LOCUS       XM_031890234           12229 bp    mRNA    linear   VRT 18-DEC-2019
DEFINITION  PREDICTED: Xenopus tropicalis dicer 1, ribonuclease III (dicer1),
            transcript variant X1, mRNA.
ACCESSION   XM_031890234
VERSION     XM_031890234.1
DBLINK      BioProject: PRJNA205740
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_030684.2) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Xenopus tropicalis Annotation
                                           Release 104
            Annotation Version          :: 104
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12229
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /strain="Nigerian"
                     /db_xref="taxon:8364"
                     /chromosome="8"
                     /sex="female"
                     /tissue_type="liver and blood"
                     /dev_stage="adult"
                     /note="F17 inbred"
     gene            1..12229
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 43 ESTs, 4 Proteins, and 99% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     59 samples with support for all annotated introns"
                     /db_xref="GeneID:100170154"
                     /db_xref="Xenbase:XB-GENE-491114"
     CDS             362..6034
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X1"
                     /protein_id="XP_031746094.1"
                     /db_xref="GeneID:100170154"
                     /db_xref="Xenbase:XB-GENE-491114"
                     /translation="

MAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNTKRTVFLVNSEKQVSQQVSAVRTHTDLKVGEYSDQEKTQCWAKERWYLEFETHQVLVMTCHIFLNVLKSGNVSLSNINLLVFDECHLAIQDHPYREIMKICESCQPCPRILGLTASILNGKCDPRDLEEKIQKLEEILRSNAETATDLVVLDRYASQPCEIVLDCGPYIDKSGLYQRLLNELDEALNFLIDCNISTHSKERDSTLISKQILSDCQTVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTILRKIHALCEEHFSPASLDMKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDEDEEIEEKEKTETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIMLADSDKIKAFEEDLKTYKAIEKILRNKCSKSIDCGNTESEPIVDDDEIFPPYVLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTREFPDGLYRSTLYLPINSPLRAPIVGPPMNCGRLADRAVALICCKKLHEIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLNLEQLELITRLHQYIFSHILRLEKPALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEARTGIPNTQYSAESPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKAVCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPDDFRYPNLDFGWKRSIDSKTFISNQSSSSVESESDCRLNKTTAPDSAASSAANSVIYMQINDQMSVNCTPPCQKSLSHLQTVCFSDDYKAINGISCNGLTNGDWEAESAACFQKDERITCKQEIPEKSTSFHVQNLPKENQPILKECTLSNSDGNVSKPTSDECPSTCTSDMHYDSGLSNRHSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKNSDKWESNETSGEDVMVNGKIDEDFDDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDSMLMGSGAFVKKIPLSSFAPPDQNYEWRAPKKPPLESSQFPCDFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGADAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPEVRKLVTNTNVISASSSYQNSTRDNCTLTARTNTDLSSCKGIDYGYLKIPPRCMFEHPDAEKTLDHLISGFENFEKKINYPFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWHVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQSQVPNS"

     misc_feature    455..1048
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(455..466,473..475,524..547,668..670,857..859,
                     950..952)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(632..637,704..709,782..784,788..793,800..802,
                     875..883)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1142..1426
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1157..1162,1169..1171,1175..1180,1355..1360,
                     1367..1372,1379..1381,1388..1393,1400..1402)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1439..2026
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1679..1687,1895..1897,1952..1954,1958..1960)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1907..1909,1913..1915,1988..1990,1994..1996)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2222..2488
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    2990..3358
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3179..3181,3218..3220,3236..3238,3248..3250,
                     3302..3304,3326..3328,3332..3334)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4169..>4444
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4220..4225,4232..4237,4244..4246,4253..4258,
                     4265..4270,4274..4282,4310..4312)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5309..5803
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5369..5374,5381..5386,5393..5395,5402..5407,
                     5414..5419,5423..5431,5459..5461,5723..5725,5756..5758)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5369..5371,5378..5380,5390..5392,5693..5695,
                     5702..5704)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5378..5380,5693..5695,5702..5704)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5816..6004
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(5816..5821,5825..5830,5837..5842,5849..5854,
                     5864..5866,5879..5887,5891..5893,5897..5899,5948..5959,
                     5966..5968)
                     /gene="dicer1"
                     /gene_synonym="dcr1; dicer; herna"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
ORIGIN      

gtgcggccgttcgcaaataggaactagcggctaccctgacgggttgggcctgtgctgggccgtgcttctccctcagcatctggagagtcattgagcgcacatccctggctaaagcatgggagagcaacttggcagctttgcgttatagacagtgtgtgcaccgcaccaactgcgcggcattaatgagttggaccccaggactgatgcttgcccattagttgcaaacaaatatcatggtgtcagaatgcatttcatgtgttattggagaatcttcacactgagacgaaaacaacaagtaggcaaattacaatgatttaagtcactggatttatgagagccctgcattttgcagaccctcagcatggcaggccttcagctcatgactccggcctcctctccaatgggtcccttctttgggctaccctggcaacaggaggctattcatgacaacatttataccccacggaaatatcaggtggaactactcgaagcagcattggatcataatactatagtatgtttgaattctggctcagggaagacatttattgcagtactactcagtaaagagctgtcataccagatccgtggggacttcagcaaaaatactaagaggactgtgtttttggtcaattccgagaaacaggtttctcaacaagtgtctgctgtcaggacccatacagacctcaaggtgggagaatattcagatcaagaaaaaacacaatgctgggcaaaagaaagatggtacctagaatttgaaactcatcaggtcttggtcatgacctgccacatcttcctgaacgttctgaaaagtgggaacgtgtcattgtcaaacattaatctgttagtgtttgatgaatgtcatcttgcaattcaggatcacccatatcgagaaatcatgaagatatgtgagagttgccagccatgccctcgaatcctgggtctaactgcttcaattttaaatggaaaatgtgaccctcgtgacctagaggaaaagatccagaaactggaggaaatattaaggagtaatgcagaaactgcaactgatttggttgttttagacaggtatgcttcccaaccatgtgaaattgtattggactgtgggccatatattgacaaaagtggactttatcaaagacttctaaatgaattggatgaagcccttaactttctcattgactgtaatatttctacacattctaaagagagagattccacattaatttcaaaacagattctatcagactgtcaaactgttcttttggtcttgggaccatggtgtgctgataaagttgcggggatgatggtgagagagctgcagaagtatatcaaacatgagcaggaggaactgcacagaaaattccttttgtttacagacactatcttaaggaagatccatgctctttgtgaggaacacttctcgccagcctctcttgatatgaagtttgtcacacctaaagttataaaactgctggaaattttacgcaaatacaaaccctacgaacgccagcaatttgaaagtgttgaatggtataacaatagaaaccaggataattatgtgtcttggagtgattcagaggatgatgacgatgaagatgaagaaattgaggagaaagagaaaactgaaacaagctttccatccccattcacaaacatcctgtgtggcatcatcttcgtggaacgaagatacacagcagtagtattaaacaggttgattaaagaagccgggaagcaagatccagagctggcctatatcagtagtaactttattactgggcacggcataggaaagaaccagccacgcaataagcagatggaagttgagtttagaaagcaagaagaggtgcttcgtaaatttcgtgcacacgaaaccaacttattgatagctactagcattgttgaggaaggagtggacataccaaaatgcaacttggtagttcgatttgatttaccttcagagtacagatcctatgtacagtccaaaggcagagcaagagcaccaatctcaaattacatcatgctagccgatagtgataaaattaaggcatttgaagaggaccttaaaacatacaaagcaattgaaaagattctgcggaacaaatgctcaaagtccattgattgtggaaatacagaatctgagcccattgtggacgatgatgaaatatttccaccatatgtgttgagacaggatgatggcagcccacgagttactatcaacaccgctattggacacattaacaggtactgtgctaggctacctagtgacccatttactcatcttgctcctaagtgcaaaacacgagagttccctgatggactttatcgctcaacactctacctgccaattaattctccacttagagcccccattgttggccctccgatgaattgtggaaggctagctgatagagctgtagctcttatatgctgtaaaaaactacatgaaattggtgaactggatgatcatttaatgccagttggcaaggaaactgtaaaatatgaggaggagcttgatttgcatgatgaggaagaaaccagtgttccaggcagaccaggatccacaaaaagaaggcagtgttatccaaaagctattcctgaatgtttacggaacagctaccccaagcctggtcagccttgttacttatatgtaataggaatggtattaaccactcctctaccagatgaacttaattttaggcgacggaagctgtatccccctgaagacacaacaagatgctttggaatactaactgccaaacccatacctcagattcctcactttcctgtctatactcgttcgggagaggtgaccatatcaattgaactaaagaagtctggttttacattaaacttagaacaacttgagctcattactagactccaccagtacattttttcacacattcttcgtcttgagaaacctgcactagaatttaaacccacagtagccgattgtgcctactgtgttctacctcttaacgttgtaaatgattctggcactttggacattgacttcaaatttgtagaagatattgagaaatcagaagcacgtactggtatacctaatacacagtattcagctgaaagtccttttattttcaaattagaagactaccaggatgctgttatcattccaagatatcgaaattttgatcagccgcacagattttatgtagctgatgtatacactgatcttacaccgctcagcaagttcccttcccctgaatatgaaacctttgctgaatattacaaaacaaagtataacctcgatctcacaaacctcaatcagccacttttggatgtggaccacacatcatcaagacttaatttgctgactcctcgccatctgaatcagaaaggtaaagctctgccattaagcagtgctgaaaagagaaaagccaaatgggagagtttacaaaacaaacagatcctggttccagagctttgtgctatacatccagtcccagcatccttatggagaaaagctgtttgtttgccaagcatactttatcgattacattgcctccttacagcagaagagctgagagcgcaaacagctattgatgctggggtaggagtcaaatcgcttcctgatgatttccgatacccaaacttggattttggatggaaacgatctatagacagtaaaacattcatctctaatcaaagttcctcatcagtcgagagtgaaagtgactgcagactcaataaaaccacggcccctgacagtgctgcaagctcagctgctaattctgtaatctacatgcaaatcaatgaccaaatgtctgtgaactgcacaccaccatgtcaaaaatctctgagtcacctccaaacagtttgcttctcagatgattacaaagcaattaacggtatttcttgcaatggtcttaccaatggtgattgggaagcagaaagcgctgcatgtttccaaaaggacgaacggataacctgcaaacaggaaatacctgaaaaatctacctcgtttcacgttcagaatttacctaaggagaaccagcccatacttaaagaatgtactctgagcaactctgatggaaatgtcagcaaacctacctcagatgagtgccctagcacctgtacttcagacatgcattatgatagtgggctttccaataggcactcttcaaaaactcttggcccaaaccctggtcttatccttcaggccttgactctgtccaatgcaagtgatggtttcaatctggagcgtcttgaaatgcttggggactctttcttaaaacatgctatcaccacatatctgttctgcacatacccagatgctcacgagggccgtctatcctatatgcgcagcaagaaggtcagtaactgtaacctttatcggcttggaaaaaagaaaggctcacccagccggatggtggtgtccattttcgatccacctgtcaactggcttccccctggttatattgttaaccaggacaaaaactctgataagtgggaaagtaatgaaacgtctggtgaggatgtgatggttaatggcaaaattgatgaagactttgatgatgaagaagatgaagatcttatgtggaggaatcccaaagaggaaactgattttgatgatgactttttggaatatgatcaagagcatataaaattcattgacagcatgttaatgggatctggggcatttgtgaagaaaattcctctttcttcatttgcaccccctgatcagaactatgaatggagggcgccaaagaaacctccactggaaagttctcaatttccctgcgattttgatgattttgattacagttcttgggatgccatgtgttatttggatcccagcaaggctgtagaggaggatgactttgtagtaggcttttggaatccatcagaagagaactgtggagctgatgctggaaagcagtctatatcttatgacctacacacagagcagtgtattgcagacaaaagtatagctgactgtgtagaggctttattaggctgctatctgaccagttgtggtg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