2024-05-03 07:40:37, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001312869 5583 bp mRNA linear ROD 08-NOV-2023 DEFINITION Mus musculus transforming growth factor, beta receptor I (Tgfbr1), transcript variant 3, mRNA. ACCESSION NM_001312869 VERSION NM_001312869.2 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 5583) AUTHORS Xu X, Guo Y, Luo X, Shen Z, Sun Z, Shen B, Zhou C, Wang J, Lu J, Zhang Q, Ye Y, Luo Y, Qu Y, Cai X, Dong H and Lu L. TITLE Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI JOURNAL Liver Int 43 (11), 2523-2537 (2023) PUBMED 37641479 REMARK GeneRIF: Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFbetaRI. REFERENCE 2 (bases 1 to 5583) AUTHORS Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y and Zhou B. TITLE Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development JOURNAL J Am Heart Assoc 12 (18), e029683 (2023) PUBMED 37702066 REFERENCE 3 (bases 1 to 5583) AUTHORS Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S, Gonzalez LE, Xin T and Greco V. TITLE Organ function is preserved despite reorganization of niche architecture in the hair follicle JOURNAL Cell Stem Cell 30 (7), 962-972 (2023) PUBMED 37419106 REFERENCE 4 (bases 1 to 5583) AUTHORS Zhou J, Tian G, Quan Y, Kong Q, Huang F, Li J, Wu W, Tang Y, Zhou Z and Liu X. TITLE The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast activation in cardiac fibrosis by regulating TGFBR1 JOURNAL JCI Insight 8 (6), e160745 (2023) PUBMED 36787190 REMARK GeneRIF: The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast activation in cardiac fibrosis by regulating TGFBR1. Publication Status: Online-Only REFERENCE 5 (bases 1 to 5583) AUTHORS McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour N, Butcher LD, Fisch K and Prince LS. TITLE Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development JOURNAL Development 150 (5) (2023) PUBMED 36762637 REFERENCE 6 (bases 1 to 5583) AUTHORS Iseki S, Osumi-Yamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani H, Hayashi Y and Eto K. TITLE Localization of transforming growth factor-beta type I and type II receptors in mouse development JOURNAL Exp Cell Res 219 (2), 339-347 (1995) PUBMED 7641785 REFERENCE 7 (bases 1 to 5583) AUTHORS Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL. TITLE Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo JOURNAL Dev Biol 166 (2), 716-728 (1994) PUBMED 7813789 REFERENCE 8 (bases 1 to 5583) AUTHORS ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K and Heldin CH. TITLE Characterization of type I receptors for transforming growth factor-beta and activin JOURNAL Science 264 (5155), 101-104 (1994) PUBMED 8140412 REFERENCE 9 (bases 1 to 5583) AUTHORS Suzuki A, Shioda N, Maeda T, Tada M and Ueno N. TITLE A mouse TGF-beta type I receptor that requires type II receptor for ligand binding JOURNAL Biochem Biophys Res Commun 198 (3), 1063-1069 (1994) PUBMED 8117262 REFERENCE 10 (bases 1 to 5583) AUTHORS Tomoda T, Kudoh T, Noma T, Nakazawa A, Muramatsu M and Arai K. TITLE Molecular cloning of a mouse counterpart for human TGF-beta type I receptor JOURNAL Biochem Biophys Res Commun 198 (3), 1054-1062 (1994) PUBMED 8117261 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL772150.11. On Oct 16, 2023 this sequence version replaced NM_001312869.1. Summary: This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK015337.1, SRR5189685.185800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-255 AL772150.11 16336-16590 256-498 AL772150.11 23348-23590 499-729 AL772150.11 26456-26686 730-897 AL772150.11 32904-33071 898-1054 AL772150.11 33471-33627 1055-1179 AL772150.11 35630-35754 1180-1310 AL772150.11 37023-37153 1311-5583 AL772150.11 40753-45025 FEATURES Location/Qualifiers source 1..5583 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="4" /map="4 26.02 cM" gene 1..5583 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="transforming growth factor, beta receptor I" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" exon 1..255 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" misc_feature 48..50 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="upstream in-frame stop codon" CDS 174..1436 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /EC_number="2.7.11.30" /note="isoform 3 is encoded by transcript variant 3; TGF-beta receptor type-1; TGF-beta receptor type I; transforming growth factor-beta receptor type I" /codon_start=1 /product="TGF-beta receptor type-1 isoform 3" /protein_id="NP_001299798.1" /db_xref="CCDS:CCDS84729.1" /db_xref="GeneID:21812" /db_xref="MGI:MGI:98728" /translation="
MDLKSLIMVMMEDYKDITPLKKLQENKGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
misc_feature 450..533 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Transforming growth factor beta type I GS-motif; Region: TGF_beta_GS; pfam08515" /db_xref="CDD:430045" misc_feature 549..1412 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; Region: STKc_TGFbR1_ACVR1b_ACVR1c; cd14143" /db_xref="CDD:271045" misc_feature order(555..569,579..581,612..614,618..620,702..704, 762..773,783..785,789..791,921..923,927..929,933..938, 942..944,975..977,984..986,1044..1055) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="active site" /db_xref="CDD:271045" misc_feature order(555..575,579..581,612..614,618..620,762..767, 771..773,783..785,933..938,942..944,975..977) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:271045" misc_feature order(567..569,783..785,789..791,921..923,927..929, 933..935,984..986,1044..1055) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature order(648..653,660..665,672..677,717..719,723..725) /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="FKBP12 binding site [polypeptide binding]; other site" /db_xref="CDD:271045" misc_feature 972..1055 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /note="activation loop (A-loop); other site" /db_xref="CDD:271045" exon 256..498 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 499..729 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 730..897 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 898..1054 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1055..1179 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1180..1310 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" exon 1311..5583 /gene="Tgfbr1" /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI; TGFR-1" /inference="alignment:Splign:2.1.0" ORIGIN
attacaggaaggacaggctccaatgagagggaagggagcacttgagataatcagatggcggaggcaatcataagaacagaaacaacagaaaccaaggttacttggcatcatcagaacccaattctcccaccacagcaagtcctggatacaccatcacaccagaaaagcaagatatggatctaaagtcacttatcatggtgatgatggaagactataaggatataactcccttaaagaaattacaggagaataaaggacctttttcagaaaagcagtcagctggccttggtcctgtggagctggcagctgtcattgctggtccagtctgcttcgtctgcattgcacttatgctgatggtctatatctgccataaccgcactgtcattcaccaccgtgtgccaaatgaagaggatccatcactagatcgccctttcatttcagagggcaccaccttaaaagatttaatttatgatatgacaacatcagggtctggatcaggtttaccactgcttgttcaaagaacaattgccaggaccattgtgttacaagaaagcattggcaaaggtcggtttggagaagtttggcgaggcaaatggcggggagaagaagttgctgtgaagatattctcttctagagaagagcgttcatggttccgagaggcagagatttatcagactgtaatgttacgccatgaaaatatcctgggatttatagcagcagacaacaaagacaatgggacatggacgcagctgtggttggtgtcagattatcatgagcatggatcccttttcgattacttgaatagatacactgttactgtggaaggaatgatcaagcttgctctgtccacagcaagtggtcttgcccatcttcacatggagattgttggtacccaaggaaaaccagctattgcccatagagatttgaaatcaaagaatatcttggtgaagaaaaatggaacctgttgtattgcagacttgggacttgctgtgagacatgattctgccacagatacaattgatattgctccaaaccacagagtaggcactaaaaggtacatggcccctgaagttctagatgattccataaatatgaaacattttgaatccttcaaacgcgctgacatctatgcaatgggcttagtgttctgggaaattgctcgacgctgttctattggtggaatccatgaagactatcagttgccttattatgatcttgtaccttctgatccatcggttgaagaaatgagaaaagtagtttgcgaacagaagttaaggccaaatattccaaacagatggcagagctgtgaggccttgagagtgatggctaaaattatgagagaatgctggtatgccaatggagcagcaaggctgacagctttgcgaattaaaaaaacattgtcacaactcagccaacaggaaggcatcaaaatgtaactgaaacaccgtgggaactctgctctcttcatatctgctcctgggtgtttaggaggctggttgttctacctcactgagagaacagagggctctgcttcctcttgcagcagtggaatatggtcaactgaaagcttcccagggtttctctgggcccagaggcagccgtggggtcctttctgtgcactatggatacttcttccagacagttacagaatgttgtgtagtctacttttgtttttattaacaaagcttgtttttaaagacaactgccagcccttagggagctgctgtgctgttgaccttctgtaagggtgaaggagctggggtgtggcactaaatgaagcacttctgattttcactcctagtagtacattctcagaggactctgaaccactagtgtttccttggttcactttgaatgtactgttctataatttttcaagatcttaaactaacactttaaactctatagtctaaaaaatatgacctcgtggaggcgtgggggcacagttgctccgttgtatttgtgcacagctccttcacactctgaacacaacacaccttcacagtagggttgtgctacaccagtaagtgctacttttgcatctgtctaagtggaaacgaacagaactacttaaaggcggtgttaagtcctgtatcattttcattcaaaaagtttatttttctgagtaacctaaaccttttctgggtttgtttttgttttttgagggtttttgtgatagatgtcattcagtcttcatgcctttctcctacccagatgtgcttgaaccactgaggcaaggctgtagcattgataagcagtgactgccatgcgggaacaccccacaggagcactggagctctgcagttgagacgtttagcctgagtttattttaagaagtgaagtggcactccaaacatgtacagtgctttatggatgtaatcattatggtatacagactccttttgaaaggggaggcttgtctattgccgaaggaaaagttgtatgctgttctgtaagccatttctttttctttatttgatcaaagcagtgttttgttttgttttgatttttcttttttggaaaggaattgcatttaaaattcaaatgtggttaatgttaaataataggcctttttctaggaaggcagatatagttaatatgaatgtacaagtgtaggtgactttcacatgttatgtagctgtaagtatttgtggattctatcttgggaagggtagagttagtggagttttgaggtctcactaccctttgaggaaggcagcttttaattcagtctttttatctcatatgtgcagatcttgcaactgcttgatttacatggtagcaatgaattcagtgccacgttgatactaggagaagcagcaactaatagctattctgagtagaggctctcttcatatattcttggtcatattaaatgtcaaagtcagtccgttgggtcttctcactgctgctggagttaggtggttgagcctgggttttacttcagtgctgtcaaatctttgcagggcttgtgtggctttcaaagtcctttttatcactgtgatcatattctgggcggggaaatgttatcatcattgcttgagacgagatgttgaacatagtgataccaatccccagataaaaaggtcaaaataacctttagtgtttagccaagaagagattgtgactattgatctgaagcagctgggctctgttaatgtcttatttcaaacctagcatacatttgaagactatttggtcttaaaccaaagtaactgtaggacgaatgacatactacctagacattagtgtccgtttcatacgtcagaaacaccatgggaaaaagtacctagagattagtatctttaatacaaatctgagttttttctgtaattatcatgatttcatcaatgtaagtaagggtttgttgttacagttgtatcacctgcttaaataagctcttgtgctataatcaggtacttttggggcctttgttttcagttttttccatttctaacccttcgagatctgctttatagaaatccagggaccaatgtattttatcactaaaactgtttttatataattttaagaccataccaaaagttatctgagttaaagttgtaatacgtttcttactttcttgcaaggaaatgggtttttactgaagacacttctcatgatatctgaagttgaagaatcattatgtttttcttacctaagtggataaaatgtgctttgatgaatcagggaattttttaaagttcgaatttagttctaaattgagtttacatgtttacagctaattttttgtgtagggatagtttgattctctaggtggccaatactgaatataaaaataacttaaaaattgagataggtcatggttaatgtggctataactatatatacatctaattagagaaatatttctatgtaattttgtagtgcagtctgttgtttctattgccaatcaaagacttccccccagccccaaagtgtagtatggctaagacatatcttctgacaaattacatattatcttgtcaataccctggttaagctagcatgaaggaagtatgacttactgaggcttacacaacttgagtcccttatatcttcagctctgtttttcccactctgcctttctgctgccccctggctcagagacttagtgttcctgaccccacctccagcctttggacctaagagctgcttttgagacctaaaatgaagtgattgatggaagctgtgtgacatttttccacttccttgagtcactgggtgttatgagggagtgatctgcaaattggggtagggggtgcccctactggtagccctgctttgatgtcagctctgggcaaagattagggtgacagctaagtggcagtggaagttggcctcagaagtagtggccagctgtgtctctagtaggacagtaaaggcatgaagctcagcctgtaatcctgctactacagtagtactccagaagtgccttgaggccctgtgtggggctgtggccatcaagaattccagattttggttctcgctgcagacttaagtggccatgtagccatttttgtaatccatacatgtttgactcttccctctgcaaattgtcagatacgtaaaaccaatgacaaactactacttaacatgcacaccaaaatctgcccagaagacattgtgatttcattccatgcactgaaggaatgattgtaaatcatttctttgttccttggtcatgggagtgttctggttctacattgtggagattccagctgttgttctgttatagcccagcagaacaagtcgacgtgttgaaattctgaagaatagtttgggagtgcagtacagcttcatgtgttggatgttgaaactttcatgggccctctttagaaaagcagaggactgtcagcacattatttttaatcctgttatgcactcgtacttattgtcagtaacaataagtacgagtattgaaaatattgtcagtaacattcagtctctttcttaaagtgaatttgcttatttttcaatgagatttgtgagtttaatattatgaactgtgttttgataatccctttttcacattgtgccaatggaatggaatatttgatatttctttatatgtcaaggagatgcttcaatatgtcatttgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtgtatataatgtttaatatttgtcagcatccaccaggtttgcaattttatttctataaagtgtgagtgttacgttgctaagttactcagatggtactgtattgtttatatctgtaccccaaatgacatcatctagactttgttttctgtgtcttattgtatttgtgcagtcctttaaccctgttggtgtgattgctgccctttcagatatgtgcaggtgtctatagaaattctcatttaaggtgaatggttttgagaaacctgtgaagagagaagcataaactgcatttccccatcagttttttaaatgtacattgtatgtgtagtaatattccagatgaattgtaaataaaagctagggagatgcttaaatttcatcctaacactacagtagaaaatggaagcaatgcaaataaacaactttttcccacca
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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