2024-03-29 01:45:31, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001008514 1626 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus claudin 19 (Cldn19), mRNA. ACCESSION NM_001008514 XM_216519 VERSION NM_001008514.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1626) AUTHORS Ziemens A, Sonntag SR, Wulfmeyer VC, Edemir B, Bleich M and Himmerkus N. TITLE Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney Inner Medullary Collecting Duct Cells JOURNAL Int J Mol Sci 20 (18), 4401 (2019) PUBMED 31500238 REMARK GeneRIF: Results suggest that claudin-19 is part of the collecting duct tight junction (TJ) complex. Its presence in the TJ is under the control of ambient interstitial tonicity. Under iso-osmotic conditions, it is responsible for a high electrical transepithelial resistance and contributes to the tonicity-induced changes in paracellular ion selectivity. Publication Status: Online-Only REFERENCE 2 (bases 1 to 1626) AUTHORS Monzon CM and Garvin JL. TITLE Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs JOURNAL Am J Physiol Renal Physiol 317 (2), F411-F418 (2019) PUBMED 31166708 REMARK GeneRIF: claudin-19 mediates the effects of the NO/cGMP signaling cascade on the paracellular pathway in the thick ascending limb of the loop of Henle. REFERENCE 3 (bases 1 to 1626) AUTHORS Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA and Rizzolo LJ. TITLE Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression JOURNAL Exp Eye Res 151, 179-189 (2016) PUBMED 27593915 REFERENCE 4 (bases 1 to 1626) AUTHORS Hu B, Arpag S, Zhang X, Mobius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J and Li J. TITLE Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP JOURNAL PLoS Genet 12 (9), e1006290 (2016) PUBMED 27583434 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 1626) AUTHORS Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S and Fujiyoshi Y. TITLE Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin JOURNAL Science 347 (6223), 775-778 (2015) PUBMED 25678664 REFERENCE 6 (bases 1 to 1626) AUTHORS Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig IE. TITLE Structure and function of claudins JOURNAL Biochim Biophys Acta 1778 (3), 631-645 (2008) PUBMED 18036336 REMARK Review article REFERENCE 7 (bases 1 to 1626) AUTHORS Lee NP, Tong MK, Leung PP, Chan VW, Leung S, Tam PC, Chan KW, Lee KF, Yeung WS and Luk JM. TITLE Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease JOURNAL FEBS Lett 580 (3), 923-931 (2006) PUBMED 16427635 REFERENCE 8 (bases 1 to 1626) AUTHORS Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T, Nakayama K, Okamura Y, Sasaki H, Miyachi Y, Furuse M and Tsukita S. TITLE Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice JOURNAL J Cell Biol 169 (3), 527-538 (2005) PUBMED 15883201 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079172.1. On Dec 16, 2004 this sequence version replaced XM_216519.2. ##Evidence-Data-START## Transcript exon combination :: BC079172.1, EX488559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760384, SAMEA5760433 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1626 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="5" /map="5q36" gene 1..1626 /gene="Cldn19" /gene_synonym="claudin-19" /note="claudin 19" /db_xref="GeneID:298487" /db_xref="RGD:1305000" exon 1..307 /gene="Cldn19" /gene_synonym="claudin-19" /inference="alignment:Splign:2.1.0" misc_feature 22..24 /gene="Cldn19" /gene_synonym="claudin-19" /note="upstream in-frame stop codon" CDS 85..720 /gene="Cldn19" /gene_synonym="claudin-19" /codon_start=1 /product="claudin-19" /protein_id="NP_001008514.1" /db_xref="GeneID:298487" /db_xref="RGD:1305000" /translation="
MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKGRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAILGGSFLCCTCPEPERANSIPQPYRSGPSTAAREYV"
misc_feature 94..630 /gene="Cldn19" /gene_synonym="claudin-19" /note="PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl21598" /db_xref="CDD:451326" misc_feature 106..168 /gene="Cldn19" /gene_synonym="claudin-19" /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1); transmembrane region" misc_feature 328..390 /gene="Cldn19" /gene_synonym="claudin-19" /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1); transmembrane region" misc_feature 436..498 /gene="Cldn19" /gene_synonym="claudin-19" /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1); transmembrane region" misc_feature 565..627 /gene="Cldn19" /gene_synonym="claudin-19" /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1); transmembrane region" exon 308..472 /gene="Cldn19" /gene_synonym="claudin-19" /inference="alignment:Splign:2.1.0" exon 473..557 /gene="Cldn19" /gene_synonym="claudin-19" /inference="alignment:Splign:2.1.0" exon 558..1594 /gene="Cldn19" /gene_synonym="claudin-19" /inference="alignment:Splign:2.1.0" ORIGIN
ctgttcctcttaccatgaccatagcgctcctccagaccctggcccatctctgagtcctggaaccctcagactcctacctgggccatggccaactcaggcctccagctcctgggctacttcctagccttgggtggctgggtgggcatcatcgccagcaccgccctgccacagtggaagcagtcctcctatgcaggcgatgccatcatcactgccgtgggcctctacgaagggctgtggatgtcctgcgcctctcagagcaccgggcaggtgcaatgcaaactctacgattcactcctggccctggacggtcatatccagtcagcaagagccctgatggtggtggctgtgctcctgggctttgtggccatggtgctcagtgtcgtgggcatgaagtgtactcgggttggagacagtaaccccactgccaagggccgtgtggccatctccggaggtgctctcttcctcttggcgggtctctgtactttgactgctgtctcatggtacgctaccctggtgacccaggaattcttcaaccccagcactcctgtcaacgccaggtatgaatttggtccagctctgttcgtcggctgggcctctgctgggctggccatcctgggcggttcctttctctgctgcacatgcccagagcctgagagagccaacagcatcccgcagccctatcgctctggaccctcaacggctgcccgagagtacgtctgagtctgcctaccctgcccagccccattgcccagcagccccattgtccagaactcgtgccagactatatagtaccctgggcagggtagatggggtacggatcacttgaactcagtctggagctccaagcacctggtcctcagcataggctctgagtcccagactcagacagtcaaagagagatcagaggcaagaccccgcccacacgtgacccagtaaggaccaggcctgttctgtctacatcagaatgagtatcagaatttatacactagcttagctacaggctccttcgcttgccaacttatttgctgaaggacccatctgcctagtataggctgggccctgagggcttcccagcaacagaaggatctcagcgcacggtgctttgggtcagacagacttccatactccatccagttctcacagcaagcacatagaagaagtactctgggttaaggactgtctccacatcagacccaaggacactgaactttagagagacacggaggcgtggctctccaatctgtgagatcatgcctcagcctctggcagtcagttacccaacattgtttggatgcccatacaggtctcgagggcagactgtcactcccacccctaggaaggggccccaggcagggctgccatcagaatcctgctcctgggcctgaactctgcagcccccgtctctctcagccatcgctcaccccactaaccagctttctctcttttgacttgcagacccgttgttaagttgtccacctcggtcaagggccccctgggtgtgtaaaggccaggttcccagccaggccctgccccctaccatctctagactgtgtgtttgatatttctggaaagagaagcgaacattcagccccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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