LOCUS       NM_001402933            3861 bp    mRNA    linear   PLN 08-NOV-2023
DEFINITION  Oryza sativa Japonica Group cadmium/zinc-transporting ATPase
            HMA2-like (LOC4341965), mRNA.
ACCESSION   NM_001402933 XM_015788173
VERSION     NM_001402933.1
KEYWORDS    RefSeq.
SOURCE      Oryza sativa Japonica Group (Japanese rice)
  ORGANISM  Oryza sativa Japonica Group
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP
            clade; Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
REFERENCE   1  (bases 1 to 3861)
  AUTHORS   Yamaji N, Xia J, Mitani-Ueno N, Yokosho K and Feng Ma J.
  TITLE     Preferential delivery of zinc to developing tissues in rice is
            mediated by P-type heavy metal ATPase OsHMA2
  JOURNAL   Plant Physiol 162 (2), 927-939 (2013)
   PUBMED   23575418
REFERENCE   2  (bases 1 to 3861)
  AUTHORS   Takahashi R, Ishimaru Y, Shimo H, Ogo Y, Senoura T, Nishizawa NK
            and Nakanishi H.
  TITLE     The OsHMA2 transporter is involved in root-to-shoot translocation
            of Zn and Cd in rice
  JOURNAL   Plant Cell Environ 35 (11), 1948-1957 (2012)
   PUBMED   22548273
  REMARK    GeneRIF: OsHMA2 is involved in the translocation of zinc and
            cadmium in rice.
REFERENCE   3  (bases 1 to 3861)
  AUTHORS   Nocito FF, Lancilli C, Dendena B, Lucchini G and Sacchi GA.
  TITLE     Cadmium retention in rice roots is influenced by cadmium
            availability, chelation and translocation
  JOURNAL   Plant Cell Environ 34 (6), 994-1008 (2011)
   PUBMED   21388416
REFERENCE   4  (bases 1 to 3861)
  AUTHORS   Kikuchi S, Satoh K, Nagata T, Kawagashira N, Doi K, Kishimoto N,
            Yazaki J, Ishikawa M, Yamada H, Ooka H, Hotta I, Kojima K, Namiki
            T, Ohneda E, Yahagi W, Suzuki K, Li CJ, Ohtsuki K, Shishiki T,
            Otomo Y, Murakami K, Iida Y, Sugano S, Fujimura T, Suzuki Y,
            Tsunoda Y, Kurosaki T, Kodama T, Masuda H, Kobayashi M, Xie Q, Lu
            M, Narikawa R, Sugiyama A, Mizuno K, Yokomizo S, Niikura J, Ikeda
            R, Ishibiki J, Kawamata M, Yoshimura A, Miura J, Kusumegi T, Oka M,
            Ryu R, Ueda M, Matsubara K, Kawai J, Carninci P, Adachi J, Aizawa
            K, Arakawa T, Fukuda S, Hara A, Hashizume W, Hayatsu N, Imotani K,
            Ishii Y, Itoh M, Kagawa I, Kondo S, Konno H, Miyazaki A, Osato N,
            Ota Y, Saito R, Sasaki D, Sato K, Shibata K, Shinagawa A, Shiraki
            T, Yoshino M, Hayashizaki Y and Yasunishi A.
  CONSRTM   Rice Full-Length cDNA Consortium; National Institute of
            Agrobiological Sciences Rice Full-Length cDNA Project Team;
            Foundation of Advancement of International Science Genome
            Sequencing & Analysis Group; RIKEN
  TITLE     Collection, mapping, and annotation of over 28,000 cDNA clones from
            japonica rice
  JOURNAL   Science 301 (5631), 376-379 (2003)
   PUBMED   12869764
  REMARK    Erratum:[Science. 2003 Sep;301(5641):1849]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK107235.1, AP014962.1, AB661672.1, HQ646362.1 and CI122344.1.
            
            On Mar 23, 2022 this sequence version replaced XM_015788173.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB697186.1, AB661672.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00008650,
                                    SAMD00020310 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK107235.1         1-17
            18-20               AP014962.1         29480886-29480888   c
            21-371              AK107235.1         21-371
            372-462             AB661672.1         129-219
            463-3282            HQ646362.1         220-3039
            3283-3861           CI122344.1         1-579
FEATURES             Location/Qualifiers
     source          1..3861
                     /organism="Oryza sativa Japonica Group"
                     /mol_type="mRNA"
                     /db_xref="taxon:39947"
                     /chromosome="6"
                     /map="6"
     gene            1..3861
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="cadmium/zinc-transporting ATPase HMA2-like"
                     /db_xref="GeneID:4341965"
     exon            1..189
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            190..433
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    235..237
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="upstream in-frame stop codon"
     CDS             244..3447
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /EC_number="7.2.2.12"
                     /EC_number="7.2.2.21"
                     /note="heavy metal ATPase 2; P1B-ATPase heavy-metal
                     transporter; heavy metal transporting ATPase; Protein
                     HEAVY METAL ATPASE 2; LOC_Os06g48720;
                     cadmium/zinc-transporting ATPase HMA3"
                     /codon_start=1
                     /product="cadmium/zinc-transporting ATPase HMA2"
                     /protein_id="NP_001389862.1"
                     /db_xref="GeneID:4341965"
                     /translation="

MAAEGGRCQKSYFDVLGICCPSEVPLVEKLLQPLEGVQKVTVIVPSRTVIVVHDVDAISQSQIVKALNQARLEASVRAYGNGSEKITNKWPSPYVLLCGLLLVVSLFEHFWHPLKWFALVAAAAGLPPIVLRSIAAIRRLTLDVNILMLIAVAGAIALKDYSEAGFIVFLFTTAEWLETRASHKATAGMSALMSMAPQKAILAETGEVVAARDVKVNTVIAVKAGEVIPIDGVVVDGRSEVDESTLTGESFPVSKQPDSQVWAGTLNIDGYIAVRTTAMADNSAVAKMARLVEEAQNSRSSTQRLIDTCAKYYTPAVVVMAGSVAAIPAIAKAHNLKHWFQLALVLLVSACPCALVLSTPIATFCALLRAARTGLLIKGGDVLESLASIKVAAFDKTGTITRGEFSVEEFQPVGERVSLQQLLYWVSSVESRSSHPMASVLVDYAQSKSVEPKSENVSEFQIYPGEGIYGEIDGAGIYIGNKRILSRASCETVPDMKDMKGVTIGYVACNNELIGVFTLSDACRTGSAEAIKELRSLGIKSVMLTGDSSAAATYAQNQLGNILAEVHAELLPEDKVRIVGELKEKDGPTLMVGDGMNDAPALAKADVGVSMGVSGSAVAMETSHVALMSNDIRRIPKAVRLARRTHRTIIVNIIFSVITKLAIVGLAFAGHPLIWAAVLADVGTCLLVIMYSMLLLREKDSRKAKKCAASHHGSPKKCCSSSHHGSHAKKNHGVSHHCSDGPCKSMVSCKESSVAKNACHDHHHEHNHHEEPAHKHSSNQHGCHDHSHGHSNCKEPSNQLITNKHACHDGHNHCADTSNLHDTKKHDCHGHEHSTCKEELNALPPTNDHACHGHEHSHCEEPVALHSTGEHACHEHEHEHIHCDEPIGSHCADKHACHDHEQVHEHHCCDEQQTPHTADLHPCHDHDHDNLEVEEVKDCHAEPPHHHNHCCHEPHDQVKNDTHPVQEHSISIEESSDHHEHHHNEEHKAEDCGHHPKPKDCAPPPTDCISRNCCSNTSKGKDICSSLHRDHHTSQASRCCRSYVKCSRPSRSCCSHSIVKLPEIVVE"

     misc_feature    280..444
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="Heavy-metal-associated domain; Region: HMA;
                     pfam00403"
                     /db_xref="CDD:425665"
     misc_feature    order(295..303,310..312)
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    523..585
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    568..2325
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="P-type heavy metal-transporting ATPase; Region:
                     P-type_ATPase_HM; cd02079"
                     /db_xref="CDD:319774"
     misc_feature    592..654
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    661..723
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    727..789
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    1180..1242
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    1267..1329
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    order(1294..1296,1300..1302,2218..2223,2284..2286,
                     2296..2298)
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="putative HM ion binding site [ion binding]; other
                     site"
                     /db_xref="CDD:319774"
     misc_feature    order(1426..1434,1630..1632,1678..1686,1876..1884,
                     1948..1950,1957..1959,1966..1968,2023..2025,2032..2034)
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319774"
     misc_feature    2188..2250
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    2260..2322
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     transmembrane region"
     misc_feature    2374..2460
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2521..2613
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3121..3231
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /note="propagated from UniProtKB/Swiss-Prot (A3BF39.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            434..697
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            698..795
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1051
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1189
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1517
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1720
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1917
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..3861
                     /gene="LOC4341965"
                     /gene_synonym="HMA2; OsHMA2; OsJ_22530"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctatccccgattcgcacagccaatctcttcttgcttcctcctcctcctcctccagccgccgccgccgacgacgattcttggtagagagattcttgcgttgttttacctgcgtcttgttcttcttgggagttgggtggatcgattgatcgaggttttggaggttggaagaagtgtgtgttgtggtggggggtttgtagagagagagagggcaaaggcacgcaaagagggagagagtgaggagagatggcggcggagggagggaggtgtcagaagagctacttcgacgtgctggggatttgctgcccgtcggaggttcccctcgtcgagaagcttctgcagccgctggagggcgtccagaaggtcaccgtgatcgttccctccaggacggtcatcgtcgtccacgacgtcgacgccatctcccaatcccaaatcgtcaaggcgctgaatcaggcaaggttggaggcgtcggttcgggcttatgggaacggcagtgagaagatcaccaacaaatggccgagcccgtatgttctcctctgcggacttcttctggtcgtgtcgctgttcgagcatttctggcacccgctcaagtggttcgcgctggtggctgcggccgccggcttgccgccgatcgtgctgaggagcattgcggccatccggagactcaccctggatgtcaacatactcatgctgattgctgttgctggagcaatagctctcaaggactattctgaggctgggttcatcgtcttcctcttcactacagctgaatggcttgagactagggccagccacaaggccaccgctgggatgtcagctctaatgagcatggcaccacaaaaggctattctggcagagaccggggaggtggttgcagcccgggatgtgaaggtcaatacagtaattgctgtcaaggcaggggaagtcattccaatcgacggtgttgttgttgatggacgtagtgaggtcgacgagagcaccctcacgggggagtccttcccagtgtccaagcagccagactcccaggtctgggctggcacactcaacattgacggttacattgctgtgaggacgactgctatggctgacaactccgcggtggccaaaatggcaaggttggttgaagaagcacaaaacagcagatccagtacacagaggctgatcgacacgtgtgctaagtattacacacctgcggtcgttgtcatggcaggatcagtagcagcaattcctgcaatagcgaaagcacataaccttaagcactggttccaattggctctagttcttctagtgagtgcttgtccatgtgcactggtactgtccacacccattgccaccttctgcgcgctactaagggccgcaaggacagggctgctcatcaaaggaggagatgtcctggaatccttggctagcatcaaagttgcagcttttgacaaaactggtacaattactagaggagagttcagtgttgaggagttccagccagttggtgaacgtgtttcattgcaacaacttctttactgggtctcgagcgttgagagcagatcaagtcaccccatggcatctgtcctggttgattatgctcaatcaaagtctgtggaaccaaaatcagagaatgttagtgaattccaaatatatcctggtgaggggatttatggtgaaatcgacggagcaggcatatatattgggaacaaaagaattttgtcaagagcttcatgcgaaacagttccggacatgaaagatatgaaaggagttaccattggatatgtggcatgtaacaatgaattgattggagtattcactctatcggatgcctgccgaactggatcagctgaggccatcaaggaactgagatcactgggcattaagtcagtgatgcttacaggtgatagtagcgctgctgccacatatgcacagaatcagctgggaaatatccttgctgaggttcatgctgaacttcttccagaggacaaagtgagaattgttggtgaactcaaggaaaaagatggccctacgctgatggttggtgatggcatgaatgatgccccggcattggctaaagctgatgttggagtctctatgggtgtatctggttcagctgttgcaatggagacaagccacgttgctctgatgtcaaatgacatccgcaggattccaaaggctgtccggctggcaaggaggacgcatcggacaatcatcgtgaacatcatattctcggtgattacgaagcttgcaatcgttgggcttgcatttgccggacatccacttatctgggcagccgtccttgcagatgttggcacatgcttgctggtgatcatgtacagcatgctgttgctgagagagaaggacagtcgaaaggcgaagaaatgtgctgcttctcatcacggatctccaaagaagtgctgttcttcttctcatcatggatctcatgcaaagaaaaatcatggcgtttcccaccattgttcggatggtccgtgcaaatcaatggtcagttgcaaagaatcatcagttgcaaagaatgcttgtcatgatcaccaccatgagcataaccatcacgaagagccagcccacaagcattcttcgaaccagcatggttgccatgatcacagccatggccatagcaactgcaaagagccaagcaaccagctgattacaaacaagcatgcttgccatgatggtcataaccactgcgcagatacgagcaatctgcacgacaccaagaagcatgactgccatggccatgagcatagcacctgcaaagaagaactcaacgctttgcctcccaccaatgaccatgcttgccatggccatgaacatagccactgtgaagaacccgttgctctgcactctaccggcgaacatgcttgccatgagcatgagcatgagcatatccactgtgacgagccaatcggctcgcattgcgctgataagcatgcttgccatgaccatgaacaggttcatgagcatcattgctgtgatgaacagcaaactccgcacaccgcagatttgcacccctgccatgaccatgaccatgacaacctggaggtcgaggaagtaaaggactgccatgctgaaccacctcaccaccacaaccattgctgccatgaacctcatgatcaggtcaagaatgatactcatccagtccaggagcactcgatctcgatcgaagaatcatcagaccaccatgagcatcaccacaacgaagaacacaaagccgaagattgcggacatcatccgaagccgaaagattgtgctccacctccaactgactgcatcagcagaaactgttgcagcaataccagcaaaggtaaagacatttgctcgagcttgcacagggatcatcataccagccaggccagccggtgctgcaggagctatgtgaaatgctccaggcccagcaggagttgctgcagccacagcatagtgaagctgcctgagatcgtagtggagtagtaggaaattcagcaatgtctgcacatatcatcagaaaatatagcaacctcgtcatcggcgaaatgtagaaaaagccgatgctgctatgcgtttgatctttttttttttagtcgtgctgcttttgcttcagctaaagaaaaaaatgttgtttgtagaggtgtctggttttgagacgaagcaggtgtttgaatcatgaaatgtataagcctgctttgtggttttctttcccggttgtgatcgaggcatcatctcctgtaagaatctgagaaggtgcatgaaatctgccatttctgggagcgggaggactagctggtgctgggattaacttgcttccaaaaactctttagattttgaaacatttgaccaacaattagtcaaatataaattaaattctattcgatgaaaacaatgtta

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