LOCUS       NM_130865               4054 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus diencephalon/mesencephalon homeobox 1 (Dmbx1),
            transcript variant 1, mRNA.
ACCESSION   NM_130865
VERSION     NM_130865.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Amadei,G., Handford,C.E., Qiu,C., De Jonghe,J., Greenfeld,H.,
            Tran,M., Martin,B.K., Chen,D.Y., Aguilera-Castrejon,A., Hanna,J.H.,
            Elowitz,M.B., Hollfelder,F., Shendure,J., Glover,D.M. and
            Zernicka-Goetz,M.
  TITLE     Embryo model completes gastrulation to neurulation and
            organogenesis
  JOURNAL   Nature 610 (7930), 143-153 (2022)
   PUBMED   36007540
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Ninou,I., Sevastou,I., Magkrioti,C., Kaffe,E., Stamatakis,G.,
            Thivaios,S., Panayotou,G., Aoki,J., Kollias,G. and Aidinis,V.
  TITLE     Genetic deletion of Autotaxin from CD11b+ cells decreases the
            severity of experimental autoimmune encephalomyelitis
  JOURNAL   PLoS One 15 (4), e0226050 (2020)
   PUBMED   32240164
  REMARK    GeneRIF: ATX genetic deletion from CD11b+ cells attenuated the
            severity of experimental autoimmune encephalomyelitis (EAE), thus
            proposing a pathogenic role for the ATX/LPA axis in
            neuroinflammatory disorders.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Switon,K., Kotulska,K., Janusz-Kaminska,A., Zmorzynska,J. and
            Jaworski,J.
  TITLE     Molecular neurobiology of mTOR
  JOURNAL   Neuroscience 341, 112-153 (2017)
   PUBMED   27889578
  REMARK    Review article
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Kato,K., Ikeda,H., Miyakawa,S., Futakawa,S., Nonaka,Y.,
            Fujiwara,M., Okudaira,S., Kano,K., Aoki,J., Morita,J., Ishitani,R.,
            Nishimasu,H., Nakamura,Y. and Nureki,O.
  TITLE     Structural basis for specific inhibition of Autotaxin by a DNA
            aptamer
  JOURNAL   Nat Struct Mol Biol 23 (5), 395-401 (2016)
   PUBMED   27043297
  REMARK    GeneRIF: The crystal structure of mouse ATX in complex with an
            anti-ATX aptamer.
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Hirono,S., Lee,E.Y., Kuribayashi,S., Fukuda,T., Saeki,N.,
            Minokoshi,Y., Iwanaga,T. and Miki,T.
  TITLE     Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of
            Agouti-Related Peptide
  JOURNAL   Endocrinology 157 (1), 245-257 (2016)
   PUBMED   26505115
  REMARK    GeneRIF: Data (including data from studies in transgenic/knockout
            mice) suggest that expression in adult brain neurons (especially in
            parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related
            peptide) is important in appetite regulation leading to leanness.
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Zhang,Y., Miki,T., Iwanaga,T., Koseki,Y., Okuno,M., Sunaga,Y.,
            Ozaki,N., Yano,H., Koseki,H. and Seino,S.
  TITLE     Identification, tissue expression, and functional characterization
            of Otx3, a novel member of the Otx family
  JOURNAL   J Biol Chem 277 (31), 28065-28069 (2002)
   PUBMED   12055180
  REMARK    GeneRIF: results suggest that Otx3 is a novel member of the Otx
            family and may be involved in the development of the central
            nervous system
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Soo,K., O'Rourke,M.P., Khoo,P.L., Steiner,K.A., Wong,N.,
            Behringer,R.R. and Tam,P.P.
  TITLE     Twist function is required for the morphogenesis of the cephalic
            neural tube and the differentiation of the cranial neural crest
            cells in the mouse embryo
  JOURNAL   Dev Biol 247 (2), 251-270 (2002)
   PUBMED   12086465
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Miyamoto,T., Kawahara,A., Teufel,A., Mukhopadhyay,M., Zhao,Y.,
            Dawid,I.B. and Westphal,H.
  TITLE     Mbx, a novel mouse homeobox gene
  JOURNAL   Dev Genes Evol 212 (2), 104-106 (2002)
   PUBMED   11914943
  REMARK    GeneRIF: provides a useful molecular marker for early mouse
            midbrain development and may play a critical role in brain
            development
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Ohtoshi,A., Nishijima,I., Justice,M.J. and Behringer,R.R.
  TITLE     Dmbx1, a novel evolutionarily conserved paired-like homeobox gene
            expressed in the brain of mouse embryos
  JOURNAL   Mech Dev 110 (1-2), 241-244 (2002)
   PUBMED   11744391
  REMARK    GeneRIF: Dmbx1, a novel evolutionarily conserved paired-like
            homeobox gene is expressed in the brain of mouse embryos. Linkage
            analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4.
REFERENCE   10 (bases 1 to 4054)
  AUTHORS   Martinez-Barbera,J.P., Signore,M., Boyl,P.P., Puelles,E.,
            Acampora,D., Gogoi,R., Schubert,F., Lumsden,A. and Simeone,A.
  TITLE     Regionalisation of anterior neuroectoderm and its competence in
            responding to forebrain and midbrain inducing activities depend on
            mutual antagonism between OTX2 and GBX2
  JOURNAL   Development 128 (23), 4789-4800 (2001)
   PUBMED   11731459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732319.1, CN455087.1 and BC050912.1.
            
            On Jul 16, 2005 this sequence version replaced NM_130865.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141654.1, AF448118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               BY732319.1         1-207
            208-679             CN455087.1         110-581
            680-4054            BC050912.1         642-4016
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.07 cM"
     gene            1..4054
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="diencephalon/mesencephalon homeobox 1"
                     /db_xref="GeneID:140477"
                     /db_xref="MGI:MGI:2153518"
     exon            1..42
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            43..207
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1200
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="isoform a is encoded by transcript variant 1;
                     homeobox gene Atx; diencephalon/mesencephalon homeobox
                     protein 1; paired-type homeobox Atx; paired-like homeobox
                     protein DMBX1; diencephalon/mesencephalon-expressed brain
                     homeobox gene 1 protein; orthodenticle homolog 3"
                     /codon_start=1
                     /product="diencephalon/mesencephalon homeobox protein 1
                     isoform a"
                     /protein_id="NP_570935.3"
                     /db_xref="GeneID:140477"
                     /db_xref="MGI:MGI:2153518"
                     /translation="

MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKVEAPASDTQLETEQPPGLPSGDPPAELQLSLSEQSASESAPEDQLDREEDSRAEEPKAEKSPGSESKVPGCKRGSPKADSPGSLAITPAAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLMHYSSFEVGGPAPAAAAAAAAAVPYLGVNMAPLSSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPTGLAPASAALNSKTTSIENLRLRAKQHAASLGLDTLPN"

     misc_feature    55..522
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZK4.1);
                     Region: Interaction with OTX2 and is required for
                     repressor activity. /evidence=ECO:0000269|PubMed:15890343"
     misc_feature    268..438
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    439..804
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1126..1167
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZK4.1);
                     Region: OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
     exon            208..402
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..745
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..4032
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4009..4014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="hexamer: AATAAA"
     polyA_site      4032
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="major polyA site"
ORIGIN      

gtagatggcagcggcagcggcggcgcgggccaaggagaccaggcggatgccgccatgcagcactatggggtgaatggctactccctgcacgctatgaactcactcagcgccatgtacaacctgcaccagcaggcagcccagcaggcccagcacgcccccgactaccggccatcagtgcatgcgcttacgttggctgagcgcctagctggctgtacatttcaagacatcatcttggaggcccgctatggctcccagcaccgtaaacaacgtcggagtcgcacggcgttcacggcccagcagcttgaggccctggagaagaccttccaaaagactcattacccagatgtggtgatgcgcgagaggctggccatgtgtaccaatcttcctgaggcccgtgtacaggtgtggtttaagaaccgcagggccaagttccgaaagaagcagcgcagcctgcagaaagagcagctccagaaacagaaggaggccgagggttcccacggagaaggcaaggtggaggccccagcctcagacacgcagctggaaacagaacagcctcctggtttgcccagtggtgatcctcctgctgaacttcaactgagcctgtcggagcagtcagccagcgagtctgccccagaagatcagctggaccgtgaagaggactcccgtgccgaggagcccaaagctgaaaagagccctggatctgagagcaaggtgccgggctgcaagaggggcagccctaaggcagattccccaggcagcctggccataacgcccgcagccccagggggcggcctccttggtccttcccactcctactcctcatccccactcagcctcttccgtctgcaggagcagttccgccagcatatggcggccaccaacaacctgatgcactactcgtcttttgaagtgggcggtcccgcacctgcggcggctgcagctgcggcggctgccgtgccctacctaggggtcaacatggccccattgagctccctacactgccagtcctattaccaatccctgtcagcagctgctgctgcccaccagggtgtgtgggggtccccattgctgccggcgccccccacaggcctggcacctgcctccgctgccctgaacagtaaaaccacgagcattgaaaaccttcgcctccgggccaagcagcacgccgcatccctgggactcgatacactccccaattgactgtctggcttctaacccaaccatggtcttgggtgtacccctgtctcggtcccatggttattctcagaaggctctccaagttctcctagaactaactttgagagcccagggatgctggggcctggagtcctttcaccttgtctcccttattcaaagtcccaatcccaagtgaaacccacacaccctctgcatggccctgcttggaccccatggaggtcaaatggggaggaggggagcaactggctacaccccctcttcagtattgcctcctccctcctgctccccccccccccgttagtaagttgaagtgtggaatgtgagatataaatataaatatataaaactatattttcaggcactgcctgccccaggccccctttccctgttctcacatcgccactacccttgcccctgagattcactccagcagattctctctctctctctctctctctctctctctctctctctctctcatcctcctttttctcctgatcccccctcccctgcagccccactgcctctgtcttgatccctgtccctctacctacccttggcctttggtgctggctttattattgtccagtattctcaaacagtgtttcttttgggggttgtaggttttttttttgtttttgtttttgttgttgttttttgttttggttttagtcattttgtttcttcctgtttctcttctgctccgcttggctatctcctcccttaacctgaactctctctaggcaactcttccattccatgccccaagattcatcaaagtcctacttggagacccaggagcaacaggcaggaggtagctctaaccccacagcatctccagatattaggaggggctcacagtcaccttttcttctctttctttgcttggaagtacccgctcccagattgcagaggggcagccgcagtagaacagagacctcattgcagggttctagaatcccttctcagtgagtgaacccttatggctacatacggtctcaggacttggcttcctgttgcagaggccggtgtgggagtaggcgcttctgtctcgttagtcactggcatggcagggtgtgttcttctatgtctaggcaaccctgctctgtggacgccctttcaagcttgctaggactgtcttgtctggataagatgatttagaagattctgtccatttccaaccacccagtgttctatgccacaaccttgtatggcagaggctttaattaagtttaataataataactgcagcataagcacttagagaagcccagtttgtaagttagaacattactgttgttttgctgaggaacagtgagtcctgcatacctgaagatctctgtggatactgcctctgtttcccagtaaatgtaaatggctcctttttaggttagacaatctggatttgatcctatttttcttggattccagtgtgagccttgggggggggggctactccattcccctgcccatggtgaggggtgggcaagattacttgaatagattcgtggttatgattccgcaaccctttggctcgccacagaaccctcaaccccacgcccacacagtggtggcctggcacgactggcctacagagccaatagtgctcaccttagtaatgtcagtctggactggggtaggagaaggttttagccagtaaaaagtgagacaggaaagcatgaaagaaagaaacaggagaagtgagccacggaacacaaggtgactggcctcgtgagaggtgaggcagagagcctaggacgcagtctcacattcccactttcacgcagcagcaccaaagtcagttgagggtttcttaagaaggggtatcttcctgggttctagaatctgcgaacatcagaggaggagagacttggacggggagatgagaggttagcaaatccttagggagatgagggggttctgggttagggagggatcagtgatcgatccatggttaccctattgtggtcagcttcaagaaattatgtttctgtattgtctcatctggaaccaggcgcagggctgaaactgtctttctattcctgggtgcaaatgactgattgtcactgggacttgggatctaacacttctgggtattaccatttccagaagccttcccaacctcctaaagagcaaggccacctgaggtcatatctggtcatgacatgagcctggtctatcccaggcttttctaaactctcttagatctttgtcatgtgttctctcatgtgctgacccaaatccccaaggccagagaagggagggaagacacacgtgggttttatcttcatgaccatgtcttcttaggaggattagagggcacgattctttgaagaaattgtgggtgagcccaccttcctgacactgctgatggaatctctctcaggcctgctggtcacttagggcagagagcccaaggattaaacccttacaagcccttctaggaagagtcctgtatgtctctgctctgtttgaggtctcctttgccctgcttcctcatttccctagagcatggttcaggggcctgggtccccatttctatgcagaggctgactggctgtatagactgcttttcaaaccagctgttttgtgaccacttgtgcttagaggttgtacaaagccttggcaaaaaacaaaacaccgtgtattgtatttatttattctgttagttgatgaagcaaaactcaaacctctcactttccctcgtcctgtcccctgcgtagcacagcatgaatctctgtcctgtatatctgtcagtcttttggccttacttcctgtgactttgtgacctgttcgttgtcttaattggctaataaaagagaacctggcagcacaaaaaaaaaaaaaaaaaaaaaaa

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