LOCUS       NM_001005878            2316 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus kinesin family member C1 (Kifc1), mRNA.
ACCESSION   NM_001005878 XM_215324
VERSION     NM_001005878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2316)
  AUTHORS   Muralidharan H and Baas PW.
  TITLE     Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon
  JOURNAL   J Neurosci 39 (20), 3792-3811 (2019)
   PUBMED   30804089
  REMARK    GeneRIF: Study shows that KIFC1, a molecular motor well
            characterized in mitosis, is robustly expressed in neurons, where
            it has profound influence on the organization of microtubules in a
            number of different functional contexts.
REFERENCE   2  (bases 1 to 2316)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2316)
  AUTHORS   Yang WX, Jefferson H and Sperry AO.
  TITLE     The molecular motor KIFC1 associates with a complex containing
            nucleoporin NUP62 that is regulated during development and by the
            small GTPase RAN
  JOURNAL   Biol Reprod 74 (4), 684-690 (2006)
   PUBMED   16371587
REFERENCE   4  (bases 1 to 2316)
  AUTHORS   Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB,
            Abraham RT and Jiang W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   5  (bases 1 to 2316)
  AUTHORS   Yang WX and Sperry AO.
  TITLE     C-terminal kinesin motor KIFC1 participates in acrosome biogenesis
            and vesicle transport
  JOURNAL   Biol Reprod 69 (5), 1719-1729 (2003)
   PUBMED   12826589
  REMARK    GeneRIF: KIFC1, perhaps in association with nuclear factors,
            assists in the formation and/or elongation of the spermatid
            acrosome
REFERENCE   6  (bases 1 to 2316)
  AUTHORS   Sperry AO and Zhao LP.
  TITLE     Kinesin-related proteins in the mammalian testes: candidate motors
            for meiosis and morphogenesis
  JOURNAL   Mol Biol Cell 7 (2), 289-305 (1996)
   PUBMED   8688559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083827.1.
            
            On Oct 22, 2004 this sequence version replaced XM_215324.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2316
                     /gene="Kifc1"
                     /note="kinesin family member C1"
                     /db_xref="GeneID:294286"
                     /db_xref="RGD:1359118"
     exon            1..141
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2133
                     /gene="Kifc1"
                     /note="kinesin-related protein KRP1; kinesin-related
                     protein 1"
                     /codon_start=1
                     /product="kinesin-like protein KIFC1"
                     /protein_id="NP_001005878.1"
                     /db_xref="GeneID:294286"
                     /db_xref="RGD:1359118"
                     /translation="

MRGRGSRDTGTQSAAFASRPVRTTVDMQAQRAPLMEVKRNLELSTTLVKSSSRLPLPGSRLKRGPDQMEDGLEPAKKRTRGMGTVTKVDTSRPRGPPLSAVSTAAQKGPRKTGPRGCSAVGPVLRNQKPAPAAPAQKPGTSTAPAVAGKKPGKRPAWDLKGQLCDLHEELKQYREKTQTLDRENQGLREQLREVQEQATTLGTERNTLEEELASVRRRAEQSQQKLETLGARVLELEECLGTKERLVQELQTERLQLQEERSTLSTQLEEREREFQASEAALSSSRAEVLCLRQKTAAQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTRLCLSRSDDRRSTLTRAPAAATRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGDCEIRRAGPGSEELTVTNARYVPVSCEKEVEALLHLAQQNRAVARTAQNERSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLAGSERLDPGLTLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK"

     misc_feature    52..123
                     /gene="Kifc1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI63.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    193..519
                     /gene="Kifc1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI63.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    205..207
                     /gene="Kifc1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q5XI63.1); phosphorylation site"
     misc_feature    226..228
                     /gene="Kifc1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q5XI63.1); phosphorylation site"
     misc_feature    <544..1032
                     /gene="Kifc1"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    1033..2106
                     /gene="Kifc1"
                     /note="Kinesin motor domain, KIFC2/KIFC3/ncd-like
                     carboxy-terminal kinesins; Region: KISc_C_terminal;
                     cd01366"
                     /db_xref="CDD:276817"
     misc_feature    order(1063..1065,1339..1341,1348..1350,1354..1365,
                     1804..1806)
                     /gene="Kifc1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276817"
     misc_feature    1186..1188
                     /gene="Kifc1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BW19; propagated from
                     UniProtKB/Swiss-Prot (Q5XI63.1); phosphorylation site"
     misc_feature    order(1957..1959,1966..1968,1975..1977)
                     /gene="Kifc1"
                     /note="microtubule interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:276817"
     exon            142..279
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..364
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..418
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..469
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..867
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1647
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1938
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2012
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2088
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2290
                     /gene="Kifc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggtggtctggctcctgggccgtctggctcgggtgttgcgtggcgcgagcccatgagaggacgcgggtctcgggacaccggcacccagtctgctgcctttgcatcccgtcctgtgcggaccaccgtggacatgcaggcacagagggcccctttgatggaagtgaagaggaacttggagctgagcacaaccctggtcaagtcctcctcccggctgcccctaccaggaagcaggctcaagaggggtcctgaccagatggaggatggcctggagcctgcaaagaaacgaacacgaggcatgggcacagtgaccaaagttgacacatcccgcccgagagggccacccctcagcgcagtgtccactgcagctcagaaaggccctaggaagactggacctcgagggtgctctgctgtcggtccagtgctgaggaaccagaagccagctcccgctgctcctgcccagaagccaggcacatccactgctcctgcggtggcaggaaagaaacctggcaagcgtcctgcctgggacttgaagggccagttgtgtgacctccatgaagagttgaaacagtatcgggagaagactcagacactggaccgtgagaaccaggggctccgagagcaactcagagaggttcaggagcaggccacgaccctggggacagagcggaacaccctggaggaggagctggccagtgtacgcaggcgagctgagcagagccagcagaagctggagactctgggtgcccgcgtcttggagctggaggaatgtctgggtaccaaggaaaggctggttcaggagcttcagacagagcggctgcaattgcaggaggaacgcagtacactgagcacccagctggaggagcgggagagggagtttcaggcctcagaagcagctctgtcaagcagccgagcagaggtactgtgtcttcggcagaagactgcagcccaggtgaccttactggccgagcagggagaccggctctatgggctagagatggagcgccgtcgactccacaaccagctgcaggaactgaagggcaacatccgggtcttctgccgggtgcgccctgtccttgagggggagtccactccatctcctggcttccttgtattccctcctggccctgctggaccctctgaccccccaactcgcctttgcctctctcggtctgatgaccggcgctccaccctgacaagggcaccagcagctgctacccgccatgacttctcctttgatcgggtgttcccaccaggaagcaagcaggaggaggtgtttgaggagatctccatgcttgtccagtcagcactggatggctaccctgtgtgcatctttgcctatggacagacaggcagcggcaagaccttcaccatggagggcgggcctcggggagacccccagttggaggggctgatcccccgggccatgcggcatctgttctctgtggcccaggagatgagtggccagggctggacttacagttttgtggccagttacgtagagatctacaatgagaccgtccgagacctgctagctacagggacccgcaagggacaagggggcgactgtgagattcgtcgggcaggcccagggagtgaggaacttactgtcaccaatgcacgatatgtccctgtttcctgtgagaaagaggtggaggctctgctccatttggcccagcagaatcgggctgtggcccgcactgcccagaatgagagatcatcacgcagccacagtgtgttccagctacagatctctggagagcatgctgcccggggcctgcagtgtggtgctcccctcaacctggtggacctggctgggagtgagcggcttgaccctggcttaaccctaggccctggagagcgggatcgtcttcgggaaacacaagccattaacagcagtctgtctacactgggactggtcataatggccctgagcaataaggagtcccacgtgccttaccgaaatagcaagcttacctacctgctgcagaactctctgggtggcagtgccaagatgctcatgttcgtgaacatttctcctctggaagagaatgtctccgagtctctgaattcactccgctttgcttccaaggtgaaccagtgcgtgatcggcactgctcaggctaataagaaatgaagatggatgcagagcctggctcctgtgcaagcgggtgtgcgtgtctgttttgtgtatatgtataacacgggggtggggcggggctgagacatgattttattgggtggacaacattatgtacccaactatcaaataaagaaaatttggtgtaggttaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//