LOCUS       NM_010836               2287 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus msh homeobox 3 (Msx3), transcript variant 1, mRNA.
ACCESSION   NM_010836
VERSION     NM_010836.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Gupta,I., Yeung,J., Rahimi-Balaei,M., Wu,S.R. and Goldowitz,D.
  TITLE     Msx genes delineate a novel molecular map of the developing
            cerebellar neuroepithelium
  JOURNAL   Front Mol Neurosci 17, 1356544 (2024)
   PUBMED   38742226
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Nie,X., Zheng,J., Ricupero,C.L., He,L., Jiao,K. and Mao,J.J.
  TITLE     mTOR acts as a pivotal signaling hub for neural crest cells during
            craniofacial development
  JOURNAL   PLoS Genet 14 (7), e1007491 (2018)
   PUBMED   29975682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Fowler,K.J., Kalitsis,P. and Choo,K.H.
  TITLE     Mouse mitotic spindle checkpoint Bub3 gene maps to the distal
            region of chromosome 7 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 91-92 (1999)
   PUBMED   10640819
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Wang,W., Chen,X., Xu,H. and Lufkin,T.
  TITLE     Msx3: a novel murine homologue of the Drosophila msh homeobox gene
            restricted to the dorsal embryonic central nervous system
  JOURNAL   Mech Dev 58 (1-2), 203-215 (1996)
   PUBMED   8887328
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Shimeld,S.M., McKay,I.J. and Sharpe,P.T.
  TITLE     The murine homeobox gene Msx-3 shows highly restricted expression
            in the developing neural tube
  JOURNAL   Mech Dev 55 (2), 201-210 (1996)
   PUBMED   8861099
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Cosgrove,D., Gray,D., Dierich,A., Kaufman,J., Lemeur,M., Benoist,C.
            and Mathis,D.
  TITLE     Mice lacking MHC class II molecules
  JOURNAL   Cell 66 (5), 1051-1066 (1991)
   PUBMED   1909605
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Holland,P.W.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012556.1 and BC051983.1.
            
            On Aug 12, 2009 this sequence version replaced NM_010836.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62523.1, BC051983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK012556.1         2-32
            32-2070             BC051983.1         1-2039
            2071-2287           AK012556.1         2140-2356
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.04 cM"
     gene            1..2287
                     /gene="Msx3"
                     /note="msh homeobox 3"
                     /db_xref="GeneID:17703"
                     /db_xref="MGI:MGI:106587"
     exon            1..303
                     /gene="Msx3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    18..20
                     /gene="Msx3"
                     /note="upstream in-frame stop codon"
     CDS             90..704
                     /gene="Msx3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox, msh-like 3; homeo box, msh-like 3"
                     /codon_start=1
                     /product="homeobox protein MSX-3 isoform 1"
                     /protein_id="NP_034966.1"
                     /db_xref="CCDS:CCDS21961.1"
                     /db_xref="GeneID:17703"
                     /db_xref="MGI:MGI:106587"
                     /translation="

MARATFDMNAAGLEARGGGHTEHGPLPFSVESLLEAERVPGSESGELGVERPLGASKPGAWPPPVAHSCPPRAPSPPPCTLRKHKTNRKPRTPFTTAQLLALERKFHQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKLAAKPLLPAAFALPFPLGTQLHSSAATFGGNAVPGILAGPVAAYGMYYLS"

     misc_feature    204..356
                     /gene="Msx3"
                     /note="propagated from UniProtKB/Swiss-Prot (P70354.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    351..521
                     /gene="Msx3"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            304..2287
                     /gene="Msx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx3"
                     /note="hexamer: AATAAA"
     polyA_site      1141
                     /gene="Msx3"
                     /note="major polyA site"
ORIGIN      

cacagagcccaaggtcctagcaaaataaaccgccgctgggtcccacgcgtcccagccgggcggctagccccgcacccgccatcccatgcatggcccgggcgacattcgacatgaacgcggcggggctcgaagctcgcggcgggggccacacagagcacggaccactccccttcagcgtcgagtctctgctggaggctgagcgcgtaccgggctccgagtctggggagctgggggtggagaggccgctcggcgcctcgaagcctggagcctggccccctccagtcgcgcactcttgtcccccacgtgccccgagccctccaccctgcaccctccgcaaacacaaaaccaatcgcaaaccacggacgccattcaccaccgcgcagctgctggcgcttgagcgcaagtttcaccagaagcaatacttatccattgcggagcgcgccgagttctccagcagcttgagcctcactgagactcaggtcaagatctggtttcagaaccgccgagccaaagccaagcggctgcaggaagctgagctggagaagctgaagctggcagcgaagccactactgccggcggcgtttgccctgcccttcccgctgggcacccagctgcacagctccgcggccactttcggcggcaacgcggttcctgggatcctcgccgggcctgtcgcggcctatggcatgtactacttgtcttagatcatggaatcaagccctaacctcttggttaggctcagggttgcgcacagttctgcctgccgctgatgctcctggtaacttttgacttttcattttagtcttccccccccccctcctcctgtttatacggtgttatacttgatgactggagcctatttatagacatcttacaaatactttaaaccttcctaaaaccttgcccacatcaatctgtttttctgaaagaaaacacaccgtcatatagtccttgaaacagacaaaagcagttcttcctatttcttacaaagcagtcgacaaagtatttctggagtgggtgtgctccctgtattcactctgcccggacaccgaggacttcagagaggctcgattgagctggcataagaaaacaaattccataagaagaaatcaaaataaaaaatgagataatcggacggttagaaattactgtctctccaactgttgtgaccaaatggaaacttttacactttttaggttttataccattattatttttttttttagagtatatgtcgttcaaggagctagaggcaaacgctggatggacttggaagtaggggaggggactgttggcgccatgccctaatgtaagggtggctgctgcccccagcatcttctgagcttcttcgaaaagagcctgctggggggagacagagggctgaaggcagcagggaccaacctctagcctcttgccagcaggtgtccagtcaataaagagaagaaagtgagagttgagcatctcagatctcccattgtgggtgcggtaggaggtgaggcctgtgaaggtcccagaagagttactctgagtgccggctgcctctgtaattctggtgctccgtagaaaagcggaggacttgtttaggaatccggacttgtacctttattctacctttatccgaggaaagaaaacaggccatctgagctgttctgtcctatcctgttcggtctcaatcctatcatgcaagattgaggcccttagggtacctgacaacgggcactaatacaccccatggctgtttccacaggacacttttgctgcaatctagagactttagctggagtgtgttgagggctcacaacagtcccctggagtcacagcccaggacctttgacaggccctcctgccagccttcgggcaggggaggaagaacctgcctgcagagggctgctggttgtgtgttcatgagaacatggaatttcacagtgatagatggcccagggttaggatgctctggttgggaggaagggaaggactgggctatgctcggcagtccaagccagctccaggaaaactgctgtcccgtgaccttcactggtccatcagctccaaataaaaccgaaaagataatattgcatggaattgcctattgatacgtattgacagtcttctgccctgtgtctcttggaaaaattggaaaccagataggtttggttttgttttgagaccaaatcgtcactatgtagccctaactgatctaggacttgctattctccaaggacagccttagacttaccttgcctccacttgcctcccaagttctgggattaaagacataccacaatgc

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