LOCUS       NM_011409               4936 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus schlafen 3 (Slfn3), transcript variant 1, mRNA.
ACCESSION   NM_011409
VERSION     NM_011409.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4936)
  AUTHORS   Vomhof-DeKrey,E.E., Rajpathy,O.K., Preszler,E. and Basson,M.D.
  TITLE     Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in
            lung, stomach, cecum, kidney, and proximal colon differentiation
            markers and Slfn family members expression levels
  JOURNAL   Biochem Biophys Rep 36, 101552 (2023)
   PUBMED   38076659
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4936)
  AUTHORS   Vomhof-DeKrey,E.E., Stover,A.D., Labuhn,M., Osman,M.R. and
            Basson,M.D.
  TITLE     Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific
            differences in intestinal differentiation markers and Schlafen
            family members expression levels
  JOURNAL   PLoS One 16 (10), e0259195 (2021)
   PUBMED   34710177
  REMARK    GeneRIF: Vil-Cre specific Schlafen 3 knockout mice exhibit
            sex-specific differences in intestinal differentiation markers and
            Schlafen family members expression levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4936)
  AUTHORS   Vomhof-DeKrey,E.E., Lansing,J.T., Darland,D.C., Umthun,J.,
            Stover,A.D., Brown,C. and Basson,M.D.
  TITLE     Loss of Slfn3 induces a sex-dependent repair vulnerability after
            50% bowel resection
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 320 (2), G136-G152 (2021)
   PUBMED   33237796
REFERENCE   4  (bases 1 to 4936)
  AUTHORS   Vomhof-DeKrey,E.E., Lee,J., Lansing,J., Brown,C., Darland,D. and
            Basson,M.D.
  TITLE     Schlafen 3 knockout mice display gender-specific differences in
            weight gain, food efficiency, and expression of markers of
            intestinal epithelial differentiation, metabolism, and immune cell
            function
  JOURNAL   PLoS One 14 (7), e0219267 (2019)
   PUBMED   31260507
  REMARK    GeneRIF: Study characterized the role of Slfn3 in the intestinal
            homeostasis. Slfn3KO mice have a phenotype of decreased weight gain
            that is unlikely caused by a single gene but instead multiple
            genes/pathways. This includes the metabolic pathways of
            glycerolipid, linoleic and arachidonic acid metabolism,
            sex-dependent disregulation of glucose transporters, Glut2 and
            SGLT1, and intestinal differentiation genes, Notch2 and Cdx2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4936)
  AUTHORS   Nakagawa,K., Matsuki,T., Zhao,L., Kuniyoshi,K., Tanaka,H.,
            Ebina,I., Yoshida,K.J., Nabeshima,H., Fukushima,K., Kanemaru,H.,
            Yamane,F., Kawasaki,T., Machida,T., Naito,H., Takakura,N., Satoh,T.
            and Akira,S.
  TITLE     Schlafen-8 is essential for lymphatic endothelial cell activation
            in experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 30 (2), 69-78 (2018)
   PUBMED   29528433
REFERENCE   6  (bases 1 to 4936)
  AUTHORS   Berger,M., Krebs,P., Crozat,K., Li,X., Croker,B.A., Siggs,O.M.,
            Popkin,D., Du,X., Lawson,B.R., Theofilopoulos,A.N., Xia,Y.,
            Khovananth,K., Moresco,E.M., Satoh,T., Takeuchi,O., Akira,S. and
            Beutler,B.
  TITLE     An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due
            to loss of immune cell quiescence
  JOURNAL   Nat Immunol 11 (4), 335-343 (2010)
   PUBMED   20190759
REFERENCE   7  (bases 1 to 4936)
  AUTHORS   Bustos,O., Naik,S., Ayers,G., Casola,C., Perez-Lamigueiro,M.A.,
            Chippindale,P.T., Pritham,E.J. and de la Casa-Esperon,E.
  TITLE     Evolution of the Schlafen genes, a gene family associated with
            embryonic lethality, meiotic drive, immune processes and
            orthopoxvirus virulence
  JOURNAL   Gene 447 (1), 1-11 (2009)
   PUBMED   19619625
REFERENCE   8  (bases 1 to 4936)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669916.7 and AL603711.6.
            
            On Feb 7, 2025 this sequence version replaced NM_011409.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099974.1, SRR7652917.286635.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL669916.7         111118-111194
            78-1147             AL603711.6         192603-193672       c
            1148-4936           AL603711.6         187940-191728       c
FEATURES             Location/Qualifiers
     source          1..4936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.3 cM"
     gene            1..4936
                     /gene="Slfn3"
                     /note="schlafen 3"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
     exon            1..77
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    25..27
                     /gene="Slfn3"
                     /note="upstream in-frame stop codon"
     exon            78..1147
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1761
                     /gene="Slfn3"
                     /codon_start=1
                     /product="schlafen 3"
                     /protein_id="NP_035539.1"
                     /db_xref="CCDS:CCDS25159.1"
                     /db_xref="GeneID:20557"
                     /db_xref="MGI:MGI:1329005"
                     /translation="

MKDIQLRRKEAKSILQAVCTLLNSGGGVVKAHIKNQNYSFTRDGMGLDLVNSLPGIMHLPHDYLDFMQHKDYFFVFVKPLKPNQKGPGITTLKTNLYRRINSISDEVKVANAVQLLKSRTDPEEKAESRPSSPGKIVCNETLNECLSLFNRDWLAYEETFCFTKSIHAEVKLTPKEKIFPKEKILELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSNLVLLESEIEKCIQQLPVTHFCGEKEKIKYTCKFIEVRKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKRQMDATAVMPGKVICCPEALYMKPFSQHEGYEHLVRTELGSLLKGTLVISKSWALDLGLQEKQEVIWDVLHISQGSLLTLYVFVQGDENLEGNSSLLGELGAELKGYYKQIALTLKQMLLNHCGYTAEIGIIVKITYLGHKTMCLYDTSTKIRYPQKYYLSAKAVKDLEKALVEILGSYESFYSLPRRNWDSFMSAFLNVGSYIVPVLRNV"

     misc_feature    <217..1122
                     /gene="Slfn3"
                     /note="hypothetical protein; Provisional; Region:
                     PHA02782"
                     /db_xref="CDD:165147"
     exon            1148..4936
                     /gene="Slfn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4915..4920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slfn3"
                     /note="hexamer: AATAAA"
     polyA_site      4936
                     /gene="Slfn3"
                     /note="major polyA site"
ORIGIN      

caaaaatgcctggggcctcggagatgaaagacggacctgaacaggagcagagacacagagctggccacacatggaaggaaaggacttcatctgggaaacagaggcagtgattggaaaacaaacatcattgttgatcaggacacagactatgctgaactggttctgtttattggagaaatcacacttggagagaaaaataggaattcaatgaaagatattcaactgagaagaaaagaagccaaaagtatattacaggctgtgtgcaccctgctgaattctggagggggcgtggtcaaggctcacattaaaaatcaaaactacagcttcaccagagatggaatgggactggatttggtaaattccttacccggtatcatgcaccttcctcatgactatctagacttcatgcagcacaaagactactttttcgtttttgtgaaaccattgaagccgaatcagaaagggccggggatcaccaccttgaaaacgaacttgtacagaagaatcaactcaatctcagatgaagtgaaagtagcgaatgcagtgcagctcctcaaatccaggacagatcccgaagagaaagcagaatccagaccaagttcacctgggaaaatcgtctgtaatgaaacactaaatgaatgtctttccttatttaacagagactggcttgcctatgaggagacattctgtttcactaaatccatacatgctgaagtaaaattgactcctaaggaaaagatttttcctaaggaaaagattttagagctcctccctcaaactgtttctgcatttgcaaacactgatgggggatttttgttcattggcttggatggcaaaacgcagcaaattattggttttgaagcagagaagagcaatctcgtgcttctagagagtgaaatagaaaagtgcatccaacagctgcctgtcactcacttctgtggggagaaggagaagatcaagtacacgtgcaaattcatcgaagtgcgcaaatccggagctgtgtgtgcatatgtgtgtgcgctcagagtggagaggttctgctgtgcagtgttcgctgcagagcccgagtcctggcacgtggaaggtggctgtgtgaagaggtttaccacagaggaatgggtgaagcgccagatggatgccactgcagtgatgcctggaaaggtgatatgctgtccagaagccctctatatgaaaccattctcacaacatgaaggctatgagcacttagtccggacagaattgggctccctgcttaaaggaacactggttatctccaagagctgggctttggatctgggcttgcaagagaagcaggaagttatctgggatgtgcttcatatttcccagggcagtctcctgaccctgtatgtctttgtccagggagatgagaacctggaaggcaacagcagtcttcttggggaactaggcgccgagttaaagggctattataaacaaattgccctaacattaaagcagatgttgttaaaccattgtggttacactgcggaaataggtattatagtaaagataacatacttgggtcataagacaatgtgtctttatgacacaagcacaaaaatacgttacccccaaaaatattatctgtcggccaaggcagtaaaggacttagaaaaagctctcgttgaaatcttaggaagttatgagtctttctacagtttacccaggagaaactgggattcttttatgtctgcatttttaaatgtgggaagttatatagtccctgttttgagaaatgtatgagaaatgtcttaactcatattcgaatctgacaagacataaaaaaaacaaatggagtatggcacaatgatgtttcacagtatgtaggtgataatgctctccaaatctataaaaaactactacaggaaaatgtgactttgagcttcagagaaatggaaaccaagttctggagaagggattggccattggagatgtcaatgacaaactatagcattaataatgtgtccctaagccatgcatgtgacccaggcctttgattctggcacctagaagaaggcaggtcatcctggtctatataaagagctacaggacagcaagagttttgcagtgagagcctctctcaacatttattaattaattggataattaattaatacatgtctctccttatctgcatagccactccttgatgataaaatgctcggtgcctttaatatatgggagaaatttttcctagagaagtcagtaaagaaaatgttgaaataggtgatatgatatagaaacgtttttgttaccggtttgtgtcttagtcagggtttctattcctgaacaaaacatcatgaccaagaagcaagtaggggaggaaagggtttattcagcttacacttctatactgttgttcatcaccaaggaaatcaggactggaactcaagcaggtcaggaagcaggtcttggtgaaggtggagcctcacctgcaattgactaccaagcccatagatggtaccacctacaaggggcccgcccctcttggtcactaattgagaaaatgcgttacagctggatctcatggacacattttctcaactgaagctcctttccctgtgataactccagcttgtgtcaagttgacacacaaaaccagccagtacaattgaccccatgtcaacttaacacacaaatacatcactataaagcctcaacccttactttcttattcatccccaagatatcaataactttaaaagtcccacagtctttacatattaacagtccaatccctttaaaatatccaatatcttttaaaatttaatgtcttttaaaaattcaaagtctcttaactgtgggctccactaaatatcttcttacttcaagagggaaaaatatcatggcacagtcacaatcaaaagcaaaattaaactccaaccatccaatgtctgggatccacttaccatcttctaggctcatccaagggcttgggtcacttctccaaccccgccctttttgcacccagtttatcttctaggctccagatgcctgtactccactgctgctgctttcttggtggtcatctcacagtactggcatctccaaaacactgctgtcttccactgtagctaggctttaccaacagcctctcataagctctcttcatggtgccaagccttacctcctttgcatgacctcttcagtcctggacagctgctcttcatgacaccttcatgcctgggaaattggtaccatctggttgattttttacacattacaagtcctgctgcagcatgaggtacaaccttggctatctctagaacacagcctctgtgttctcagaaaacacttcccagaagatgtcacctcaatgatgctggtctcttcttaatcaccaataatttcttagctccagctaaacagcatcaaaagtctcagtaatgcaaaggttttgctttagtagttctggtatcctgttaatcacagctgattcttcagcctcatctaaccagaaaccacagaatcttcacaatcaaaatagcatcggccctgaaaaaaatctttaatcttccctgtgaaatttcacaagccagacctccatcttctgcactgttttcaacattacctgccaaactcctatacaacatcccaccaatcttctagcctaaagttccaaagtctttccacagtcctccccaaaacatggtcaggttgtcacaggaataccccactcttggtaccaatttgtcttagttagggtttcttttcctggacaaaatattatgaccaagatcaagtgaaggagcaaagggtttattcagcttacactttctcaactgaagctcctttctctgtgataactccagcttgtgccaagttggcacacaaaactagccagtacaggttgctgtccacccttgtgtgttattgctcttaaatacttgatttgtttctgacaacctgagcaaagatttcccacgcgtccaaaatcacagaagcaaatgtcagagtatgtggagattaaatggcaactgctcacaccatcatatattataaagaagagatttctagaaaggtcaaagagacatggaaacaaatacaattattttctgtgaggagagtacaatctgtcttaaagaaaaacattgtacctcttggatgtaagacagttcacaagcaggtcttaggccatgctggcagtttctatggggctatagcatgggatctatttttctatttgtgggatcatttcctatgaaatgatcccacaaatagaaatagaaaatgatcctattgagaacagattttatgttgtggacattgttcatttagggtttgattgttgtatttttcgtgatggtattgtcatgatgtttgcgctgtagataacactactaaagatatttacagcattaagtttgcaggagagtattacgcattaattgaaatgttggtattcccttcataaagaatgcagtgtcctcattgtacatctacatttgtgaaggataaaatttctcaacattcagcccttagtggctattgtatttgaattgtggtaacctgttgtgacttttgatgaagctcaacaaaagactggttactctacatgacagttctgatgacaagtgtggagagccgtgcctcgagcaatcgctgtggagagcccgtgccgtgagcaatcgctgtggagagcagtgtgtgcagcgagcaatcgcaattataagatggccctggcctccactgtgcctaactagtaaacaagccttgtacacaggtgcgagagtgaactcactcctagtcactgcccattctcggggcataatagtggggtgatgagcaaacaacaaatcaggagctgacacgccatatcaggtgctgaaacgccatggctgagggctatataagcgactccattttctgcagtcggggtcttccagagaagtaagcaataaagttttgccgcagaaga

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