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Previous release (v1)
2024-05-02 12:58:22, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001364321 6023 bp mRNA linear ROD 03-SEP-2023
DEFINITION Mus musculus piwi-like RNA-mediated gene silencing 2 (Piwil2),
transcript variant 2, mRNA.
ACCESSION NM_001364321 XM_006519328
VERSION NM_001364321.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 6023)
AUTHORS Lu X, Zhu Q, Du H, Gu M and Li X.
TITLE PIWIL2 restrains the progression of thyroid cancer via interaction
with miR-146a-3p
JOURNAL BMC Endocr Disord 23 (1), 184 (2023)
PUBMED 37641092
REMARK GeneRIF: PIWIL2 restrains the progression of thyroid cancer via
interaction with miR-146a-3p.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 6023)
AUTHORS Gasperini C, Tuntevski K, Beatini S, Pelizzoli R, Lo Van A, Mangoni
D, Cossu RM, Pascarella G, Bianchini P, Bielefeld P, Scarpato M,
Pons-Espinal M, Sanges R, Diaspro A, Fitzsimons CP, Carninci P,
Gustincich S and De Pietri Tonelli D.
TITLE Piwil2 (Mili) sustains neurogenesis and prevents cellular
senescence in the postnatal hippocampus
JOURNAL EMBO Rep 24 (2), e53801 (2023)
PUBMED 36472244
REMARK GeneRIF: Piwil2 (Mili) sustains neurogenesis and prevents cellular
senescence in the postnatal hippocampus.
REFERENCE 3 (bases 1 to 6023)
AUTHORS Ramakrishna NB, Battistoni G, Surani MA, Hannon GJ and Miska EA.
TITLE Mouse primordial germ-cell-like cells lack piRNAs
JOURNAL Dev Cell 57 (23), 2661-2668 (2022)
PUBMED 36473462
REFERENCE 4 (bases 1 to 6023)
AUTHORS Lowe MG, Yen MR, Hsu FM, Hosohama L, Hu Z, Chitiashvili T, Hunt TJ,
Gorgy I, Bernard M, Wamaitha SE, Chen PY and Clark AT.
TITLE EED is required for mouse primordial germ cell differentiation in
the embryonic gonad
JOURNAL Dev Cell 57 (12), 1482-1495 (2022)
PUBMED 35679863
REFERENCE 5 (bases 1 to 6023)
AUTHORS Ito T, Osada A, Ohta M, Yokota K, Nishiyama A, Niikura Y, Tamura T,
Sekita Y and Kimura T.
TITLE SWI/SNF chromatin remodeling complex is required for initiation of
sex-dependent differentiation in mouse germline
JOURNAL Sci Rep 11 (1), 24074 (2021)
PUBMED 34912016
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6023)
AUTHORS Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita
Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y and Nakano T.
TITLE Mili, a mammalian member of piwi family gene, is essential for
spermatogenesis
JOURNAL Development 131 (4), 839-849 (2004)
PUBMED 14736746
REFERENCE 7 (bases 1 to 6023)
AUTHORS Sasaki T, Shiohama A, Minoshima S and Shimizu N.
TITLE Identification of eight members of the Argonaute family in the
human genome
JOURNAL Genomics 82 (3), 323-330 (2003)
PUBMED 12906857
REFERENCE 8 (bases 1 to 6023)
AUTHORS Tan CH, Lee TC, Weeraratne SD, Korzh V, Lim TM and Gong Z.
TITLE Ziwi, the zebrafish homologue of the Drosophila piwi:
co-localization with vasa at the embryonic genital ridge and
gonad-specific expression in the adults
JOURNAL Mech Dev 119 Suppl 1, S221-S224 (2002)
PUBMED 14516689
REFERENCE 9 (bases 1 to 6023)
AUTHORS Kuramochi-Miyagawa S, Kimura T, Yomogida K, Kuroiwa A, Tadokoro Y,
Fujita Y, Sato M, Matsuda Y and Nakano T.
TITLE Two mouse piwi-related genes: miwi and mili
JOURNAL Mech Dev 108 (1-2), 121-133 (2001)
PUBMED 11578866
REFERENCE 10 (bases 1 to 6023)
AUTHORS Wang PJ, McCarrey JR, Yang F and Page DC.
TITLE An abundance of X-linked genes expressed in spermatogonia
JOURNAL Nat Genet 27 (4), 422-426 (2001)
PUBMED 11279525
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC122268.5, AB032605.1 and AC025669.19.
On Jun 14, 2018 this sequence version replaced XM_006519328.1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660819.162413.1,
SRR1660815.201434.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1259 AC122268.5 59963-61221 c
1260-6020 AB032605.1 153-4913
6021-6023 AC025669.19 125171-125173 c
FEATURES Location/Qualifiers
source 1..6023
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="14"
/map="14 36.32 cM"
gene 1..6023
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="piwi-like RNA-mediated gene silencing 2"
/db_xref="GeneID:57746"
/db_xref="MGI:MGI:1930036"
exon 1..1259
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
misc_feature 1080..1082
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="upstream in-frame stop codon"
CDS 1092..4220
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="isoform 2 is encoded by transcript variant 2; Miwi
like; piwi-like protein 2; Miwi likw; piwi-like homolog 2"
/codon_start=1
/product="piwi-like protein 2 isoform 2"
/protein_id="NP_001351250.1"
/db_xref="GeneID:57746"
/db_xref="MGI:MGI:1930036"
/translation="
MSLRLACATESGPGKSKTHPSGAFCSSSLFPFSPQHLSSFHFLSEIPLIVYDHRVQIRNWNRTNSRFYSLSMDPVRPLFRGPTPVHPSQCVRMPGCWPQAPRPLEPAWGRAGPAGRGLVFRKPEDSSPPLQPVQKDSVGLVSMFRGMGLDTAFRPPSKREVPPLGRGVLGRGLSANMVRKDREEPRSSLPDPSVLAAGDSKLAEASVGWSRMLGRGSSEVSLLPLGRAASSIGRGMDKPPSAFGLTARDPPRLPQPPALSPTSLHSADPPPVLTMERKEKELLVKQGSKGTPQSLGLNLIKIQCHNEAVYQYHVTFSPSVECKSMRFGMLKDHQSVTGNVTAFDGSILYLPVKLQQVVELKSQRKTDDAEISIKIQLTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVIRNDSVLDVMHAIYQQNKEHFQDECSKLLVGSIVITRYNNRTYRIDDVDWNKTPKDSFVMSDGKEITFLEYYSKNYGITVKEDDQPLLIHRPSERQNNHGMLLKGEILLLPELSFMTGIPEKMKKDFRAMKDLTQQINLSPKQHHGALECLLQRISQNETASNELTRWGLSLHKDVHKIEGRLLPMERINLRNTSFVTSEDLNWVKEVTRDASILTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRISPPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDLYGAIKKLCCVQSPVPSQVINVRTIGQPTRLRSVAQKILLQMNCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKYYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAFDNYHPKMVVFVVQKKISTNLYLAAPDHFVTPSPGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGQILHHEPAIQLCGNLFFL"
misc_feature <1308..1904
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="large tegument protein UL36; Provisional; Region:
PHA03247"
/db_xref="CDD:223021"
misc_feature 2313..2456
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="Argonaute linker 1 domain; Region: ArgoL1;
pfam08699"
/db_xref="CDD:430160"
misc_feature 2457..2810
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="PAZ domain, Piwi_like subfamily. In multi-cellular
organisms, the Piwi protein appears to be essential for
the maintenance of germline stem cells. In the Drosophila
male germline, Piwi was shown to be involved in the
silencing of retrotransposons in the...; Region:
PAZ_piwi_like; cd02845"
/db_xref="CDD:239211"
misc_feature order(2589..2591,2628..2630,2652..2654,2664..2666,
2718..2720,2769..2771,2775..2777)
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239211"
misc_feature 2832..4166
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="PIWI domain, Piwi-like subfamily found in
eukaryotes. This domain is found in Piwi and closely
related proteins, where it is believed to perform a
crucial role in germline cells, via RNA silencing. RNA
silencing refers to a group of related...; Region:
Piwi_piwi-like_Euk; cd04658"
/db_xref="CDD:240016"
misc_feature order(3339..3341,3351..3353,3387..3398,3405..3407,
3435..3437,3444..3446,3456..3458,3468..3470)
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="5' RNA guide strand anchoring site [active]"
/db_xref="CDD:240016"
misc_feature order(3531..3533,3537..3539,3741..3743,4140..4142)
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/note="active site"
/db_xref="CDD:240016"
exon 1260..1496
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 1497..1584
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 1585..1723
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 1724..1930
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 1931..2041
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2042..2159
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2160..2284
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2285..2365
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2366..2479
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2480..2668
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2669..2753
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2754..2843
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2844..2984
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 2985..3098
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3099..3287
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3288..3389
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3390..3506
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3507..3595
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3596..3701
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3702..3955
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 3956..4063
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
exon 4064..6023
/gene="Piwil2"
/gene_synonym="mili; Piwil1l"
/inference="alignment:Splign:2.1.0"
ORIGIN
gcagttgatacaagggtgcaaatgaatgcaaatgtattactacctgcatctgtgtgtatgtattttgtgttagaaacagaaagaactaaagacttgttcatttctttgtgtaaagtggctctgtaggcttcagtcagccttgggattggcttcaattccacaagtaaccttggagaggaaaaaaagtcacttgtcttccctcagtttattttttttaaattgtttttaaacagaagaatgttatcaccatatctctatttgcacagtggttttttttttaatttattaaaatggttactttgcatgagttgggggtacgtagatgtggaggtcagaagacaatttttaggagtcagctctcaactttatgccctgttgatacaggatctcttgtttctgctgctgctttgaatgtggggttcaagttatcaagtgcagccaaggacttttacccactgaaccagtttcctagtttgcttttatttttttataaaaagatttgagtgttctgagtaattttcctgtatgtatgtgtgtgtactaagtgcatgcctagtgtctggaggtcaaaaaagggcatcagattttctggaacttcagttatggatggttgggagctaccacatggatactgggaacccaaaccaggtctgctgcaagaatatgtgctcttaatctgagccatctctctagtccctttcccttccccttttgcttttaaattagagtgattgtaaagactttattgagtatcagataagtccagtaagagacatgtgtgatcagcaagcttttattaagccaatatgtgttgtttatgctctataaagcataggacccttctgtgatttctgcaacttttcccagccacacagaccttgctgccctgtcacagtgggcaagctgcacccttcccccaccccatgtcctttccctcaggtctagactcaactttatccagatgtttctaggtcttacttctgaaatccttcagttctctgagattccctggccactctacataaattagctaactcgggtgcaatgtgctccgcttgttgccagcacttaggatactatagccagcgggtatgagtttgaggctagcctgtgctacagagtcaggtccaggtaaatctaaaactcacccctctggtgctttttgctcctcttcactgtttcccttctctccacagcatttgtcatcctttcatttcttatctgagatcccactgatagtctatgaccacagagtacagataaggaattggaacagaaccaacagtcgtttctacagcctctcaatggatcctgtcaggccgttgttcagggggcccaccccagtccacccatctcagtgtgtgcggatgccaggctgttggcctcaagctcctagacctttggaaccagcttggggtagggcaggacctgcaggcagaggccttgtgtttagaaaaccagaagactccagcccaccactccagccagtacaaaaggattctgtaggtttggtgtccatgttccgtggcatgggtcttgacacagcattccggcctccttcaaaacgagaagtgcctcctttaggcagaggagttctaggtcgaggcttgtctgctaacatggtccgcaaggacagagaagaaccccgttcctctttgcctgatccttcggtgctggcagctggggacagcaaactggcagaggcttctgttggttggagtagaatgctgggaagaggtagttctgaggtctctctgttaccactgggacgagcagccagtagtataggcagaggaatggacaaacctcccagtgcctttggcctcacagctcgggatcccccacggctgccacagcctccagctctgtctccaacttcactgcactctgccgatccccctccggtcctgactatggaacgaaaggaaaaagagcttttggtcaagcaaggatcaaaaggaactcctcagtctttgggactgaacctcatcaaaatccagtgtcataacgaagcagtttatcagtaccatgtgactttcagccccagtgtggaatgcaaaagcatgaggtttggcatgttgaaggaccaccagtctgtcactggaaacgtcactgcttttgatggctctattctttatcttcctgttaagcttcaacaagttgttgagttaaaaagtcagaggaaaactgacgatgccgagatcagtatcaagattcagctgacaaagatcctggagccgtgttctgacctgtgcatccccttctacaatgttgtcttccggcgggtaatgaaacttctggatatgaagcttgtggggagaaacttctatgaccctacaagtgccatggtactgcagcaacacagattgcagatctggcctggctatgcggctagtatccggaggacagacgggggtctcttcctgctcgctgatgtctctcataaggtcattcggaacgactctgtgctggatgtcatgcatgctatctaccagcagaacaaggagcacttccaggacgagtgcagcaagcttctggttggcagcattgtcatcacgcgctacaacaatcgtacctaccgaatcgatgatgtggactggaacaagacccctaaagacagctttgtcatgtcggacgggaaggaaatcacattcctggaatactacagcaaaaactatgggatcacagtcaaggaagatgaccagccgctgctgatccaccggcccagtgagagacagaataaccatggcatgttgctgaagggcgagatcctgctgctgcccgagctctccttcatgacggggatccctgagaagatgaagaaggacttcagggccatgaaggacttgactcagcagattaacctgagccccaagcagcaccacggtgctttggaatgcctgctgcagagaatttcacaaaacgagacagccagcaatgagctgacccgctgggggctcagtctgcataaagatgtccacaagattgaaggtcggcttctgccaatggagaggatcaacttaaggaacacttcatttgtcacatcggaggacctgaactgggttaaggaagtgaccagagatgcttccattctaactattcccatgcatttctgggcactcttttatccaaagagagcaatggaccaagccagagaactggttaacatgttggaaaagattgccgggcccattggcatgcgcataagccccccagcctgggttgagctgaaggatgaccgaatagagacctatatcaggaccattcagtccttactgggagttgaggggaagatacaaatggtcgtttgcatcatcatgggcacacgtgatgatctctatggagccatcaagaagctgtgctgcgtgcagtccccagtgccctcacaggtcatcaatgtccgaaccattggtcagcccaccaggcttcggagcgtggctcagaaaattttacttcagatgaactgtaaactgggtggtgagctctggggagtggatattccgctgaaacaactaatggtgattggaatggatgtgtaccatgaccccagcagaggcatgcgctctgtggtcggcttcgtggccagcataaatctcacactcaccaaatggtactcgagggtggtgttccagatgccacatcaggagattgtggacagcctgaagctctgcctggtgggttccttgaaaaagtattatgaggtgaaccattgtctcccagagaaaattgtggtgtaccgagatggagtgtctgatggccagctaaagacagttgccaactacgagatccctcagctgcagaagtgttttgaagcctttgataactaccaccccaagatggtggtgtttgtagttcagaagaaaatcagcaccaatctgtaccttgctgctcctgatcacttcgtaaccccctcccccgggactgtggttgatcataccataaccagctgtgagtgggtggatttctaccttcttgcccatcatgtgcgacagggctgtggcatacctacacactacatctgtgttctgaacactgcaaatctgagccctgatcacatgcagaggttgactttcaaactatgccacatgtactggaattggcctggtaccatccgagttccagctccttgcaagtatgcccacaagctagctttcctgtccggacagattttgcatcatgagccagccatccagctgtgtgggaacctgttcttcctgtaactgggaacttggacaccggctgcaaggagcaactggactcagctcagctcctccttacagaatcaacagaaatggcagtggaattttatgtttgcattttctctttctccatccttgtagaattagatttctgttcttcttttaaccctgatatcatagtagggtgttgtggtgcatgccttttatcccagcacttgggagactgaagcaggagtatctttagttcaaggccagcctagactacatggtgagttctaggctagccaagattacagagtgagaccctgtctcaaaaaacaaaaacaaaccactgtcccctcaaagcccacaacaaaaccaaagcctggggtcaaggaagcaagtttgtaggtagccgctggctgcccgctgccttcatggagtgtgtgccgtcagcgctgcttctcctcagccgagcgtggagcttcggacagggcagtgatgacatgttcttagcatgtcaaatccccctaccaaataagtcaagcaaggaaaaaatagcccccaaggcagcctgagcatcagttcctagaggttatgcctacagaaccatcctatttctggtggcagaagtgacatgaagtcattgcagacatcttaaaggagagttactgtgcagctgtctacatgtgtgaaagacatgtagaaaaaccagcgtagggtacagtcgggcgtatgtgcccacctgacccagggctgtgagtctgacttcccgagagtctggctagagctgcttttctggtccttttggttatttgcaaccatcatcagattgctttcctgcagcccgactgatacacgcatgtgcgcacgcacacacttttgttctttgtgactaatcttgaataaattcaattagaacacatggaaaggattcagcagacctaggaacatttggggtggagtgtagtttttctgcaaaagtctgtaaatgagattacgcaagagtctcttccagctgtgggctggtgttgcttggaaaatttcaaaatcccaaagtttcaggcttcccaaagttggcttggaaaaatgtgatagtctcacctgagtctagacatgtaggaaattttcctagggcctctgggcttcagtatttgggggaagcactggttttctgtgttatttttttccttctgtttcagaatcttcaagtttcttcaggcttcagtgggccatccctttactgggctctaaaagctaattttacttaaccttttcaaatgtgtatgtatctatttatgttttggtgtggtggatggatggtaggggactgagcagaaatagtcattttaaataacagtgtgctaggagagcctcagtgtgaagtcctgaggagcagcgggggctgtgggagtcagtgtcagccctcactcagacaggccaagcctgggctcgaagacaacattgtccagggaagcctttagtttgctatagcacccagaggttggcgaggaataagggttagggtcctcaaatacacccatggcttttggagtctatgaccaaggccaggctgagacctgaaatgtaaaagccatagaattaaacagaacagactgaaaaacgagtcttaagttccactttctggatttctctggaagtcttttgaatttgtctgtagaagttgctgttcctagcactccttttctctttaggtagaacagatacttgaccataatgccagaatgtactttctctgccttggtttttctatgccttgtttttcagtttcagggccaaacaattgggccctgtggtgtaaaataaaaacaatgtatgtgtata
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]