LOCUS       XM_050151504            3797 bp    mRNA    linear   ROD 12-SEP-2024
DEFINITION  PREDICTED: Alexandromys fortis NRDE-2, necessary for RNA
            interference, domain containing (Nrde2), transcript variant X1,
            mRNA.
ACCESSION   XM_050151504
VERSION     XM_050151504.1
DBLINK      BioProject: PRJNA868355
KEYWORDS    RefSeq.
SOURCE      Alexandromys fortis (reed vole)
  ORGANISM  Alexandromys fortis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Cricetidae; Arvicolinae; Alexandromys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_026067953) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_014885135.2-RS_2024_09
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 09/12/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3797
                     /organism="Alexandromys fortis"
                     /mol_type="mRNA"
                     /isolate="MF-2015"
                     /db_xref="taxon:100897"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="muscle, liver, lung and blood"
                     /note="4th-generation inbreeding"
     gene            1..3797
                     /gene="Nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins"
                     /db_xref="GeneID:126507235"
     CDS             126..3623
                     /gene="Nrde2"
                     /codon_start=1
                     /product="nuclear exosome regulator NRDE2 isoform X1"
                     /protein_id="XP_050007461.1"
                     /db_xref="GeneID:126507235"
                     /translation="

MALFPAFADVSEASGGGASRKELDWLSNPSFCVGNLTSLSQRTEEVTALAAEGSPLTRSPLRSALSGESDTGRAAARLSRNKKREKRKKRKHQHRKKTKRTHEQSSSGGSESDTDSGKDRSSRSIKDRQKESEKPSQGSDAVGAAAAGHRSIWLEDIQTLAEVFMTDRKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSAVKKHAHKHLERYFTKKSVGLMRTEGIAVCANTEPPSSEPVPFIPVKDSADVAAPVATWLNPLGIYDQSTTQWLQGQGPLEQEPKQPDSQRDRESAVLKARVEEFNRKVRENPRDTQLWMAFVAFQDEVMRSPGLYALEDGEQEKHRKSLKLLLEKKLAVLERAIESNPSSVDLKLAKLQLCAEFWEPSALAKEWQKLLFLHPNNTDLWQRYLSFCQSQFGTFSVSKLHSLYGKCLSTLSAVKDGSILSHPVLPGTEEAMFALFLQQCHFLRQAGHSEKVVSLFQAMVDFTFFKPDSVKELPTKVQVEFFEPFWDSGEPRVGEKGARGWRAWMHQQERGGWVLVNPDEDEEEPEEDDQEIKDKTLPRWQIWLAVERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSPDLHFQLIEAFLQFLGVPSGFLPPASCLYLAMDESSVFDSELYDEKPLTYFNPSFSGISCVGYMEQLGCPRWTKGHSREGEDFIRNVFHLVLPLFSGKQKSQLCLSWLRYEVAKVIWCLHTKKKRLKSQGKNCKKLAKNLLKEPENRNNFCLWKQYAHLEWLLGNIEDARKVFDTALSMAGSSELKDRELCELSLLYAELEMELSPDSPGVATGRAVHVLTRLTESSPYGPYAGQVMATQVLKARKAYERALQDCLGQTCASDPAPAESLDCLGSLVKCFMLFQYLTVGIDAAVQIYGQVFAKLKGSVLPEVPGPEDSARSQSLSSVLEAVTLMHTSLLRFHMNSSVYPLAPLRETLSEALKLYPGNQVLWRAYIQIQNKSHSANKTRRFLDVVTRSARHLEPWLFAIEAEKTRKRLVDSVQRVGGREVHATIPETGLTHRIRNLFENAIRSDKGSQCPLLWRMYLKFLVSLGNKERSKGVFYKALQSCPWAKVLYMDAMEYFPDELQEILDVMTEKELRVRLPLEELELLLED"

     misc_feature    615..902
                     /gene="Nrde2"
                     /note="MTR4-interacting domain (MID) found in nuclear
                     exosome regulator NRDE2 and similar proteins; Region:
                     NRDE2_MID; cd22200"
                     /db_xref="CDD:412062"
     misc_feature    order(615..638,645..650,660..665,669..671,675..719,
                     726..734,738..746,768..776,786..791,795..800,807..827,
                     852..863,873..902)
                     /gene="Nrde2"
                     /note="MTR4 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:412062"
     misc_feature    1068..2066
                     /gene="Nrde2"
                     /note="necessary for RNA interference; Region: NRDE-2;
                     pfam08424"
                     /db_xref="CDD:462472"
     polyA_site      3797
                     /gene="Nrde2"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

tgaagccccggcggagttcaagaaagactacatttcccagagtgcatcgcgggacagagtcctccaaccagagcgctccagccggcgccatttctgtggagggagtgttggtgcggcctgtgaacatggcgctgttcccggcctttgcggacgtaagtgaggcctccggtggtggggcatccaggaaagaattagactggctgagcaacccaagcttttgtgttgggaatctaacgtctctgagccaacgaactgaagaggtcacagcccttgctgctgaagggtcaccactgacaaggagccctctgaggtcagcactctccggtgagagtgacaccggcagagcagccgcccggcttagcagaaacaagaagagagagaaaaggaaaaagaggaaacatcagcaccgcaagaaaaccaagaggacacacgagcagtcgagcagcggtgggtctgagtcagacacagattctgggaaggacaggtcttccagaagcatcaaggacaggcagaaggaatctgagaaacccagtcagggaagtgatgctgttggtgctgctgctgctggacaccggtccatttggctggaagacattcagactctggcagaagtcttcatgacagataggaaaccagatcctgccaactgggagtataaatctctttaccgaggggatatagcaaggtacaagaggaaaggagactcctgcctgggcattaatcctaagaaacagtgtatatcttgggaagggacttctgcagttaagaagcatgcacacaagcacctggagcgctattttaccaagaagagtgtgggattaatgcgcactgaggggattgctgtgtgtgctaacaccgagcctccctcctctgagccagtcccatttatcccagtgaaggactctgctgatgtggctgctcctgttgcaacatggctgaatcctctggggatttatgatcagtcaactacacagtggttacaaggacagggtccactagagcaagaaccaaagcagccagactcacagcgggacagggagagcgctgttcttaaggccagagtggaggagttcaacagaaaagtgcgggagaatcctcgggatactcagctgtggatggcctttgtagctttccaggatgaggtcatgaggagccctggcctgtatgcccttgaggacggagagcaggagaagcacaggaagtccctgaagctcctcctggagaagaagctggctgtgctagagcgggccattgagagcaacccaagcagtgtggacctgaagctcgccaagctgcagctgtgtgcggagttctgggagcccagtgcgttggccaaggagtggcagaagctcctctttctgcaccccaacaacacggacctgtggcagcgctacctctccttttgccagagtcagtttggcaccttctctgtgtccaaactccacagtctgtacggcaagtgcttgagtaccttgtctgctgttaaggatggcagcatcttgtcccacccggtactgccgggcacagaggaggccatgtttgcactatttcttcagcagtgccacttcctgcggcaggccggccactcggagaaggtcgtctctttgttccaggccatggtcgacttcaccttcttcaagcctgacagtgtaaaagagctgcctaccaaagtgcaggtggaattctttgaacccttctgggacagcggagagccccgtgttggggagaagggcgcccgaggctggcgggcgtggatgcaccagcaggagcgtggtggctgggtgcttgtcaatccagatgaggatgaggaggagccagaagaggatgaccaggagataaaagataagactctgcccaggtggcagatctggcttgctgttgaacgttctcgagaccagaggcactggcggccctggcgtccagataagaccaagaagcaaacagaagaagactgtgaggaccccgagagacaggtgctgtttgatgacattgggcaatctctgatcagactttccagcccagatcttcatttccaactcattgaggcctttctgcagttcttgggcgtgccttccggttttcttcctccagcctcctgcctttacctggccatggacgagagcagcgtttttgatagtgaactttatgatgaaaagcccttgacttacttcaacccttcattttcgggcattagctgtgttggctacatggagcagttgggctgtcctcgctggaccaaaggtcacagccgcgagggcgaggattttatccgcaatgtcttccaccttgtgctgcctttgttctcaggcaagcagaagtctcagctctgcctctcctggttgcggtatgaggttgccaaggtcatttggtgtctgcacactaaaaagaagcgattaaagtctcagggaaagaactgcaaaaaactagccaagaatctccttaaagagccagaaaaccgcaacaacttttgcctctggaaacagtatgcacacctggagtggttgcttggcaacatagaggatgccagaaaagtgtttgatacagcactcagcatggcaggcagcagtgagctgaaggaccgtgaactctgtgaactcagtctactttatgccgagctggagatggaactgtcgcccgactccccaggagtggccacaggccgagctgtccacgtgttaacccggctgaccgaaagcagtccctacgggccctacgctgggcaggtcatggccactcaggttctgaaagcccgaaaagcttatgaacgcgctttgcaggactgtctgggacagacttgtgcctcagatccagctcctgcagagtccctggactgcctggggagcttggtcaaatgctttatgcttttccagtatttgactgtcgggattgatgctgctgtgcagatatatggacaggtgtttgccaagctgaagggctctgttctcccggaagtccctggcccggaggacagtgccaggtcccagagtttgagcagtgttctcgaggccgttaccctgatgcataccagtctgctgcgattccacatgaacagtagtgtgtaccctctggctccacttcgagagacactctcagaggctctaaagctatatccaggcaaccaggttctctggagggcatatatacagattcagaataagtcccacagtgctaacaagaccaggagattcttggacgtggtcaccaggtctgccagacatttggagccgtggctgtttgcaatcgaagctgagaagacgaggaaaagactggtagactctgttcagagagtaggtggtagagaggtccacgccaccatcccagagaccggccttacgcatcggatcaggaacttgtttgaaaatgcaattcggagcgacaagggcagccagtgcccccttctgtggaggatgtatttgaagtttttggtttccttaggaaacaaggagagaagcaaaggtgtgttctacaaggccctccagagctgtccctgggcaaaggtgctgtacatggatgccatggagtacttcccagatgagctgcaggagatcctggatgtgatgactgagaaggagcttcgtgtacgcctgcccctggaggagctggagctactgctggaggactagtcaacctccgtagaacagagcgagcgaggacagtggggcccaggagagcccccgctgtgcaagggctttctccactgtttgggtggggtttggacttactgttttatacatattatatatgtgatcaaccatgtacagatggagccaggccaatgataaaccttttatggttga

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