LOCUS       NM_001097507            2045 bp    mRNA    linear   MAM 06-FEB-2024
DEFINITION  Sus scrofa WEE2 oocyte meiosis inhibiting kinase (WEE2), mRNA.
ACCESSION   NM_001097507
VERSION     NM_001097507.2
KEYWORDS    RefSeq.
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Shimaoka,T., Nishimura,T., Kano,K. and Naito,K.
  TITLE     Analyses of the regulatory mechanism of porcine WEE1B: the
            phosphorylation sites of porcine WEE1B and mouse WEE1B are
            different
  JOURNAL   J Reprod Dev 57 (2), 223-228 (2011)
   PUBMED   21123961
  REMARK    GeneRIF: results suggest pWEE1B is activated after phosphorylation
            of the Ser77 residue, which is different from phosphorylation site
            that activates mWEE1B; that pWEE1B is localized in the nucleus; and
            that the nuclear localization is essential for its function
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Nishimura,T., Shimaoka,T., Kano,K. and Naito,K.
  TITLE     Insufficient amount of Cdc2 and continuous activation of Wee1 B are
            the cause of meiotic failure in porcine growing oocytes
  JOURNAL   J Reprod Dev 55 (5), 553-557 (2009)
   PUBMED   19550110
  REMARK    GeneRIF: insufficient amount of Cdc2 and continuous activation of
            Wee1 B are the cause of meiotic failure of small oocytes in pigs
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Shimaoka,T., Nishimura,T., Kano,K. and Naito,K.
  TITLE     Critical effect of pigWee1B on the regulation of meiotic resumption
            in porcine immature oocytes
  JOURNAL   Cell Cycle 8 (15), 2375-2384 (2009)
   PUBMED   19633431
  REMARK    GeneRIF: These results suggest that the inhibitory phosphorylation
            of CDC2, which is catalyzed by pigWee1B, but not pigMyt1, is
            involved in the meiotic arrest of porcine oocytes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB276373.2.
            
            On Mar 31, 2010 this sequence version replaced NM_001097507.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB276373.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 21123961
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2045              AB276373.2         1-2045
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Sus scrofa"
                     /mol_type="mRNA"
                     /db_xref="taxon:9823"
                     /chromosome="18"
                     /map="18"
     gene            1..2045
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="WEE2 oocyte meiosis inhibiting kinase"
                     /db_xref="GeneID:100048934"
                     /db_xref="VGNC:VGNC:98413"
     exon            1..395
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    33..35
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="upstream in-frame stop codon"
     CDS             51..1748
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /EC_number="2.7.10.2"
                     /note="Wee1-like protein kinase 1B; Wee1B protein kinase;
                     WEE1 homolog 2"
                     /codon_start=1
                     /product="wee1-like protein kinase 2"
                     /protein_id="NP_001090976.2"
                     /db_xref="GeneID:100048934"
                     /db_xref="VGNC:VGNC:98413"
                     /translation="

MGDNGDNKELKQKLNFSYSEEEQEDEGQKEAQESKKVQYHTPERCGHQDSEAKFTPPRTPLNHVCELSTPQVKDRASPDQGLRTPVSRPHTRPETPAPPDKSKPPPHCESPFTPRGHSSQSVISTGKLPSRGSKHLRLTPGPLTDEMTSLALVNINPFTPESYRRQFLKSNGKRKTRRDLEEAGPEEGKVEKGLPAKRCVLRETNMACRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSTKPVSGLSDENLAMHEVYAHSVLGHHPHVVRYYSSWAEDDHMMIQNEYCNGGSLQAAISENAKSGNHFQEPKLKDILLQISLGLKYIHNYGMVHMDIKPSNIFICHKIPSDSPVVPEEAENEADWFLSANVTYKIGDLGHVTSISEPQVEEGDSRFLAKEILQENYQHLPKADIFALGLTIAVAAGAEALPTNGTSWHHIREGQLPNIPQDLSKEFYNLLKDMIDPDPVARPSAAALTRSRVLCPSLGRTEELQQQLNLEKFKTATLERELKEVQRAQSSKEGQSSPGVTGTHTGSRSTRRLVGGKSAKSSSFTWGQSSP"

     misc_feature    51..476
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="propagated from UniProtKB/Swiss-Prot (A4PES0.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    279..281
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:21123961; propagated from
                     UniProtKB/Swiss-Prot (A4PES0.2); phosphorylation site"
     misc_feature    555..617
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="propagated from UniProtKB/Swiss-Prot (A4PES0.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    567..575
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="propagated from UniProtKB/Swiss-Prot (A4PES0.2);
                     Region: Nuclear localization signal"
     misc_feature    687..1502
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; Region: Protein
                     Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:473864"
     misc_feature    order(708..719,726..728,732..734,771..773,777..779,
                     873..875,921..932,1071..1073,1083..1088,1092..1094,
                     1191..1196)
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    999..1043
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="propagated from UniProtKB/Swiss-Prot (A4PES0.2);
                     Region: Nuclear export signal. /evidence=ECO:0000250"
     misc_feature    1602..1745
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /note="propagated from UniProtKB/Swiss-Prot (A4PES0.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            396..589
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            590..641
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            642..814
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            815..936
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1083
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1191
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1277
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1448
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1591
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1853
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2022
                     /gene="WEE2"
                     /gene_synonym="WEE1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tccccttctgctgggccttcttgcctctgctgtaaagctctttggctgagatgggtgacaatggtgacaacaaagaactgaagcagaaattaaacttttcctattctgaagaagagcaggaggatgaagggcagaaggaggcacaggagagcaaaaaggtgcagtaccacacgccagagaggtgtggacatcaggactccgaggccaagttcacacctcccaggactcccctcaatcacgtctgtgagctcagcacccctcaggtgaaagacagagcgagtccggatcagggtttgaggactccagtgtcacgcccccacacccggcctgaaacaccggccccgccagacaagagcaagccgccaccacactgtgagagccccttcactcccagaggccattcaagccagtcagtgatttcaacagggaagctcccttcccgaggatctaagcacctgagactcacgcctggtcccctcaccgatgagatgacctctctggctctggtcaatattaatcccttcaccccagagtcctacagaagacagttccttaaatccaatggcaagaggaaaactcgacgcgatctggaggaagctggtccggaagaaggcaaagtagaaaaagggctgccggccaagagatgtgttctacgagaaaccaacatggcttgtcgctatgaaaaagaattcttggaggtagaaaaaatcggggttggggaatttgggacagtctacaagtgcattaagaggctggatggatgtgtttatgcgataaaacgctccacaaaacctgtgtcaggattgtcagatgagaacctggctatgcatgaagtttatgctcactcggtgcttgggcaccacccccatgtggtccgctactactcttcgtgggcggaagatgaccacatgatgattcagaatgaatactgcaacggtgggagcttgcaggctgctatatctgaaaatgcaaagtctggcaatcatttccaagagccgaaactcaaggacatccttctacagatttccctggggcttaagtacatccacaactatggcatggtgcatatggacatcaaacccagtaacatcttcatctgtcataagataccgagtgactctcctgttgtcccggaagaggctgaaaatgaagctgactggttcctctctgccaatgtgacgtataaaattggggacttgggtcatgtgacatcaatcagtgaaccccaagtggaagagggagacagtcgcttcctggcaaaggagattctgcaagagaattaccagcaccttcccaaagcggacatatttgccttgggactgaccatcgccgtggctgcgggagcagaggcgttacccaccaatggcacctcctggcatcacatccgtgaggggcaacttccgaacattcctcaggacctctccaaagaattttacaatctactcaaggacatgatcgaccctgatccagtggcgagaccttctgcggcagctctgaccagaagtcgagttctttgtccctccctggggagaacagaagagcttcagcagcaactgaacttggaaaagttcaagacagccacactggaaagggagctgaaagaagtccagcgggcccagtcctccaaggagggccagagtagccccggggtcactgggacccacacaggatcaagaagcaccagacgcctggtgggagggaagagtgccaagtcttcaagcttcacctgggggcagtcttccccataggaactccttctgccgccccaactcgcctttcatccccaacctagataccgaccttgtaaacctttctcttgtaaagggagagactaaccaacttgagtgcccaaagattttttattttctgggtgtcaccaatttctccttgattttatcagaaattggcttttcttcccgtgatttaccgtattttatccaaatcctttactctgtacatattttgaaaggaacagaatgtctgtaaataaaggtttttatcttgtccaaagccaaatagaaaaaaaaaaaaaaaaaaaaaaaaaa

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