LOCUS       NM_001008303            1170 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus small nuclear ribonucleoprotein polypeptide A
            (Snrpa), mRNA.
ACCESSION   NM_001008303 XM_214845
VERSION     NM_001008303.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1170)
  AUTHORS   Kondo Y, Oubridge C, van Roon AM and Nagai K.
  TITLE     Crystal structure of human U1 snRNP, a small nuclear
            ribonucleoprotein particle, reveals the mechanism of 5' splice site
            recognition
  JOURNAL   Elife 4, e04986 (2015)
   PUBMED   25555158
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1170)
  AUTHORS   Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia
            Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y,
            Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M,
            Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE,
            Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ and Peng J.
  TITLE     U1 small nuclear ribonucleoprotein complex and RNA splicing
            alterations in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16562-16567 (2013)
   PUBMED   24023061
REFERENCE   4  (bases 1 to 1170)
  AUTHORS   Pabis M, Neufeld N, Steiner MC, Bojic T, Shav-Tal Y and Neugebauer
            KM.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   5  (bases 1 to 1170)
  AUTHORS   Zhang L, Li X and Zhao R.
  TITLE     Structural analyses of the pre-mRNA splicing machinery
  JOURNAL   Protein Sci 22 (6), 677-692 (2013)
   PUBMED   23592432
  REMARK    Review article
REFERENCE   6  (bases 1 to 1170)
  AUTHORS   Novakova Z, Man P, Novak P, Hozak P and Hodny Z.
  TITLE     Separation of nuclear protein complexes by blue native
            polyacrylamide gel electrophoresis
  JOURNAL   Electrophoresis 27 (7), 1277-1287 (2006)
   PUBMED   16502463
REFERENCE   7  (bases 1 to 1170)
  AUTHORS   Sinha K, Perumal K, Chen Y and Reddy R.
  TITLE     Post-transcriptional adenylation of signal recognition particle RNA
            is carried out by an enzyme different from mRNA Poly(A) polymerase
  JOURNAL   J Biol Chem 274 (43), 30826-30831 (1999)
   PUBMED   10521474
REFERENCE   8  (bases 1 to 1170)
  AUTHORS   Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P,
            Sleeman J, Lamond A and Mann M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   9  (bases 1 to 1170)
  AUTHORS   Nagai K, Oubridge C, Jessen TH, Li J and Evans PR.
  TITLE     Crystal structure of the RNA-binding domain of the U1 small nuclear
            ribonucleoprotein A
  JOURNAL   Nature 348 (6301), 515-520 (1990)
   PUBMED   2147232
REFERENCE   10 (bases 1 to 1170)
  AUTHORS   Craft J, Mimori T, Olsen TL and Hardin JA.
  TITLE     The U2 small nuclear ribonucleoprotein particle as an autoantigen.
            Analysis with sera from patients with overlap syndromes
  JOURNAL   J Clin Invest 81 (6), 1716-1724 (1988)
   PUBMED   2968364
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086331.1.
            
            On Dec 16, 2004 this sequence version replaced XM_214845.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086331.1, SRR8487227.335273.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1170
                     /gene="Snrpa"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
     exon            1..63
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            64..158
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="Snrpa"
                     /note="upstream in-frame stop codon"
     CDS             86..931
                     /gene="Snrpa"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_001008304.1"
                     /db_xref="GeneID:292729"
                     /db_xref="RGD:1307416"
                     /translation="

MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPAAKKAVQGGAAAPVVGAVQPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK"

     misc_feature    104..370
                     /gene="Snrpa"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1A); Region:
                     RRM1_U1A; cd12477"
                     /db_xref="CDD:409906"
     misc_feature    <119..>706
                     /gene="Snrpa"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; Region: PABP-1234; TIGR01628"
                     /db_xref="CDD:130689"
     misc_feature    order(122..124,128..133,140..142,215..217,221..223,
                     227..247,251..253,323..325,332..334,338..361)
                     /gene="Snrpa"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:409906"
     misc_feature    671..928
                     /gene="Snrpa"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A
                     or U1A); Region: RRM2_U1A; cd12480"
                     /db_xref="CDD:409908"
     exon            159..331
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            332..508
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            509..682
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            683..771
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1146
                     /gene="Snrpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaagctgtgtgtctttgcagcgtagcttggcgggcgctgtcggtctgagcgacggcttaggtgcagtacctgaacatctcacaccatggcagttcccgagacccgtcccaaccacactatttatatcaacaatctcaatgagaagatcaagaaagatgagctcaagaagtccctgtatgccatcttctcccagtttggccagatcctggatatcctggtgtctcggagcctgaagatgaggggccaggccttcgtcatcttcaaggaggtcagcagtgccaccaacgccctgcgttccatgcagggcttccctttctacgacaagcccatgcgtatccagtacgcaaagactgactcagacatcattgccaaaatgaagggcacctttgtggagagagatcgcaaacgtgagaagaggaagcccaagagtcaggagacacctgctgccaaaaaggctgttcagggtggggcagctgcccctgtggttggcgctgtccagcctgtaccgggcatgccaccgatgactcaggcaccccgcatcatgcaccacatgccaggacagcctccctacatgccaccacctggcatgatcccgccaccaggccttgctcctggccagatccctcctggggcaatgcccccacagcagctcatgcctgggcagatgccacctgcccaacctctctcggagaatccacccaatcacatcctgttcctcaccaacctgcctgaggagaccaacgagctcatgctctccatgctcttcaaccagttccctggcttcaaggaggtgcgtctggtccctgggcgccatgacattgccttcgtggagtttgacaatgaagtgcaggctggggcagcacgagatgccctgcaaggcttcaagatcacacagaacaatgcaatgaagatctcttttgccaagaagtagcacctttccctacggagtgccccagtccccattctggggctgccccttccccctctcttggctcagtccctgaaggtaagtcccccttgggggccttctcagagccgtgagtgagtgtgtgtctgccacacagcattgtacccagggtcttcccagacattgcacctggcgctgttgggttgtgattaaagtgagtttttaggtttggtttttcaaaaaaaaaaaaaaaaaaaaaaaaa

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