LOCUS       XM_014737387            8598 bp    mRNA    linear   MAM 07-AUG-2024
DEFINITION  PREDICTED: Equus caballus argonaute RISC component 1 (AGO1),
            transcript variant X2, mRNA.
ACCESSION   XM_014737387
VERSION     XM_014737387.2
DBLINK      BioProject: PRJNA19129
KEYWORDS    RefSeq.
SOURCE      Equus caballus (horse)
  ORGANISM  Equus caballus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_009145.3) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 23, 2018 this sequence version replaced XM_014737387.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_002863925.1-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8598
                     /organism="Equus caballus"
                     /mol_type="mRNA"
                     /isolate="Twilight"
                     /db_xref="taxon:9796"
                     /chromosome="2"
                     /sex="female"
                     /breed="thoroughbred"
     gene            1..8598
                     /gene="AGO1"
                     /note="argonaute RISC component 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1 EST,
                     25 Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 147 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:100055148"
                     /db_xref="VGNC:VGNC:50644"
     CDS             143..2716
                     /gene="AGO1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X2"
                     /protein_id="XP_014592873.2"
                     /db_xref="GeneID:100055148"
                     /db_xref="VGNC:VGNC:50644"
                     /translation="

MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    242..634
                     /gene="AGO1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    662..814
                     /gene="AGO1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    815..1177
                     /gene="AGO1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(971..973,1016..1018,1058..1060,1070..1072,
                     1124..1126,1145..1147,1151..1153)
                     /gene="AGO1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1310..2587
                     /gene="AGO1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1721..1723,1733..1735,1769..1780,1787..1789,
                     1811..1813,1820..1822,1832..1834,1844..1846)
                     /gene="AGO1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1925..1927,1931..1933,2141..2143,2555..2557)
                     /gene="AGO1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gggcggccgtgcgagcggccgggcttggggggggagccgagcccggcccgggagcccgagcagctagagtgcggggtatctaggcccctcacgctggactccacagtctccgggccgcctgacctccgcacgggtatatgggatggaagcgggaccctcgggagcagctgcgggcgcctacctgccccccctgcagcaggtgttccaggcacctcgccggcctggcattggcactgtggggaaaccaatcaagctcctggccaactactttgaggtggacatccctaagattgacgtctaccactacgaggtggatatcaagccagataagtgtcctcgaagagtcaaccgggaagtggtggaatacatggtccagcatttcaagcctcagatctttggtgatcgcaaacccgtgtatgatggaaagaagaacatttacactgtcacggcactgcccattggcaacgaacgggttgactttgaggtgacaatccctggggaagggaaggatcgaatcttcaaggtctccatcaagtggctagccattgtgagctggcgcatgctgcatgaggccctggtcagtggccagatccctgttcccctggagtctgtacaagccctggatgtggccatgaggcacctggcatccatgaggtacacccccgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccactgccttctacaaggctcagccggtgattgagttcatgtgtgaggtgctggacatcaggaacatagatgagcagcccaagcccctcacagactctcagcgtgtgcgcttcaccaaggagatcaagggcctgaaggtggaagtgacccactgtggacagatgaagaggaaataccgcgtgtgtaatgttacccgccgccctgccagccatcagacatttcccttgcagctggagagtggacagactgtggagtgcacggtggcacagtatttcaagcagaaatataaccttcagctcaagtatccccacctgccctgcctgcaagttggccaggaacaaaagcatacctacctgcccctagaggtctgtaacattgtggctgggcagcgctgcattaagaagctgaccgacaaccagacttcgaccatgataaaggctacagctaggtcggccccagacagacaggaggagatcagccgcctgatgaagaatgccagctacaacctagatccctacattcaggaatttgggatcaaagtaaaggatgacatgacggaggtgacgggacgagtgctgccggcgcccatcttgcagtacggcggccggaaccgggccattgccacaccaaatcagggtgtctgggacatgcgagggaaacagttctacaatgggattgagatcaaagtctgggccatcgcctgcttcgcaccccaaaagcagtgtcgagaagaggtgctcaagaacttcacagaccagctgcggaagatttccaaggatgcagggatgcccatccagggccagccttgcttctgcaaatatgcacagggggcagacagcgtggagcccatgttccggcatctcaagaatacctactcagggctgcaactcattatcgtcatcctgccagggaagacgccagtgtatgctgaggtgaaacgtgttggagatacactcttgggaatggctacacagtgtgtgcaagtgaagaacgtggtgaagacctcgcctcagactctgtccaacctctgcctgaagattaatgttaaacttggtggcataaacaacatcctagtcccacaccagcgctctgctgtctttcaacagccagtgatcttcctgggagcagatgttacacaccctccagcaggggatgggaaaaaaccttctatcacagcagtggtaggcagtatggatgcccaccccagccgttactgtgctactgtgcgggttcagcgaccacggcaagagatcattgaagacttatcctacatggtgcgtgagctgctcatccagttctacaagtccacccgcttcaaacctacccgcatcatcttctaccgagatggggttcctgaaggccagcttccccagatcctccactatgagttgctggccattcgtgatgcctgcatcaaactggaaaaggactaccagcctgggatcacttatattgtggtgcagaaacgccatcacacccggcttttttgtgctgacaagaatgagcgaattgggaagagtggtaacatcccagctgggaccactgtggacaccaacatcacccacccatttgagtttgacttctatctgtgcagccacgcaggcatccagggcaccagccgaccatcccattactatgtcctttgggatgacaaccgtttcacagcggatgagctccagatcttgacgtaccagctgtgccacacttatgtacgatgcacacgctccgtctctatcccagcacctgcctactatgcccgcttggtggctttccgggcacgataccacctagtggacaaggagcatgacagtggagaggggagccacatatcggggcagagcaatgggcgggacccccaggccctggccaaagccgtgcaggttcaccaggatactctgcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaagagctgtgctgcccaaatccagaagaagcagggagggaggtggggtatggagagtgcagaaggccttgtttccttctacagagggggcaaaagggtagggaacagggccagtaagacagaccaccagccagaagtctctgatatccacctcatacccccccactcctcaccccatcttgtcacatctggccctgaccccactggaccaagaggggcagcaccggtgcccaccatatacacaggtgtctcatgtgactcacagtgctaaagactcatgcctgacagcttggtaaggttggctctgcagccctacggacaaaagctggtaggtttgggtttgatactttagatgggaaagtgaggggcttgcgaaagtgggtgggaggagggaaggatttttttaggagccttaatcagaaaaggtctagatttgtttaaggagaaaaacgaaaccagacccagatcaatattttaggatactagatgttttaatgggttgagaatccagtttgtaggaagatttttaatgctaatggttttggttgctcctcccccagctgccaccccccccctctttcccttattccaccttttctaccccactttacacctgctccctgatggacatccagccctagtaagacttaaggcactatggcacttagctctgaagtgacatgaccctgtcttccttccgcctgctggtgggtaaccagtgccttccctgtaacggtaatgctgcagaactgcaaccttttgtacctttctttggggggatggggtgggggtgggagaggaggtaggtggggaagaaatatccctaacccaacaagcctccagcctgagcgccagccattttacatttgaaggaattgacttccatattcattgagcttttaaaaagataacaacctcaagttggttaaaatccattgacctttgcactttcagacctgatgagtcctggagctgctgagatgactggcccctggcctttcaacttatgcctccctttctccctgtcctccctacctccccacctgcctgggtctggagttactttcataacatttctcactcttggcttcttttttcccctgatggtcaagtctcttatgtttcaatatttcttaactggggtgtcttataacaaatgatccttaggtctaaaataagaaaaaagaacaaaagctaatgttatttttataccataacttgagtgtattgccaaaatctggaaatccctcccatgcccaatgagtttacatcccagaaacattgagccatcagaaggaactatgtatgtgacttgttctttggcctggctaggtaggaggtggttatctccccaaggtggggctcaggctccatccttcctctgtgcagataatacctttttcttgctacaaactccctcacctgcactgccctgcactcttgcactcttcctgcaagtgcatcttcccttcctctggactgtcctctgacactttggctcatcagagattccagcatgtcctttggacaggctggggggattttgctgctctctgttgcttctgtttacacaaatgaatttttcctggtttcccactagggcatgtgagtgggtagcatgggcgtttttttttttttttaaatctccctggatagagatggggtttggctgtcttgcagaactggaaaagtagggggttctagcttggtgcctgctggccttgaggcaaggccccctctttccttgaccgtttattttttcctgtcccactgcttgggatgaggagttgcagcttcagtgcagaaattcctctttttgaggagcctgggcttgggtttgccccagtctgatgatgaagccatgacactttagacctagctcaggcttggaggccaggcggaggaaggccggtctgaatctgggcttgtgcagttagaggtaccatttcccctccccagcagcccttgtacagagccaaatttgctatgcaaaacagtctatcccaggttctgttctgattggctactttgttcagcgacttcacaaaacgtagcacaaacattgattatagagaaggcatcaggactgttgagtaactcctcctttacttctttcctactggctacagcgtggggtgccccatgggcacagcccagctgcagagcagaatggagggctctgggaggaggcagctcactggagagcctacattccttacacaagtgcctaaagagagtgatgccaacactccatctgccctgtccatcgccttcatatactgtctacttcgtgttcagtcaccctttggggatgggagctctcttggaacaatgggctctgcatgttctcttcttgggtgcattttggggctgggatcagggcactatttctggagggtccactcgttcaccagcatttgcaaatgtccatagggagctggtggtagccccctactctcagcaacaagtttgtgttctctcctttttctctctttgcctcactctctccagttgggttttgagctggggcttgaaatgcattttttagccctttggcattgcacatgccattcaagaaataaaagcaagagaagcagcttgggcaatggcaagaaaatgacttcttactctgctttttctttttagtcattgagacttgaaaaatacccttgaccttgaggattgttcttgtttgaaagatggtgcatgcaaattgagaagtggtgttggcaacaagctttggctttgttttaaggggtgcttcttacttaagctctaaggaaatgcttgggagacctcagcctcatcctcttagacaggtctcttgttcccttcattccactcttttgccttccttttcgtcttctctctttccctggcttccttttcctgttttctcttcactcagcttgcttgctggcctgcctgcctacctacgtgatgatgaattctctgcatggctacaatgatcccactgttagctggcaaggtcaagcttagctccttggctgcagaagaccaagaatctgtccccaagtccagtgatgtcctctctgggatggactgccctcaagcttacatgagggcagagcagcaggcctgcccaaatggcatgaaatcagggggcttctggcaacttccacacctgtccattccttggagttgttcctctcgttgctttttctggacctggttctatttctccctacctggggcttctcttttctgaggatttcctaggattgagctacttgtatccagggttgaagggttagggaatggacatgggggaagaagagagtgatgggaagaaaatggagagaatttggataaaaggtgggaaaggagagcactgcatattgatcatttttccagtccagcctgacctgttgggagttgaggtgctattgctggcctctggggatgagcctggggctgttgttgctgggaacttaggtttaaaataatgctgaagaagaaggtacccaaaagtgtgaaacctccctaaaaagctcttggttcccacctagatagctcctctgtggcctcctctttggctaagcaacaatgttcttgggtagttttcttatccagaattctgtaaacgaggctagcactgacgatgggcagctgaggggacactttgacttcttagctggcccataggatatctgcaaggctggtgggacagtgttttagacgtggcatcatgtgtaacaaagaaggatggaggttccttccccttcagggtaggaggtcaactcaaactagccaaaatgcggttttggaaactacatcgggggaagttatttttatttatatttactgggcctaggccaattcaggatggtagctgggatgccttccttcttaaagtctgatcatggcagggatatgcagggcactctttcctatttggccttttacgcagattggggaaaagagattctctggttttctctttacccccatttattaggacttgccttctccctgggcagggagggaggctaggttggtgctctccccttactctactcctactgacttagaacctctggctgctgtttgggagcccaagaaagggagtggagggaatgggctcaaaacaaaatgaaaaaaccagaataaagtggggaaggcaaatttccttctttaaaaaggaaaataggaaaccctccaaggattgtgcaagtaaagacaatgtgtcgaatgcactgagttccctggtgtagtagcaataaggaaaaatgaaatgactttcctgtgcacacagtccaacctgattgctgtgtgatgtttgcacttagcagccgtctggtgggcatgtgtgactactctgggtttcacattagtttctaaactttttatccctctcaagtccagcatggatggggaaatgtccctggagccccacagctgtgtacttgtttgcatttgtttccctttgagacttgtgtttgtgtcctgctttgagctgtaccttgtccagtccattgtaaagttatcccagcagctgtaatgtacagttccttctgaagcaagcaacaacagcagcacaattctgtgttttataaagacaacagtggcttctatttctaaagtgcggtctctctctctctttttttttcctatcaggaaagcaaactgttgggattaattatatttcttgtagattttaggttagaatagtagattgttagaagagcagaaccatcccttctaaaggaggaaagtggataaaacaaattccggagtgttgaaactgtggattgtatgtaatcatacattacagggcctccatttatttattcaacaaacacgcaaagcactgtgtccagcagtattgtggaggagaagtcagacacaattcaaaaataaggaaaacagtgtctctctccttgaggagcttacagtttggtggaggatatgagtagccaaatggtcccctggtacaggagaaaaatgatgagggactggaacaaggctatagggctatagcagtgaagatagagaggaaaaggcagatttgagagacactcagtagatataattaataggactcaatggataacggaaggagaatagaggagtagagcctaatgcccaggtttctgcttgaggaagtgagtatattgggacattcctctaatcaagattaagggaaagcggggaaactagaaggaaggtgatgaattttgtgaagaaagacaattagccttgtatagactgagttttgagttcccatgtgacaatgaggttgaggtttccagtaaacacgttttggtgctgaaggaagactacaaaactacagttatagatatgggattcatactcatatagatggtagttacagccataggaattcatgggaatgaacaagatgacttagaagaaagtagagcgagagaaacatagtgtacaactctaggaaacacaatttaacagttgaggagaggaagcagagcctaagatgactgtcagttcactagtagagaccttgtatatttttgactgatttaatgaggtggaagaaaagagagtggaatacgatccaagaagggtgtaattaaccacgtgaactgctgcagtgagaaggaggtaatttttctacttactttaccatcctccaccccatcttctctggaatcttataactgtatggtcattctccagtatttcttgaaaatgatcactggaaaaacctaatttaaataaatctaggactaggacttccaagttgttcaccaccgccacctccacctccagcttcctcctgtcctcaggagatccttgtaaaagaataaaataaacaaacctaattttgttcctaa

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