacgagattaaggaacagtgctgccattttctaaaaaattatgcagttgcaattgagttctgtggtttacagcaggtctgggggctgctgccagtgtcgcccacgggtctgaaagatgacctgcactcgggctgcagagcgagaggacgctggccctggtgggcggtgagtgctcacaacacacttcagttctctcgggcagcatttgcctgtttcatttgctatatagaaaaagaaactcctatttttaccttgctgggattattggataaaaagctatttttataaatcagttattaattggattatgactatattgaggataaatttctagagaagcaacagcacacgcttgtctttctactcggaaagttgtgaaaggcagccacccatgcatggcctcctgctccctgcggaagaggaggaggctcaccttagctgctaaaagggaacaactgtcacgtgagctttgatatctccagtttctgttcatatatgatgtgcagattgtgttttacactcgctgtagcatctcacagagtgtgctagcatctcacagagtgtgctagcatctcacagagtgtgctagcatcttacagagtgtgctctgtaggacgtacggttagtgagggctctgccgtgcctcgtctgactgcagttacgtggctgccgcctggccatgttaactgggtggtaattttagatttttttttttagttaaaacccgttatacatagaatgtttattataaactaatataaagtgtgctctacaccactggctcagagctggggtaaacagcaaacccctaaactgtccttctgactagaagacacctggaagttagaactgtggaggtgccatggcggtgggccactggtggctctcactgccactcccctccttcttgggtcctcccctctccgttcccactccagcttcaggacagtttgggaacttcatttcccagtgtcaaggcagagcagactgtaggctgaggtctggtttgattcattttggtttacttgggaagctttctcttaggaaacaagtgcccgcttcatgctgagcgtctgtttccacagtgcgccgaggcccacctgctgaaagggaaccgctgtgccttgggccccatgggtggtaattgcttatggaccaaggttaccctaaggggagctcgttagccaattcacacttttctggaacacttcacagtccccccaaatgtcttgattctcttcagccattgagcacacctggacagccaagtagtcagcacgaaaagtgggggctcctttagaaccacttacggtgcctccactacaagaaaaagaaaacagcaaaataaacaaaacctaaaagctcccagcaactccttagaggagagaaggacatcttaagcagcccttctcctccctattcacgactgctttaggatttaagtcaggcgcacggaagcctcacagtcagctggctacactgggtttagagcagaggtacatcaccctgcgagccctgcagaagtctgccactcccctccgcaaaggatgcacagcccctgccgtcccgcctctgtcccagctgctctagctgggatttgaacaccatgactctcgtgtccttcccagttgagatcatcttccctaagcactgaactctcacctgctaaccccagaggaaaccatgaagatcataagagatcctgggcatggtgacacactcctgttatcccaacactcaggagcctgagacaggaggtaagcctgggctatttaacttgaccctgtctaaaaaaaaaataaaaaagggttgtaaaagagctggcacagggtcatatccttccacctccccatgcatagagatgcatagagtgagtcctgtgaggcaagccttgctggttcatagagttcctgtccagcagacttgtctccccgttgcaccttttcaagacacctgattactgggcattgtggcatttgcctgtatacaagcacttaggaagctgaagcaggaggattgctgggaggttgaatctgcctctggtgcctagggaaaccctgtctcacaaaaccaagcaaaattcctgctctcctttcccctggccagtggagaaaacctgaaagtacatctcctttgagctttgtttaaatggccggattctagcattcgttcccgttaaagttctccctaacattggagccctttgaatgtcttctgagacctacagtcaacccgtgtcatacctgctgtttggctgcctagcagaaaatctagactggttgacccacccatctggtgggctccggttttctgcttccttgagtccagattgtcgaatagaagtgtatatgcaatatgcaccgtgacccttcccgctagggctgatgggccactgtgtagcctgctgcgtggccggcgcacctgtgggggctgcgggagacttgctcctcccccatggctggcagggaacgcccatcccgcaggcccctcccacaggtagtgacggaacccgcaggctgccttcttcagttaagttccgtctttgaaactgacaatctttaaaatgtgaatactgtaacaatatgttttcttggattgttgtctttaaaaggattttttgtgaagcaactgatttatcaaagaaaaaaaaattaaaaccagaaacatg

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