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Previous release (v1)
2025-08-21 17:06:58, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_001422897 3832 bp mRNA linear ROD 14-JUN-2024
DEFINITION Mus musculus Casitas B-lineage lymphoma-like 1 (Cbll1), transcript
variant 4, mRNA.
ACCESSION NM_001422897 XM_006514940
VERSION NM_001422897.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3832)
AUTHORS Roca-Lema,D., Quiroga,M., Khare,V., Diaz-Diaz,A.,
Barreiro-Alonso,A., Rodriguez-Alonso,A., Concha,A., Romay,G.,
Cerdan,M.E., Gasche,C. and Figueroa,A.
TITLE Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation
and cancer bowel disease
JOURNAL Sci Rep 12 (1), 17571 (2022)
PUBMED 36266428
REMARK GeneRIF: Role of the E3 ubiquitin-ligase Hakai in intestinal
inflammation and cancer bowel disease.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3832)
AUTHORS Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
TITLE Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
Stem Cell Self-Renewal
JOURNAL Mol Cell 69 (6), 1028-1038 (2018)
PUBMED 29547716
REFERENCE 3 (bases 1 to 3832)
AUTHORS Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
and Liu,J.
TITLE VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
stop codon and associates with alternative polyadenylation
JOURNAL Cell Discov 4, 10 (2018)
PUBMED 29507755
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3832)
AUTHORS Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
Trevanion,S. and Wilming,L.G.
TITLE The Vertebrate Genome Annotation browser 10 years on
JOURNAL Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
PUBMED 24316575
REFERENCE 5 (bases 1 to 3832)
AUTHORS Mukherjee,M., Chow,S.Y., Yusoff,P., Seetharaman,J., Ng,C.,
Sinniah,S., Koh,X.W., Asgar,N.F., Li,D., Yim,D., Jackson,R.A.,
Yew,J., Qian,J., Iyu,A., Lim,Y.P., Zhou,X., Sze,S.K., Guy,G.R. and
Sivaraman,J.
TITLE Structure of a novel phosphotyrosine-binding domain in Hakai that
targets E-cadherin
JOURNAL EMBO J 31 (5), 1308-1319 (2012)
PUBMED 22252131
REFERENCE 6 (bases 1 to 3832)
AUTHORS Figueroa,A., Kotani,H., Toda,Y., Mazan-Mamczarz,K., Mueller,E.C.,
Otto,A., Disch,L., Norman,M., Ramdasi,R.M., Keshtgar,M., Gorospe,M.
and Fujita,Y.
TITLE Novel roles of hakai in cell proliferation and oncogenesis
JOURNAL Mol Biol Cell 20 (15), 3533-3542 (2009)
PUBMED 19535458
REMARK GeneRIF: Results suggest that Hakai is an important regulator of
cell proliferation and that Hakai may be an oncoprotein and a
potential molecular target for cancer treatment.
REFERENCE 7 (bases 1 to 3832)
AUTHORS Kim,T.S., Nakagawa,T., Endo,T., Iguchi,F., Murai,N., Naito,Y. and
Ito,J.
TITLE Alteration of E-cadherin and beta-catenin in mouse vestibular
epithelia during induction of apoptosis
JOURNAL Neurosci Lett 329 (2), 173-176 (2002)
PUBMED 12165405
REMARK GeneRIF: E-cadherin distribution and expression is altered in
utricle epithelia with induction of apoptosis.
REFERENCE 8 (bases 1 to 3832)
AUTHORS Fujita,Y., Krause,G., Scheffner,M., Zechner,D., Leddy,H.E.,
Behrens,J., Sommer,T. and Birchmeier,W.
TITLE Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis
of the E-cadherin complex
JOURNAL Nat Cell Biol 4 (3), 222-231 (2002)
PUBMED 11836526
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CR974423.21.
On Jun 27, 2023 this sequence version replaced XM_006514940.3.
##Evidence-Data-START##
Transcript exon combination :: SRR17784645.570791.1,
ERR3363658.4952623.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849380,
SAMN00849381 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-35 CR974423.21 23095-23129
36-194 CR974423.21 27903-28061
195-295 CR974423.21 30473-30573
296-379 CR974423.21 31057-31140
380-453 CR974423.21 32111-32184
454-3832 CR974423.21 34338-37716
FEATURES Location/Qualifiers
source 1..3832
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="12"
/map="12 13.49 cM"
gene 1..3832
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="Casitas B-lineage lymphoma-like 1"
/db_xref="GeneID:104836"
/db_xref="MGI:MGI:2144842"
exon 1..35
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
CDS 23..1489
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/EC_number="2.3.2.27"
/note="isoform 4 is encoded by transcript variant 4;
E-cadherin binding protein E7; E3 ubiquitin-protein ligase
Hakai; c-Cbl-like protein 1; casitas B-lineage
lymphoma-transforming sequence-like protein 1; RING-type
E3 ubiquitin transferase Hakai"
/codon_start=1
/product="E3 ubiquitin-protein ligase Hakai isoform 4"
/protein_id="NP_001409826.1"
/db_xref="GeneID:104836"
/db_xref="MGI:MGI:2144842"
/translation="
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ"
misc_feature 23..82
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIY2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 332..496
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="RING finger, HC subclass, found in E3
ubiquitin-protein ligase Hakai, zinc finger protein 645
(ZNF645), and similar proteins; Region:
RING-HC_HAKAI-like; cd16508"
/db_xref="CDD:438171"
misc_feature order(374..376,386..397)
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:438171"
misc_feature 455..631
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIY2.1);
Region: HYB domain. /evidence=ECO:0000269|PubMed:22252131"
misc_feature 494..589
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="C2H2 Hakai zinc finger domain; Region: zf_Hakai;
pfam18408"
/db_xref="CDD:465753"
misc_feature 614..616
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q75N03; propagated from
UniProtKB/Swiss-Prot (Q9JIY2.1); phosphorylation site"
misc_feature 776..1486
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIY2.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 866..868
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q75N03; propagated from
UniProtKB/Swiss-Prot (Q9JIY2.1); phosphorylation site"
misc_feature 881..883
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q75N03; propagated from
UniProtKB/Swiss-Prot (Q9JIY2.1); phosphorylation site"
exon 36..194
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
exon 195..295
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
exon 296..379
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
exon 380..453
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
exon 454..3832
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/inference="alignment:Splign:2.1.0"
regulatory 1847..1852
/regulatory_class="polyA_signal_sequence"
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="hexamer: ATTAAA"
polyA_site 1872
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="major polyA site"
regulatory 3809..3814
/regulatory_class="polyA_signal_sequence"
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="hexamer: AATAAA"
polyA_site 3832
/gene="Cbll1"
/gene_synonym="c-Cbl-like; Hakai"
/note="major polyA site"
ORIGIN
actgtgccccgcgagccgaatcatggatcacactgacaatgagttacaaggcactaatagttctggatccttgggtggtcttgatgttcgcagaagaatccctataaagctcatctccaaacaagccagcaaagttaagccggcacctcggactcaaaggactgtcagcaggatgcccgcaaaggccccgcaagaaggatttgattataacgaagaacagcgatatgactgtaaaggaggcgaactctttgggaatcagcgaagatttccaggacaccttttttgggatttcaagataaacatcttaggtgaaaaggacgatacaccagtacatttctgtgacaaatgtggactgcctattaaagtctatgggagaatgattccatgcaagcatgtcttttgctatgactgtgctattttacatgaaaaaaaaggagataagatgtgcccaggatgtagtgatcctgtgcagcggattgagcagtgcacacgaggttctctctttatgtgtagcattgttcaaggatgcaagagaacatatctgtctcagagagacttacaagctcatatcaaccatcgccatatgagagctggaaagcccgttacccgtgcttcacttgagaatgttcatcctcctattgcccccccaccaactgacatccccgatcggttcataatgccaccagacaagcatcatatgagccatattcctccaaagcagcacatcatgatgccaccgcctcctctgcagcatgtgccacatgagcactataatcagccacatgaggatattcgtgctcctccggcagaattgtccatggctccacctccacctcgttcggtcagtcaggaaacctttcgtatttcaacaagaaaacacagcaatttaataacggtccctattcaggatgactccagttcaggtgctagagaaccaccacctcctgccccagcacctgctcatcaccatcctgaatatcagggtcagcccgtggtatctcaccctcatcatattatgcctccacagcaacattacgcaccacccccacctcctccaccaccaataagccatccaatgccacaccctccccaggctgcaggtactcctcacttggtatatagccaagctccacctccaccaatgacctctgctccacccccaataacccctccccctggacatattattgcccagatgccaccttatatgaatcatcctcctccaggaccccctccacctcagcatggtggtccacctgtaactgcaccccctcctcaccattacaatcctaactctttaccccagtttactgaagaccaaggaactctgagccctccatttacacaaccaggaggaatgagtcctggtatatggcctgcaccaagagggccacctcctcctccacgaatgcagggcccgccttctcaaaccccactacctggaccgcatcatccagatcaaacaagatacagaccgtattaccagtgatcatagtgttttgaactgaagatatgacaaggaaaaaaaagattagtcaatcttaattgacctttgactgtggaaggaaaactacctcttttgaggtagctattaacacaagtcttgtctctcaaaatggttttaatctgactaggattgctttcaagtactattctgtagtgcagataagtggcttggttgagcacaattctatcttaactgttactttgatgtgataaattttcccaaaacgaccatttgtaaaaaattgaaaaaaaattcactgttccactttgagaaatactgactttattaaacccaatgtttagttttcttgtgatgcattttgttaacctgtgtaaaagaattaaatttcaaaatggttgtaaaaatgctatttttatgtgaatttaagtgcagccatatcattttttaacccatattttaccactaattttccaaggttaaaatcctaaaagtaaaaatctactaaatcgttaccaggcagactgttaaatgtagggaattattcacactttaggcactgaaagttcaaagtgtagttctgtaatacggttcactcggatgccttttcacagcagctgcagatcatcagcgtttctgtaactgtgcttggctggcatgtctccaggtagtgtgtaattgggaaaccgacctgctctacaggctctaagctgccagtgagtgctgttctcattgacgctttttctgagtggctacaatcacataacttgtcacacttaaaggtcttaagttacattattttataggactgtttaaagttgttattggatgaaatgtgctctctgttcactgtcttaacctacatgtttggggctgactaggctttatttaaatctcctttttctcagtttgattctgtgttttagtgcatagtgtgttcttatttatggaattacacactgcagtttgaatgatgtggaggaatctgactaatgtattagcagacggtgttccttgtagtcacaagctagcatgtactcgggtttttgtggctgtggtgagtttttcctctaagttgaaattttaaaactatcatttcttttattggtaaaacagtcaaaaattggaacaatttactgtcgaatcaatagtaaggacaaccagataattttgaattggacagaagaaaagtcatggttagattgtgaatttcagtgccatgtaaggtgcctttagagtcagtgtttgcattataggggcttgttacagtccattggagatgaccactcagtttatacatatttctaagtcagcatccttaggatattatcgtatatcctttggattgactaaactcttgtgaagcttttcttcccctttaaaatggtgcataatataaacatggtgtgtagtgtgcagataacatttattagatagtttgtagtatataaatttagaacattggtttttgacaaggggtatactgattgctaattaaccattttattctgtcaggtacaggaaaacattctcatggtggatgatcagatacaaaatcatttctgaactttcagaagaaataatgtacatggccattcatccttggctggccagaaataactaatgcagttttttcttgagcaaataattttattttcacatgtagcattttgagaatctggtttgctcatgcactatttctagtgagaaattcttgttattagaagcatggacgtgaaatagtgtgacatgtggtgagtgtttctgtcattactgtaggtacttggactggtgcaaacttgattctttttcatgcccctgtttaggagctattaaatattactgttaaaatccaaataacccctttgtttcatgtagttagaaaatagccagattcatgtaagagctttttaactatttatgagaagctcttatattgagatttcctggggttaagtgtggtaagaaaccacttagcctgtattttggaccaaaaaaatcagtatcatgaaaaaaaaaaaatcccacattatgagaattcttgtaggctttaaaaaacaatgtaaaaaccattatgctgggaggcaggccagatgaatgttttgtaatagaattttaattgttagacttcagttcatcagttaattgtttgaatgagggtgggtgggtagacagataacaagattattattaagtgtttctgttcttaaggaaaaagatgtgaatcccagcacatttcagggaagccttcgaagctatctatgatggacataagtctaaatgtatgtatgtttcattaattgctcttaagactactgaggtggcagtttaattctttaaaacaataaaatggaagcataaatacta
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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