LOCUS       NR_039558                 74 bp    RNA     linear   ROD 11-MAR-2025
DEFINITION  Mus musculus microRNA 5099 (Mir5099), microRNA.
ACCESSION   NR_039558
VERSION     NR_039558.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 74)
  AUTHORS   Ding,Z., Guo,T., Tang,Q., Hong,Y., Lv,Z., Lu,L. and Zhuang,W.
  TITLE     DEmiRNA-mRNA regulatory network reveals miR-122-5p as a regulatory
            factor of arginine metabolism in necrotizing enterocolitis
  JOURNAL   Front Genet 15, 1480431 (2025)
   PUBMED   39911307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 74)
  AUTHORS   Yang,R., Yang,F., Huang,Z., Jin,Y., Sheng,Y. and Ji,L.
  TITLE     Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are
            potential toxicological biomarkers for the hepatotoxicity induced
            by Airpotato yam
  JOURNAL   Toxicol Lett 280, 125-132 (2017)
   PUBMED   28844483
  REMARK    GeneRIF: This study demonstrated that miR-122-3p and miRNA-194-5p
            were two sensitive biomarkers, and miR-5099 might be a specific
            biomarker for reflecting the liver injury induced by Airpotato yam.
REFERENCE   3  (bases 1 to 74)
  AUTHORS   Polikepahad,S. and Corry,D.B.
  TITLE     Profiling of T helper cell-derived small RNAs reveals unique
            antisense transcripts and differential association of miRNAs with
            argonaute proteins 1 and 2
  JOURNAL   Nucleic Acids Res 41 (2), 1164-1177 (2013)
   PUBMED   23185045
REFERENCE   4  (bases 1 to 74)
  AUTHORS   Spierings,D.C., McGoldrick,D., Hamilton-Easton,A.M., Neale,G.,
            Murchison,E.P., Hannon,G.J., Green,D.R. and Withoff,S.
  TITLE     Ordered progression of stage-specific miRNA profiles in the mouse
            B2 B-cell lineage
  JOURNAL   Blood 117 (20), 5340-5349 (2011)
   PUBMED   21403133
REFERENCE   5  (bases 1 to 74)
  AUTHORS   Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and
            Enright,A.J.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
   PUBMED   16381832
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from AC122337.4.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC122337.4         128648-128721       c
FEATURES             Location/Qualifiers
     source          1..74
                     /organism="Mus musculus"
                     /mol_type="transcribed RNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.84 cM"
     gene            1..74
                     /gene="Mir5099"
                     /gene_synonym="mmu-mir-5099; mu-mir-5099"
                     /note="microRNA 5099"
                     /db_xref="GeneID:100628578"
                     /db_xref="MGI:MGI:4950417"
                     /db_xref="miRBase:MI0018007"
     precursor_RNA   1..74
                     /gene="Mir5099"
                     /gene_synonym="mmu-mir-5099; mu-mir-5099"
                     /product="microRNA 5099"
                     /db_xref="GeneID:100628578"
                     /db_xref="MGI:MGI:4950417"
                     /db_xref="miRBase:MI0018007"
     exon            1..74
                     /gene="Mir5099"
                     /gene_synonym="mmu-mir-5099; mu-mir-5099"
                     /inference="alignment:Splign:2.1.0"
     ncRNA           46..65
                     /ncRNA_class="miRNA"
                     /gene="Mir5099"
                     /gene_synonym="mmu-mir-5099; mu-mir-5099"
                     /product="mmu-miR-5099"
                     /db_xref="miRBase:MIMAT0020606"
                     /db_xref="GeneID:100628578"
                     /db_xref="MGI:MGI:4950417"
                     /db_xref="miRBase:MI0018007"
ORIGIN      

agaattcagttagaaattacattgatttaagaagtggtaatgggcttagatcgatgtggtgctcctgagttctc

//