LOCUS       NM_001432286            3767 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus mohawk homeobox (Mkx), transcript variant 2,
            mRNA.
ACCESSION   NM_001432286 XM_008771811
VERSION     NM_001432286.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3767)
  AUTHORS   Kishimoto,Y., Ohkawara,B., Sakai,T., Ito,M., Masuda,A.,
            Ishiguro,N., Shukunami,C., Docheva,D. and Ohno,K.
  TITLE     Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and
            Tnmd in tendon-derived cells
  JOURNAL   PLoS One 12 (7), e0182051 (2017)
   PUBMED   28750046
  REMARK    GeneRIF: Wnt/beta-catenin decreased Mkx and Tnmd expressions
            without suppressing Scx expression in Scx-programmed tendon
            progenitors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3767)
  AUTHORS   Suzuki,H., Ito,Y., Shinohara,M., Yamashita,S., Ichinose,S.,
            Kishida,A., Oyaizu,T., Kayama,T., Nakamichi,R., Koda,N.,
            Yagishita,K., Lotz,M.K., Okawa,A. and Asahara,H.
  TITLE     Gene targeting of the transcription factor Mohawk in rats causes
            heterotopic ossification of Achilles tendon via failed tenogenesis
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7840-7845 (2016)
   PUBMED   27370800
REFERENCE   3  (bases 1 to 3767)
  AUTHORS   Anderson,D.M., George,R., Noyes,M.B., Rowton,M., Liu,W., Jiang,R.,
            Wolfe,S.A., Wilson-Rawls,J. and Rawls,A.
  TITLE     Characterization of the DNA-binding properties of the Mohawk
            homeobox transcription factor
  JOURNAL   J Biol Chem 287 (42), 35351-35359 (2012)
   PUBMED   22923612
REFERENCE   4  (bases 1 to 3767)
  AUTHORS   Kimura,W., Machii,M., Xue,X., Sultana,N., Hikosaka,K.,
            Sharkar,M.T., Uezato,T., Matsuda,M., Koseki,H. and Miura,N.
  TITLE     Irxl1 mutant mice show reduced tendon differentiation and no
            patterning defects in musculoskeletal system development
  JOURNAL   Genesis 49 (1), 2-9 (2011)
   PUBMED   21254332
REFERENCE   5  (bases 1 to 3767)
  AUTHORS   Liu,W., Watson,S.S., Lan,Y., Keene,D.R., Ovitt,C.E., Liu,H.,
            Schweitzer,R. and Jiang,R.
  TITLE     The atypical homeodomain transcription factor Mohawk controls
            tendon morphogenesis
  JOURNAL   Mol Cell Biol 30 (20), 4797-4807 (2010)
   PUBMED   20696843
REFERENCE   6  (bases 1 to 3767)
  AUTHORS   Ito,Y., Toriuchi,N., Yoshitaka,T., Ueno-Kudoh,H., Sato,T.,
            Yokoyama,S., Nishida,K., Akimoto,T., Takahashi,M., Miyaki,S. and
            Asahara,H.
  TITLE     The Mohawk homeobox gene is a critical regulator of tendon
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10538-10542 (2010)
   PUBMED   20498044
REFERENCE   7  (bases 1 to 3767)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
REFERENCE   8  (bases 1 to 3767)
  AUTHORS   Anderson,D.M., Arredondo,J., Hahn,K., Valente,G., Martin,J.F.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     Mohawk is a novel homeobox gene expressed in the developing mouse
            embryo
  JOURNAL   Dev Dyn 235 (3), 792-801 (2006)
   PUBMED   16408284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 30, 2024 this sequence version replaced XM_008771811.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1834545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000017.1  59850742-59850894   c
            154-426             JAXUCZ010000017.1  59848804-59849076   c
            427-583             JAXUCZ010000017.1  59846953-59847109   c
            584-740             JAXUCZ010000017.1  59840074-59840230   c
            741-1076            JAXUCZ010000017.1  59839333-59839668   c
            1077-1119           JAXUCZ010000017.1  59774874-59774916   c
            1120-3767           JAXUCZ010000017.1  59772113-59774760   c
FEATURES             Location/Qualifiers
     source          1..3767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..3767
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="mohawk homeobox"
                     /db_xref="GeneID:291228"
                     /db_xref="RGD:1305652"
     exon            1..153
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    53..55
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="upstream in-frame stop codon"
     exon            154..426
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1309
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="isoform 2 is encoded by transcript variant 2;
                     iroquois homeobox protein-like 1; homeobox protein Mohawk"
                     /codon_start=1
                     /product="homeobox protein Mohawk isoform 2"
                     /protein_id="NP_001419215.1"
                     /db_xref="GeneID:291228"
                     /db_xref="RGD:1305652"
                     /translation="

MNTIVFNKLGGAVIFDDRGTPDRERGSRPYGGVLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARPGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSADDSCSEDGENPPRTHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDKGDSTANRRGPSKDDTHWKEINAAMALTNLAQGKDEAQGTTTSCIIQKSSHIAEVKTVKLPLVQHF"

     exon            427..583
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            584..740
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1076
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1119
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..3767
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtgggggacccgccccgtgtgtcggtcaaagcttcatggtgggtatgggaagtagctagcaacccacctggccgccctcgctttgctttcgaattatccgcggggcagttctgcagggatcgcgctggtcagcactgctaagagcgtatctggaacccgagccctgctgcggagctcctggtggccggactctgaggcgctgcggcaaggccgccgcgcgtccctgtcagcccttaccatgaataccatcgtctttaacaagcttgggggagctgtgatttttgacgaccgaggcaccccagatcgggaacgtggcagccggccatacggcggcgtcctggacaatccacatacaggcccggaggtgggcattccagacggcccgcccctcaaggacaacctcagcctgagacaccggaggaccggggcgaggcctggagggaaggtgaggcacaagcgacaggccctgcaagacatggcgcggccgcttaagcagtggctttacaagcaccgtgacaacccgtaccctacgaagactgagaagatactcttggctctaggctcgcagatgacgctagtgcaggtgtcaaattggttcgctaatgctagacgacggctgaagaacactgtccggcagccggatttaagttgggccttaagaataaagttgtacaacaagtatgttcagggcaacgccgagcggctcagtgtgagcagtgcggatgactcctgctctgaagatggagaaaatcccccaagaactcacatgaacgaagagggctatagcacccctgcccaccacactgtgattaaaggggagagctcagcgataaaagctggtgggagaccggagtcaagggcagctgaggactatgtgtcaccgcccaagtataagagcagcttgttgaaccgttaccttaacgactctttgagacatgtcatggccaccagcactgccatgatggggaaaacaaggcgaaggaaccattcggggtcttttagctcgaacgaatttgaagaagaactggtgtctccatcatcatcagaaactgaaggcacctttgtctatcgcacagacaccccagacattggatctactaagggtgataagggtgacagcactgctaacagaagggggccgagcaaggatgacacacactggaaggagatcaacgcagccatggccttaacaaacctcgcccagggaaaagacgaagcgcaggggacgaccaccagttgcatcatccagaagtcttcccacatagcagaagtaaagacagtcaagctgccactggtgcagcacttctagagtggccagggagtgctgggcttgtcagtgggtttgtttgtttgtttgttgtttgttgtttgttgtttgttttttaccgtaatcctcatcctaagagccaaagcaggggtgaagaggactcccatttaaacctcctgagttcaactatcctaaatatatccgttgcttctataaaaagatgtataagttataaaaattcattttagtcaaaaatattaacttattttatgttactgaaactatgcataaagcgtctgcattgccattacagtaagtgccttgcttccctgaggtaagctccaacgtgggcacagtggagcgctgtgcctcaaactgtcaacgccaatacttgctagactacatcactccagactggcccaggactgaagccaatcgcggaaagctcccgaaacaaactcagtcattcacacgttcaaacttggagatctgttcagcccagatgaggtgatcttttatttgccttttaatgccttcaggactggaaactgttctttgtgttttccagggcgatggtgagagttttatgtgtgggttttgtttgcataggctagcgcatccaaaatggaaggcccagcagggccacgtgatgcgtatgtttaagaagggatgttttcaaatcggtttaacattgccagagtatattgtcgtgaggatttgttttcccaagcactgttggaaagtatcccaaagccctttacaactaattgggattttttttcctgaggttttaaaaagaaccttattatataaatctttgaattttttcctgaggaaaactaaacctaaagtttagttttaaattataatcttgtttgcactagagctcagggttcctttgtgatggaagcagctttcatatggagtaactaaaagcgttttatttggttcatttctttttttaacggatttttttttttttttcggagctggggaccgaacccagggccttgcgcttcctaggtaagcgctctaccactgagctaaatccgcagccccttatttggttcatttcaaatcccagttcagatggacaatttgtattgcaatgagaacaagacaacgaagaaaataatctgtgtgtgtggatatacatatacatgcagaaggattaatgtttaaaatttaaagcgtatgggtaacaaaacatgaatggtctctgatttttgccaagcaggacattcaagtaaaaattaagtgaaatcttgagtcgaaaggaagaaagtcttatttctaaatgtcactaccacagagtgagagtaatggatatcaaggaagaagagtgtcttttccatcaaacaataacgtcctccccagcttcggaagactgcgaacggaagggatgtggagacgcccaatagaaaaggaaatctggagatgccttaatgtaggagagcaaaggtttaacggcaaactaggctcttgggggaagggcattttttctggatatgtgatatattttgtaattggtttaggctggaaaacatttttgcaagtgtgaatgacatctggtttcaccgcacacactgacatttttttcttcattttacaaaacgctttttaccctgaaggttaatctggttgctcagcagacacgacggcctcgatggccatcgtaggacactttctcctgtatcatagcatagtggggtgggggttatctagtgtaatgaagataatttgatatgaaaatattttgtatgtatatttttactttgttttcttaagtgccgttggcagttgcagtaagccctaggtgagatgtgtaagtgctgactgtatgagtggatgaagtattggcttcttctggtgcatccttgatactgggatgcgaagtgggagtcactacaaaacaagcctgcccagatgtatgcgaggcagtgagaaacaagaatgaatacttcactccttttcatactattataagttattctggtattaaatattttaataaaaatgttcttgttttaacatgttgcaattagataagtgaactctgggttgtattttatttgaaattgtcatgttttatttttttctgtcctttgggggaaaattcagctaatttgttctgtattatgaacacaaccaatgagaggatactatcccataatttctgtaaagtaacaaagcttggagtctggcctatgcacacatgaaaaataggtaattagcatattctgggcaatgtctccaattgcaatcattttgaatttattatttttcttgtgttgctgttgttttatctggaaatcagagtcccttgtccctcaaaagaaccttgaacaatgccaagccagcagccgagagagagagcttggctgacatgtaatttatatgaaagagaaagagacttgctctcattttacagttgtatttgaataaaattaaaatctgtcaggagttcttgacagatttaaaataaaagttcatttctaga

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