LOCUS       NM_031700               1501 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus claudin 3 (Cldn3), mRNA.
ACCESSION   NM_031700
VERSION     NM_031700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Wang,J., Chen,J., Tang,Z., Li,Y., Hu,L. and Pan,J.
  TITLE     The Effects of Copper on Brain Microvascular Endothelial Cells and
            Claudin Via Apoptosis and Oxidative Stress
  JOURNAL   Biol Trace Elem Res 174 (1), 132-141 (2016)
   PUBMED   27038183
  REMARK    GeneRIF: identified four claudin isoforms (1, 3, 5, and 12) and
            showed that their expression levels were regulated as a group by
            copper
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Peng,S., Wang,S.B., Singh,D., Zhao,P.Y., Davis,K., Chen,B.,
            Adelman,R.A. and Rizzolo,L.J.
  TITLE     Claudin-3 and claudin-19 partially restore native phenotype to
            ARPE-19 cells via effects on tight junctions and gene expression
  JOURNAL   Exp Eye Res 151, 179-189 (2016)
   PUBMED   27593915
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   Milatz,S., Piontek,J., Schulzke,J.D., Blasig,I.E., Fromm,M. and
            Gunzel,D.
  TITLE     Probing the cis-arrangement of prototype tight junction proteins
            claudin-1 and claudin-3
  JOURNAL   Biochem J 468 (3), 449-458 (2015)
   PUBMED   25849148
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Martinez,C.A., de Campos,F.G., de Carvalho,V.R., de Castro
            Ferreira,C., Rodrigues,M.R., Sato,D.T. and Pereira,J.A.
  TITLE     Claudin-3 and occludin tissue content in the glands of colonic
            mucosa with and without a fecal stream
  JOURNAL   J Mol Histol 46 (2), 183-194 (2015)
   PUBMED   25649016
  REMARK    GeneRIF: Colonic glands without a fecal stream showed a reduction
            in claudin-3 content independent of the time and reduction in
            occludin content after 12 weeks of intestinal exclusion.
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Rahner,C., Mitic,L.L. and Anderson,J.M.
  TITLE     Heterogeneity in expression and subcellular localization of
            claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut
  JOURNAL   Gastroenterology 120 (2), 411-422 (2001)
   PUBMED   11159882
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   10 (bases 1 to 1501)
  AUTHORS   Briehl,M.M. and Miesfeld,R.L.
  TITLE     Isolation and characterization of transcripts induced by androgen
            withdrawal and apoptotic cell death in the rat ventral prostate
  JOURNAL   Mol Endocrinol 5 (10), 1381-1388 (1991)
   PUBMED   1723140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1 and BC062411.1.
            
            On Nov 23, 2005 this sequence version replaced NM_031700.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC062411.1, M74067.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JAXUCZ010000012.1  27346173-27346547   c
            376-1501            BC062411.1         1-1126
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1501
                     /gene="Cldn3"
                     /note="claudin 3"
                     /db_xref="GeneID:65130"
                     /db_xref="RGD:68425"
     exon            1..1473
                     /gene="Cldn3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    348..350
                     /gene="Cldn3"
                     /note="upstream in-frame stop codon"
     CDS             441..1100
                     /gene="Cldn3"
                     /note="RVP1; ventral prostate.1 protein"
                     /codon_start=1
                     /product="claudin-3"
                     /protein_id="NP_113888.2"
                     /db_xref="GeneID:65130"
                     /db_xref="RGD:68425"
                     /translation="

MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAAVLTLVPVSWSANTIIRDFYNPLVPEAQKREMGTGLYVGWAAAALQLLGGALLCCSCPPREKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV"

     misc_feature    447..941
                     /gene="Cldn3"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    465..527
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    681..743
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    786..848
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    924..986
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    1029..1031
                     /gene="Cldn3"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site"
     misc_feature    1032..1034
                     /gene="Cldn3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site"
     misc_feature    1092..1097
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     Region: Interactions with TJP1, TJP2 and TJP3.
                     /evidence=ECO:0000250"
ORIGIN      

ccccatccccacccacacgcacacacatatatagttctgcattgaggttggttctagctaattcctttctcccatggtgaagagggttggggagtaccgatcggactggacgggacacacgtcactgtcccctgggccagaagagcgagctccgccctcctcctctgggcaccaagctaagtccaacccaccccatcccagagccaacccagtctcagaaagacgtctccaaagccacaggcaggtgcaggggcagtctccgtgcgagccccgggaaaggagccgttagcgtgctccgtccattgccatccaccggtcgttcccggcgacagacctccgtcaacttttgaaggggagttggttctcaggtccagcggccgcgatccctggtctcccagcctacggagttacccggcggagccggttcaagtccagcagccatgtccatgggcctggagatcaccggcacgtcgctggccgtgctgggctggctgtgcaccatcgtgtgctgcgcccttcccatgtggcgcgtttcggcattcatcggcagcagcatcatcacggcgcagatcacctgggaaggcctgtggatgaactgcgtggtgcagagcaccggccagatgcagtgcaagatgtacgactcgctgctggccctgccgcaggacctccaggccgcccgagctctcatcgtggtgtctatcctactggcagccttcgggctcctcgtggcgctcgtgggggcccagtgtaccaactgcgtacaagatgagacggccaaggccaagatcaccatcgtggcgggagtgcttttcctgttggcggctgtgctcaccttagtgccggtgtcctggtccgccaacaccatcatccgggatttttataacccgctggtacctgaggcccagaagcgagagatgggaactgggttgtacgtgggctgggctgccgccgcgctgcaattgctagggggcgccttgctgtgttgctcctgcccaccacgcgagaagtacgcacccaccaagatcctctattccgcgccgcgatccaccggccctggcaccggtaccggcaccgcctatgaccgtaaggactacgtctgagaggccgggtgcgcgcacaccgcaccatcaccactaccaaccgtcgatgtaccccacccgtccagcgtgcagcctcgcctcagagaccaccccaccttccagatggttacagacgccacgcagtctgcttgctaggctggaagaggacagacagcctggcgtccccttttctccggttgccacctgattacctggcctaggaactgtccaagtcgaatggacaaagacacctcgcccttcccaagtacagggttggggtggccatcgcagctacttgccagccccgcagccagaaggctcatagtgggcagagacaggcaaactataaaaagggccgtttcgtatttttcaataaaagcctttcgtttttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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