LOCUS       NM_001039653            2241 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus LIM homeobox protein 3 (Lhx3), transcript variant 1,
            mRNA.
ACCESSION   NM_001039653 XM_001052045 XM_001052046 XM_001052047
VERSION     NM_001039653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Renaux,E., Baudouin,C., Marchese,D., Clovis,Y., Lee,S.K.,
            Gofflot,F., Rezsohazy,R. and Clotman,F.
  TITLE     Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of
            spinal V2a interneurons
  JOURNAL   Cell Mol Life Sci 81 (1), 286 (2024)
   PUBMED   38970652
  REMARK    GeneRIF: Lhx4 surpasses its paralog Lhx3 in promoting the
            differentiation of spinal V2a interneurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Dang,W., Gao,D., Lyu,G., Irwin,D.M., Shang,S., Chen,J., Zhang,J.,
            Zhang,S. and Wang,Z.
  TITLE     A Nonsynonymous Substitution of Lhx3 Leads to Changes in Body Size
            in Dogs and Mice
  JOURNAL   Genes (Basel) 15 (6), 739 (2024)
   PUBMED   38927675
  REMARK    GeneRIF: A Nonsynonymous Substitution of Lhx3 Leads to Changes in
            Body Size in Dogs and Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2241)
  AUTHORS   Engelhardt,D., Marean,A., McKean,D., Petersen,J. and Niswander,L.
  TITLE     RSG1 is required for cilia-dependent neural tube closure
  JOURNAL   Genesis 62 (3), e23602 (2024)
   PUBMED   38721990
REFERENCE   6  (bases 1 to 2241)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   7  (bases 1 to 2241)
  AUTHORS   Zhadanov,A.B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Westphal,H.
  TITLE     Genomic structure and chromosomal localization of the mouse
            LIM/homeobox gene Lhx3
  JOURNAL   Genomics 27 (1), 27-32 (1995)
   PUBMED   7665181
REFERENCE   8  (bases 1 to 2241)
  AUTHORS   Zhadanov,A.B., Bertuzzi,S., Taira,M., Dawid,I.B. and Westphal,H.
  TITLE     Expression pattern of the murine LIM class homeobox gene Lhx3 in
            subsets of neural and neuroendocrine tissues
  JOURNAL   Dev Dyn 202 (4), 354-364 (1995)
   PUBMED   7626792
REFERENCE   9  (bases 1 to 2241)
  AUTHORS   Bach,I., Rhodes,S.J., Pearse,R.V. 2nd, Heinzel,T., Gloss,B.,
            Scully,K.M., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     P-Lim, a LIM homeodomain factor, is expressed during pituitary
            organ and cell commitment and synergizes with Pit-1
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2720-2724 (1995)
   PUBMED   7708713
REFERENCE   10 (bases 1 to 2241)
  AUTHORS   Seidah,N.G., Barale,J.C., Marcinkiewicz,M., Mattei,M.G., Day,R. and
            Chretien,M.
  TITLE     The mouse homeoprotein mLIM-3 is expressed early in cells derived
            from the neuroepithelium and persists in adult pituitary
  JOURNAL   DNA Cell Biol 13 (12), 1163-1180 (1994)
   PUBMED   7811383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773595.10, L38248.1 and CD741809.1.
            
            On Mar 12, 2014 this sequence version replaced NM_001039653.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L38248.1, BC132554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL773595.10        66061-66094         c
            35-2213             L38248.1           1-2179
            2214-2241           CD741809.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.44 cM"
     gene            1..2241
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="LIM homeobox protein 3"
                     /db_xref="GeneID:16871"
                     /db_xref="MGI:MGI:102673"
     exon            1..231
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1346
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="isoform a is encoded by transcript variant 1;
                     LIM/homeobox protein Lhx3; homeobox protein LIM-3;
                     homeobox protein P-LIM; LIM homeo box protein 3"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx3 isoform a"
                     /protein_id="NP_001034742.1"
                     /db_xref="CCDS:CCDS38081.1"
                     /db_xref="GeneID:16871"
                     /db_xref="MGI:MGI:102673"
                     /translation="

MEARGELDPSRESAGGDLLLALLARRADLRREIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGSSKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPPMRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF"

     misc_feature    234..398
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="The first LIM domain of Lhx3b; Region: LIM1_Lhx3b;
                     cd09467"
                     /db_xref="CDD:188851"
     misc_feature    order(243..245,252..254,306..308,315..317,324..326,
                     333..335,384..386,393..395)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188851"
     misc_feature    420..587
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="The second LIM domain of Lhx3-Lhx4 family; Region:
                     LIM2_Lhx3_Lhx4; cd09376"
                     /db_xref="CDD:188762"
     misc_feature    order(420..422,429..431,486..488,495..497,504..506,
                     513..515,573..575,582..584)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188762"
     misc_feature    order(456..458,531..533)
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Isl binding site; other site"
                     /db_xref="CDD:188762"
     misc_feature    624..794
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            232..403
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            404..606
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            607..758
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            759..927
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     exon            928..2227
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="hexamer: AATAAA"
     polyA_site      2224
                     /gene="Lhx3"
                     /gene_synonym="Lim3; mLim-3; mLIM3; P-LIM"
                     /note="major polyA site"
ORIGIN      

agaggcctcccgtgggcacagcgcccagcagcgacacgagtcgctccgacgccagctcggagtccctgcaacggtggcctcgccagacccaggggaagttcagggtcggagggcggcagcaccaggcacctggccccatggaagctcgcggggagctggacccgtcccgggaatccgcgggcggagacctgctgctggcgttgttggcgcgaagggctgacctgcgccgagagatcccgatgtgtgcaggctgtgaccagcacatcttggaccgtttcatccttaaggctctggaccgacattggcacagcaagtgtctcaagtgcagtgactgccacgtccctctggctgagcgctgcttcagccgcggggagagcgtctactgcaaagacgacttctttaagcgcttcgggaccaagtgcgccgcatgccagctgggcatcccgcccacgcaggtggtgcgccgcgcccaggacttcgtgtaccacctgcattgcttcgcctgcgtggtctgcaagcggcagctggccacgggcgacgagttctacctcatggaagacagccggctggtgtgcaaggcggactacgaaacagccaagcagcgagaagccgaggccacagccaagcggccgcgcaccaccatcaccgccaagcagctggagacgctgaagagcgcctacaacacttcgcccaagccggcgcgccacgtgcgcgagcagctctcctccgagaccggcctggacatgcgagtggtgcaggtgtggttccagaatcgccgggctaaggaaaagagactgaagaaagacgctggccggcagcgctggggacagtatttccgcaatatgaagcgctcccgcggcagttccaagtccgacaaggacagcatccaggagggacaagacagcgacgccgaagtctccttcactgatgagccgtccatggctgacatggggcctgctaatggcctgtacagcagcctgggagagcctgcccctgcgttgggccggcccgtaggaggcctgggcagctttaccctggatcacggaggcttgacgggtccagagcagtaccgagagctacgcccaggcagcccctatggcatccccccatctcctgcagccccccagagccttcctggcccccagcctctcctctccagcctggtatacccagacaccaacttgagccttgtcccttcagggcccccaggtggacccccacccatgagggtgctggctggaaatgggcccagctccgacctgtccacagagagcagttctggctacccagactttcctgctagccctgcttcctggctggatgaagtagaccatgctcagttctgaccgaggcctctgcttcccctggctctaactcaggggtcttggtgctgcctctgggtggatggctagccccatcccatgctgtccattccaaggacctctgagggaaggacagggttcccaagtgagagaatagggactgtcccacttccaggctctctggcagctccctggggctgagggactccaaagtccttccttggacacaagggtggcctgcctggtggctgtccacaagccagtgaccatttcttgtaagcatttctctttctttactggccagttaacccttgctgctatttccgacagggcaggaggctaggcctacctaatgtcctggcagaaaacaacagtaacgccttgcttcatcgcttctgatggggcttggtaggagactgtgcttgtgtccttcctggccactgacaaaacctgggagcacacctctcctccttactgctgccagctctccctccccggagtctccagatcattctgttctggaatgccgtgtgttgggggagtagagctttctggagccccttctccaaggcgtagcctctaaatgcgagaacaattccccttcggaggcacagcctccctcgggtgcaaagcagaattgtgcaccgtgaacagacacctttgccaaacagactgtggtcccgagcagggtcggggggtggttccactggaggaggctgggctgggggtcctcccaacccaatctgtctcagacacaaagcttgaccacgtgaaagttaagatcattcctgaaaacaggatcttggctacctgttggttctgtaaacaccctgtaacttttatttattccctggtgatccgctctttccaagacttcaataaatttgtcagtttcagtgctagaaaaaaaaaaaaaaaa

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