LOCUS       NM_009501               3092 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ventral anterior homeobox 1 (Vax1), mRNA.
ACCESSION   NM_009501 XM_906499
VERSION     NM_009501.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Van Loh,B.M., Yaw,A.M., Breuer,J.A., Jackson,B., Nguyen,D.,
            Jang,K., Ramos,F., Ho,E.V., Cui,L.J., Gillette,D.L.M.,
            Sempere,L.F., Gorman,M.R., Tonsfeldt,K.J., Mellon,P.L. and
            Hoffmann,H.M.
  TITLE     The transcription factor VAX1 in VIP neurons of the suprachiasmatic
            nucleus impacts circadian rhythm generation, depressive-like
            behavior, and the reproductive axis in a sex-specific manner in
            mice
  JOURNAL   Front Endocrinol (Lausanne) 14, 1269672 (2023)
   PUBMED   38205198
  REMARK    GeneRIF: The transcription factor VAX1 in VIP neurons of the
            suprachiasmatic nucleus impacts circadian rhythm generation,
            depressive-like behavior, and the reproductive axis in a
            sex-specific manner in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Bosze,B., Suarez-Navarro,J., Cajias,I., Brzezinski Iv,J.A. and
            Brown,N.L.
  TITLE     Notch pathway mutants do not equivalently perturb mouse embryonic
            retinal development
  JOURNAL   PLoS Genet 19 (9), e1010928 (2023)
   PUBMED   37751417
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Min,K.W., Kim,N., Lee,J.H., Sung,Y., Kim,M., Lee,E.J., Kim,J.M.,
            Kim,J.H., Lee,J., Cho,W., Yang,J.M., Kim,N., Kim,J., Lee,C.J.,
            Park,Y.G., Lee,S.H., Lee,H.W. and Kim,J.W.
  TITLE     Visuomotor anomalies in achiasmatic mice expressing a
            transfer-defective Vax1 mutant
  JOURNAL   Exp Mol Med 55 (2), 385-400 (2023)
   PUBMED   36737666
  REMARK    GeneRIF: Visuomotor anomalies in achiasmatic mice expressing a
            transfer-defective Vax1 mutant.
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Constam,D.B. and Robertson,E.J.
  TITLE     SPC4/PACE4 regulates a TGFbeta signaling network during axis
            formation
  JOURNAL   Genes Dev 14 (9), 1146-1155 (2000)
   PUBMED   10809672
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Hallonet,M., Hollemann,T., Pieler,T. and Gruss,P.
  TITLE     Vax1, a novel homeobox-containing gene, directs development of the
            basal forebrain and visual system
  JOURNAL   Genes Dev 13 (23), 3106-3114 (1999)
   PUBMED   10601036
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Bertuzzi,S., Hindges,R., Mui,S.H., O'Leary,D.D. and Lemke,G.
  TITLE     The homeodomain protein vax1 is required for axon guidance and
            major tract formation in the developing forebrain
  JOURNAL   Genes Dev 13 (23), 3092-3105 (1999)
   PUBMED   10601035
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Jean,D., Bernier,G. and Gruss,P.
  TITLE     Six6 (Optx2) is a novel murine Six3-related homeobox gene that
            demarcates the presumptive pituitary/hypothalamic axis and the
            ventral optic stalk
  JOURNAL   Mech Dev 84 (1-2), 31-40 (1999)
   PUBMED   10473118
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Ohsaki,K., Morimitsu,T., Ishida,Y., Kominami,R. and Takahashi,N.
  TITLE     Expression of the Vax family homeobox genes suggests multiple roles
            in eye development
  JOURNAL   Genes Cells 4 (5), 267-276 (1999)
   PUBMED   10421837
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Hallonet,M., Hollemann,T., Wehr,R., Jenkins,N.A., Copeland,N.G.,
            Pieler,T. and Gruss,P.
  TITLE     Vax1 is a novel homeobox-containing gene expressed in the
            developing anterior ventral forebrain
  JOURNAL   Development 125 (14), 2599-2610 (1998)
   PUBMED   9636075
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124459.5.
            
            On Jun 25, 2019 this sequence version replaced NM_009501.2.
            
            Summary: This gene encodes a member of the EMX homeobox protein
            family. The encoded protein functions as a transcription factor
            which is important in the development of anterior ventral forebrain
            and visual system. Disruption of this gene causes impairment in the
            developing forebrain, where the encoded protein is necessary for
            axon guidance and major tract formation. [provided by RefSeq, Dec
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.27712.1, AF064554.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               AC124459.5         740-1348
            610-797             AC124459.5         2479-2666
            798-3092            AC124459.5         4363-6657
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.61 cM"
     gene            1..3092
                     /gene="Vax1"
                     /note="ventral anterior homeobox 1"
                     /db_xref="GeneID:22326"
                     /db_xref="MGI:MGI:1277163"
     exon            1..609
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    255..257
                     /gene="Vax1"
                     /note="upstream in-frame stop codon"
     CDS             369..1385
                     /gene="Vax1"
                     /note="ventral anterior homeobox containing gene 1"
                     /codon_start=1
                     /product="ventral anterior homeobox 1"
                     /protein_id="NP_033527.1"
                     /db_xref="CCDS:CCDS29933.1"
                     /db_xref="GeneID:22326"
                     /db_xref="MGI:MGI:1277163"
                     /translation="

MFGKPDKMDVRCHSDTEAARVSKNAHKESREIKGAEGSLPAAFLKEPQGAFSGSGASEDCNKSKSNSSADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQGKDSELRSVVSETAATCSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAAATAPGPAGAASQHQPAVGGAPGPGPAGPGGLHAGAPTASHGLFSLPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSARYLSSSAFEPYSRTNNKEGAEKKALD"

     misc_feature    369..575
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2NKI2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    669..839
                     /gene="Vax1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1083..1175
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2NKI2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1320..1382
                     /gene="Vax1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2NKI2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            610..797
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..3092
                     /gene="Vax1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vax1"
                     /note="hexamer: AATATA"
     polyA_site      3092
                     /gene="Vax1"
                     /note="major polyA site"
ORIGIN      

aaccacaactcggccgtctcagtaacaggcggagccgcagcgtttcggagttgcgctgttcgctacctgatcgccaggctggggacactggacgtgctcaaaggacgcgggcgctgacgaggcggcctcgccaccgggatcctggacaagacccgccgcctctctaccagcgcgccactctcctgtctgcgctgaccctccgcggccgccgaagccaccccgcggggacattcattctggcgggcgaccgagcttaggtgctgcgttgtaggggttttgtccccttttgcttcttcttttcccaccctccttcttttctgtgtttttttgtttttgttgttgttttctttctttctttctttttgcctatgttcgggaaaccagacaaaatggacgtccggtgccactcggacaccgaggccgccagggtctcgaagaacgcgcacaaggagagccgggagatcaagggcgccgaggggagccttccggccgccttcctcaaggagccgcagggcgccttttccgggtctggcgcttcggaagattgtaacaaaagtaaatccaattcctcagcggacccagattactgtcgccggatcctagtccgagatgccaaggggtctatccgagaaatcatcctgcccaaaggcttggatctggaccggcccaagaggactcgcacgtccttcaccgcggagcagctctacaggctggagatggagttccagcgttgccaatacgtggtgggccgggagagaaccgagctggctcggcagctcaatctctctgagacccaggtgaaggtctggttccagaatcggcggactaagcagaagaaggaccagggcaaggactcggagctgcgctcggtggtgtcggagaccgccgccacgtgcagcgtgctgcggctcttggagcaaggccgcctgttgtcgcctcccgggctgcccgccttgctgccgccctgtgccactggcgctctaggctcggcgttgcgcgggcccagcctcccggccctgggtgcaggcgctgccgcgggctccgccgctgccgccgccgctgccgccgccgccactgccccgggtcccgcaggcgcggcgtcccagcaccagccggccgtgggcggcgctcccggcccagggcctgcagggccgggaggactgcacgcgggagcaccgactgccagccacggtctcttcagcctgccggtgccgtcgctgctaggctctgtcgccagccgcctgtcctccgccccgttgacgatggctggttcgctagccgggaatttgcaagaactctcagcccgttacctgagctcctcggccttcgagccttactcccggaccaacaataaagaaggggccgagaaaaaagcgctggactgattttaagtgttaccctgtatttatatttataacatctcttgtggtggtatttatgaactcgcctgcgttaggcgcccagtgctcctgcgctggccttcctggcccccactaggcttctgacgcccccaccctcaccccaccccaccccgcaccccacccaccccgtgcaggctactggtttcaacttactcgggctgttttgctctctctacttttcctccctccctccaacccggcttctttctgaatccaggaatgatccaaagaattggggagaaatacccgaattagccaacccccaccctgctagccagggaaggaacagactgagcctaagtccaggtcctgacacctgttctggataggagcactacacagtgcttctatgaatattcgcaagaggaactatgtttgtagggcgccagggaccggaaaggcttcttggtttttaagacccaaacagaagggcctatgccctcttgtcagagaaaccagggctttgggagaattcctggccccgatttttagacctctcaggataattggtgcatactcagctcctgtctagaacagagctgatgggttttattccctttaggaagattatcgcaggctctccgacccccagaaacgatcaagcaaacatcctgttaggcaaaggtggttataaatttgatctaacagcaataaagcaagagtaatttttacataaaaccagatgaagttttacctgtttttaaatattcataaatagttgagtttgcaagatgtacggaaatcgggctagagaacgcactacgggacgtgcgaaattaaaatctctcgggtgttgtgactttaggtaggaatttaaagaggagaagaaaagccaatgacagaaggttgagaatcttttctgggactgttctgggcggtggcccacagcttcctgctcctcgcaggagagagctcggtggctggtgtcagtctcctgtcacaggggcttcttctttctagaggctccccgaaggagctacagcagaatagttggggctggaagtaaatcagcatgcattatatttgctttggcttctaaacactatctacaaaggcttttcaccaagcaggaagggccggaattttcgagcagttgcttttcgaaggacaggttggggtgcctggcttggccttcacagttcatagtttcttggtgccagtggttccttgtatggcaggcagggcaagtacttcctctcccttctcaaccctagggcgtcagacatcccatcccaagttaaaacccttaccaccacgcgggtgcagccccagccctcgcagcaagggcagcccccagagccatcgccactcgcaatttaaccaaaaccacaggcccagagagcgaggtgcctcagtatctagaatgtattcacccatctgaaacaagctcaaaacattttaaagaaaaaagtaactttattgtaaattatttacatccgaattttttcatctttctttttcccatttcttctctctctctctctctctctctctctctctctctctctctctctctctctctctgcaaatagcgaagaaaataacgaacgattcaaacgcgggtaggtgtcactgaatcctggctactaattgtgttctggacgtcttggctctttggatgtttttgtatttatgtggtgagagtgaaatatatatatctatgatgataaa

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