LOCUS       NM_001416446            2731 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus core binding factor beta (Cbfb), transcript variant 6,
            mRNA.
ACCESSION   NM_001416446 XM_036153738
VERSION     NM_001416446.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2731)
  AUTHORS   Zhang,Y., Chen,H., Wu,J., McVicar,A., Chen,Y., Su,J., Li,Y.P. and
            Chen,W.
  TITLE     Deficiency of Cbfbeta in articular cartilage leads to
            osteoarthritis-like phenotype through Hippo/Yap, TGFbeta, and
            Wnt/beta-catenin signaling pathways
  JOURNAL   Int J Biol Sci 20 (6), 1965-1977 (2024)
   PUBMED   38617544
  REMARK    GeneRIF: Deficiency of Cbfbeta in articular cartilage leads to
            osteoarthritis-like phenotype through Hippo/Yap, TGFbeta, and
            Wnt/beta-catenin signaling pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2731)
  AUTHORS   Rahmawati,M., Stadler,K.M., Lopez-Biladeau,B., Hoisington,T.M. and
            Law,N.C.
  TITLE     Core binding factor subunit beta plays diverse and essential roles
            in the male germline
  JOURNAL   Front Cell Dev Biol 11, 1284184 (2023)
   PUBMED   38020932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2731)
  AUTHORS   Malik,N., Kim,Y.I., Yan,H., Tseng,Y.C., du Bois,W., Ayaz,G.,
            Tran,A.D., Vera-Ramirez,L., Yang,H., Michalowski,A.M., Kruhlak,M.,
            Lee,M., Hunter,K.W. and Huang,J.
  TITLE     Dysregulation of Mitochondrial Translation Caused by CBFB
            Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in
            Breast Cancer
  JOURNAL   Cancer Res 83 (8), 1280-1298 (2023)
   PUBMED   36799863
REFERENCE   4  (bases 1 to 2731)
  AUTHORS   Cao,W., Sturmlechner,I., Zhang,H., Jin,J., Hu,B., Jadhav,R.R.,
            Fang,F., Weyand,C.M. and Goronzy,J.J.
  TITLE     TRIB2 safeguards naive T cell homeostasis during aging
  JOURNAL   Cell Rep 42 (3), 112195 (2023)
   PUBMED   36884349
REFERENCE   5  (bases 1 to 2731)
  AUTHORS   Jiang,Q., Qin,X., Nagano,K., Komori,H., Matsuo,Y., Taniuchi,I.,
            Ito,K. and Komori,T.
  TITLE     Different Requirements of CBFB and RUNX2 in Skeletal Development
            among Calvaria, Limbs, Vertebrae and Ribs
  JOURNAL   Int J Mol Sci 23 (21), 13299 (2022)
   PUBMED   36362086
  REMARK    GeneRIF: Different Requirements of CBFB and RUNX2 in Skeletal
            Development among Calvaria, Limbs, Vertebrae and Ribs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2731)
  AUTHORS   Hernandez-Munain,C. and Krangel,M.S.
  TITLE     c-Myb and core-binding factor/PEBP2 display functional synergy but
            bind independently to adjacent sites in the T-cell receptor delta
            enhancer
  JOURNAL   Mol Cell Biol 15 (6), 3090-3099 (1995)
   PUBMED   7760805
  REMARK    Erratum:[Mol Cell Biol 1995 Aug;15(8):4659]
REFERENCE   7  (bases 1 to 2731)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
REFERENCE   8  (bases 1 to 2731)
  AUTHORS   Bae,S.C., Ogawa,E., Maruyama,M., Oka,H., Satake,M., Shigesada,K.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Ito,Y.
  TITLE     PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess
            differential transactivation potentials
  JOURNAL   Mol Cell Biol 14 (5), 3242-3252 (1994)
   PUBMED   8164679
REFERENCE   9  (bases 1 to 2731)
  AUTHORS   Ogawa,E., Maruyama,M., Kagoshima,H., Inuzuka,M., Lu,J., Satake,M.,
            Shigesada,K. and Ito,Y.
  TITLE     PEBP2/PEA2 represents a family of transcription factors homologous
            to the products of the Drosophila runt gene and the human AML1 gene
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6859-6863 (1993)
   PUBMED   8341710
REFERENCE   10 (bases 1 to 2731)
  AUTHORS   Ogawa,E., Inuzuka,M., Maruyama,M., Satake,M., Naito-Fujimoto,M.,
            Ito,Y. and Shigesada,K.
  TITLE     Molecular cloning and characterization of PEBP2 beta, the
            heterodimeric partner of a novel Drosophila runt-related DNA
            binding protein PEBP2 alpha
  JOURNAL   Virology 194 (1), 314-331 (1993)
   PUBMED   8386878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164311.4 and AC124713.5.
            
            On Feb 2, 2023 this sequence version replaced XM_036153738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1539059.1,
                                           SRR7345562.2353614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC164311.4         187262-187575
            315-401             AC164311.4         187828-187914
            402-518             AC124713.5         104694-104810
            519-645             AC124713.5         128553-128679
            646-2731            AC124713.5         142005-144090
FEATURES             Location/Qualifiers
     source          1..2731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2731
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="core binding factor beta"
                     /db_xref="GeneID:12400"
                     /db_xref="MGI:MGI:99851"
     exon            1..314
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="upstream in-frame stop codon"
     CDS             237..668
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="isoform 6 is encoded by transcript variant 6;
                     core-binding factor subunit beta; CBF-beta; PEA2-beta;
                     PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV
                     core-binding factor beta subunit; polyomavirus
                     enhancer-binding protein 2 beta subunit"
                     /codon_start=1
                     /product="core-binding factor subunit beta isoform 6"
                     /protein_id="NP_001403375.1"
                     /db_xref="GeneID:12400"
                     /db_xref="MGI:MGI:99851"
                     /translation="

MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTARP"

     misc_feature    237..620
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="Core binding factor beta subunit; Region: CBF_beta;
                     pfam02312"
                     /db_xref="CDD:396750"
     exon            315..401
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..518
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..645
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..2731
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2705..2710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="hexamer: ATTAAA"
     polyA_site      2731
                     /gene="Cbfb"
                     /gene_synonym="PEA2; Pebp2; PEBP2b; Pebpb2"
                     /note="major polyA site"
ORIGIN      

ggacggccggcaacggctgaggcgggcggcggtagcgtgggttgggctccaagcacacggccgcacctcagcctccctggagcgggaggccacgcgggcgggctcctgaaacaaagagaagcgggagtccgggtgccgcgggtgggcggtcaaggcggtcagcaccggagcccgccagcgggtgcccgcgcgagcctggggagcgcggccggccggcgcggcctgagggcgggaagatgccgcgcgtcgtcccggaccagaggagcaagttcgagaacgaggagttcttcaggaagctgagccgcgagtgcgagattaagtacacgggcttcagggaccggccccacgaggagcgccagacacgcttccagaacgcctgccgcgacggtcgctcggagatcgcttttgtggctacaggaaccaatctgtctctccagttttttccggccagctggcagggagaacagcgacaaacacctagccgggaatatgtcgacttagagagagaagcaggcaagcaggaagatgcattagcacaacaggcctttgaagaggctcgaagaagaactcgagaatttgaggatagagacaggtctcaccgggaggaaatggaggtgagagtttcacagctgctggcagtaactggcaagaagacagcaagaccctagtcctggttctaacttaggtggcggtgatgatctcaaacttcgttaagtggagcacagcttatgtgccccatctctacacacactgcttctagttggtataaataactcattgggcgaccagaaactgtgacaactggagggactgcagttggtttcatggcctgaggcagtgaagacgtcacccactgccatggttttgcactataatgcctgcatttctaatttttaaaatatgtagccagtaataatttgaaatttttttctatgcaagcttatcttgttggcattattttagttgtatcgaaagtatatactttcttcattttaacttaaaagctcatgtcatttagaaacaagataagaaattaaaatttgtatcagggttgcttaacattcttttatactttcagacgagttggttatacagctttcctccttagataagggttcttggtttttgtttgttttctctacatcatttcgtgtttttgtattctgcaccattttacaaatgaagatgtgtttgcagttattttttccagctataaacctagaatagagctgtctgccacagcctcctaaaacaaacgtttacagttgttaaagccacagtatcctttcaaatgctgatagtcaccctatcccctttagacaaaaattcacattagtattaaattttgtctcagaccctgtttcaaggtatatcttgtaatcatgagtttgggtagagatgctcttcacaggtgagaatgctctacagaaatgcccaaagaagccacagactggcttctgttttattcagggattttttttttaatcagtcagaaaaaggatactggaacttgttgtatgtaacagcatattaaactggaggcagtgataaatcagctacacaggtaaattgtgttaaaataatgtttaagatagctgctttcatgtgtattttgtattttgtattgcatgcttttgtagaaacaaaattgggtgatgaagatgagtcttagaaaatgttcatctgggcagaagatgcatttctcccattgattccgggcaaaacattcacagatatagatgatggtattttacaaaaggactattaatagtgccttttgagatgaatcaatgtaacgatatttttaaaacaggcttagtgtcaaattgcaattttttaaatataaaactggaaaaagtgctaagtcattggcacatgcttacaatactttccgtggtcgtattcattaaatgttactacatttctgaatttttgcaaaaatgtattttatcataaaatggcattattttagaaaattttaaaaactgacatggtcaattcagaaaagtctgaataaggtcattgcatttaaaaagcatataaagatacttgattgtggaagtgtgtctttcattgtatataggtcttataattcataaacaagtaccctgtatctcaaaataaaaatatttgttatatatttgaagtcgtgcatgataaggattgtgtttgaattattataaacaataatgtgttacagaagctgatgctgaccttgtgttactgagcactatgaatgaatttgcttggtatttggtgttgtacagctcacatgtttacactctcagtgccctgatgcctctcgggagttacctttttaaagtgatcctttcttttttaaaataacatctcggtggtacattttctctgttgcttctcgccaagagcttccagtccggcagtcagtaagatcacatggtgttaatgtggccgtccctctgtaaatagcaaatgttccttactggttctgcactgcttctgtctgtcttaatgctggcgttaagatcataaactccttttcttcggtagtgcaggctttgaaaattaagttattgatgcaatttcatatttttcataatctgtatttaaaatgacatcattgcatcattttttaaagattcatctccattaaaacttgccttaagcttccagattgctttgccgttagctttactgtatatttgtatgttttatttactttcacattaaaattctgtgtactgaaaacaaa

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