LOCUS       NM_080693               3548 bp    mRNA    linear   ROD 05-MAY-2025
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            gamma 5 (Cacng5), mRNA.
ACCESSION   NM_080693 XM_346411
VERSION     NM_080693.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Schwenk,J., Harmel,N., Zolles,G., Bildl,W., Kulik,A., Heimrich,B.,
            Chisaka,O., Jonas,P., Schulte,U., Fakler,B. and Klocker,N.
  TITLE     Functional proteomics identify cornichon proteins as auxiliary
            subunits of AMPA receptors
  JOURNAL   Science 323 (5919), 1313-1319 (2009)
   PUBMED   19265014
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Soto,D., Coombs,I.D., Renzi,M., Zonouzi,M., Farrant,M. and
            Cull-Candy,S.G.
  TITLE     Selective regulation of long-form calcium-permeable AMPA receptors
            by an atypical TARP, gamma-5
  JOURNAL   Nat Neurosci 12 (3), 277-285 (2009)
   PUBMED   19234459
  REMARK    GeneRIF: Whereas gamma-5 interacts with all AMPA-type glutamate
            receptor subunits, it predominantly regulates the functions of
            calcium-permeable AMPA receptor subunit combinations lacking
            short-form subunits in Bergmann glia.
            Erratum:[Nat Neurosci. 2009 Jun;12(6):808]
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Kato,A.S., Siuda,E.R., Nisenbaum,E.S. and Bredt,D.S.
  TITLE     AMPA receptor subunit-specific regulation by a distinct family of
            type II TARPs
  JOURNAL   Neuron 59 (6), 986-996 (2008)
   PUBMED   18817736
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 3, 2024 this sequence version replaced NM_080693.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.64852.1,
                                           SRR26643287.25958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000010.1  93336416-93336667   c
            253-339             JAXUCZ010000010.1  93334987-93335073   c
            340-480             JAXUCZ010000010.1  93333984-93334124   c
            481-626             JAXUCZ010000010.1  93330372-93330517   c
            627-3548            JAXUCZ010000010.1  93327142-93330063   c
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3548
                     /gene="Cacng5"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 5"
                     /db_xref="GeneID:140726"
                     /db_xref="RGD:628805"
     exon            1..252
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..884
                     /gene="Cacng5"
                     /note="neuronal voltage-gated calcium channel gamma-5
                     subunit; TARP gamma-5; transmembrane AMPAR regulatory
                     protein gamma-5; calcium channel, voltage-dependent, gamma
                     subunit 5"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-5
                     subunit"
                     /protein_id="NP_542424.1"
                     /db_xref="GeneID:140726"
                     /db_xref="RGD:628805"
                     /translation="

MSTCGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQNQSTEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNSQMTSESTVNVLKMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQFLHPDAWIRGRSPSDISSDASLQMNSNYPALLKCPDYDQMSSSPC"

     misc_feature    78..140
                     /gene="Cacng5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHW8.1);
                     transmembrane region"
     misc_feature    108..641
                     /gene="Cacng5"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    363..425
                     /gene="Cacng5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHW8.1);
                     transmembrane region"
     misc_feature    441..503
                     /gene="Cacng5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHW8.1);
                     transmembrane region"
     misc_feature    597..659
                     /gene="Cacng5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHW8.1);
                     transmembrane region"
     exon            253..339
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            340..480
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            481..626
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            627..3548
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cccattctgccctctgtgaggcagcactccttgctgcccagtcaccatccaggaagatgagcacctgtgggaggaaggccctgaccctgctgagcagtgtctttgctgtctgtggcctgggcctgctgggcatcgcggtcagcacggactactggctgtacttggaagaaggcataatccttccccagaaccagagcacggaggtcaagatgtccctgcactcgggcctctggcgggtctgcttcctcgcaggtgaggagcgaggacgctgtttcaccatagagtatgtgatgcccatgaactcccagatgacgtcagaatccacagtcaatgttctaaaaatgattcgctcggccaccccgttcccactggtcagcctattcttcatgttcatcgggttcatcctgagcaacatcggacacatccgtccgcaccggaccatactggcttttgtctctggcatcttctttatcctatccggcctctctcttgtggtgggcctggtgctgtacatctccagcatcaatgacgagatgctcaacagaaccaaggatgcagagacctatttcaactacaaatatggatggtcgtttgcctttgctgccatctccttcctcttaacagagagtgctggggtgatgtctgtgtatctgtttatgaagaggtatactgctgaggacatgtacaggccccacccaggcttctaccggccacggctgagcaactgttctgattactctggccagtttctacatccagatgcctggatccggggccgcagcccctcggacatctccagtgatgcctccctacagatgaacagtaactacccagctttgctcaagtgcccagactatgaccagatgtcatcatctccctgctgagccagccctagcgtcctccccacctgaacttttggatggctcaacagcatttccctctccccctgagccgaggcccaagctgttccctgcttagccattgttacttgaccacatcctctccctacacccagaatagctagctcttccttcggtgggcatcagagactggagtcagaggcatgctgattggctgagagcatggctgaagccctgcctctagagtgccaatcatagccacgggctcctgggaagccacagcagcccaagcagtgctgtgccggaagatgcctatgttctagttgagttttgttcctgcacttccgggttagccaaggtcagtctggagttgccaagtttctgatacagacaaagccagacttggaggcttgcctccaagcctggctctccatccatgagctggactgtgagaccaaaaggtgactctgctccagtgatctaactggctcagaaacctcaagccgactgttccttttatgtcatccacaaaacacatctctctgtgtagcactgccccaccccacccctcccccaggctctggaccattcccgattttcatccttccagaacacagctgccctggtcagggactaagataagtattcagcagtgccaatgatgtcacaaaggtgttaatggcggaagatgtcttaatacacatgatccctcgacaagctatttcatggggtcttttgatgccttaacccaaagaagtgactgataatgagaactcaagaatttgacggttttgtgttcagagcgccaagcactgtgtccaaccctgggggcattgtccctggctttcagggaccatatttctatccaattctctaagatcgaatcgtgtagacaggtttctgtaccaccatagctgtgagctgcatttgatgacgcgatttgatgacgcagtgcgttttgagcccaaacaagccagactccagatgacccagctgctttgccgaggatgcctgtgaacatttgggggttgccaacttaatccgaatatggggaagcatctgcttcccagtttcatggcatatgtgggcaaatcacatgcctccacgatgccagacaatgtgacaactgctttcctgacggaatcgctgagctgggaaattgcaagcgctactgagaagaccatgaaacccccatagttctccgggtgtcagctcagctggaccatcctgagagttctgagaggcaagtcaaggtagcattctctatgcggtgtgtttttgctggacttcctctcgcctcgttccctttaagatgccaaatgtacccgaatatacaaagccacagcgggcgacttgcaagctctggcaaatggcaccggaaaccacacagctggtgcctacaggaggacatggactcaatcagcatggaggaggccagcagttcaagatcaagttgtcagaggactgatctctgaggcatctgctcctggcttacagatggcagtcttcttgttgtatgctcatggggtacacctgaggcttttttttttttttgcatatccaaattacctcttaaaaggacacaccaggggctggggagataactcagcagaattctggtctagcatgcatgaaactctggatttgacccccaacaccgtagagtccaggggtggcggtacacatctgtaatcctaacacttggaatgcagaggcaggcggagcttcaaggttactctcaactacatagctagtttgaggctaacctgggctacacgagactctgtctcaagaaatttaaaatcaggtatgggttagagttcattccaataaattcaatgatcacgattaataactatgaatataatttaagtgctcatgtacaaatatattcacattctgaggtactgaagatggcggtctcggagtacaaaactgggagagggcataactccgcccctaacgtgcagattgctttgtagattgatccatcagtttcacagacagtggaaggaacatttttgcctctcggttcagtccctgactcaatgcttgggcaaccccttcagttctgagaagctcagctaagatggcttccatgcatcctccccgcacccacacccacacctccagcgatccagtccacattgttattgtgtgccgatttctgtatcggcctgtgagccgagggcgactggcaggccctggccctggcttccggctccatcctcacctcacaatggccgtcgttcgcttttgccgctgtttgctggagtctgcttgccggagtctgtttggagacggctgagaggcattttcaagctggacaggcgtttggatgtgcttggctacaacttttgtcaatgttattaacacctgcgatgtacttttctctctctaaagcacatctctatcactgtgccaggtttgcctgtgtacacgtggggaagaatctattccccccttactgtaagctgactgcagagtgtggtattgttagagcgtgctattcccagtttgaggctgagctgtcaagtccaagggtgttcccaccctggaatgggtcctgtacacttaccatagtaatggctctgggtccctttcttccccatgaggggattggagaatgtatcaacacatatgaccatcgtcatttcttttccatctataaactggtttcaaaaacta

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