LOCUS       NM_183389               2146 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus double homeobox B-like 1 (Duxbl1), mRNA.
ACCESSION   NM_183389 XM_918041
VERSION     NM_183389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Vega-Sendino,M., Luttmann,F.F., Olbrich,T., Chen,Y., Kuenne,C.,
            Stein,P., Tillo,D., Carey,G.I., Zhong,J., Savy,V., Radonova,L.,
            Lu,T., Saykali,B., Kim,K.P., Domingo,C.N., Schuler,L., Gunther,S.,
            Bentsen,M., Bosnakovski,D., Scholer,H., Kyba,M., Maity,T.K.,
            Jenkins,L.M., Looso,M., Williams,C.J., Kim,J. and Ruiz,S.
  TITLE     The homeobox transcription factor DUXBL controls exit from
            totipotency
  JOURNAL   Nat Genet (2024) In press
   PUBMED   38509386
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Bademci,G., Lachgar-Ruiz,M., Deokar,M., Zafeer,M.F., Abad,C.,
            Yildirim Baylan,M., Ingham,N.J., Chen,J., Sineni,C.J., Vadgama,N.,
            Karakikes,I., Guo,S., Duman,D., Singh,N., Harlalka,G., Jain,S.P.,
            Chioza,B.A., Walz,K., Steel,K.P., Nasir,J. and Tekin,M.
  TITLE     Mutations in MINAR2 encoding membrane integral NOTCH2-associated
            receptor 2 cause deafness in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2204084119 (2022)
   PUBMED   35727972
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   De Iaco,A., Verp,S., Offner,S., Grun,D. and Trono,D.
  TITLE     DUX is a non-essential synchronizer of zygotic genome activation
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31806660
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Klein,F., Mitrovic,M., Roux,J., Engdahl,C., von Muenchow,L.,
            Alberti-Servera,L., Fehling,H.J., Pelczar,P., Rolink,A. and
            Tsapogas,P.
  TITLE     The transcription factor Duxbl mediates elimination of pre-T cells
            that fail beta-selection
  JOURNAL   J Exp Med 216 (3), 638-655 (2019)
   PUBMED   30765463
  REMARK    GeneRIF: Duxbl is a regulator of beta-selection by inducing
            apoptosis in T cells with a nonfunctional rearrangement.
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Rivera-Reyes,R., Kleppa,M.J. and Kispert,A.
  TITLE     Proteomic analysis identifies transcriptional cofactors and
            homeobox transcription factors as TBX18 binding proteins
  JOURNAL   PLoS One 13 (8), e0200964 (2018)
   PUBMED   30071041
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Wu,S.L., Tsai,M.S., Wong,S.H., Hsieh-Li,H.M., Tsai,T.S.,
            Chang,W.T., Huang,S.L., Chiu,C.C. and Wang,S.H.
  TITLE     Characterization of genomic structures and expression profiles of
            three tandem repeats of a mouse double homeobox gene: Duxbl
  JOURNAL   Dev Dyn 239 (3), 927-940 (2010)
   PUBMED   20063414
  REMARK    GeneRIF: Duxbl proteins play regulatory roles during myogenesis and
            reproductive developments
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Kawazu,M., Yamamoto,G., Yoshimi,M., Yamamoto,K., Asai,T.,
            Ichikawa,M., Seo,S., Nakagawa,M., Chiba,S., Kurokawa,M. and
            Ogawa,S.
  TITLE     Expression profiling of immature thymocytes revealed a novel
            homeobox gene that regulates double-negative thymocyte development
  JOURNAL   J Immunol 179 (8), 5335-5345 (2007)
   PUBMED   17911620
  REMARK    GeneRIF: Involved in thymocyte development. Knockdown by shRNA
            impaired CD4/8 double-negative thymocyte differentiation.
            Overexpression impaired TCR-beta expression and CD4/8
            double-positive thymocyte production. Expressed also in
            B-lymphocytes.
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Clapp,J., Mitchell,L.M., Bolland,D.J., Fantes,J., Corcoran,A.E.,
            Scotting,P.J., Armour,J.A. and Hewitt,J.E.
  TITLE     Evolutionary conservation of a coding function for D4Z4, the tandem
            DNA repeat mutated in facioscapulohumeral muscular dystrophy
  JOURNAL   Am J Hum Genet 81 (2), 264-279 (2007)
   PUBMED   17668377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC055782.1 and AK141686.1.
            
            On Mar 29, 2018 this sequence version replaced NM_183389.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141686.1, EF472598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1812              BC055782.1         199-2010
            1813-2146           AK141686.1         1687-2020
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 15.3 cM"
     gene            1..2146
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="double homeobox B-like 1"
                     /db_xref="GeneID:278672"
                     /db_xref="MGI:MGI:1916048"
     exon            1..343
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    280..282
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="upstream in-frame stop codon"
     CDS             322..1374
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="Dux in lymphoid lineage; double homeobox B-like 2;
                     doubl homeobox B-like 2; double homeobox B-like 3; double
                     homeodomain protein"
                     /codon_start=1
                     /product="double homeobox B-like 1"
                     /protein_id="NP_899245.1"
                     /db_xref="CCDS:CCDS26878.1"
                     /db_xref="GeneID:278672"
                     /db_xref="MGI:MGI:1916048"
                     /translation="

MELSCSTGLLEKEARRRRIILTQSQKDTLRVWFEKNPNPDLATRGHLAKELGISESQIMTWFQKHRKIRKQAEFACCSEESQEQEQDKPRVKEARRSRTHFTKFQTDILIEAFEKNRFPGIVTREKLAQQTGIPESRIHIWFQNRRARHPDPGQNTQKTPHPPQSSQGPTQKTVGKLAPSKTLTSSASVILPLSPPHTPNGPLDLSKGRQKQLPGTTLLQSSQVVQQRSDDQNPNKGHLSPTTTPGEQGFHSQPPLQLLTQNRGHNPRESGGLAVPRLEDCTQVPAVNQHFRKLDQNDSSFLQHWDEWFGSMLAEWMPDKEYWSEKAELHPWQVQLRQLASVSPQAHQTP"

     misc_feature    364..534
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(364..378,382..384,433..435,451..453,490..492,
                     496..501,508..513,517..519,520..522,526..531)
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(370..372,379..381,499..501,508..513)
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    604..768
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            344..498
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            499..592
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            593..738
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
     exon            739..2146
                     /gene="Duxbl1"
                     /gene_synonym="1110051B16Rik; Duxbl; Duxbl2; Duxbl3; Duxl;
                     Gm10391; Gm10394"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tcacagtccatcatctgtcaagagtcttttaaaacttcagtccatcaaggagttaaaccagtgattagctcaactctctcatgatataatcttctctggaaaccaccccagacacacccagaggcgggtttcactaatctcccaggaacctcttaatccaatcaagttgactatcaagatttgccacagtgctgcatatttaatgaaaggattaaacaaccaacaggtatttaagaaatgggtgggccactctgggctctactacatcctgtgtctctgtgacagctctcttgggcctcttgggatccagatggctgcagcatggagctgagctgcagtactggcctactggaaaaagaagcccggagaaggagaatcattctaacccagagtcaaaaggacactcttcgtgtgtggtttgaaaagaatcccaatcctgatctagctaccagaggacatctggctaaggaactcggcatctctgagtctcaaattatgacttggtttcaaaagcatagaaaaatacggaagcaagcagagtttgcatgctgttctgaagaaagccaagagcaggagcaggataaacctagagttaaagaagctagaaggagcagaacgcacttcacaaagttccagactgatattctaattgaagcttttgagaagaatcggttccctgggattgttaccagggaaaaactggctcaacaaacaggcatcccagaatccaggattcatatatggtttcagaaccggagagcacggcacccagacccaggacagaacactcagaaaactcctcatccaccccagagcagtcagggccctacccagaaaactgtgggtaaactcgctccttccaaaactctcaccagcagcgcttcagttatactgcctctttctccaccccacactccaaatgggcctttggatctctctaagggccgtcagaagcagttaccagggaccacactacttcagtcctcccaggttgtacagcaaaggagtgatgatcaaaatcccaataaaggtcacttatcaccgacaacaactccaggagagcagggcttccattctcagcctcctttacagctcctaacccaaaacagagggcataatcccagagagagcggtggtttggcggtaccgcgcttagaagattgtactcaggtcccagctgtcaatcaacacttccggaaactagaccaaaatgattcctcctttctccaacactgggacgagtggttcggatccatgcttgctgaatggatgcctgacaaagaatactggtctgagaaagctgagctgcatccgtggcaggtgcagctgcggcagcttgccagcgtgtctcctcaagcacaccaaactccgtagcagtaggtttaagcctcaagccttttccgttcattcctcttgagcacaggtttttcaggaaaagatctcttccttcggcacccaggtccccacgtggattcctgtgcatggcttggagagcttctcaggagagtgttgggttcttcacaggggaacgagtacatcagtgaggacctgccctcgggcgtgaaatcagtggctatactgaagagtaggcatgcagaattagggaacaagatcaagttagtatgtgcataaaccacatggacacaaaaagggggcaattatttttattcttaatttattcttgagatctgatctcactgttactctggctggtcttgaactcctgtgctcaagtcaatttcctgcctcagcctcctaaataatcggtgctacaaatatatccctccgggtccgtcttggttttaattttaattatttatttatttttaattcacggtttcatctaccatctgttatgtttcaaagctgaagtgtctctcacaaattcatgttctgaaatcttgcctctcagccaatggtgctgtttgaaatctgtagaggttttaggtgggtcctgaccggcaggtgcaggccagggtggtaccttgaaagttatacccaccatgtgaacagcatgcaccacgcgttcccaatgtgtagacggacttatgtccccacgcctctctgtgacaatgggctaaaacattctgacaagaatccaaataaacactctcctgtcacgttgcttctggtagttgtttggatc

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