LOCUS       NM_008770               1872 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus claudin 11 (Cldn11), mRNA.
ACCESSION   NM_008770
VERSION     NM_008770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Zhang,Y., Song,Z., Wu,R., Kong,X., Zhang,H., Li,S., Gong,X.,
            Gong,S., Cheng,J., Yuan,F., Wu,H., Wang,S. and Yuan,Z.
  TITLE     PRRC2B modulates oligodendrocyte progenitor cell development and
            myelination by stabilizing Sox2 mRNA
  JOURNAL   Cell Rep 43 (3), 113930 (2024)
   PUBMED   38507412
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Yang,S., Dong,D., Bao,X., Lu,R., Cheng,P., Zhu,S. and Yang,G.
  TITLE     CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis
            in Gastric Cancer
  JOURNAL   Cancer Control 31, 10732748241238616 (2024)
   PUBMED   38553809
  REMARK    GeneRIF: CCL21 and CLDN11 Are Key Driving Factors of Lymph Node
            Metastasis in Gastric Cancer.
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Maezawa,S., Yukawa,M., Hasegawa,K., Sugiyama,R., Iizuka,M., Hu,M.,
            Sakashita,A., Vidal,M., Koseki,H., Barski,A., DeFalco,T. and
            Namekawa,S.H.
  TITLE     PRC1 suppresses a female gene regulatory network to ensure
            testicular differentiation
  JOURNAL   Cell Death Dis 14 (8), 501 (2023)
   PUBMED   37542070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Jiang,X., Cheng,Y., Zhu,Y., Xu,C., Li,Q., Xing,X., Li,W., Zou,J.,
            Meng,L., Azhar,M., Cao,Y., Tong,X., Qin,W., Zhu,X. and Bao,J.
  TITLE     Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression
            and maturation in mice
  JOURNAL   Nat Commun 14 (1), 3729 (2023)
   PUBMED   37349316
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Morita,K., Sasaki,H., Fujimoto,K., Furuse,M. and Tsukita,S.
  TITLE     Claudin-11/OSP-based tight junctions of myelin sheaths in brain and
            Sertoli cells in testis
  JOURNAL   J Cell Biol 145 (3), 579-588 (1999)
   PUBMED   10225958
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Rajan,L., Kozak,C.A. and Dudley,J.P.
  TITLE     Chromosomal localization of acquired MMTV proviral integration
            sites in T-cell lymphomas
  JOURNAL   Mamm Genome 9 (1), 84-85 (1998)
   PUBMED   9434954
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Gay,D., Lavi,E., Zhao,H., Mumin,A. and Bhandoola,A.
  TITLE     OlP-1, a novel protein that distinguishes early oligodendrocyte
            precursors
  JOURNAL   J Neurosci Res 50 (4), 591-604 (1997)
   PUBMED   9404721
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Bronstein,J.M., Popper,P., Micevych,P.E. and Farber,D.B.
  TITLE     Isolation and characterization of a novel oligodendrocyte-specific
            protein
  JOURNAL   Neurology 47 (3), 772-778 (1996)
   PUBMED   8797478
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Bronstein,J.M., Kozak,C.A., Chen,X.N., Wu,S., Danciger,M.,
            Korenberg,J.R. and Farber,D.B.
  TITLE     Chromosomal localization of murine and human
            oligodendrocyte-specific protein genes
  JOURNAL   Genomics 34 (2), 255-257 (1996)
   PUBMED   8661061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY110541.1, AK005088.1 and
            BB798247.1.
            
            On Aug 10, 2010 this sequence version replaced NM_008770.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The protein encoded by this gene is a major
            component of CNS (central nervous system) myelin and plays an
            important role in regulating proliferation and migration of
            oligodendrocytes. The basal cell tight junctions in stria
            vascularis are primarily composed of this protein, and the
            gene-null mice suffer severe deafness. This protein is also an
            obligatory protein for tight junction formation and barrier
            integrity in the testis and the gene deficiency results in loss of
            the Sertoli cell epithelial phenotype in the testis. [provided by
            RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005088.1, AK161698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY110541.1         2-27
            27-1540             AK005088.1         2-1515
            1541-1872           BB798247.1         66-397
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.14 cM"
     gene            1..1872
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="claudin 11"
                     /db_xref="GeneID:18417"
                     /db_xref="MGI:MGI:106925"
     exon            1..456
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    153..155
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="upstream in-frame stop codon"
     CDS             231..854
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="oligodendrocyte transmembrane protein;
                     oligodendrocyte-specific protein"
                     /codon_start=1
                     /product="claudin-11"
                     /protein_id="NP_032796.1"
                     /db_xref="CCDS:CCDS17290.1"
                     /db_xref="GeneID:18417"
                     /db_xref="MGI:MGI:106925"
                     /translation="

MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"

     misc_feature    234..296
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    246..746
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    477..539
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    597..659
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    702..764
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    807..809
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99P82; propagated from
                     UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site"
     misc_feature    810..812
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site"
     misc_feature    819..821
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site"
     misc_feature    822..824
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60771.1); phosphorylation site"
     exon            457..621
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     exon            622..1872
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="hexamer: AATAAA"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="hexamer: AACAAA"
     polyA_site      1864
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
     polyA_site      1870
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="major polyA site"
ORIGIN      

gagggggcggggacgcgctgcccagcagcgctgcagtcccctccaggcgcacctgtccccgctgcacgctgtcgcagcagtgcttgcagccgctctctccccatctcgagtagcccggagccagcggctcgcgagggccaagagggcaagcctagggaaggctctgtccaggacgacacagggggcacaatccgtgtgagtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgccttcaggtggtgggtttcgtcacgagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgaaaaatggacgaactgggctccaagggcctgtgggctgactgcgtcatggccactggtctctaccactgcaaacccctggtggacatcctcatccttccaggctacgtgcaggcttgtagagccctcatgattgctgcctccgttctgggcctgcccgccatcttgctgctgttgacagttctcccctgcatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgtgcccaccgcgagatcaccatcgtgagctttggctactcgctgtacgcaggttggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcatttggagaaaaccgtttctattactcttctggttccagctcgccaacgcatgccaagagtgcccatgtctaagagggctgctccactgcccgccgaggtgctgtaaatgctgggcctgggccctgggtttgctcgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgccccggcattttgaagtcgtaacaccccacccacccacccaccacttcttggctgccttaaaagaaagctctagctcagttaatgcccacatagttttctcctggagttgcgggctgtggctgtttgctctttcctcgggcattccattgttgttgattaaaaaaatattttgtttctctcttaaattcaaatgtcttgggaacattgctgacttgggtgtggattgggaaagaaataaaagatgcttttcaaagggttaccaacgacagtggaagccttatagagacagctctcttctccctttcggcttagtttcaaggtcacttatatataagagatagaaatggatagattgggaacacgggtgggaggggaactcagagctttccctccacgggaagcttctcttttataagttgaggggttgggtgtctttttttttttagtttgcgattttacatttttctgtacgtactttttcaagattgatcatttttataaccacgggtttcctgaaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataaataatagtacgaagattataactttaactgactgcccacggtttccaggtttgtatgctatagtttttaatcctatggttgcatatgcttcaaattaacacatttaaaaatcttttctccccttctatttctgtctccattctgttagagaccatgaagcagtattgtttaacataagttgtactgttaagtttggcttcatgggtgtaaacaccaatggtctgtcagtgtctaagactctggatactgcaagctccgtccggtgcatttgttcaggtaaaatctgtgcaataaaataacaaactgtctccaaagc

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