LOCUS       XM_017319462             705 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus glutathione S-transferase, mu 4 (Gstm4),
            transcript variant X4, mRNA.
ACCESSION   XM_017319462
VERSION     XM_017319462.3
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000069.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_017319462.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="3"
     gene            1..705
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="glutathione S-transferase, mu 4; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 12 ESTs, 14 long SRA reads, 1 Protein, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 36 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:14865"
                     /db_xref="MGI:MGI:95862"
     CDS             202..657
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 4 isoform X2"
                     /protein_id="XP_017174951.1"
                     /db_xref="GeneID:14865"
                     /db_xref="MGI:MGI:95862"
                     /translation="

MPMTLGYWDIRGLAHAIRLLLEYTGSSYEEKRYTMGDAPDYDRSQWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYIARKHNLCGETEEERIRVDILENQAMDTRIQLAMVCYSPDFVSWSWPRTLALASALALFATRASQCCSWHSV"

     misc_feature    208..453
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="GST_N family, Class Mu subfamily; GSTs are
                     cytosolic dimeric proteins involved in cellular
                     detoxification by catalyzing the conjugation of
                     glutathione (GSH) with a wide range of endogenous and
                     xenobiotic alkylating agents, including carcinogens;
                     Region: GST_N_Mu; cd03075"
                     /db_xref="CDD:239373"
     misc_feature    order(220..225,337..339,349..351,376..381,415..420)
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="GSH binding site (G-site) [chemical binding]; other
                     site"
                     /db_xref="CDD:239373"
     misc_feature    order(229..237,244..246,253..255,265..267,274..276,
                     304..306,421..423,430..435)
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="C-terminal domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:239373"
     misc_feature    order(367..372,403..405,415..417,433..438,445..447)
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239373"
     misc_feature    475..>561
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="C-terminal, alpha helical domain of the Glutathione
                     S-transferase family; Region: GST_C_family; cl02776"
                     /db_xref="CDD:470672"
     misc_feature    order(493..498,505..510,517..519)
                     /gene="Gstm4"
                     /gene_synonym="1110004G14Rik; Gstb-4; Gstb4; GSTM4-4;
                     GSTM7-7"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:198286"
ORIGIN      

tgggggcggagctcagtaatttggcttctgtaggtgactgtcaggggaaaagctgtagagcagggtgtgtgttgcggggcagagtctggaggggcaggatcacgccgggcaccagccccgcccagggacccgagggcactaggataaagtcaaagttgctcacaccggaggccggtggactcagtctcaggcaccagcatcatgcctatgacactgggttactgggacatccgtgggctagctcacgctattcggctgctcctagaatacacaggctcaagctatgaagagaagagatacaccatgggagacgctcctgactatgaccgaagccagtggctgagtgagaagttcaaattgggcctggactttcccaatttgccttacttgattgatgggtcacacaagatcacgcagagcaatgccatcctgcgctacattgcccgcaagcacaacctgtgtggagagacagaggaggagaggattcgtgtggacattttggagaaccaggctatggacacccgcatacagttggccatggtttgctacagccctgactttgtgagttggagctggccccgcactcttgcccttgcatctgctctggccctgtttgccaccagagcctctcagtgctgctcatggcacagtgtttgaaattgccaacagagtaacctcaaagcttagtttgccaaatgaaaactt

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