LOCUS       NM_001439207            1043 bp    mRNA    linear   ROD 30-APR-2025
DEFINITION  Rattus norvegicus TNF receptor superfamily member 9 (Tnfrsf9),
            transcript variant 2, mRNA.
ACCESSION   NM_001439207 XM_006239472
VERSION     NM_001439207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1043)
  AUTHORS   Zhao,X., Su,H., Huang,X., Xie,L., Liu,Z., Liu,X. and Suo,X.
  TITLE     Molecular cloning and protein characterization of swine 4-1BB
  JOURNAL   Vet Immunol Immunopathol 153 (1-2), 35-44 (2013)
   PUBMED   23453329
REFERENCE   2  (bases 1 to 1043)
  AUTHORS   Shi,Y., Hu,S., Song,Q., Yu,S., Zhou,X., Yin,J., Qin,L. and Qian,H.
  TITLE     Gene silencing of 4-1BB by RNA interference inhibits acute
            rejection in rats with liver transplantation
  JOURNAL   Biomed Res Int 2013, 192738 (2013)
   PUBMED   23484089
  REMARK    GeneRIF: gene silencing of 4-1BB by RNA interference inhibits the
            acute rejection in rats with liver transplantation.
REFERENCE   3  (bases 1 to 1043)
  AUTHORS   Zhang,J., Chen,G., Zhou,D. and Wang,Z.
  TITLE     Expression of CD137 in the cerebral artery after experimental
            subarachnoid hemorrhage in rats: a pilot study
  JOURNAL   Brain Res 1386, 200-208 (2011)
   PUBMED   21352817
  REMARK    GeneRIF: Upregulation of CD137 in the cerebral arterial wall may be
            important in the development of cerebral vasospasm following
            subarachnoid hemorrhage.
REFERENCE   4  (bases 1 to 1043)
  AUTHORS   Haga,T., Suzuki,J., Kosuge,H., Ogawa,M., Saiki,H., Haraguchi,G.,
            Maejima,Y., Isobe,M. and Uede,T.
  TITLE     Attenuation of experimental autoimmune myocarditis by blocking T
            cell activation through 4-1BB pathway
  JOURNAL   J Mol Cell Cardiol 46 (5), 719-727 (2009)
   PUBMED   19233196
  REMARK    GeneRIF: Blockade of T cell activation through the 4-1BB/4-1BBL
            pathway regulates development of experimental autoimmune
            myocarditis.
REFERENCE   5  (bases 1 to 1043)
  AUTHORS   Abe,J., Ueha,S., Suzuki,J., Tokano,Y., Matsushima,K. and
            Ishikawa,S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   6  (bases 1 to 1043)
  AUTHORS   Shao,Z., Sun,F., Koh,D.R. and Schwarz,H.
  TITLE     Characterisation of soluble murine CD137 and its association with
            systemic lupus
  JOURNAL   Mol Immunol 45 (15), 3990-3999 (2008)
   PUBMED   18640726
REFERENCE   7  (bases 1 to 1043)
  AUTHORS   Goodwin,R.G., Din,W.S., Davis-Smith,T., Anderson,D.M., Gimpel,S.D.,
            Sato,T.A., Maliszewski,C.R., Brannan,C.I., Copeland,N.G.,
            Jenkins,N.A. et al.
  TITLE     Molecular cloning of a ligand for the inducible T cell gene 4-1BB:
            a member of an emerging family of cytokines with homology to tumor
            necrosis factor
  JOURNAL   Eur J Immunol 23 (10), 2631-2641 (1993)
   PUBMED   8405064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 28, 2025 this sequence version replaced XM_006239472.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1636160.1,
                                           SRR22399484.124910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000005.1  166674434-166674495
            63-187              JAXUCZ010000005.1  166675530-166675654
            188-292             JAXUCZ010000005.1  166676610-166676714
            293-430             JAXUCZ010000005.1  166678454-166678591
            431-500             JAXUCZ010000005.1  166679396-166679465
            501-631             JAXUCZ010000005.1  166680797-166680927
            632-766             JAXUCZ010000005.1  166681891-166682025
            767-1043            JAXUCZ010000005.1  166690558-166690834
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1043
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="TNF receptor superfamily member 9"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
     exon            1..62
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            63..187
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    76..78
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="upstream in-frame stop codon"
     CDS             88..864
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="tumor necrosis factor receptor superfamily, member
                     9"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 9 precursor"
                     /protein_id="NP_001426136.1"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
                     /translation="

MGSSCYNMVVTVLLVVGTEEVRATRNPCDSCEAGTFCSKYPPVCTSCPPSTYSSTGGQPNCDICRVCQGYFRFKKPCSSTHNAECECVEGFHCLGPKCTRCEKDCRPGQELTEQGCKNCGLGTFNDQDGAGVCRPWTNCSLDGRSVLKNGTKEKDVVCGPPVVSLSPSTTPSAVTTPERESGERPLQVLTLFLALTLALLLFLIFIILWFSVPKWLRKKFPHIFKQPFKKAVRTAQEEDACSCRFPEEEEGGGGSYEL"

     sig_peptide     88..156
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     exon            188..292
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            293..430
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..500
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            501..631
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            632..766
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1043
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agaacctcgccgagctgctaaggagcagaacgtttctttcttcgctgccccgagatcgcaagtgtcctgtgcatgtgacgtttcgctatgggaagcagctgttacaacatggtggtcaccgtgctgctggtggtgggcaccgaggaggtgagagccacgcggaacccctgtgacagctgtgaggctgggactttctgcagtaaataccctccggtctgcaccagctgccctccaagtacctactccagcacaggtggacagccgaactgtgacatctgcagagtgtgtcaaggctatttcaggttcaagaagccttgctcctctacccacaacgcagagtgtgagtgcgtggagggattccactgcttggggccaaagtgtaccaggtgtgagaaggactgcaggcccggccaggaactaacggagcagggttgtaaaaactgtggcttgggaacgtttaatgaccaggacggcgccggcgtctgccgaccctggacgaactgctctctagacggaaggtctgtgcttaagaatgggaccaaggagaaagacgtggtctgtggaccccctgtggtcagcctctctcccagtaccactcctagtgctgtgactactccagagagagaatcaggagagcgccccttgcaggttcttaccttgttcctggcgctgacattagcgctgctcctgttcctgatcttcatcattctctggttctctgtgcccaaatggctcaggaagaagttcccccacatattcaagcaaccatttaagaaggcggttagaactgctcaagaggaagatgcttgtagctgccggtttccagaggaagaagaaggaggaggaggaagctacgagctgtaatgtgccatcctaggagatgtggggaccctcaggaaaccgagaagcactaagacccccaccctcctagggagtagcacaagttaccccacccccctgttcttaaaaccatcctagatggcatttgagcacgcaccccgtccaagtctcttctgatgctaatatatttgttaatttttaaa

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