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Previous release (v1)
2026-01-18 13:20:31, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_001429669 4269 bp mRNA linear ROD 05-MAY-2025
DEFINITION Rattus norvegicus SID1 transmembrane family, member 2 (Sidt2),
transcript variant 2, mRNA.
ACCESSION NM_001429669 XM_039081438
VERSION NM_001429669.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4269)
AUTHORS Takahashi,M., Contu,V.R., Kabuta,C., Hase,K., Fujiwara,Y., Wada,K.
and Kabuta,T.
TITLE SIDT2 mediates gymnosis, the uptake of naked single-stranded
oligonucleotides into living cells
JOURNAL RNA Biol 14 (11), 1534-1543 (2017)
PUBMED 28277980
REFERENCE 2 (bases 1 to 4269)
AUTHORS Contu,V.R., Hase,K., Kozuka-Hata,H., Oyama,M., Fujiwara,Y.,
Kabuta,C., Takahashi,M., Hakuno,F., Takahashi,S.I., Wada,K. and
Kabuta,T.
TITLE Lysosomal targeting of SIDT2 via multiple YxxPhi motifs is required
for SIDT2 function in the process of RNautophagy
JOURNAL J Cell Sci 130 (17), 2843-2853 (2017)
PUBMED 28724756
REFERENCE 3 (bases 1 to 4269)
AUTHORS Aizawa,S., Fujiwara,Y., Contu,V.R., Hase,K., Takahashi,M.,
Kikuchi,H., Kabuta,C., Wada,K. and Kabuta,T.
TITLE Lysosomal putative RNA transporter SIDT2 mediates direct uptake of
RNA by lysosomes
JOURNAL Autophagy 12 (3), 565-578 (2016)
PUBMED 27046251
REFERENCE 4 (bases 1 to 4269)
AUTHORS Gao,J., Yu,C., Xiong,Q., Zhang,Y. and Wang,L.
TITLE Lysosomal integral membrane protein Sidt2 plays a vital role in
insulin secretion
JOURNAL Int J Clin Exp Pathol 8 (12), 15622-15631 (2015)
PUBMED 26884831
REMARK GeneRIF: Sdit2 may play a vital role in the regulation of insulin
secretion via two SNARE proteins synap1 and syanp3.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4269)
AUTHORS Li,W., Koutmou,K.S., Leahy,D.J. and Li,M.
TITLE Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain
Selectively Binds Long Double-stranded RNA and Is Required for RNA
Transport by SID-1
JOURNAL J Biol Chem 290 (31), 18904-18913 (2015)
PUBMED 26067272
REFERENCE 6 (bases 1 to 4269)
AUTHORS Gao,J., Gu,X., Mahuran,D.J., Wang,Z. and Zhang,H.
TITLE Impaired glucose tolerance in a mouse model of sidt2 deficiency
JOURNAL PLoS One 8 (6), e66139 (2013)
PUBMED 23776622
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 4269)
AUTHORS Jialin,G., Xuefan,G. and Huiwen,Z.
TITLE SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal
membrane protein
JOURNAL Biochem Biophys Res Commun 402 (4), 588-594 (2010)
PUBMED 20965152
REFERENCE 8 (bases 1 to 4269)
AUTHORS Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
TITLE Integral and associated lysosomal membrane proteins
JOURNAL Traffic 8 (12), 1676-1686 (2007)
PUBMED 17897319
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000008.1.
On Apr 25, 2024 this sequence version replaced XM_039081438.2.
##Evidence-Data-START##
Transcript exon combination :: SRR21887623.3132240.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-501 JAXUCZ010000008.1 55144408-55144908 c
502-623 JAXUCZ010000008.1 55142846-55142967 c
624-788 JAXUCZ010000008.1 55142480-55142644 c
789-834 JAXUCZ010000008.1 55142351-55142396 c
835-936 JAXUCZ010000008.1 55141697-55141798 c
937-1020 JAXUCZ010000008.1 55141507-55141590 c
1021-1120 JAXUCZ010000008.1 55140061-55140160 c
1121-1186 JAXUCZ010000008.1 55139803-55139868 c
1187-1280 JAXUCZ010000008.1 55138472-55138565 c
1281-1333 JAXUCZ010000008.1 55138095-55138147 c
1334-1420 JAXUCZ010000008.1 55137871-55137957 c
1421-1492 JAXUCZ010000008.1 55137253-55137324 c
1493-1564 JAXUCZ010000008.1 55137033-55137104 c
1565-1683 JAXUCZ010000008.1 55135961-55136079 c
1684-1757 JAXUCZ010000008.1 55135597-55135670 c
1758-1824 JAXUCZ010000008.1 55135442-55135508 c
1825-1898 JAXUCZ010000008.1 55134919-55134992 c
1899-2022 JAXUCZ010000008.1 55134659-55134782 c
2023-2140 JAXUCZ010000008.1 55134258-55134375 c
2141-2277 JAXUCZ010000008.1 55133732-55133868 c
2278-2386 JAXUCZ010000008.1 55133389-55133497 c
2387-2463 JAXUCZ010000008.1 55133109-55133185 c
2464-2510 JAXUCZ010000008.1 55132893-55132939 c
2511-2616 JAXUCZ010000008.1 55132549-55132654 c
2617-2727 JAXUCZ010000008.1 55132029-55132139 c
2728-2841 JAXUCZ010000008.1 55130609-55130722 c
2842-4269 JAXUCZ010000008.1 55129087-55130514 c
FEATURES Location/Qualifiers
source 1..4269
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q22"
gene 1..4269
/gene="Sidt2"
/gene_synonym="RGD1308311"
/note="SID1 transmembrane family, member 2"
/db_xref="GeneID:315617"
/db_xref="RGD:1308311"
exon 1..501
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
CDS 319..2904
/gene="Sidt2"
/gene_synonym="RGD1308311"
/note="isoform 2 precursor is encoded by transcript
variant 2"
/codon_start=1
/product="SID1 transmembrane family member 2 isoform 2
precursor"
/protein_id="NP_001416598.1"
/db_xref="GeneID:315617"
/db_xref="RGD:1308311"
/translation="
MIAWRLPLCVLLVAAVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLVAIDRACPESGWALGSPLHSHLETVLCPYWCLRQCHSASGHPRVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESTGSGDLSYSYQDRSFDPVGARPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF"
sig_peptide 319..372
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
exon 502..623
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 624..788
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 789..834
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 835..936
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 937..1020
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1021..1120
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1121..1186
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1187..1280
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1281..1333
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1334..1420
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1421..1492
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1493..1564
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1565..1683
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1684..1757
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1758..1824
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1825..1898
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 1899..2022
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2023..2140
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2141..2277
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2278..2386
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2387..2463
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2464..2510
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2511..2616
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2617..2727
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2728..2841
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
exon 2842..4269
/gene="Sidt2"
/gene_synonym="RGD1308311"
/inference="alignment:Splign:2.1.0"
ORIGIN
gagttctgtgccgcgtccgccgcccttaaagggcccgcgtccgggaagcctacgggccagggccaccgccgcctcggctctccgggcgcgagcggacgccgggtctccagccgggctgggccgggctggggttgcgggtcgcggtgccgcccacgcgagccggggtccgcgcgaggcccaggagcggctccagggaggggacgcgtcctatctcaggccggggttaaagttctggtcccggtgagatgctggaagctgctgcggcagccgcaacgcgcccggtcgccgtcccgtcgccagcccccgccgccccgggccatgatcgcctggcgtctgcccttgtgcgtgctcctggtggccgccgtcgagagccacctgggggctctggggcccaagaacgtctcgcagaaagacgcggagtttgagcgcacctacgcggacgacgtcaacagcgagctagtcaacatctacaccttcaaccacaccgtgacccgcaaccggaccgagggcgtgcgagtgtctgtgaacgtcctgaacaaacagaaaggggcgcctttgctgttcgtggtccgccagaaggaggctgttgtgtccttccaggtgcccctaatcctgcgagggctataccagcgtaagtacctctaccaaaaagttgaacgaactctgtgtcagccccccaccaagaatgagtctgagatccagtttttctatgtggatgtgtctaccctgtcaccagtcaataccacttaccagctccgagtcaaccgtgtggacaatttcgtgctcaggactggggagctgtttaccttcaataccactgcagcccaaccccagtacttcaaatacgagtttcctgatggtgtggactctgtcattgtcaaggtgacctccaagaaggccttcccctgctctgtcatctccatccaggatgtcctgtgcccagtctatgatcttgacaacaatgtagccttcatcggcatgtaccagacaatgactaagaaggcagccatcactgtgcagaggaaagacttccccagcaacagtttttatgtggtggtggtggtgaagactgaggaccaggcctgcggggggtccttgcccttctaccctttcgtggaagatgaaccagtggatcaagggcaccgtcagaaaaccctgtcagtgctggtctctcaggctgtcacttctgaggcctacgttggtgggatgctcttttgcctgggcatattcctgtcgttctacctgctgactgtgctgctggcctgttgggagaactggaggcaaaggaagaagaccttgctggtggccatagaccgagcctgcccagaaagcggttgggcccttggctcacccctccatagccacctggaaactgtcctttgcccgtactggtgtctcaggcagtgccactcagcctcaggtcaccctcgggtcttggctgattcgtttcctggcagtgccccctatgagggttacaactatggctcctttgagaatggttccggatccactgacgggttggttgaaagcacaggttcaggggacctctcctacagttaccaggaccgctcctttgacccagtgggagctcggccacgactggactccatgagctccgtggaagaggatgactatgacacactgactgacatcgactcagacaaaaacgtcattcgaaccaagcaatacctctgtgtggctgatctggcacgaaaggacaaacgtgttttacggaaaaagtaccagatttacttctggaacatagccaccattgcagtcttctacgcccttcctgtggtgcagctggtgatcacctaccagacggtggtgaatgtcacggggaaccaggacatctgctactacaacttcctctgtgcccacccactgggcaacctcagcgccttcaacaacatcctcagcaacctggggtacattctgcttggtctgctcttcctgctcatcatcctgcagcgggagatcaatcataaccgggccctgctgagaaatgacctctatgctctggagtgtgggatccccaaacactttggtctattttatgccatgggcacagcgttgatgatggaggggctactgagtgcctgttaccacgtctgccccaactacaccaacttccagttcgatacctcgttcatgtacatgattgctggcctctgcatgctgaagctctaccagaagcggcacccagatatcaacgccagcgcctacagcgcatacgcctgcctggccattgtgatcttcttctccgtcctgggtgtggtttttggcaaagggaacacagccttctggatcgtcttctcagtcatccatatcatttccacgcttctcctcagcactcagctgtattacatgggccgctggaagctggactccggaatcttccgccgcatccttcatgtgctctacacagactgcatccggcagtgcagcgggcccctttacacggaccgcatggtgcttctggtcatgggcaacattatcaactggtcgctggctgcctacggactcatcatgcgcccaaatgactttgcgtcctacttgctggcaattggcatctgcaacttgctgctgtattttgctttctacatcattatgaagctccggagcggcgagaggatcaagctcatccctctgctctgcatcgtgtgcacctccgtggtctggggcttcgcactcttcttcttcttccagggactcagcacgtggcagaaaacccccgcagagtccagggagcacaaccgagactgcatcctccttgacttctttgatgaccacgacatctggcacttcctgtcctccattgctatgtttgggtccttcctggttttattgacgttggatgacgacttggacactgtacagcgggacaagatctatgtcttctagcagcgtctgtggtccaggcttcacttcatgggcccagcgcctctgcgtcaccttccagttgccacaggagcaccaagggtgtgagtcccagctctgctacccagcactggacgtcgtggcaagacagcgagttccagctcaggcctgactcaggacagttactggtgacactgaaccttgcagttacctctgctgcggaggaggcctgctccgcaaccccagacactggccaaattgctgctgcttgcttctcagtgtccggtcctccccaggaccctggtctgtccatctgtcttgtttatccactggctctccatttgtccctttggagaggaaggcaggaagtcaatgtcctgcccccttcatgccttgcattctacccatcccttccctccttttggcctaggacacagcctttcttcttcccgtgctctgccccaggacatagtctggtgcctgattctctgtccagcaccaggacctacattctccctgggtctgtagctggctatcactgcccactctggcctgccaggatggatgcaggtaggagactttgggggctggccggctggtgccaggctttcggtgctaaggcccacaaggggtctaggtacgaccctcctccctgacctgtgcgtggagctggctctacagcagtgagggccagcccaggctgaatcttttgatctggggactgaattcagaggccacctcatcctaccagccactagaatgatgccagcaccggggttggtgggaagtggcaacttactgtcctcttccgtaccctcagtcctgccaagccccagatgggggcccctcagtgccattgacactgcccaagaatgtccagaggccatgggatggtgccaagcacacaaccccttttgcctctttcaggggagcaggagtcccagtgcctgtcttagaaagggagggacatgccaagtccctgtgagtccttagtcctgtctcaccaaaggactcagggctggtttctgagtttccgtccagtatttagccaagttctgtgttagtcacataggcctaagagccttgacgtttacagagtcacccagctctggcccctggccactctggtccttggcgtttacagagtcacccagctctaggccccggccactctagtccttggctatccttcactccaccaggtccattccagatgccaagagtcctctccaccatggttttctagctcttgggctgggagaagaggcaggtctgggcctttgtttctgagctctgttctgtgttcctccatgctacggttgcaattctgttttctatgaacgagtgcattcaataaagacagcccgacctgggatctggtcttactga
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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