LOCUS       NM_001291509            6890 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus pre B cell leukemia homeobox 1 (Pbx1), transcript
            variant d, mRNA.
ACCESSION   NM_001291509
VERSION     NM_001291509.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6890)
  AUTHORS   Wang,F.C., Zhang,X.N., Wu,S.X., He,Z., Zhang,L.Y. and Yang,Q.E.
  TITLE     Loss of PBX1 function in Leydig cells causes testicular dysgenesis
            and male sterility
  JOURNAL   Cell Mol Life Sci 81 (1), 212 (2024)
   PUBMED   38724675
  REMARK    GeneRIF: Loss of PBX1 function in Leydig cells causes testicular
            dysgenesis and male sterility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6890)
  AUTHORS   Ning,Y., Duo,S., Lin,X., Zhang,H., Fei,J., Zhang,B., Zeng,Y.,
            Xie,D., Chen,J., Liu,X. and Han,C.
  TITLE     Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice
  JOURNAL   Cell Prolif 57 (5), e13580 (2024)
   PUBMED   38230761
REFERENCE   3  (bases 1 to 6890)
  AUTHORS   Choi,S.C., Park,Y.P., Roach,T., Jimenez,D., Fisher,A., Zadeh,M.,
            Ma,L., Sobel,E.S., Ge,Y., Mohamadzadeh,M. and Morel,L.
  TITLE     Lupus susceptibility gene Pbx1 controls the development, stability,
            and function of regulatory T cells via Rtkn2 expression
  JOURNAL   Sci Adv 10 (13), eadi4310 (2024)
   PUBMED   38536923
  REMARK    GeneRIF: Lupus susceptibility gene Pbx1 controls the development,
            stability, and function of regulatory T cells via Rtkn2 expression.
REFERENCE   4  (bases 1 to 6890)
  AUTHORS   Roach,T., Park,Y.P., Choi,S.C. and Morel,L.
  TITLE     Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1
            in T cells
  JOURNAL   Mol Immunol 165, 1-10 (2024)
   PUBMED   38056350
  REMARK    GeneRIF: Regulation of the STAT3 pathway by lupus susceptibility
            gene Pbx1 in T cells.
REFERENCE   5  (bases 1 to 6890)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J Immunol 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Pbx1 is a novel lupus susceptibility gene that regulates T
            cell activation and tolerance.
REFERENCE   6  (bases 1 to 6890)
  AUTHORS   Knoepfler,P.S. and Kamps,M.P.
  TITLE     The pentapeptide motif of Hox proteins is required for cooperative
            DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA
            binding by Pbx1
  JOURNAL   Mol Cell Biol 15 (10), 5811-5819 (1995)
   PUBMED   7565734
REFERENCE   7  (bases 1 to 6890)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
REFERENCE   8  (bases 1 to 6890)
  AUTHORS   Kagawa,N., Ogo,A., Takahashi,Y., Iwamatsu,A. and Waterman,M.R.
  TITLE     A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for
            the homeodomain protein Pbx1
  JOURNAL   J Biol Chem 269 (29), 18716-18719 (1994)
   PUBMED   7913464
REFERENCE   9  (bases 1 to 6890)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   10 (bases 1 to 6890)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK144346.1, AC096625.25,
            AC116129.13 and AK083616.1.
            
            Summary: This gene encodes a homeobox protein that belongs to the
            three-amino-acid loop extension/Pre-B cell leukemia transcription
            factor (TALE/PBX) family of proteins. The encoded protein is
            involved in several biological processes during embryogenesis
            including steroidogenesis, sexual development and the maintenance
            of hematopoietic stem cells. This protein functions in the
            development of several organ systems and plays a role in skeletal
            patterning and programming. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (d) lacks two alternate in-frame
            exons in the 3' coding region compared to variant a. The encoded
            isoform (d) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM369110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               AK144346.1         1-665
            666-856             AC096625.25        102039-102229
            857-930             AC096625.25        105601-105674
            931-1175            AC116129.13        185417-185661       c
            1176-1366           AC116129.13        179413-179603       c
            1367-1502           AC116129.13        171814-171949       c
            1503-1592           AC116129.13        159596-159685       c
            1593-5204           AC116129.13        131279-134890       c
            5205-6890           AK083616.1         4-1689
FEATURES             Location/Qualifiers
     source          1..6890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 75.95 cM"
     gene            1..6890
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="pre B cell leukemia homeobox 1"
                     /db_xref="GeneID:18514"
                     /db_xref="MGI:MGI:97495"
     exon            1..856
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    582..584
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="upstream in-frame stop codon"
     CDS             666..1685
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="isoform d is encoded by transcript variant d;
                     pre-B-cell leukemia transcription factor 1; homeobox
                     protein PBX1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform d"
                     /protein_id="NP_001278438.1"
                     /db_xref="CCDS:CCDS78739.1"
                     /db_xref="GeneID:18514"
                     /db_xref="MGI:MGI:97495"
                     /translation="

MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN"

     misc_feature    666..785
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    789..1361
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:461052"
     misc_feature    798..1037
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2);
                     Region: PBC-A.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    1044..1361
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2);
                     Region: PBC-B.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    1419..>1511
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            857..930
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1175
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1366
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1502
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1592
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..6890
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6845..6850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="hexamer: AATAAA"
     polyA_site      6873
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /note="major polyA site"
ORIGIN      

ggagtcctgagcctgggctaaacaaaagcaggaggctgacggggctgctggagtttgcagagacacggaggaggaaagagcttgggctttgcctgccgccacggctgggggtgatctggcttctgctacagcccaccccctttgagatcactctggcccggagtgggggtggggggcagcggggggtgggggggaaagtttgcattgcaatccccctgccttcctctcctttctcccgatcaatgcatatttgcaaaaggattaagccacagatttaagcgccgggagcccatttctgccttgcaaaggagatcggactgaaaaacccaaaggcggctctgatttcttttcgccaagtgggaaggtggtttatttttcttgcttttttggagtcaacacccttccccaccagcccttatccccaccctcaccccgcaaccccttcacgcccccctccccctccccatcctcccaccatcctctaaagaggcaaagagattttttttttccccttttggtcttcttcttctttttttaaaaccctggtccctgtttatcctgaaaaggatttgaagacagcttgaaggataaaaagcctcggtgcttcccaggcgccgatccgaggagccgaagaggaagagccggggctgccggagccttcagagatggacgagcagccgaggctgatgcattcccacgctggggtcgggatggccggacaccccggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaagcaggacatcggggacattttacagcaaattatgaccatcacagaccagagtttggatgaagcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtgttgtgtgaaatcaaagaaaaaacagttttgagtattcggggagcccaagaagaggagcccacagacccccagctcatgcgactggacaacatgctgctagcagaaggggtggcggggcctgagaagggcggaggctcggcagcggcggcggcggcagcggcagcttctgggggtgcaggttcagacaactcagtggagcattccgactacagagccaaactctcacagatcagacaaatctaccacacagagctggagaagtatgagcaggcatgcaatgaattcaccacccacgtgatgaacctccttcgagagcaaagccggaccaggcccatctctccgaaggagatcgagcggatggtgagcatcatccaccgcaagttcagctccatccagatgcagctgaaacagagcacgtgcgaggccgtcatgatcctgcgctcccggttcctggatgcgaggcggaagagacggaatttcaacaagcaagccacagaaattctgaatgaatatttctattcccatctcagcaacccttaccccagtgaggaagccaaagaggagttagccaagaagtgcggcatcacagtctcccaggtggatacccttcgccatgttatcagccagacaggaggatacagtgacggactcgcagccagtcagatgtacagtccgcagggcatcagtgctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggccctggcagtgttcactctgatacctccaactgatctcccagcaatcgcatcccggctgaccctgtgccgcagttggggcagggccaggagggagggtttctctcccaacgctgaagcggtcagactggaggtcgaagcaatcagcaaacacaataagagtctccttctcttctcttctttgggatgctatttcagccaatctggacacttctttatactctcttccctttttttctgggtagaagccacccttccctgcctccagctgtcagactggtttctgtcatcttccctggcccctgctctctgttatagacgcccggtccctgccctctatgacttcactgaaggatttttttttcttccacaattagaggaatttaaaaaggaaaaacaaattacaaagaaaacaataaacgcatttgtatgttttcatgctggtggtttgaggaggcaaatttacctcactaggagccctcatccctatgttgacaggcaatccttctgtctcccttgttactctcactacctcttagcaggaatacaccacactgccctactcattccaagccactctgtctccattttccccttctttctgggaacaatcctgattttttcctcttctttctggccccaggtgttttttggggatggccataactgggcttctaaaggtgccacatatcccaatgtagttccatcaggttgagtcctaggcaggaagtctggcaggtaagggcacaaagaacagcaaaggcagagctcctatcagctttctcatcctcttagaaacagctcttggtcttagaggcacagtctatgaacatccaaccattcaatgttcagaacctcaggcaagccaggtctaagagaggcatcctgatgagggtgtctataaagagtgaaggatctcatcttgaaaggctgcactgtcccttcatagacatacacacacataggtaacacacaggtggacacatgcacaaccttatagttttgcttggcaggatgctagtaacctttcatcagtgacttctgctacagaaggccctggcagcgttcactctgatacctcccagatggtctcccagcaatcaaatcctgtacattagcaagcatagtgctctacctggtgagcccaagagaggagcagtatgtggctaaggcttctaggacccactaacatgtacttaccacagtaggatgtgcaggacttcattaacatgggccaggattcaagagtaaactgtcttcattcctaccacctctgaagctctcagggagccacacacaggacttcctatatctatgatggatttggatgctttgtttgtgtttttttattatattatcttttcaaaatactatagtaaaccatggtcttcactctggattcttcctccagagaagagaatcatataagtatatggttaacttttactaattaatttgaagacataagaatcatggagtaaggatgatgaatttgttgttgttgttgttgttgttgttgttgttgttgttgagatatcaacagtgatctatctataatgccaagggatcgacagaaaatcagttactagaaaggtagtcttgcttttgacatgagcttaaattctccagatggttctgccagccataaagatggcagctttgccagtagattaagtggcaagtggtcagatatctttggggcctcatgcacttcctctgtaaaatgggaattgttatccatggctcaccaagggtcttgtaagaggcccaagaaactgatcttgcttgtatttaatctccaggtctgatggtcagggaaggcagtctccctataatgaacatgtcatgctaggtcagaataatacatggttttcttgttctaatttctacttgttctcagtaccttgatgccatcaccatcatgagagtgtttcagaggctttctgctctgatttggttttggtctgtttgtcttcttaggatagagaagagattcaaaactagaggagtagaacctggttttattagtttcaacttgaatccagttatgagaccttgcaagtccttgtccctatgacaactcttctgcttcagggactcccaggaagaagtacaagagcttgagggctgagagacaagcccacagtgccaaacacattccacatgcagtgataaataggagacatgcttcatgtgtgtttggaggagttgggcctgtatacctggaacctgggggactgagtatttgaagataatgcagaacagaattgtttggcaaatgtaaatttgtccagctgaccccagtcactagaaagactgtcatctaacctctgccatgctcagaacgcgtgcctagaagggacaatacaagtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtggtagtgatgagaaccggtgatttttgtctttgtggcaggaatacattgaaaccactctcagaacaatggttggaccacatcattttccataaagcacattataagatttgctgaagggttctcttggaaacaagagtgaccccagctctggatggaacacatgaagggacatgagtggatcaggccacagcagtgccaccctcacagaatgcttctctctaggcagtggctgtgctgagaggcccacctacccagcacttcattaggcctcctgaaggttcaacatgtagccagcagtctgttctccatgcccactgtcacctccaatgtggcagccaccagatctctgtggtcaagcaaggctagggaaaactggcagcctccagatagaagtggaaagagtgtgcctctaaaaacttggctccctatgatttcaggtcaggtcaactttctagatcccaaaaaatctgtgcccgagaattcttcatagtctttaagtacaagtgggagttctctgtcttccacaatagcaattctctctccctgagagatggtagcagaccttggggttgctaccgtatagcttgtttatcatcgcctcttccccttagagtagaatggacttctgggtagctgttgagcccacaggcaccttctctccacttccttccctgtggtagtagtattaattattattatttttttattattattttgattgcttttgcccacacctgtcttcacttctttcttcctcctctttatttttttctgcccagaaaaacctgacttcgataccaaaaaaagataaaactacagaaactcaaatttaaaaaaaaaagaaaaaaactcttagaaaaaaaaaaaagaaaaaaaagaaaaaaaacctcaattctttcagctttattaacattttccattgtttcttgcgaattgtgtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcagataaagaaaaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaaaaaatttaaaaatgaccctcatagcacgcaaaacaggaaggggaagtgtcccttctttctgtgacaatacacatcattcctgcatactttttttttttaacaccaaactacctatgttcctcatttctcccgtttttctttttaattttcttgcatttgtgaattagttcaagaatgctagaaaagtgtcaaggtgtgtacatccatttcttctctcacgatgtttaaaagtgaccgtacttcattttgtaaactaagaaaaaaaaaaaagaaaaaaaaaagaaaaaaggaaaaaaaaaaaggttggaatagtgtgaacataataggttcaacctaacacatgtttattaattttgagacccagaaatgaattcttctctttattcctgctcttaaaaatacaaaaaaagagaaagttttgttttgtgttcttttttggttttgtttatttgagggggggtgctccttttccgctgttgggtttgtgggtcttgctgggtttattcttacgtatgtatacagggtgatgtgaaaagaggtacctgggagagaaggctgcttccatgctctgctttgcttcagtccatgtcaaaaccatcgagaaagctcatggcctcatgtccctgctttcttgcatgcccggggtgtgtggcactctggtagtccctgagataacaagacagggacttccttccttaaatactcatcttttcttatattgaaaagaaaggcttttgttgattctgattgtcccaaccaagggttttctttctccctgattaacttcaacagtccacaagtatgcttccaacaagacaggatctttctccaggcagaaaagcactgctgtggagggcaccataacccagtagagtagatctgtgaagcaggccctgggcccatcttcttgggatccagagtccccgtattctgtgtgcagtgtgggtaaagtgaggagcctgggtcaaggctgcaattagaatgctaagaagctatctttcaattggtgccacttgttgctaacctctggtgaggttaactctttaaattgccaggtgggcttcatcggaaagtctgtattggtcataggggaaaagaaagccatgtggttggacagactttcagtttcagacattgctcattcaaacactcaggtgttcagaaagcagacagaattccaaccagatatgtaaagaagacaagcgtgagtagtggagctctgctgtaggaagcagtccacctggagacagcttagctcttgtttctgtgtcctaagagatgaaagagatgaaaggcacccttttcacgtcacctttgtggttttcagcctagctcaaagctttctggaaacttttattattttattttattttattttattttatttttgtaagctacttctttccctttcgttaaaataaataaaacattgaatgttttgccctctttctctctctttcttcttccctttgggggtttccttttgaagtgtgttcctttggttgttggttttatctccccctcactttttctccttattattgagagtataaacctgcaaagctcagctctactttggttttgaaagttgaagcttctctgcttccgtgcgagcacaggcctctgtccccttcgattgcagcggaacgaacgtttgtgttctctaatgatactaacacgatgtaggttttacagtctcctaatttgtactggtaatgcagattccaaataaatagtttcttttgttgcaaaaaaatatatatacacacttgt

//