LOCUS       NM_001427742            3675 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus NRDE-2, necessary for RNA interference, domain
            containing (Nrde2), mRNA.
ACCESSION   NM_001427742 XM_234465
VERSION     NM_001427742.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3675)
  AUTHORS   Wang,J., Chen,J., Wu,G., Zhang,H., Du,X., Chen,S., Zhang,L.,
            Wang,K., Fan,J., Gao,S., Wu,X., Zhang,S., Kuai,B., Zhao,P., Chi,B.,
            Wang,L., Li,G., Wong,C.C.L., Zhou,Y., Li,J., Yun,C. and Cheng,H.
  TITLE     NRDE2 negatively regulates exosome functions by inhibiting MTR4
            recruitment and exosome interaction
  JOURNAL   Genes Dev 33 (9-10), 536-549 (2019)
   PUBMED   30842217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 2, 2024 this sequence version replaced XM_234465.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.25594.1,
                                           SRR26643429.24878.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000006.1  125176214-125176299 c
            87-195              JAXUCZ010000006.1  125163599-125163707 c
            196-426             JAXUCZ010000006.1  125162164-125162394 c
            427-582             JAXUCZ010000006.1  125156998-125157153 c
            583-1033            JAXUCZ010000006.1  125154823-125155273 c
            1034-1439           JAXUCZ010000006.1  125152746-125153151 c
            1440-1573           JAXUCZ010000006.1  125150735-125150868 c
            1574-1694           JAXUCZ010000006.1  125148777-125148897 c
            1695-1870           JAXUCZ010000006.1  125146002-125146177 c
            1871-2257           JAXUCZ010000006.1  125143569-125143955 c
            2258-3183           JAXUCZ010000006.1  125141812-125142737 c
            3184-3322           JAXUCZ010000006.1  125140707-125140845 c
            3323-3394           JAXUCZ010000006.1  125137825-125137896 c
            3395-3675           JAXUCZ010000006.1  125137121-125137401 c
FEATURES             Location/Qualifiers
     source          1..3675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3675
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing"
                     /db_xref="GeneID:314381"
                     /db_xref="RGD:1565082"
     exon            1..86
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3520
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /codon_start=1
                     /product="nuclear exosome regulator NRDE2"
                     /protein_id="NP_001414671.1"
                     /db_xref="GeneID:314381"
                     /db_xref="RGD:1565082"
                     /translation="

MALFPAFAGVSEASGDGASRKELDWLSNPSFRVGNLTSLSRQTEEVPALASEASPLTRSPLKSELSDESDTNEKLTQISKKKKKEKKKKRKHQHHKKTKRRHEQSSSSGSGSDTEAGKDRASRSIRDSQESEKARQGSNAVPAAPATGHSSIWLEDIYTLTDVFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGASAAKKHSHRHLERYFTKKNVALLRTEGIAVCSNPEPSSSEPAPFIPVKDSADVATPVTTWLNPLGIYDQSTTQWLQGQGPAEPELKQPDSQQERDSAALKARVEEFNRRVRENPRDTQLWMAFVAFQDEVMRSPGIYALGEGEQEKHRKSLKLLLEKKLAVLERAIESNPSSVELKLAKLQLCSEFWEPSALTKEWQKLLFLHPNNTSLWQRYLSFCQSQFGTFSVSKLHSLYGKCLSTLSAVKDGSMLSHPVLPGTEEAMFGLFLQQCHFLRQAGHSEKVVSLFQAMVDFTFFKPDSVKELPTKVQVEFFEPFWDSGEPRVGEKGARGWRAWMHQQERGGWVLVNPDEDDEEPEEEDQEIKDKTLPRWQIWLAMERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDVGQSLIRLSSPDLQFQLIEAFLQFLGVPSGFLPPASCLYLAMDESSIFESKLYDEKPLTYFNPLFSGISCVGYMEQLDCPRWTKGHNREGEEFVRNVFHLVLPLFSGKQKCQLCLSWLRYEIAKVIWCLHTKKKRLKSQGKNCKKLAKSLLKEPENRNNLCLWRQYAHLEWLLGNTEDARKVLDAALSMAGSSDLKDRELCELSLLYAELEVELSPDSRGATTGRAVHVLTRLTESSPCGPYTGQVSSTQVLKARKAYEHALQDCLGQSCASSPPTAESLDCLGSLVKCFMLFQYLTVGIDAAVQVYRQVFSKLEGSALLEGPGPEDSASSQSVTSVLEAVTLMHTSLLRFHMNICVYPLAPLRETLSDALKLYPGNQGLWRAYVQIQNKSHSANKTRRFFDTVTRSAKHLEPWLFAIEAEKLRKRLVESVQRVGGREVHATIPETGLTHRIRALFENAIRSDQGGQCPLLWRMYLKFLVSLGNKERSKGVFYKALQSCPWAKVLYMDAVEYFPEELQEILDVMTEKELRVRLPLEELELLLED"

     exon            87..195
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            196..426
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            427..582
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1033
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1439
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1573
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1694
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1870
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2257
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..3183
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3322
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3394
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3675
                     /gene="Nrde2"
                     /gene_synonym="RGD1565082"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtggtggtgcggcctgtgatcatggcgctgttcccggccttcgcgggcgtaagtgaggcctccggtgatggagcatccaggaaagagttagactggctgagcaacccaagctttcgtgttggaaatctcacgtctctgagccgacaaactgaagaggtcccggcccttgcttctgaagcgtcaccactgacaaggagtccgttgaagtcagagctctcagatgagagtgacactaatgagaagctcacacagataagcaagaaaaagaagaaagagaaaaagaagaaaaggaaacaccagcaccacaagaaaaccaagaggagacacgagcagtcgagcagcagtgggtccgggtcagacacagaggctgggaaggacagggcttcccgaagtatcagggatagccaagagtctgagaaagcccgtcaaggaagtaatgctgttcctgctgctcctgctactggacatagctccatttggctggaagatatttacactctgacagacgtcttcaggacagataagaaaccagatcctgccaactgggagtataaatctctgtatcgtggggatatagcaaggtacaagaggaagggagactcctgcctgggtatcaaccctaagaagcagtgtatatcttgggaaggggcttctgcagcaaagaagcactcacacagacacctggagcgctattttaccaagaagaatgtggcattgttacgaactgaggggattgccgtgtgcagtaaccctgagccctcctcctctgagccagccccattcatcccagtgaaggactctgccgatgtggctactcctgttacaacatggctgaatcctctgggcatttatgatcagtctaccacacagtggttacaagggcagggtccagcagagccagagttaaagcagccagactcacagcaggagagggacagtgctgctcttaaggccagagtggaagagtttaacaggagagttcgggaaaaccctcgggacacgcagctatggatggcattcgtggctttccaggatgaagtcatgaggagtcctggcatctatgctcttggggaaggagagcaggagaagcacaggaagtccctgaagctcctcctggagaagaagctggctgtactggagcgggccatcgagagcaacccaagcagcgtggagctgaagctcgccaagttgcagctgtgctcagaattctgggagcctagtgcgctgaccaaggagtggcagaagctcctcttcctgcaccccaacaacacaagcctgtggcagcgctatctctccttttgccagagtcagtttggcaccttttctgtgtccaaactccacagtctatatggcaagtgcttgagtaccttgtctgctgttaaagacggcagcatgttatcccaccctgtgttgccgggcactgaggaggccatgtttgggctctttcttcagcagtgccactttctacggcaggctggccactcggagaaggtcgtctctctgttccaggccatggttgacttcaccttcttcaagcctgacagtgtgaaagagctgcccacaaaagtgcaggtggaattctttgaacccttctgggacagcggagagccccgtgttggggagaagggagcccgaggctggcgggcgtggatgcaccagcaggagcgtggtggctgggtgcttgtcaacccagatgaggatgacgaggagccggaagaagaggaccaagagataaaagacaagaccctgcccaggtggcagatctggcttgctatggaacgttctcgagaccagaggcactggcgtccctggcgccctgataagaccaagaagcaaacggaggaagactgtgaggaccccgagagacaggtgctgtttgatgacgttgggcaatctttgatcagactttccagcccagatcttcagttccagctcattgaggcctttctgcagttcctgggtgtaccttctggcttccttcccccagcctcctgcctttatctggccatggacgagagtagcatctttgagagtaaactttatgatgaaaagcccttgacttacttcaaccctttattttctggcattagctgtgtgggctacatggaacagttggattgtcctcgctggaccaaaggtcacaaccgagagggcgaggagtttgtccgcaatgtcttccacctggtgctgcctctgttctcaggcaagcagaagtgccagctctgcctctcttggttacggtacgagattgccaaggtcatttggtgtctacacactaaaaagaagagattgaagtctcagggaaagaactgcaaaaagctagccaagagtctcctcaaggagccagaaaaccgcaacaacctctgcctctggaggcagtatgcacacctggagtggttgctcggcaacacagaggatgccagaaaggtgttggatgcagccctcagcatggcaggcagcagcgacctgaaggaccgggagctctgtgagctcagtctgctctatgctgagctggaggtagagctgtctcctgactcgagaggagccaccacaggccgtgccgtccacgtactaactcggctgacggagagcagcccctgtgggccctacactgggcaggtctcgtccactcaggttctgaaagcccggaaggcttatgagcatgcgctgcaggactgtctgggacagagctgtgcctccagcccacctactgcagagtcgttggactgcctgggtagcctggtcaaatgcttcatgctcttccagtatttgactgtaggaattgacgctgctgtgcaggtgtacagacaggtgttttccaagctggagggctctgctctcctggaaggcccggggccagaggacagtgccagctcccagagtgtgaccagtgttctcgaggccgtcaccctgatgcacacaagcctgctgcgattccacatgaacatttgtgtgtaccctctggctccactccgagagaccctctcagacgctttaaagctgtatccaggcaaccagggtctttggagggcttacgtgcagattcagaataagtcccacagtgctaacaagaccagaagattctttgacacagtcactaggtctgccaagcatttggagccttggctgtttgcaatcgaagctgagaagctgaggaaaaggctggtggaatctgttcagagggtaggtggcagggaggtccatgctacaatccccgagactggtcttacgcatcggatcagagctttgtttgaaaatgcaatccggagcgaccagggtggccagtgcccgctgctgtggaggatgtatttgaaatttttggtttccttaggaaacaaagaaaggagcaaaggtgtgttctacaaggccctccagagctgtccttgggcaaaggtgctgtacatggacgccgtggagtatttcccagaggagctgcaggagatcctggatgtgatgactgagaaggagctccgtgtgcgcctgcccctcgaggagctggagctgctgctggaggattagactagggctgtgcagcctgcagagcccagagccgcagcctcgcgaggccttcctccatggtctggtggggtttgggtgcatcgctttacatattatatatgtgatctctgtacagacggagatgccagtgataaaccttttgtggttgacatgta

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