2024-05-02 20:28:04, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001425673 3521 bp mRNA linear ROD 22-NOV-2023 DEFINITION Mus musculus claudin 12 (Cldn12), transcript variant 6, mRNA. ACCESSION NM_001425673 XM_011240673 VERSION NM_001425673.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 3521) AUTHORS Chen JT, Hu X, Otto IUC, Schurger C, von Bieberstein BR, Doppler K, Krug SM, Hankir MK, Blasig R, Sommer C, Brack A, Blasig IE and Rittner HL. TITLE Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency JOURNAL Neurobiol Dis 185, 106246 (2023) PUBMED 37527762 REMARK GeneRIF: Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency. REFERENCE 2 (bases 1 to 3521) AUTHORS Xing W, Pourteymoor S, Chen Y and Mohan S. TITLE Targeted Deletion of the Claudin12 Gene in Mice Increases Articular Cartilage and Inhibits Chondrocyte Differentiation JOURNAL Front Endocrinol (Lausanne) 13, 931318 (2022) PUBMED 35937800 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3521) AUTHORS Cao H, Ni C, Han L, Wang R, Blasig R, Haseloff R, Qin Y, Lan J, Lou X, Ma P, Yao X, Wang L, Wang F, Zhu L, Lei N, Blasig IE and Qin Z. TITLE Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells JOURNAL Cancer Res 82 (13), 2472-2484 (2022) PUBMED 35580275 REFERENCE 4 (bases 1 to 3521) AUTHORS Beggs MR, Young K, Pan W, O'Neill DD, Saurette M, Plain A, Rievaj J, Doschak MR, Cordat E, Dimke H and Alexander RT. TITLE Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis JOURNAL Proc Natl Acad Sci U S A 118 (48) (2021) PUBMED 34810264 REMARK GeneRIF: Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis. REFERENCE 5 (bases 1 to 3521) AUTHORS Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M and Chiba H. TITLE Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland JOURNAL Sci Rep 11 (1), 21642 (2021) PUBMED 34737342 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 3521) AUTHORS Hashizume A, Ueno T, Furuse M, Tsukita S, Nakanishi Y and Hieda Y. TITLE Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland JOURNAL Dev Dyn 231 (2), 425-431 (2004) PUBMED 15366020 REFERENCE 7 (bases 1 to 3521) AUTHORS Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M and Nishinakamura R. TITLE Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice JOURNAL Mech Dev 121 (6), 547-557 (2004) PUBMED 15172686 REFERENCE 8 (bases 1 to 3521) AUTHORS Kitajiri SI, Furuse M, Morita K, Saishin-Kiuchi Y, Kido H, Ito J and Tsukita S. TITLE Expression patterns of claudins, tight junction adhesion molecules, in the inner ear JOURNAL Hear Res 187 (1-2), 25-34 (2004) PUBMED 14698084 REMARK GeneRIF: Claudin-12 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area. REFERENCE 9 (bases 1 to 3521) AUTHORS Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M and Tsukita S. TITLE Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice JOURNAL J Cell Biol 161 (3), 653-660 (2003) PUBMED 12743111 REFERENCE 10 (bases 1 to 3521) AUTHORS Niimi T, Nagashima K, Ward JM, Minoo P, Zimonjic DB, Popescu NC and Kimura S. TITLE claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing JOURNAL Mol Cell Biol 21 (21), 7380-7390 (2001) PUBMED 11585919 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068663.5. On Nov 22, 2023 this sequence version replaced XM_011240673.4. Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]. Transcript Variant: This variant (6) differs in the 5' UTR, as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR17784643.163838.1, SRR12282455.34354319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-85 AC068663.5 33556-33640 86-175 AC068663.5 35154-35243 176-3521 AC068663.5 39951-43296 FEATURES Location/Qualifiers source 1..3521 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="5" /map="5 2.98 cM" gene 1..3521 /gene="Cldn12" /note="claudin 12" /db_xref="GeneID:64945" /db_xref="MGI:MGI:1929288" exon 1..85 /gene="Cldn12" /inference="alignment:Splign:2.1.0" exon 86..175 /gene="Cldn12" /inference="alignment:Splign:2.1.0" exon 176..3521 /gene="Cldn12" /inference="alignment:Splign:2.1.0" misc_feature 178..180 /gene="Cldn12" /note="upstream in-frame stop codon" CDS 205..939 /gene="Cldn12" /codon_start=1 /product="claudin-12" /protein_id="NP_001412602.1" /db_xref="GeneID:64945" /db_xref="MGI:MGI:1929288" /translation="
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTIYTGLWVKCARYDGSSDCLMYDRTWYLSVDQLDLRVLQFALPLSIVIAMGALLLCLIGMCNTAFNSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWAIFYNSHLNRKFEPVFTFDYAVFVTIASSGGLFMTALLLFVWYCACKSLSSPFWQPLYSHAPGMHTYSQPYSSRSRLSAIEIDIPVVSHST"
misc_feature 235..297 /gene="Cldn12" /note="propagated from UniProtKB/Swiss-Prot (Q9ET43.2); transmembrane region" misc_feature 466..528 /gene="Cldn12" /note="propagated from UniProtKB/Swiss-Prot (Q9ET43.2); transmembrane region" misc_feature 610..672 /gene="Cldn12" /note="propagated from UniProtKB/Swiss-Prot (Q9ET43.2); transmembrane region" misc_feature 727..789 /gene="Cldn12" /note="propagated from UniProtKB/Swiss-Prot (Q9ET43.2); transmembrane region" misc_feature 886..888 /gene="Cldn12" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P56749; propagated from UniProtKB/Swiss-Prot (Q9ET43.2); phosphorylation site" misc_feature 895..897 /gene="Cldn12" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9ET43.2); phosphorylation site" ORIGIN
agaacgcacttccgcggcagcggagggagaccaaggagccgcggctcggagtgggtgagcgggatgcccgagccgtgaggagccggtccagattatctctgctttgtgtgcagatgtgctcctgttgcatctgagttcactaagctgactttggaggatcaggcacagggaaaggactgaccatacagctcaagccctcctgccatgggctgccgagatgtccacgcagccaccgtcctgtccttcctgtgtggtattgcctctgtcgcaggcctctttgcggggactctgcttcctaactggaggaaactgcggctgatcacattcaacagaaacgagaagaacctgacgatttacacgggcctgtgggtgaagtgtgcccggtatgatggaagcagtgactgcctgatgtacgaccgtacgtggtacctgtcggttgaccagctggacctgcgtgtcctccagtttgccctgcctctcagcatcgtgatcgcaatgggtgccttgctactctgcctgattggaatgtgtaacacggccttcaattcttccgtgcctaacatcaaactggccaagtgtctggtcaatagtgcaggctgccacctggtggccggactcctgttttttctggcaggtaccgtgagcctctctccgtccatctgggccatcttttataacagccatctcaacaggaagtttgagccggtctttacctttgactatgcagtatttgtcactattgctagctcagggggtctgtttatgactgctctcctgctgttcgtttggtattgtgcatgcaagtctttgtcctctcctttctggcaaccgctgtactctcacgctcccgggatgcacacttactcacagccctattcatcacggtcccgcctctctgccattgaaatcgacattccagtagtctcacacagcacttaacagagatacaattaactgttcaaaggatgtcttgtagcctcacagccccctgcataatgagcctttttggacctgtgtacatttttcctatgttccttatcagtcagtggagccaaatttgtatatcttggtagaatgaaatgctgctagattttatgaggtacatattacattcttctaaatgtgaaccattccttttatcttgcttctgagactagaagggtctctagcctccttgttgatgtctgatcaatagcttatgtgaaaggacccatgataacactggaggcagtgaagacagcatattgaacaatgctgtttgatcttcacccgtatttcagattgtgcattgactccgatgattgaaaggtggaaggggcagtttcaaacttaagacgtttcagtcggatgaggctaggagtttgtctgtctccagaactcttccagcttgaaggtataatttcattctctctggggactaattgaataggcatcagtatactgaagattgctatcttctacctcattccagggaaaagtaaaacgcattttacatgacagagtaaagctaatatttaagcatggttaacatttggcttcttcattggtttcagatggggtcttgctgtgtagctctggctggcctagagatcactgcagaccagtgtgtactcagactttctacccgcttgcctcctgagcactaactacaaggcacacccaattacactaacaatgcgtcaggagacagtcagtatgttgcttcatttgaagcaagaatccctttccagatccccttatcaggtagtgctcatgcgctggccaagctcttagtgcctaggacaaaattgtttttcagggcgcgggagtctgttctttagtgtcagcgccaaagattcatttggtggctactatttgagtagtggctttagtctgttcagttcctgcttcagaactgatttcttgcttctgacactgcttaacgtttgagtaagtacttcagaggatacacaaataggagaaatagccatgtctatgtaggaatgttgatctaattcacctgataaccagtgggaagtctgacattatggtagctggtaagcttgtcaagcattgacccaggagtgtatttcatctgaaagatgtctttgtgacacagacagcctgtggtccaccaccagcaatagcctggacgctggaaattccctttaatcaggtctcctcccatagccgtaataatggtctcagatcatgagaatggtaagataggagagagattaaattatacctattctacctctgaagctaagatgataaattaaagaggggcaaattttaaaaatatctcttctgatgtgatatcaaatggataaaaccatgttagtactaacatgacattgaggggtgttgggtcttagcttagggatttgagctgctcatttagataatgtccacgtactagcattgtttgtaaggactgtagtacattgtgcttatagatttttacaagcagctgattttatgataacagtttctgatgcctcttttgcaaatctgagtctttctgtagagatatgtagtacttttccctaagtccaacactactgtatgtaggccaacactactgtatgtaggcaagttaatccaattgtataattttaaaacgccgtcaatacaaagcatgcacatctatggttttttaaaattacaacttctagccttttccacctctggttcttctcactcataaatggagctgagtgttggtcattccaagacagtggcagctcgaattctgagactaataatagtgttttccctttgttaattaatcttagttcttctctcactaaactgtttccagatggaattctaccatgccttggtgttagtatacagagataaaagtagggccaggtgtagtggcttttgactttaataccagcactcaggaggcagtgacaggtgcatttctggaaattctggtctccatagcaagttccaggccagtcagagctacacagtgagaacctgtctttaaaaacaattagaaaaagtggactcagcaatgagaatactagacagttttcagctcacaggattgtaactacaaacatttaagctttcttatgagaatctttcggcattatcatctatagcctcaaattactgttatgaattcactcaggaagagaaacagctgtttctgtattatctttttagtgttccagattgggcataaatagctgttttttaaagccatcaaaggaaagcacgtatttacaatgcttttgagtcactggggctgttattgagatggggtggataacttcttttgttgctaaaaagctgttgattttaaaggccttctaaggagccagttaggcaaagaaccttgaatgtgagacggtgcatagaatttctgttacccagctttgggagaagaataaacctgagattctgagttcactctgcttgtacatacgccctatgacggatagtgtgtgctgtaaaccacaaggtagaatcctcagtgggtgtgctgtgctgcctcatgtttattaaaagatgtatttttacaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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