LOCUS       NM_001422654            4637 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus solute carrier family 8 (sodium/calcium exchanger),
            member 3 (Slc8a3), transcript variant 3, mRNA.
ACCESSION   NM_001422654 XM_036157166
VERSION     NM_001422654.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4637)
  AUTHORS   Sheikh,I.A., Midura-Kiela,M.T., Herchuelz,A., Sokolow,S.,
            Kiela,P.R. and Ghishan,F.K.
  TITLE     The Na+/Ca2+ exchanger NCX3 mediates Ca2+ entry into matrix
            vesicles to facilitate initial steps of mineralization in
            osteoblasts
  JOURNAL   J Extracell Vesicles 13 (6), e12450 (2024)
   PUBMED   38859730
  REMARK    GeneRIF: The Na[+]/Ca[2+] exchanger NCX3 mediates Ca[2+] entry into
            matrix vesicles to facilitate initial steps of mineralization in
            osteoblasts.
REFERENCE   2  (bases 1 to 4637)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4637)
  AUTHORS   Trendafilova,T., Adhikari,K., Schmid,A.B., Patel,R., Polgar,E.,
            Chisholm,K.I., Middleton,S.J., Boyle,K., Dickie,A.C.,
            Semizoglou,E., Perez-Sanchez,J., Bell,A.M.,
            Ramirez-Aristeguieta,L.M., Khoury,S., Ivanov,A., Wildner,H.,
            Ferris,E., Chacon-Duque,J.C., Sokolow,S., Saad Boghdady,M.A.,
            Herchuelz,A., Faux,P., Poletti,G., Gallo,C., Rothhammer,F.,
            Bedoya,G., Zeilhofer,H.U., Diatchenko,L., McMahon,S.B., Todd,A.J.,
            Dickenson,A.H., Ruiz-Linares,A. and Bennett,D.L.
  TITLE     Sodium-calcium exchanger-3 regulates pain 'wind-up': From human
            psychophysics to spinal mechanisms
  JOURNAL   Neuron 110 (16), 2571-2587 (2022)
   PUBMED   35705078
  REMARK    GeneRIF: Sodium-calcium exchanger-3 regulates pain ''wind-up'':
            From human psychophysics to spinal mechanisms.
REFERENCE   4  (bases 1 to 4637)
  AUTHORS   Afewerky,H.K., Li,H., Zhang,T., Li,X., Mahaman,Y.A.R., Duan,L.,
            Qin,P., Zheng,J., Pei,L. and Lu,Y.
  TITLE     Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.)
            Dunal therapeutic intervention ameliorates cognition in the 5xFAD
            mouse model of Alzheimer's disease
  JOURNAL   Sci Rep 12 (1), 1537 (2022)
   PUBMED   35087161
  REMARK    GeneRIF: Sodium-calcium exchanger isoform-3 targeted Withania
            somnifera (L.) Dunal therapeutic intervention ameliorates cognition
            in the 5xFAD mouse model of Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4637)
  AUTHORS   Di Martino,R., Sisalli,M.J., Sirabella,R., Della Notte,S.,
            Borzacchiello,D., Feliciello,A., Annunziato,L. and Scorziello,A.
  TITLE     Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to
            Neuroinflammation in Striatum of A53t-alpha-Synuclein Transgenic
            Old Mice
  JOURNAL   Int J Mol Sci 22 (15), 8177 (2021)
   PUBMED   34360942
  REMARK    GeneRIF: Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads
            to Neuroinflammation in Striatum of A53t-alpha-Synuclein Transgenic
            Old Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4637)
  AUTHORS   Pyrski,M., Koo,J.H., Polumuri,S.K., Ruknudin,A.M., Margolis,J.W.,
            Schulze,D.H. and Margolis,F.L.
  TITLE     Sodium/calcium exchanger expression in the mouse and rat olfactory
            systems
  JOURNAL   J Comp Neurol 501 (6), 944-958 (2007)
   PUBMED   17311327
REFERENCE   7  (bases 1 to 4637)
  AUTHORS   Sokolow,S., Manto,M., Gailly,P., Molgo,J., Vandebrouck,C.,
            Vanderwinden,J.M., Herchuelz,A. and Schurmans,S.
  TITLE     Impaired neuromuscular transmission and skeletal muscle fiber
            necrosis in mice lacking Na/Ca exchanger 3
  JOURNAL   J Clin Invest 113 (2), 265-273 (2004)
   PUBMED   14722618
  REMARK    GeneRIF: NCX3 plays an important role in vivo in the control of
            Ca(2+) concentrations in the skeletal muscle fibers and at the
            neuromuscular junction
REFERENCE   8  (bases 1 to 4637)
  AUTHORS   Wakimoto,K., Fujimura,H., Iwamoto,T., Oka,T., Kobayashi,K.,
            Kita,S., Kudoh,S., Kuro-o,M., Nabeshima,Yi., Shigekawa,M., Imai,Y.
            and Komuro,I.
  TITLE     Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and
            swollen mitochondria in cardiomyocytes
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 135 (1), 9-15 (2003)
   PUBMED   12781968
REFERENCE   9  (bases 1 to 4637)
  AUTHORS   Yamaji,R., Fujita,K., Takahashi,S., Yoneda,H., Nagao,K., Masuda,W.,
            Naito,M., Tsuruo,T., Miyatake,K., Inui,H. and Nakano,Y.
  TITLE     Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in
            mouse brain capillary endothelial cells: involvement of Na+/Ca2+
            exchanger
  JOURNAL   Biochim Biophys Acta 1593 (2-3), 269-276 (2003)
   PUBMED   12581871
REFERENCE   10 (bases 1 to 4637)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124384.4.
            
            On Jun 20, 2023 this sequence version replaced XM_036157166.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.132977.1,
                                           SRR17784647.1359146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC124384.4         165920-166150       c
            232-2076            AC124384.4         146678-148522       c
            2077-2180           AC124384.4         46484-46587         c
            2181-2305           AC124384.4         37310-37434         c
            2306-2405           AC124384.4         36472-36571         c
            2406-2681           AC124384.4         34661-34936         c
            2682-4637           AC124384.4         30330-32285         c
FEATURES             Location/Qualifiers
     source          1..4637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.44 cM"
     gene            1..4637
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="solute carrier family 8 (sodium/calcium exchanger),
                     member 3"
                     /db_xref="GeneID:110893"
                     /db_xref="MGI:MGI:107976"
     exon            1..231
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..2076
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    281..283
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="upstream in-frame stop codon"
     CDS             293..3058
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; Na(+)/Ca(2+)-exchange protein 3; solute carrier
                     family 8 member 3; sodium/calcium exchanger 3"
                     /codon_start=1
                     /product="sodium/calcium exchanger 3 isoform 1 precursor"
                     /protein_id="NP_001409583.1"
                     /db_xref="GeneID:110893"
                     /db_xref="MGI:MGI:107976"
                     /translation="

MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAGDSGDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNFTPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPEDFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLAEGMLPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISEVTDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAGGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF"

     misc_feature    293..3055
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="sodium/calcium exchanger 1; Region: caca;
                     TIGR00845"
                     /db_xref="CDD:273296"
     sig_peptide     293..388
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     exon            2077..2180
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2305
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2405
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2681
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..4637
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="hexamer: AATAAA"
     polyA_site      4530
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
     regulatory      4594..4599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="hexamer: AATAAA"
     regulatory      4605..4610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="hexamer: AATAAA"
     polyA_site      4617
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
     polyA_site      4637
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="major polyA site"
ORIGIN      

cacacacacacacacattgccaacctccatccccctcgagtcttcccctaggcctgggtggaccttgcctgggtaatcattccctgctatatttaaaaaccacaatgtgtttggagggaacttaatttcgggactgcgggcggtggcgtctcccgaggacaagaggaaagcctgtgccgagcttcttgcctgctgccgggacttcaggactaccaactcccgggaatccaggtcacaggcctgtcaggaggaccattggtgctgtggtggagccagaacctaagtcttgtgtatggcgtggttacggctgcagcctctcacctctgccttcctccattttgggctggttacttttgtgctcttcctgaattgtcttcgagcagaggctggtgactcgggggatgtgcccagtgcagggcagaacaatgagtcctgttcggggtcatcagactgcaaggagggtgtcattttgccaatctggtatccagagaacccttcccttggggacaagattgccagggtcattgtctattttgtggccctgatatacatgtttcttggggtgtctatcattgctgaccgattcatggcatctattgaagtcattacttcccaagagagggaagtgaccatcaagaagcccaatggagagaccagcacaactacaattcgggtatggaatgaaactgtctccaatctgaccctgatggccctgggctcttctgctccagagattctcctgtctttaattgaggtgtgtggtcacgggttcattgctggtgatctgggaccatctaccatcgttggcagtgcagccttcaacatgttcatcatcattggcatctgtgtctatgtgatcccagatggggagactcgaaagatcaagcacctgcgagtcttcttcgtcacggctgcttggagcatcttcgcctacatttggctctatatgatcctggcagtcttctctcctggtgtggtccaggtttgggaaggcctccttactctcttcttctttcccgtgtgtgtcctgctggcttgggtggcagataagcgactgctcttctacaaatacatgcacaaaaaataccgcacagataaacaccgaggaattatcattgagacagagggtgaccaccctaagggcattgagatggatgggaaaatgatgaattctcactttctagatgggaactttacacctttggaaggaaaggaggtagatgaatctcgcagggaaatgatccggattctaaaggatctgaaacaaaaacacccagaaaaggacctagatcagctggtggagatggccaattactatgctctttcccatcaacagaagagccgtgctttctaccgcatccaagccacccggatgatgactggtgcgggcaatatacttaagaagcatgcagccgagcaagccaagaagacctccagcatgagcgaggtgcataccgatgagccggaggactttgcctctaaggtcttctttgacccatgttcttatcagtgcctggagaactgtggagctgtcctcctgaccgtggtgaggaaagggggagatatatccaagaccatgtacgtggactacaaaacagaggacggctccgccaatgcaggggcagactatgagttcacagagggcactgtggttctgaagccaggagagacccagaaggagttctctgtgggcatcattgatgatgacatttttgaggaggatgaacacttctttgtgaggctgagcaatgtccgtgtagaagaggagcagctggcggaggggatgctcccagcaatactcaatagtcttcctttgcctcgggctgtcctggcctccccttgtgtggccacagtaaccatcttggatgatgaccatgcaggaattttcacttttgaatgtgataccattcatgtcagtgaaagtattggtgttatggaagtcaaggttttgaggacatcaggtgccaggggcacagtcatcgtcccttttaggacagtagaagggacagccaagggtggtggcgaggactttgaagatgcatatggggagctggagttcaagaatgatgaaacagtgaaaaccataagggttaaaatagtagatgaggaggagtacgagaggcaagagaatttcttcattgcccttggtgaaccgaaatggatggaacgtggaatatcagaagtgacagacaggaagctgactgtggaggaagaggaagccaagagaatagcagagatgggaaagccagtattgggtgaacaccccaaactagaggtcatcattgaagagtcctatgagttcaagagtacagtggataagctgatcaagaagacaaacctggcattggttgtggggacccattcctggagggaccagttcatggaagccatcactgttagtgcaggaggggatgaggatgaagacgaatctggagaggagaggctgccatcctgctttgactacgtcatgcacttcctgacggtcttctggaaggtgctctttgcctgtgtgccccccacagagtactgccacggctgggcctgcttcgtggtctccatcctcattattggcatgctcaccgccatcatcggggacctggcctctcacttcggctgcaccatcgggctcaaggattcggtcacagctgttgtttttgtggcattcggcacctctgtgccagatacatttgccagcaaagccgctgccctgcaggacgtgtatgcagatgcttccattggcaacgtcacaggcagtaatgccgtcaatgtcttcctgggtattggtttggcctggtccgtggccgccatctactgggccatgcagggacaggagttccatgtgtccgctggcactctggccttctcggtcactcttttcaccatctttgcatttgtctgcctcagtgtgctcttgtatcgtcggcggccccatctgggcggggagctcggaggtcctcgtggctgcaagcttgccacgacatggctctttgtgagcctatggctcctctacatactatttgccacgctggaggcctactgctacatcaaggggttctgaaccgccggaacaagaccgccacagggcagacctgggacttctcctgagagaaggacgcatcctcaccaaccttcccaggttactcatccctggagcagacacatcgggacccgagccccaggaacttcacctgaccttggccctggcactgcacagaaagggcaaaacttaaccaatccaataaactggagaaggcatccactgtccaaagtatttaattaaaaacaaaccaacaacagcaaaaaatccacctctccccatcctgccactcacagccctgagcgtccccttctatcccaccacccaactattcctttgactctagttccccacaaggggcaggatctgccctgtctccagcaagatgcatcaagactccctcactcagctgtcagggtatgagaaggagccatctggacaatggctgccttgggatgctctcttcacctggtcgtcattgtagtcattttcattctcctaccaggttattgtcttgtcttctcttcctgaagttagtgacaaaggaccctgaaggaattccaaatctgagtgacagacaccctcccactctcatcaggccgctgccatctcttggctccaactcagggcataggaggagcttcattcttcgtgcattgacatcaaagccaaaccacagaggaatcaccttcttctcagtggaagccattctacgtctctgtgctgcacctgtgtgtgtgtgtgccctcccacaaagagacttcagagcagagataagagtgttccaggctgaccaagggcacccggggacacacggggaacacctctccaatgtttctgagtttgtgtctgaggtgggggagaagagggtcttcaactggggaggtctctaagggagtgtgtctctaagggtctcttaaagtgtcagtgattgggggcatggcagcgtcaccacccctccctggctgatgtgccatactccgagggctgaagaggtggcttgaaatgaatttggaggcttgtaagagaacaggggcttccttccccctctcctggccttcaggccacttttgaaagcatgttcattggatggggaccggaatccttcatttcccccatgttcctgcttgtttttaaaccgcataaagctccctcttcccagactgtggggcatttcttatgccctgcccccaagggatccaagtcaccacattgccaaagaatccaggcttctagaaaacaagaactgacacgctgacaccccacctcccagacctttcccctgtgtgttttgaaaagacctggctttaaatcacacacacacacacacacacacacacacacacacacacacacactacaaaactgcccacgggtcttgaggctttctgcattgacataaatacattttctaagagagaaagacaaaattaaaacgacacctgtttaattttaaacagattttttaaaaagaaaataaaaaataaaacaatgctcgtgtcctaagctgtgttgacagttgccggtggaaatgttgggttggttcaaaaaaaaataataaaaataaaataaaaggtctacttatatgtctctacacaca

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