LOCUS       NM_001432285            3721 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Rattus norvegicus mohawk homeobox (Mkx), transcript variant 1,
            mRNA.
ACCESSION   NM_001432285 XM_017600733
VERSION     NM_001432285.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Kishimoto,Y., Ohkawara,B., Sakai,T., Ito,M., Masuda,A.,
            Ishiguro,N., Shukunami,C., Docheva,D. and Ohno,K.
  TITLE     Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and
            Tnmd in tendon-derived cells
  JOURNAL   PLoS One 12 (7), e0182051 (2017)
   PUBMED   28750046
  REMARK    GeneRIF: Wnt/beta-catenin decreased Mkx and Tnmd expressions
            without suppressing Scx expression in Scx-programmed tendon
            progenitors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Suzuki,H., Ito,Y., Shinohara,M., Yamashita,S., Ichinose,S.,
            Kishida,A., Oyaizu,T., Kayama,T., Nakamichi,R., Koda,N.,
            Yagishita,K., Lotz,M.K., Okawa,A. and Asahara,H.
  TITLE     Gene targeting of the transcription factor Mohawk in rats causes
            heterotopic ossification of Achilles tendon via failed tenogenesis
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7840-7845 (2016)
   PUBMED   27370800
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Anderson,D.M., George,R., Noyes,M.B., Rowton,M., Liu,W., Jiang,R.,
            Wolfe,S.A., Wilson-Rawls,J. and Rawls,A.
  TITLE     Characterization of the DNA-binding properties of the Mohawk
            homeobox transcription factor
  JOURNAL   J Biol Chem 287 (42), 35351-35359 (2012)
   PUBMED   22923612
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Kimura,W., Machii,M., Xue,X., Sultana,N., Hikosaka,K.,
            Sharkar,M.T., Uezato,T., Matsuda,M., Koseki,H. and Miura,N.
  TITLE     Irxl1 mutant mice show reduced tendon differentiation and no
            patterning defects in musculoskeletal system development
  JOURNAL   Genesis 49 (1), 2-9 (2011)
   PUBMED   21254332
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Liu,W., Watson,S.S., Lan,Y., Keene,D.R., Ovitt,C.E., Liu,H.,
            Schweitzer,R. and Jiang,R.
  TITLE     The atypical homeodomain transcription factor Mohawk controls
            tendon morphogenesis
  JOURNAL   Mol Cell Biol 30 (20), 4797-4807 (2010)
   PUBMED   20696843
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Ito,Y., Toriuchi,N., Yoshitaka,T., Ueno-Kudoh,H., Sato,T.,
            Yokoyama,S., Nishida,K., Akimoto,T., Takahashi,M., Miyaki,S. and
            Asahara,H.
  TITLE     The Mohawk homeobox gene is a critical regulator of tendon
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10538-10542 (2010)
   PUBMED   20498044
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Anderson,D.M., Arredondo,J., Hahn,K., Valente,G., Martin,J.F.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     Mohawk is a novel homeobox gene expressed in the developing mouse
            embryo
  JOURNAL   Dev Dyn 235 (3), 792-801 (2006)
   PUBMED   16408284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 30, 2024 this sequence version replaced XM_017600733.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.52685.1,
                                           SRR26360172.916407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000017.1  59851023-59851129   c
            108-380             JAXUCZ010000017.1  59848804-59849076   c
            381-537             JAXUCZ010000017.1  59846953-59847109   c
            538-694             JAXUCZ010000017.1  59840074-59840230   c
            695-1030            JAXUCZ010000017.1  59839333-59839668   c
            1031-1073           JAXUCZ010000017.1  59774874-59774916   c
            1074-3721           JAXUCZ010000017.1  59772113-59774760   c
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..3721
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="mohawk homeobox"
                     /db_xref="GeneID:291228"
                     /db_xref="RGD:1305652"
     exon            1..107
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    88..90
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="upstream in-frame stop codon"
     exon            108..380
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1263
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /note="isoform 1 is encoded by transcript variant 1;
                     iroquois homeobox protein-like 1; homeobox protein Mohawk"
                     /codon_start=1
                     /product="homeobox protein Mohawk isoform 1"
                     /protein_id="NP_001419214.1"
                     /db_xref="GeneID:291228"
                     /db_xref="RGD:1305652"
                     /translation="

MNTIVFNKLGGAVIFDDRGTPDRERGSRPYGGVLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARPGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSADDSCSEDGENPPRTHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDKGDSTANRRGPSKDDTHWKEINAAMALTNLAQGKDEAQGTTTSCIIQKSSHIAEVKTVKLPLVQHF"

     exon            381..537
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            538..694
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1030
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1073
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..3721
                     /gene="Mkx"
                     /gene_synonym="Irxl1; RGD1305652"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcggtgagcgcgttggagcctgcgccgagaacatgcggcggggatgggagtgtgcctagtcctgagaccggacaaccagccactggctgaggtcttcgcggccatagaacccgagccctgctgcggagctcctggtggccggactctgaggcgctgcggcaaggccgccgcgcgtccctgtcagcccttaccatgaataccatcgtctttaacaagcttgggggagctgtgatttttgacgaccgaggcaccccagatcgggaacgtggcagccggccatacggcggcgtcctggacaatccacatacaggcccggaggtgggcattccagacggcccgcccctcaaggacaacctcagcctgagacaccggaggaccggggcgaggcctggagggaaggtgaggcacaagcgacaggccctgcaagacatggcgcggccgcttaagcagtggctttacaagcaccgtgacaacccgtaccctacgaagactgagaagatactcttggctctaggctcgcagatgacgctagtgcaggtgtcaaattggttcgctaatgctagacgacggctgaagaacactgtccggcagccggatttaagttgggccttaagaataaagttgtacaacaagtatgttcagggcaacgccgagcggctcagtgtgagcagtgcggatgactcctgctctgaagatggagaaaatcccccaagaactcacatgaacgaagagggctatagcacccctgcccaccacactgtgattaaaggggagagctcagcgataaaagctggtgggagaccggagtcaagggcagctgaggactatgtgtcaccgcccaagtataagagcagcttgttgaaccgttaccttaacgactctttgagacatgtcatggccaccagcactgccatgatggggaaaacaaggcgaaggaaccattcggggtcttttagctcgaacgaatttgaagaagaactggtgtctccatcatcatcagaaactgaaggcacctttgtctatcgcacagacaccccagacattggatctactaagggtgataagggtgacagcactgctaacagaagggggccgagcaaggatgacacacactggaaggagatcaacgcagccatggccttaacaaacctcgcccagggaaaagacgaagcgcaggggacgaccaccagttgcatcatccagaagtcttcccacatagcagaagtaaagacagtcaagctgccactggtgcagcacttctagagtggccagggagtgctgggcttgtcagtgggtttgtttgtttgtttgttgtttgttgtttgttgtttgttttttaccgtaatcctcatcctaagagccaaagcaggggtgaagaggactcccatttaaacctcctgagttcaactatcctaaatatatccgttgcttctataaaaagatgtataagttataaaaattcattttagtcaaaaatattaacttattttatgttactgaaactatgcataaagcgtctgcattgccattacagtaagtgccttgcttccctgaggtaagctccaacgtgggcacagtggagcgctgtgcctcaaactgtcaacgccaatacttgctagactacatcactccagactggcccaggactgaagccaatcgcggaaagctcccgaaacaaactcagtcattcacacgttcaaacttggagatctgttcagcccagatgaggtgatcttttatttgccttttaatgccttcaggactggaaactgttctttgtgttttccagggcgatggtgagagttttatgtgtgggttttgtttgcataggctagcgcatccaaaatggaaggcccagcagggccacgtgatgcgtatgtttaagaagggatgttttcaaatcggtttaacattgccagagtatattgtcgtgaggatttgttttcccaagcactgttggaaagtatcccaaagccctttacaactaattgggattttttttcctgaggttttaaaaagaaccttattatataaatctttgaattttttcctgaggaaaactaaacctaaagtttagttttaaattataatcttgtttgcactagagctcagggttcctttgtgatggaagcagctttcatatggagtaactaaaagcgttttatttggttcatttctttttttaacggatttttttttttttttcggagctggggaccgaacccagggccttgcgcttcctaggtaagcgctctaccactgagctaaatccgcagccccttatttggttcatttcaaatcccagttcagatggacaatttgtattgcaatgagaacaagacaacgaagaaaataatctgtgtgtgtggatatacatatacatgcagaaggattaatgtttaaaatttaaagcgtatgggtaacaaaacatgaatggtctctgatttttgccaagcaggacattcaagtaaaaattaagtgaaatcttgagtcgaaaggaagaaagtcttatttctaaatgtcactaccacagagtgagagtaatggatatcaaggaagaagagtgtcttttccatcaaacaataacgtcctccccagcttcggaagactgcgaacggaagggatgtggagacgcccaatagaaaaggaaatctggagatgccttaatgtaggagagcaaaggtttaacggcaaactaggctcttgggggaagggcattttttctggatatgtgatatattttgtaattggtttaggctggaaaacatttttgcaagtgtgaatgacatctggtttcaccgcacacactgacatttttttcttcattttacaaaacgctttttaccctgaaggttaatctggttgctcagcagacacgacggcctcgatggccatcgtaggacactttctcctgtatcatagcatagtggggtgggggttatctagtgtaatgaagataatttgatatgaaaatattttgtatgtatatttttactttgttttcttaagtgccgttggcagttgcagtaagccctaggtgagatgtgtaagtgctgactgtatgagtggatgaagtattggcttcttctggtgcatccttgatactgggatgcgaagtgggagtcactacaaaacaagcctgcccagatgtatgcgaggcagtgagaaacaagaatgaatacttcactccttttcatactattataagttattctggtattaaatattttaataaaaatgttcttgttttaacatgttgcaattagataagtgaactctgggttgtattttatttgaaattgtcatgttttatttttttctgtcctttgggggaaaattcagctaatttgttctgtattatgaacacaaccaatgagaggatactatcccataatttctgtaaagtaacaaagcttggagtctggcctatgcacacatgaaaaataggtaattagcatattctgggcaatgtctccaattgcaatcattttgaatttattatttttcttgtgttgctgttgttttatctggaaatcagagtcccttgtccctcaaaagaaccttgaacaatgccaagccagcagccgagagagagagcttggctgacatgtaatttatatgaaagagaaagagacttgctctcattttacagttgtatttgaataaaattaaaatctgtcaggagttcttgacagatttaaaataaaagttcatttctaga

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