LOCUS       NM_007957               1615 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus extraembryonic, spermatogenesis, homeobox 1 (Esx1),
            mRNA.
ACCESSION   NM_007957 XM_906956
VERSION     NM_007957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Nobs,E., Laschanzky,K., Munke,K., Movert,E., Valfridsson,C. and
            Carlsson,F.
  TITLE     Cytosolic serpins act in a cytoprotective feedback loop that limits
            ESX-1-dependent death of Mycobacterium marinum-infected macrophages
  JOURNAL   mBio 15 (9), e0038424 (2024)
   PUBMED   39087767
  REMARK    GeneRIF: Cytosolic serpins act in a cytoprotective feedback loop
            that limits ESX-1-dependent death of Mycobacterium marinum-infected
            macrophages.
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Solmonson,A., Faubert,B., Gu,W., Rao,A., Cowdin,M.A.,
            Menendez-Montes,I., Kelekar,S., Rogers,T.J., Pan,C., Guevara,G.,
            Tarangelo,A., Zacharias,L.G., Martin-Sandoval,M.S., Do,D.,
            Pachnis,P., Dumesnil,D., Mathews,T.P., Tasdogan,A., Pham,A.,
            Cai,L., Zhao,Z., Ni,M., Cleaver,O., Sadek,H.A., Morrison,S.J. and
            DeBerardinis,R.J.
  TITLE     Compartmentalized metabolism supports midgestation mammalian
            development
  JOURNAL   Nature 604 (7905), 349-353 (2022)
   PUBMED   35388219
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Shafiei,S. and Dufort,D.
  TITLE     Maternal Cripto is critical for proper development of the mouse
            placenta and the placental vasculature
  JOURNAL   Placenta 107, 13-23 (2021)
   PUBMED   33730615
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Rhee,C., Edwards,M., Dang,C., Harris,J., Brown,M., Kim,J. and
            Tucker,H.O.
  TITLE     ARID3A is required for mammalian placenta development
  JOURNAL   Dev Biol 422 (2), 83-91 (2017)
   PUBMED   27965054
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Chou,A.M., Sem,K.P., Lam,W.J., Ahmed,S. and Lim,C.Y.
  TITLE     Redundant functions of I-BAR family members, IRSp53 and IRTKS, are
            essential for embryonic development
  JOURNAL   Sci Rep 7, 40485 (2017)
   PUBMED   28067313
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Morasso,M.I., Grinberg,A., Robinson,G., Sargent,T.D. and Mahon,K.A.
  TITLE     Placental failure in mice lacking the homeobox gene Dlx3
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 162-167 (1999)
   PUBMED   9874789
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Li,Y. and Behringer,R.R.
  TITLE     Esx1 is an X-chromosome-imprinted regulator of placental
            development and fetal growth
  JOURNAL   Nat Genet 20 (3), 309-311 (1998)
   PUBMED   9806555
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Pitman,J.L., Lin,T.P., Kleeman,J.E., Erickson,G.F. and MacLeod,C.L.
  TITLE     Normal reproductive and macrophage function in Pem homeobox
            gene-deficient mice
  JOURNAL   Dev Biol 202 (2), 196-214 (1998)
   PUBMED   9769172
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Li,Y., Lemaire,P. and Behringer,R.R.
  TITLE     Esx1, a novel X chromosome-linked homeobox gene expressed in mouse
            extraembryonic tissues and male germ cells
  JOURNAL   Dev Biol 188 (1), 85-95 (1997)
   PUBMED   9245514
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Branford,W.W., Zhao,G.Q., Valerius,M.T., Weinstein,M.,
            Birkenmeier,E.H., Rowe,L.B. and Potter,S.S.
  TITLE     Spx1, a novel X-linked homeobox gene expressed during
            spermatogenesis
  JOURNAL   Mech Dev 65 (1-2), 87-98 (1997)
   PUBMED   9256347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF085715.1.
            
            On Sep 7, 2007 this sequence version replaced NM_007957.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085715.1, AF017735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1615              AF085715.1         2-1616
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..1615
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="extraembryonic, spermatogenesis, homeobox 1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
     exon            1..383
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="upstream in-frame stop codon"
     CDS             299..1447
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="similar to Prd protein"
                     /codon_start=1
                     /product="homeobox protein ESX1"
                     /protein_id="NP_031983.2"
                     /db_xref="CCDS:CCDS53199.1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
                     /translation="

MESHKKCPCCYCTDLKTFVGAVKEETLQDPQPSLSSTLLEGADYQENAESETTFYSDFGASPKEEEVEMENSLFNSMFLEEANYQEPEGFEPSRGEAAAPVAEAPQAWNGNENLGGGFLESNAQLGEADAAPVRQSLMRPLMQPVAQSSPQPLPANPLQAPQQPEEQEEEEEEQPGEEQPQQEPKPRRYRICFTPIQLQELEAFFQRVQYPDLFARVELARRLGLPEPRVQVWFQNRRAKWRRLRRAQAFRNMVPVAMSPPVGVYLDDHYGPIPIVEVIWKCYPMVPRPMHPQMMPLPPRPPPGFRMPPPFRPPPLPPFPWPPVPPDAHIPNAAREYNPFPFPFPFPFPFPNPFPNPNPNPNPNPNPNPNPNQNFAGPRYRY"

     misc_feature    857..1012
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            384..509
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..945
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..991
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1600
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="major polyA site"
ORIGIN      

aacaaacacactccctgtcaccagagcaccccctacaatgtagtcccaccctacagtgtagtcccacccattccgaatggaaacactcctatttctaatgggggcttgagcggaggcacactacgtaaaatctgatccctaagaggcacaagggctgaccaccctataaaaggggcgtgactcctcaacgagcgccactcgggtacgggagaagcagctggtaccacctctggccaggacctcggaagccaagaagtccgcagaagctggtgacttaacaacccaccgcgctccggtcatggaatctcacaaaaagtgcccctgctgctactgcactgacttgaagacctttgttggagcagtgaaggaggaaacacttcaggatccacagcctagcttgagctcaacgcttttggagggagcagactaccaggaaaacgcggaatctgaaacaactttctactccgactttggagccagcccgaaggaggaagaagtggagatggagaactctctgttcaactccatgtttctggaagaagcaaactaccaggaacccgagggattcgaaccctcaagaggagaagcagcagcgccggttgcagaagcaccgcaagcctggaatgggaatgaaaaccttggaggcggcttcctggagtccaacgctcagctgggggaggcggatgccgcccctgtgcggcagtccctgatgcgtcctctgatgcagcctgttgctcagtcttcgccgcaacccctgcccgcaaacccgctgcaggccccgcagcagcccgaggagcaggaggaggaggaggaggagcagccgggggaggagcaaccccaacaggagccgaagcctcgccgctaccgcatctgcttcaccccgatccaactgcaggagctggaggcctttttccagcgcgtccagtacccggacctgtttgctagagtggagcttgcccgacgcctgggcttacctgaacctagagtgcaggtttggtttcagaacagaagggccaagtggagacgacttcggcgggcacaggcattcagaaacatggttccagtcgccatgagtccccctgtgggtgtctatcttgatgatcattatggccccatccctattgtggaggttatttggaagtgctacccaatggtgcctcgtcccatgcatcctcaaatgatgcctcttccacccaggccccctccaggattcagaatgcctccaccatttaggccacctcctctgccaccttttccctggccacctgtaccacctgatgcgcacatacccaatgcagcaagggaatataaccccttccccttccccttcccctttccctttcccttccccaacccattccccaaccccaaccctaaccccaaccccaaccccaaccccaaccccaaccccaaccaaaattttgcaggtcccagatacagatactgaagtctacatcagttttccaaaagtgtttttcaatcagatttatatcgtttgtaaacactatcacgcattacctgtcaagaagctgttaaacgaaatgtacaaagttaatgccttctttgttttgattttcaataaaagtttggattagcagcaaaaaaaaaaaaaaaa

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