LOCUS       XM_029442467           11264 bp    mRNA    linear   VRT 09-JUL-2025
DEFINITION  PREDICTED: Cottoperca gobio argonaute RISC catalytic component 2
            (ago2), transcript variant X3, mRNA.
ACCESSION   XM_029442467
VERSION     XM_029442467.1
DBLINK      BioProject: PRJNA530544
KEYWORDS    RefSeq.
SOURCE      Cottoperca gobio
  ORGANISM  Cottoperca gobio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Neoteleostei;
            Acanthomorphata; Eupercaria; Perciformes; Notothenioidei;
            Bovichtidae; Cottoperca.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_041365.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_900634415.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/09/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11264
                     /organism="Cottoperca gobio"
                     /mol_type="mRNA"
                     /db_xref="taxon:56716"
                     /chromosome="11"
     gene            1..11264
                     /gene="ago2"
                     /note="argonaute RISC catalytic component 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 1 sample with
                     support for all annotated introns"
                     /db_xref="GeneID:115015305"
     CDS             280..2901
                     /gene="ago2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X3"
                     /protein_id="XP_029298327.1"
                     /db_xref="GeneID:115015305"
                     /translation="

MYSSTGATEMQEGPPRSTGSPGSDPSSSPVPEYVFKPPSRPDFGTMGRTIKLQANFFEMEIPKLEVYHYDIDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVYDGRKNLYTAMPLPIGRDKVELEVTIPGEGKDRSFKVSIKWVSCVSLQALHEALAGRLPSVPFETVQALDVVMRHLPSMRYTPVGRSFFTPSEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTIECTVAQYFKDKYKLILRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQDEISKLMRSANFNTDPYVREFGVMVRDEMTEVNGRVLQAPSILYGGRNKAIATPIQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTELLLKAFTDQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKYTYQGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQVKNVQKTTPQTLSNLCLKINVKLGGVNNILLPQGRPLVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQQHRQDIIQDLATMVRELLIQFYKSTRFKPTRIIYYRDGISEGQFNQSQVLQHELLAIREACIKLEKDYQPGITFVVVQKRHHTRLFCMDRNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNHFSSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDQQALAKAVQIHQDTLRTMYFA"

     misc_feature    589..813
                     /gene="ago2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    841..993
                     /gene="ago2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    994..1356
                     /gene="ago2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1150..1152,1195..1197,1237..1239,1249..1251,
                     1303..1305,1324..1326,1330..1332)
                     /gene="ago2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1489..2772
                     /gene="ago2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1900..1902,1912..1914,1948..1959,1966..1968,
                     1990..1992,1999..2001,2011..2013,2023..2025)
                     /gene="ago2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2104..2106,2110..2112,2320..2322,2740..2742)
                     /gene="ago2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gaaaggagggaaccctcttgccctacatgggtcttttctgtgctatcttttctctcggctcccgttttgtgtgttggggggatggggccgtgccgaggatgagagactccaaatatttaccacttggctaactaaatatctttatttcctaactggatttcctccctcggtcttgtaaatataactacttttcgatcacgcatgagtttaggtggaatttgtccaaaataaagtggagtatctgtacgtccacgacacacgcttaaaaaagtcgacaaaatgtattcctctactggagctaccgagatgcaagagggacctccccgttccactgggtcaccaggctctgacccgtcatcctccccagtgcccgaatatgtgttcaagccaccatcacggccggactttggcaccatgggcaggacaatcaagctccaggccaacttctttgagatggaaatccccaaactggaggtctaccattatgacatcgacattaagcctgagaaatgccctaggagggtcaaccgtgaaattgtggagcacatggtccagcactttaaaacacaaatatttggtgatcgaaagccggtgtatgacgggaggaagaatctctacactgccatgcccttgcccataggcagagacaaagtggagctcgaggtaaccattcctggtgaaggcaaagaccgcagcttcaaagtatccatcaagtgggtgtcctgcgttagcctgcaagcgctgcacgaggctctagcagggcggctacccagcgtccccttcgagaccgtccaagccttggatgtggtcatgagacatttgccctctatgaggtataccccggtgggccgctctttcttcactccctcagagggatgttcgaaccccctcggtggtggcagagaggtgtggtttggcttccaccagtcagtcagaccttccctttggaagatgatgctcaacatcgacgtttccgccactgcgttctacaaagcccagcctgtaattgagttcatgtgtgaggtcttggatttcaaaagcattgaagaacaacaaaagcccttaacagactctcaacgagtgaaatttaccaaggaaatcaaaggtctgaaggtggagatcactcactgtgggcagatgaagaggaagtacagagtgtgcaatgtgaccagaagaccagccagccaccaaacgttccccctgcagcaggaaaacggccaaactattgaatgcacagtagcacagtacttcaaagacaagtacaagctcatcctgagatacccacacctcccgtgtctacaggtgggacaggagcagaagcacacctacctacctctcgaggtgtgtaacatagtggcaggacagcgctgcatcaaaaagctgacagacaatcagacctccactatgattcgtgccacagcccgatctgcaccagaccgccaggacgaaattagtaaattgatgagaagtgcgaacttcaacacggacccttacgttcgtgaatttggtgtgatggtgagggatgagatgacagaagtgaatggccgtgtcctacaagccccttccattctgtatggcggcaggaacaaagcaatagccacaccaatccagggagtatgggacatgagaaacaagcagttccacactggcattgagatcaaagtgtgggccatcgcctgctttgcaccacagaggcagtgcactgaactcctgctcaaagcattcacagatcagctgaggaagatctctagggatgcagggatgcccatccagggtcagccttgcttctgtaagtacgcccaaggagcggacagcgtggagcccatgttcaggcacctcaagtacacctaccagggcctccagctggtggtcgtcatcctcccggggaagacgcctgtttacgctgaggtgaaacgtgtcggggacacggtacttggcatggccacgcagtgtgtgcaggtgaagaatgttcaaaagacgacacctcagaccctctccaacctctgtctgaagatcaacgtcaagctgggcggagtcaataacatcctccttccacagggcaggccgttagtcttccagcagccagtgatcttccttggggcagatgtgactcatccacctgcaggagatggaaaaaagccttccatcgctgctgttgttggtagtatggatgcccatcccagcagatactgtgccacagtgcgggtgcagcagcaccgtcaggacatcatccaggacctggccaccatggtgagggagctgctcatccaattctacaagtccacccgcttcaagcccaccagaatcatctactaccgcgatggcatctctgagggccaattcaaccagtcacaggtccttcagcatgagctgctggcgatccgggaggcttgcatcaaactagagaaggactaccagcccggtatcaccttcgtggtcgtgcagaagaggcatcacacaagactgttctgtatggacagaaatgagagggttgggaagagtggcaacattcccgcaggcaccacagtggacaccaaaatcactcacccatcagaatttgacttctacctttgcagtcacgctggcattcagggtaccagcaggccgtctcattaccatgtgctctgggacgacaaccacttctcatcagatgaactgcaggtcctgacctatcagctgtgccacacttatgtgcgctgcacccgttcagtttccatcccagcaccagcttactacgcccatttggtggctttccgggctcgctatcacttggtggataaagagcacgacagtgccgagggcagtcacacatcaggccagagtaacgggcgggaccaacaggccttggccaaggctgtgcagatccaccaggacaccctgcgcaccatgtactttgcctgagagcaaacaaccccaggttggcgtgggtgagaccccactgatggaacacactacccctcgctgtctcactgtcggctgtagatagcgtcacagtgggttcacatagtgatctccctacctaacagaccggtcggttccccatatgtctacaattgtacttcagcccctgacccacccaaattacgccagctattagactgtacgatgcaaaggaatccctctttcttggggtttgcgttggaagaggtttttatttacatgttgtgcattagtgtgtatttgttgttgggaaatacgttgcaaagtatgaaaggaaatggacaagtttgtacactgatggaagaactctaccatttctaaactagtgggcagtatcgttataaattggggtgattttataatttaaaagaagcagtttatccctccttctcctatttccattgtttgttagggtcttggtgcttgaagggagacggatcaaattcattaagataaaggggggggggggggtcactgtttatatgcctaaagagttgctcctctgacaaacattatttatcagccaatcaaagcaaagtgcactgaccacaatgggtacttcaatcaggacaaaagtacttaatatattgagggttgtgtgtgtgtgatttttcacatagggcactatgtgacaaaaagtgccatttgagaccagctttccgttgtcatgtctgtgtaaaactatgaactattaggcccacatctgctggggtttcagtatttgtccatgattgacactgacatgccaaatctgctgacaatttatttacaaaaaggattctttgcatcagatttgttatcaacccttgaaccaacacttagtttattctagatgaaagggggcgttcagtgtttagatagaaattggagaaaaaaacgcaattgtatccttctctgccttctgagtctgaactggcatactttcaccggtaactctaggattcccttgccgagacttcgtgtattgggaccggttcccaacaaggacacttttctaatgtagtctgagccgtgttgataaagacacatgatttagaaatcaacatggaggggaacttgatgaaatccttttttgttccctttttttagtctaatttaatttcaatcagttttattttgtttgtttttatgcatgtagctgactcatgttttagacatttaggcatttgtgataattgtttttttttttcctttctacacattaaccctacttgtatgttttaatgtatatagcaacaggatagtgttttctgcagtgtatttgtcagagcgggatatttgtgtggcgtctcaatatccaggcattcggtacaggggagtgaaagctgcaacattttagagattaactgatttgaaattccctttaaaaaaaaaacacaaaaaaactagtgtttgctccatgaattggaacagtcgtcgcacaaaagcttgggttttatgcaaatgactttttgtgagtctttatactatatagtaatgttggtaataaggtatattttgaataagctttcagtggaggctgctgaaaatataatctttttttttttttttttatgactggcccacatgtagtctaaattaacactgtctatttgtataaagattttaaatgttctcttgccttctaagactgttaaagtcttactaataattctatacatttcctaacatcccacctaagttttactctcaaattaagctcgcgaatgttctcatagtcttgattggaggcgagtagtctatattttctaactatgcatcatttttaaccaagatatttagcagtggggtatctcacataaatttggctcatttatagaggtagataatcagggcttttttttttttattattattgacgttttttagcatgttgcatttagtagcgtttttttagtgcttatcggcgtcttcatgtctttctaacgggctgaagtatttgtggtcatttgtaacaatgtagattttatagcctgaacatttggtgtatcctttgtaacacacaatctttcttagccaaacaagattacaaacttttacatgattaatattcaaaagacatggaagcacaaaaggacatctggagtctaggtgcttgaagttttcactgtaaaccaccttaaatcctcactggactggtcaaacgagactttttaacttgtacgcaaaaaaaaaaaaaaagatgcttcatcatgttgaggatcttttctctttccctttgacgacctctctgtgttaccctttttactcattacctgtaaagcaactagaaatccgacggactgtgtttgtggggcattctgaaatcatgtacttgatatttactgttatgatgtcaatattgttcttatcggtgctggtctcacaacatgtaaatttgatgcacttttgataacagaacgttggtatgacttctatagatgtatgttcctcaatcgaagcaggaggctcggccatatgttgcgtgacactggtgtaattgtatggaaatggccgtgtgttctacctcttgttacctgttttagtgttatggtaacatcacactgctggccatttctgtataattacccctgctatctatctaattggcattgtttgagtcttgcattgacagtagaggttggtgtgcatgactgtgtacgcgcttcgtcagtttatgaagttgcgtgatattttatttcatatttactcaaactgataagagagaatgtgtttcgtttcttcttcttttaagggttttgagcgttgagctgtgcgaccaaattcttgaagtgtttgtgttcaaacacacctttcccttctttctttcctttttttattctatgcaccagttaaatgacagacttttttttgacaccttggttttccacctgagcagtaaaacaataattgcaaagcctacatcagctacgatcattgcatacgctttgagttagaggagttgtgaatgcacccttgtggtgccgttggtcagaagcgcgtattgagatccatgtgaaaatagatttgtatgggtttcagcaaagccttttgatcagttaaatgtcatcacaaaatggtcatgcattgaaatctttcattcaagtacaagtgtgatcttcagttgtgttttgtggagcctcgttgttgggtctgtgtttggaaacgcgaatgtcgtattgtggggaaagtgtcctaaatgaaagtgcgctgaaattgagaacatccagttgtcgttgggaggtggctttgtacttgtcgtcgccgctcctttcgtgttttacatgacctataccagcaccttaacatagcagatcagaacgccattgcttttcctggagagaaaactcaaacatttgacaatgtttttgcactaaacatgaatgaacttttgtagctgttgcagcattaaagagtatttataaggtggcagacttgcagcttctttcttttttttttggatttttagaagggagcagttggtataggtggcgcaccagtgtgcgcacttgccgttcagaaagccacgcctgctgatcaacagagattctacctagctaaccagcattcagtcatgtagtcttggagcaatatcctaatgcctttttttaaatgttaacgaaatagggaagcgtgtagttgcgtaggtggggttgcctttgtacagtgacgtgggagaaaggtgctttatgcaaatcaacaaaactgacaggtgctcgaaaaaaaaagagccaattttagttttggacaacaagatttctgcagaggcttgttggatgccaaaatgcagtgtgaggatgaagtgtgcaggtaggtttgacacggtcgtaatgcttaaagtaaggcctctttatcggtcggaccccaacattagacgatcatatcaagatgcagaagagggttttccctttttttttacataaatctgcttgatcatgatcagctaaacttaacaaacgaatgaacacaacagcctggatgaatgtgccgctactttaacggtgcccgaggtgcttaggtaggcccctgttacctttgccgtggtaacactaatgacatcacttcacctcagtttttctgtatctttgagtttccaaaactaggaacaagcaggtggtagaaacggatggtttgtaaactaaatggcatatcataagctaatttaattgatcagttaatttgtgttttctcaataccaggttctttttctttttatacgtatgttcaaatgttgggttgaaagaggctaaagagataaaaattcctccaattgtaacgatcagcctgtttttttttacttttgatcttttgaatggtcttggaataaaatacagctcgccttccaatgaagcaaaaacctataaatcagtttattccaaaccacaaccctctgtatagtaacgtctctctctgcctctcatccgtctcttgtagagaaactattgctgacataaagacacctcttgtagagtagaacctattttcctagctccaaataataactgaatgtacttaaagcctgcgtggtttgtaatattgtataggctatccatccagtacatttatacttatgtttgcttctcgtgtacagcctttttcttttgggtgtttttctcttatttatagggtataataattgcagaaagtattatgttttcttctttaatatttcatttatttagatatcacccacatcacagctgatatcattaatcttttcactgatcaacaggaggtatacaagtctacagttaagatgtttgctactgtagtttttaggagacaacgtttcacactgttgcaaagagtagtcttttccatttctggcgtcatgcttgtgtgaggtgctgtaacataagagctgtgtgtgtgtgtgtgtgtgtgtatatatgatggttgctttgatgtgtgatcttgtttgcagttagattttttggcttctgcgtaagccctccggtctgatattcctgtcctctaaaatcctccctgagttcagctcactaactcattagcgcagtgccacttgaaagcggaattggaaagaagctaaggtttttgtttgagtgttgcttgtgttccttactttttgtagttgtatgacaacgcagctgtttttacagattttaaagagtactgtttatgtgtgtatatttacatggcacctggctggcttcagcaagcatcattttcctcctattcctagataaacttttctgaagcatcactatgtcctagacagatagtctttatcatgccaatgtccaccctgtcacctgtactggtagacctgaggaaagaagcactacgcctcatgtccaccggatgcagctacgtcacattttggttttgccttcgtctcgattgtactttgtgttaagagctaagtagcaaatgttagcatgctatcacgccacagtaagatagcgatgttggtgagactgggagccgataatctctggcagcctggagttagtcaaaatgcattgttgtagtagcgtccggtggacatttgggttaggcttggggttgtaggaaatctgaccttgactgagtagaaatgttaccgagcttcaccaaaccaaaccaatgccatccagctgatctacatgtatccaaatcatgcaagactcatgtgggtatttttgtattttcaaagcatttctagtcttcagaatgacttggctttttatttaccaacttgaaaaaaaaaaaaactacctcagagcagtgtcaggtgctagctaatattagccctcattaataataatggtaacaaaatcaaaaattgttgtgaccaaaccaatacaagccaatattgtgtgagagcactgttcttttcttgaaccttaataaatggaaaaccaagtaatcatgtatgactggttggttgctttagttggttacagtttaggggaccaaatttttgtaattggagtctcattgtgtcatgcgagtccttcatttttcaaaagattgcaacaaaaataacccagcacaacctaggattcatgcggagaagttaactgtaatcatgactggatcatttgtcgacaaatgtgccaccatgaagtaattgctgttcactatgacatgtgttggccatattgaggaacgtttgtagtggcggtgaaggtttgttggaaagatgtatgtacagcaataatgtctgtgggctgtggattgttggtaattagtttgtctttacaccagtctgtcctctttacgcaggtcaaggcaatgctcaaacagttttgacttttagttaacaggacactttgcaaatgggtagattaatttgtctcaatatttggaaccagctttttctgtttgttttaccagaatgttgaaatattaagattgcatactagatatagccactccttgtgatcaaatgcctacatttctctgccgtgttaacccagtactgcaataaaatcagggtggatatccctgtctcctactcagttcatttcagcttcttttacaattagccagactcgacgccatttttgttaagattataagatgtagtttttgcatgcaacaatttacaaagggaatatacacattttaacatacttttacaatgtagcagaacattgtaaaacttcatggaaaggtacaatgaggcggtgtggcaattaactgcagattgttttaatttagtctaaactgaaaacatgtttgtagtcgtttttatgtgtgccttttgtcagatctctctcttctccatctgccccaacattgggtttgtgagtccttttttttaacaaaaaggtttgacaaaatctgctgcgtcacataaataaaaatattccatttttaattatcatgcaaccttgcgtgtagatgctgcatagaacgatcagtatttgtgttttgcactttcaaagcagtctcaaaaagaaatggcccacttgaggttgggcagaaagtaaaaagaaataactgacgaggtattttatgctatcaataggaattataaggaataatatgattttgaagagcttttctaaaaaggttgatatatctatatatatatattcatgaagtacctcataagcctgatatatgctgcattgacttttttttttcttcatattgtccaataaaattttaattttccccttttgggaggtttgaatgtcactacaggctgtgcacacgccacaaccagtaaatctgatggcgttctcttgtaacaaaagagtacattacactttgtggccaaatgataatgtgtcatttatgcaatttctacgcaaatctcaacataatattactcacttgtagccacgtcatatttctgtgctgtctttttattttttgcatattctctgtgtctgtgtagccaaaaaaaatatattgggtgtagttgacaaagagttgacgagcaccaagcgtcctgcgaggctctgtggtatgacgagactgttgactcaggtattgtcgtgaaaagggctgtatctgcttactgtgtccctgtcccaaacctaccccttctgcacctttgtcttaaaatagccttagatctacacatgaggttcccatttggccttaaaagttgaacaaattatgcactacaatttcacagacttgacagagagctcgattcccgttcagacacatttcttgaagagtttgcgtcgcgtcattgccgtgttatctacctcctatgaatgtaggggctgtcctggagctgtagtggactgcaaaaacctttcttgctcatttaaaggaaaacagacaatcatctgtacttttctttataaaatatattcccctattcattcatacatagaactgattccaggacactccagttttcatgtttttccccctcattggccattttcattttatacattgtgctttttttttttcattgtaaaccatgatggagaagcaaagtgaccaaagtctcttggcaaaggcagccctgcacagccgtgtgaattcaaacctcccttcatttgtgtcattttaagctcagttttgagttgttttattttctctctctgtctctctctctcttctcccttatttaaaccacgacatgccaaaactgaatttgctgtcattcctgttctgctgagggtctttatgttgcttatttttaatttgttcacatccactgctaagctccttgtttcttgttgttgtaaaaggtgtaagctttgatttctattttacatttccttatttttgttaacaattatgcttacagaacacaagatatgctgtaaaccctgttaggacataatgtgaatacgtatcacttaatatagttcactctttggcttgactgtaagttgcgttaattaataaaaatgttttaaaaggtt

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