LOCUS       NM_001433002            2012 bp    mRNA    linear   ROD 23-AUG-2024
DEFINITION  Rattus norvegicus double homeobox 4 (Dux4), mRNA.
ACCESSION   NM_001433002
VERSION     NM_001433002.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Dong,X., Zhang,H., Cheng,N., Li,K. and Meng,G.
  TITLE     DUX4HD2-DNAERG structure reveals new insight into
            DUX4-Responsive-Element
  JOURNAL   Leukemia 33 (2), 550-553 (2019)
   PUBMED   30315230
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Li,Y., Wu,B., Liu,H., Gao,Y., Yang,C., Chen,X., Zhang,J., Chen,Y.,
            Gu,Y., Li,J., Ma,J. and Gan,J.
  TITLE     Structural basis for multiple gene regulation by human DUX4
  JOURNAL   Biochem Biophys Res Commun 505 (4), 1161-1167 (2018)
   PUBMED   30322619
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Xu,H., Wang,Z., Jin,S., Hao,H., Zheng,L., Zhou,B., Zhang,W., Lv,H.
            and Yuan,Y.
  TITLE     Dux4 induces cell cycle arrest at G1 phase through upregulation of
            p21 expression
  JOURNAL   Biochem Biophys Res Commun 446 (1), 235-240 (2014)
   PUBMED   24589735
  REMARK    Erratum:[Biochem Biophys Res Commun. 2014 Jul 18;450(1):927]
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Dixit,M., Ansseau,E., Tassin,A., Winokur,S., Shi,R., Qian,H.,
            Sauvage,S., Matteotti,C., van Acker,A.M., Leo,O., Figlewicz,D.,
            Barro,M., Laoudj-Chenivesse,D., Belayew,A., Coppee,F. and Chen,Y.W.
  TITLE     DUX4, a candidate gene of facioscapulohumeral muscular dystrophy,
            encodes a transcriptional activator of PITX1
  JOURNAL   Proc Natl Acad Sci U S A 104 (46), 18157-18162 (2007)
   PUBMED   17984056
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Kowaljow,V., Marcowycz,A., Ansseau,E., Conde,C.B., Sauvage,S.,
            Matteotti,C., Arias,C., Corona,E.D., Nunez,N.G., Leo,O.,
            Wattiez,R., Figlewicz,D., Laoudj-Chenivesse,D., Belayew,A.,
            Coppee,F. and Rosa,A.L.
  TITLE     The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein
  JOURNAL   Neuromuscul Disord 17 (8), 611-623 (2007)
   PUBMED   17588759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.727738.1,
                                           SRR26360190.817404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000016.1  1568949-1569058
            111-265             JAXUCZ010000016.1  1569648-1569802
            266-359             JAXUCZ010000016.1  1572097-1572190
            360-505             JAXUCZ010000016.1  1572653-1572798
            506-2012            JAXUCZ010000016.1  1573811-1575317
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2012
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /note="double homeobox 4"
                     /db_xref="GeneID:306226"
                     /db_xref="RGD:1311053"
     exon            1..110
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /note="upstream in-frame stop codon"
     CDS             89..1162
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /note="double homeobox protein 4C-like; double homeobox
                     B-like 1; double homeobox protein B"
                     /codon_start=1
                     /product="double homeobox 4"
                     /protein_id="NP_001419931.1"
                     /db_xref="GeneID:306226"
                     /db_xref="RGD:1311053"
                     /translation="

MDLNCTGGLLEKEARRRRIILNQSQKDTLRVWFEKNPNPDLATRGHLAKKLGISESQIMTWFQKHRKIRKQVEFECCSEESQEQGQDKPRVKEAGRSRTHFTKFQIDILIEAFEKNRFPGIVTREKLAQETGIPESRIHIWFQNRRARHPDPKQGTRATSHPPESSQCPAQKTTGQLAPSKDPTSSCSVILPLSPPHTPNGPLDLSRGRQKQLPETTVLQPSQVVQRRGDDQNPSLFIDHLSEVKSPGEKEGFHTQAPLQLPIQKRGHNPSENSGLSVPPLEDSTQVSAVNQHFRKPDQKDLAFLQHWDEWFQSMLAEWMPDKGYWAVKTDLHPWQAQLLQLLYVSEQTDQTPQQPV"

     exon            111..265
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /inference="alignment:Splign:2.1.0"
     exon            266..359
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /inference="alignment:Splign:2.1.0"
     exon            360..505
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /inference="alignment:Splign:2.1.0"
     exon            506..2012
                     /gene="Dux4"
                     /gene_synonym="Duxbl; Duxbl1; RGD1311053"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggatgggtgggccactctgggctttgctacatcctgtgtctctgtgaatagctctcttgggcctcgtgggatccaggtggctgcagcatggatctgaactgcactggtggcctactggaaaaagaagcccggagaaggaggattattctaaaccagagtcaaaaggacacccttcgtgtgtggtttgaaaagaatcccaatcctgacttagctaccaggggacatctggctaagaaactcggcatctctgagtctcaaataatgacttggtttcagaagcacagaaaaatacggaaacaagtagagtttgaatgttgctctgaagaaagccaagagcaaggacaggataaacccagagttaaagaagctgggaggagcaggacgcatttcacaaagtttcagattgatattctaatcgaagcttttgagaagaatcgattcccagggatcgttaccagggaaaaactggctcaagaaacaggcatcccagaatccagaattcatatatggtttcagaaccggagagcacggcacccagacccaaaacagggtactcgggcaacttctcatccgcctgagagcagccagtgccctgcccagaagactactggtcaacttgctccttccaaagatcccaccagcagctgttccgttatattgcctctctctccaccccacacgccaaatggtcctttggatctctctaggggccgtcagaagcagttaccagagaccacagtactacagccctcccaggttgtacagcgaaggggcgatgatcaaaatccctcactgtttattgatcacttatcagaggtaaaaagtccaggagagaaggagggcttccatactcaggctcctttacagctcccaatccaaaaaagagggcataatcccagtgagaacagtggtttgtctgtaccgcccttagaagattctactcaggtttcagctgtcaatcaacacttccggaaaccggaccaaaaagatctcgcctttctccaacactgggacgaatggttccaatccatgcttgccgagtggatgcctgacaaaggatactgggccgtgaaaactgacctgcacccgtggcaggcacagctgctgcagctcctctatgtgtctgagcagacagaccaaactccacagcagccggtttaagcctcaagcctttttcgttaattcctcttggacatggattttctattctttctgcatccaagtccccaacatgggttcctgcacatggctcggggagcttctcagaagagtttcaggttcttcttcacatggggagaagtacatcagtgagtcagattcaggagaaacctgtccttgggcatgaaatcagtggatttattgaagcctaggtatgcagaattacagaacaagttcaagttagtatatgcataaacctcatggacacacaaagggagccattatttttattcttaatttattcttgagatctgatcttgctgttattccggttggccttgagctcctgcgcttaagtcagtctcctgcctccgcctcctcaagagtcagcactacaaatacatccatgtccaccttggtctcaattttaattatggtttaaaaaaaaatcatatagaaaagtcacggtttcatttaccatctgttgtgtttttaatctgaagtgtctctcacaagttcatgctttgaaatcttgcctctcagccgatggcggtttgaatctgtggagtttttacatgggtcctgacaggcagacataggccagggtgataccttgaaagttatacccagggctggggatttagctcagtggtagagcgcttgcctagcaaacacaaggccctgggtacggtccccagctctgaaaaaaatagaaaaaagaaagttatacccaccacgtgaatagcatgtaccacacactcccgaagtgtagacagattcacatcaccatgcctctctgtgatgatggactgaaacattctgaaaagaatcccaataaacactcttctgtcaa

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