LOCUS       NM_134072               2445 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member C14 (Akr1c14),
            mRNA.
ACCESSION   NM_134072
VERSION     NM_134072.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Bakalar,D., O'Reilly,J.J., Lacaille,H., Salzbank,J., Ellegood,J.,
            Lerch,J.P., Sasaki,T., Imamura,Y., Hashimoto-Torii,K., Vacher,C.M.
            and Penn,A.A.
  TITLE     Lack of placental neurosteroid alters cortical development and
            female somatosensory function
  JOURNAL   Front Endocrinol (Lausanne) 13, 972033 (2022)
   PUBMED   36313771
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Vacher,C.M., Lacaille,H., O'Reilly,J.J., Salzbank,J., Bakalar,D.,
            Sebaoui,S., Liere,P., Clarkson-Paredes,C., Sasaki,T.,
            Sathyanesan,A., Kratimenos,P., Ellegood,J., Lerch,J.P., Imamura,Y.,
            Popratiloff,A., Hashimoto-Torii,K., Gallo,V., Schumacher,M. and
            Penn,A.A.
  TITLE     Placental endocrine function shapes cerebellar development and
            social behavior
  JOURNAL   Nat Neurosci 24 (10), 1392-1401 (2021)
   PUBMED   34400844
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Di-Luoffo,M., Brousseau,C. and Tremblay,J.J.
  TITLE     MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in
            mouse MA-10 Leydig cells
  JOURNAL   Andrology 4 (2), 335-344 (2016)
   PUBMED   26748576
  REMARK    GeneRIF: results identify a novel cooperation between MEF2 factors
            and NR2F2 in the expression of the Akr1c14 gene
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Provost,P.R. and Tremblay,Y.
  TITLE     Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung
            maturity
  JOURNAL   J Steroid Biochem Mol Biol 103 (1), 61-64 (2007)
   PUBMED   17064890
  REMARK    GeneRIF: In conclusion, our data show that m3alpha-HSD mRNA is a
            reliable marker of lung maturity in normal pregnancy.
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Agis-Balboa,R.C., Pinna,G., Zhubi,A., Maloku,E., Veldic,M.,
            Costa,E. and Guidotti,A.
  TITLE     Characterization of brain neurons that express enzymes mediating
            neurosteroid biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 103 (39), 14602-14607 (2006)
   PUBMED   16984997
  REMARK    GeneRIF: This study evaluates 5alpha-reductase type I and
            3alpha-hydroxysteroid dehydrogenase mRNA expression level in mouse
            brain by using in situ hybridization.
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Bellemare,V., Labrie,F. and Luu-The,V.
  TITLE     Isolation and characterization of a cDNA encoding mouse
            3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating
            enzyme selectively expressed in female tissues
  JOURNAL   J Steroid Biochem Mol Biol 98 (1), 18-24 (2006)
   PUBMED   16191478
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   Hardy,D.O., Ge,R.S., Catterall,J.F., Hou,Y.T., Penning,T.M. and
            Hardy,M.P.
  TITLE     Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase
            activity of rat Leydig cells as type II retinol dehydrogenase
  JOURNAL   Endocrinology 141 (5), 1608-1617 (2000)
   PUBMED   10803568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122840.3.
            
            On Jan 23, 2019 this sequence version replaced NM_134072.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013482.1, AK033537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC122840.3         79923-80047
            126-293             AC122840.3         83886-84053
            294-410             AC122840.3         85657-85773
            411-488             AC122840.3         98302-98379
            489-611             AC122840.3         99386-99508
            612-721             AC122840.3         100951-101060
            722-887             AC122840.3         101322-101487
            888-970             AC122840.3         107567-107649
            971-2445            AC122840.3         109280-110754
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.26 cM"
     gene            1..2445
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="aldo-keto reductase family 1, member C14"
                     /db_xref="GeneID:105387"
                     /db_xref="MGI:MGI:2145458"
     exon            1..125
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="upstream in-frame stop codon"
     CDS             42..1013
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /EC_number="1.1.1.213"
                     /EC_number="1.1.1.50"
                     /note="3-alpha-hydroxysteroid dehydrogenase type 1"
                     /codon_start=1
                     /product="3-alpha-hydroxysteroid dehydrogenase"
                     /protein_id="NP_598833.1"
                     /db_xref="CCDS:CCDS26218.1"
                     /db_xref="GeneID:105387"
                     /db_xref="MGI:MGI:2145458"
                     /translation="

MNSVSPRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYFDDHPNHPFTDEY"

     misc_feature    57..965
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="AKR1C family of aldo-keto reductase (AKR); Region:
                     AKR_AKR1C1-35; cd19108"
                     /db_xref="CDD:381334"
     misc_feature    order(105..113,189..191,201..206,291..293,297..299,
                     390..395,399..401,423..428,537..542,609..611,687..707,
                     711..713,720..722,747..749,798..800,843..860,867..869,
                     876..881,957..959,963..965)
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="active site"
                     /db_xref="CDD:381334"
     misc_feature    order(189..191,204..206,291..293,390..392)
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381334"
     exon            126..293
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..410
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            411..488
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..611
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..721
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            722..887
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            888..970
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            971..2445
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2445
                     /gene="Akr1c14"
                     /gene_synonym="9030611N15Rik"
                     /note="major polyA site"
ORIGIN      

cagaagtctcaagacctgcgtggttgcatgagtaacaagctatgaattctgtatccccacgtgtggtactaaacgatggtcacttcatccctgcactggggtttggaaccactgtgcccgataaggttcctaaggatgaacttatcaaggctactaaaatagctatagatactggattccgccattttgactccgcttatttgtaccaaatagaagaggaagtaggccaggccattagaagcaagattgaagatggcactgtgaagagagaagatatattctatacttcaaagctttggagcactttccatcgaccagaattggtccgatcttgcttggaaaagacactgaagaatgcacaactggactatgttgatctttacattattcatttcccaatggctttgcagcctggagataaactatttccacgagacgaacatggaaaactgttggctgaagcagtggatctctgtgacacatgggaggccatggaaaagtgtaaagatgccggactggccaagtccatcggagtgtcgaactttaacttcaggcagctggagacgattctgaacaagccggggctcaagtacaagcctgtgtgcaaccaggtagaatgccatctttatttaaaccagagccaaatgctggactattgtaagtcaaaagacatcattctggtttcctactgcacattgggaagttcacgagacaaaatctgggtggaccagaaaagtccagttctcttagatgatccagttctttgtgccatggcaaataagtacaagcaaacaccagcactgattgccattcgttaccaattacagcgtggaattgtggtcctgaccaggagtttcaaggagaagcggatcaaagagttcatgaaggtttttgaattccagttggcttcagaggacatgaaagtcctggatggcttgcacagaaatttaagatacaatactgcgagttattttgatgaccatcccaatcatccatttactgatgaatattaacatggtggcctttgccagcatttctatcagaagatctgctgatgcatcatgatatgagagatatcttggatactggtgactgaacacatcccttctcatcagatcactgtatctattaattcacagtcagatggagcaaagtccaaagagctatgagggaagccatatttttgtcacacgctgaaatggaacaccacgttgcttttcctattcttgtgtttttaaagattcatttattttattttacatatgtaagtgtacatgtatgtatatctcatgaatgtctgtgtctatgaagggaagaagagagttataggtcacttggaactggagctacggatgattgtgaatcaccatgtgggcactgggagccaaacctaagtcttctgttagagcagcaagtgccattaaatgccgagccatctcattaggtcccactctaaagattcttgcctgctactatttctagaacctcaatgttttgttttcttctgatttctgacaccaacctgttttgctagaagttttgggcatgaagtcattgttgaggataatcattgcaaaggcatctctgggtgggaatttgaaggatttttcaacattaagggaattaattgttagtggttattgataagtaaatattcctcatgtgctttgaggaagaagaaaatactccatagctcttcgctttttcttattttggaggtaaggcacatgtgaggagtgaccaagagactcagggttctctccagcaacccaagaaccagagctccaagagcctggggagtatgttctccttgtgggaaatttgggaggttggtaagaagagaactaatctaaaagcatcatcatggctcagatgtagggaagttgagaagaaagctgaatatgtctctgcttgggaagtatcttttttggtaattacacgtgacagtaaaaggaaaatctacagatttcattcaagacagactgctagactggatgtttatattttcaagggattcagaagttgcattactgagctatgttagaagaaaccaattcacatgagtataaactccatattcaagttttctctgatttaaaagtcggttttctgaaacatgatctcatatgtttataggtaaacgagtcagacttacaaaagatctcaaagttactaaattgtatagtcgaattaagattaaaagaatatatttgatgagacaagttatttaaattttcaaaaattatatgaaatactgtatttgaatcagcagtgtttaaggaagttgttaacatttagtcatcttttttgcacaaagagtatcttcagagaaatcagagagaaaagatagtatgtttatagaagattcagaataatgtggaggtaaatattgtttagaatatagttggatttatatatttcattaataaatgcctcaaataagaa

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