2024-11-23 10:04:52, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001401996 5784 bp mRNA linear ROD 24-JUN-2024 DEFINITION Rattus norvegicus mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), transcript variant 2, mRNA. ACCESSION NM_001401996 VERSION NM_001401996.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 5784) AUTHORS Yang,J., Zheng,X.G., Wu,Y.L., Wang,A.P., Wang,C.H., Chen,W.X., Zhong,S. and Yang,H. TITLE Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4 JOURNAL Biomed Pharmacother 149, 112810 (2022) PUBMED 35303564 REMARK GeneRIF: Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4. REFERENCE 2 (bases 1 to 5784) AUTHORS Li,W., Liu,S., Su,S., Chen,Y. and Sun,G. TITLE Construction and validation of a novel prognostic signature of microRNAs in lung adenocarcinoma JOURNAL PeerJ 9, e10470 (2021) PUBMED 33510968 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5784) AUTHORS Chen,S., Tang,Y., Yang,C., Li,K., Huang,X. and Cao,J. TITLE Silencing CDC25A inhibits the proliferation of liver cancer cells by downregulating IL-6 in vitro and in vivo JOURNAL Int J Mol Med 45 (3), 743-752 (2020) PUBMED 31922225 REFERENCE 4 (bases 1 to 5784) AUTHORS Lin,J.C., Lee,Y.C., Tan,T.H., Liang,Y.C., Chuang,H.C., Fann,Y.C., Johnson,K.R. and Lin,Y.J. TITLE RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell JOURNAL Biochim Biophys Acta Mol Cell Res 1865 (2), 259-272 (2018) PUBMED 29138007 REFERENCE 5 (bases 1 to 5784) AUTHORS Gao,X., Chen,G., Gao,C., Zhang,D.H., Kuan,S.F., Stabile,L.P., Liu,G. and Hu,J. TITLE MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance JOURNAL Mol Oncol 11 (6), 628-639 (2017) PUBMED 28306189 REFERENCE 6 (bases 1 to 5784) AUTHORS Bouzakri,K., Ribaux,P. and Halban,P.A. TITLE Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion JOURNAL J Biol Chem 284 (41), 27892-27898 (2009) PUBMED 19690174 REMARK GeneRIF: Results identify MAP4K4 as a key upstream mediator of TNF-alpha action on the beta cell, preventing tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. REFERENCE 7 (bases 1 to 5784) AUTHORS Loh,S.H., Francescut,L., Lingor,P., Bahr,M. and Nicotera,P. TITLE Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen JOURNAL Cell Death Differ 15 (2), 283-298 (2008) PUBMED 18007665 REFERENCE 8 (bases 1 to 5784) AUTHORS Machida,N., Umikawa,M., Takei,K., Sakima,N., Myagmar,B.E., Taira,K., Uezato,H., Ogawa,Y. and Kariya,K. TITLE Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase JOURNAL J Biol Chem 279 (16), 15711-15714 (2004) PUBMED 14966141 REFERENCE 9 (bases 1 to 5784) AUTHORS Yao,Z., Zhou,G., Wang,X.S., Brown,A., Diener,K., Gan,H. and Tan,T.H. TITLE A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway JOURNAL J Biol Chem 274 (4), 2118-2125 (1999) PUBMED 9890973 REFERENCE 10 (bases 1 to 5784) AUTHORS Su,Y.C., Han,J., Xu,S., Cobb,M. and Skolnik,E.Y. TITLE NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain JOURNAL EMBO J 16 (6), 1279-1290 (1997) PUBMED 9135144 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAXUCZ010000009.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA5760393, SAMN12840105 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on computational evidence ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-370 JAXUCZ010000009.1 49696700-49697069 371-436 JAXUCZ010000009.1 49697292-49697357 437-493 JAXUCZ010000009.1 49757176-49757232 494-619 JAXUCZ010000009.1 49769595-49769720 620-730 JAXUCZ010000009.1 49772429-49772539 731-821 JAXUCZ010000009.1 49776143-49776233 822-952 JAXUCZ010000009.1 49778846-49778976 953-1007 JAXUCZ010000009.1 49779626-49779680 1008-1086 JAXUCZ010000009.1 49781456-49781534 1087-1262 JAXUCZ010000009.1 49784543-49784718 1263-1335 JAXUCZ010000009.1 49786963-49787035 1336-1546 JAXUCZ010000009.1 49788129-49788339 1547-1708 JAXUCZ010000009.1 49791732-49791893 1709-1795 JAXUCZ010000009.1 49795070-49795156 1796-1918 JAXUCZ010000009.1 49795805-49795927 1919-2080 JAXUCZ010000009.1 49796679-49796840 2081-2311 JAXUCZ010000009.1 49798980-49799210 2312-2418 JAXUCZ010000009.1 49800019-49800125 2419-2570 JAXUCZ010000009.1 49802206-49802357 2571-2668 JAXUCZ010000009.1 49802939-49803036 2669-2677 JAXUCZ010000009.1 49803841-49803849 2678-2853 JAXUCZ010000009.1 49805130-49805305 2854-2974 JAXUCZ010000009.1 49805939-49806059 2975-3092 JAXUCZ010000009.1 49809457-49809574 3093-3263 JAXUCZ010000009.1 49809881-49810051 3264-3407 JAXUCZ010000009.1 49813188-49813331 3408-3542 JAXUCZ010000009.1 49815656-49815790 3543-3643 JAXUCZ010000009.1 49817167-49817267 3644-3793 JAXUCZ010000009.1 49818759-49818908 3794-3953 JAXUCZ010000009.1 49819432-49819591 3954-4093 JAXUCZ010000009.1 49820323-49820462 4094-5784 JAXUCZ010000009.1 49820663-49822353 FEATURES Location/Qualifiers source 1..5784 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="9" /map="9q22" gene 1..5784 /gene="Map4k4" /note="mitogen-activated protein kinase kinase kinase kinase 4" /db_xref="GeneID:301363" /db_xref="RGD:1305322" exon 1..370 /gene="Map4k4" /inference="alignment:Splign:2.1.0" CDS 314..4177 /gene="Map4k4" /EC_number="2.7.11.1" /note="isoform 2 is encoded by transcript variant 2" /codon_start=1 /product="mitogen-activated protein kinase kinase kinase kinase 4 isoform 2" /protein_id="NP_001388925.1" /db_xref="GeneID:301363" /db_xref="RGD:1305322" /translation="
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEDEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLHDHRRPHAQQPPPPQQQDRSKPSYHAPEPKPHYDPADRAREVEDRFRKTNHSSPEAQAKQTGRGLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEGLSQSSDSKSEVPEPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAAKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCTIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW"
misc_feature 335..1180 /gene="Map4k4" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; Region: Protein Kinases, catalytic domain; cl21453" /db_xref="CDD:473864" misc_feature order(404..415,422..424,428..430,467..469,473..475, 560..562,626..637,770..772,782..787,791..793,821..826) /gene="Map4k4" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270806" misc_feature 3218..4114 /gene="Map4k4" /note="Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2; Region: CNH; smart00036" /db_xref="CDD:214481" exon 371..436 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 437..493 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 494..619 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 620..730 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 731..821 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 822..952 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 953..1007 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1008..1086 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1087..1262 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1263..1335 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1336..1546 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1547..1708 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1709..1795 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1796..1918 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 1919..2080 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2081..2311 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2312..2418 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2419..2570 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2571..2668 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2669..2677 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2678..2853 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2854..2974 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 2975..3092 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3093..3263 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3264..3407 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3408..3542 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3543..3643 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3644..3793 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3794..3953 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 3954..4093 /gene="Map4k4" /inference="alignment:Splign:2.1.0" exon 4094..5784 /gene="Map4k4" /inference="alignment:Splign:2.1.0" ORIGIN
gtttcgcggcctcgcgttcgcttgctcgctcgccgcgctctccggccccagctccgggcggctcgtgcaggcgcgcgcgcgcggggcgccggggcctgaggcggcgggcgacgcccggggggtgggtgggggccgagggagggccgccgcgccatggtgtgagccccgtggcccgcgctcgccgcgctccgctcagaccagacgacacgccgcgccggcggcggcctgcttgtgcggcccgagccccggcgccgccgagcccctgcccgtcgctcgctcgctcgcctgctcttggggcggcgacccggggaagatggcgaacgactctccggctaaaagcttggtggacatcgacctgtcgtccctgcgggaccctgctgggatttttgagctggtggaagtggttggaaatggcacctatggacaagtctataagggtcgacatgttaaaacgggtcagctggcggccatcaaggttatggatgtcaccgaggatgaagaggaagaaatcaaactggagataaatatgctgaagaaatattctcatcatagaaatattgcaacatactatggtgctttcattaagaagagccctccaggacacgatgaccagctctggctcgttatggagttttgcggggctggttccatcacagaccttgtgaagaacaccaaagggaacacgctcaaagaagactggattgcttacatctcccgggaaatcctcagggggttggcccatctccacattcaccatgtcattcaccgagacatcaaggggcagaacgtgctgctgactgagaacgcggaggtgaaacttgttgattttggtgtaagcgctcagctggacaggacggttggacggagaaatacattcataggcacaccatactggatggctccggaggtcatcgcctgcgacgagaatccagatgccacttacgactacagaagtgacctctggtcttgtggcatcacggccatcgagatggcagaaggagccccccctctctgtgacatgcatccaatgagagcgctgtttctcatccccagaaaccctcctcccaggctgaagtcaaaaaaatggtcaaagaaatttttcagcttcatagaaggctgcctggtgaagaattacatgcagcggccctctacagagcagcttttaaaacaccctttcataagggatcagcccaatgaaaggcaggttcgaatccagcttaaggatcacatagaccggaccaggaagaagagaggcgagaaagatgagacggagtacgagtacagtggcagtgaggaggaggaggaggaagtgcctgagcaggagggagagccaagttccatcgtcaatgtgcctggagagtcgactctgcgacgtgatttcctgaggctgcagcaagagaacaaggaacggtctgaggctctgcggagacagcagcttctgcaggagcagcagctccgggagcaggaggagtataagaggcagctgctggctgagaggcagaagcggattgaacagcagaaagaacagaggaggcggctggaagagcaacaaaggagagagcgtgaagccaggaggcagcaggaacgtgagcagcggcggcgagaacaggaggagaagaggcgtctggaggaactggaaaggcggcgtaaggaagaggaagagaggagacgggcagaagacgagaagaggcgagtggagcgggagcaggagtacatcaggcggcagctagaggaagagcagcggcacctggagatcctgcagcagcagctgctccaggagcaggctatgttactgcacgaccacaggaggccacacgcacaacagccgccacccccgcagcagcaggacaggagcaaacccagctatcacgctccagagcccaagcctcactacgaccctgctgacagagctcgggaggtggaagatagatttagaaagactaaccacagctcccctgaggcccaggctaagcagacaggcagaggactggagccacccgtgccttcccggtcagaatctttttccaatggcaactcagagtctgtgcaccctgccctgcagagaccagcggagccacaggtacagtggtcccacctggcatctctcaagaacaatgtctcccctgtctcgagatcccattccttcagtgacccttctcccaaattcgcacaccaccatctccgctctcaggacccatgtccaccttcccgcagtgaggggctcagtcagagctctgactctaagtcggaggtacctgagcccacccaaaaggcttggtctagatcagacagtgacgaggtgcctccaagggttcctgtgagaacgacatctcgttcccctgtcctgtcccgtcgagattctccactgcagggcagtgggcagcaaaatagccaagcaggacagagaaattccaccagcagtattgagccccggcttctatgggagagagtggaaaagctggtccccaggccaggcagtggcagctcttcagggtccagcaactcaggatcccagcctggctcccatcctgggtctcagagtggctctggtgaacgcttcagagtgagatcatcatccaagtctgaaggttctccatctcagcgccttgaaaatgcagccaaaaaacctgaagataagaaagaagtatttcgacctctcaaacctgctggagaagtggacttgactgcgttggccaaagagcttcgagcagtggaagatgtgcggccacctcacaaagtgacagactattcctcctccagtgaggagtctgggaccacggatgaggaggaggaggatgtggaacaggagggggctgatgattccacctcggggccagaggacaccagagcagcgtcgtctctgaatctgagcaacggtgagacagaatctgtgaaaacaatgattgttcatgatgacgtagaaagtgaaccagccatgaccccatccaaggagggcaccctaatcgtccgccagactcagtccgctagtagcacactccagaaacacaaatcttcctcctcctttacaccttttatagaccccaggttactacagatctctccatctagtggaacaacagttacttccgttgtgggattttcctgtgatgggctgagaccagaagccataaggcaagatcctactcggaaaggctcagtggtcaatgtgaaccccacgaacactaggccacagagtgatacccccgagattcgtaaatacaagaagagatttaactcagagatcctgtgtgctgccttatggggagtgaatttgctagttggcacagagagtggcctgatgctcttggacagaagtggccaagggaaagtgtaccctctgatcagccggagacggttccagcaaatggatgtacttgagggcctgaatgtcctggtgacaatatctggcaaaaaggataagttacgcgtctactatttatcctggttaagaaataaaatacttcataatgatccggaagttgagaagaagcaggggtggaccaccgtgggcgacctggaagggtgcgtgcactataaagtcgtaaaatatgaaagaatcaagtttctggtaatcgctttgaagagttctgtggaagtctatgcatgggcaccgaagccatatcacaaatttatggcctttaagtcatttggagaactggtacataagccattactggtggatctcactgtcgaggaaggccagaggttgaaagtgatctatggatcctgtgctggattccatgctgttgatgtggattccggctcagtctatgacatttatctaccaacacacattcagtgtaccatcaaaccccatgcaatcattatcctccccaacacggatggaatggagcttctggtgtgctacgaagatgaaggggtttatgtgaacacgtacggaagaatcaccaaggacgtggttctgcagtggggagagatgccaacatctgtagcatacatccggtcgaatcagacaatgggctggggagagaaggcaatagagatacgctctgtggaaactggtcatttggacggtgtgtttatgcacaaaagggctcagagactaaagttcctgtgtgaacgtaatgacaaggtgttctttgcttccgtccgctctggcggcagcagccaggtctacttcatgaccttaggcaggacttcccttctgagctggtagaggcagtgtgagccgggatcactgacctctggagtcggcaagaccccaagaacttggaattccttgcaactggagctcagagctgtgccggtgcagccatgacagctgtctatgcaggcctcttgtggcgtggcgtgtcgggtcgggtcctctcccctccctcctacactttctgccagtttattcccattctctcctcctcctttctcaaaaaaataaaccaaggctgcattgcagctggtgctgttcagactctaccatcggtgctaggaatgcttggggatgaacacatcagaccgggaagagcgcctttcctacagctccaggattcctcgtctccgagccactgtcccgtgggcgtctgctggttgtgacgattgcgccacccgacgttggcggcaggcacagagaggtgaaaagttggtgtaagaagccgcttgctgaagcagagaacagagttaatatagtaacattaacaatgtatttaattgacatttctctctttttgtaatgtgacagtatgtggacaaagaagaaggtgcaggtctaagaggttaatatttataaaatgtgaaagacacagttactaggataactttttttgtgggtggggcttggggtggggcagggcgggttaaagggtcccattttgtttctttgaaagctttttggagagggttgtcctggccaagaactcagtcatttttctgtgtaccaagttttgcctaaattgtgcagatggttcttaaaaaagaaaggaaaggaaaaggaaatgtgtgcgtcttgttggagggccagaagttttgttgtgtaacagtattagcaaggcctgggctaagggtttaatgtccgttaagcctaaagtgcggcagcagctccaccacggtctgcatgcaccataggaaaggccagctttcctgtgggttctcatttcgtttcgttttgttttttgcctacctcattgttcttaatgcattgagaggtgacttagcttaatggttttggcagaaaacatttaatgtttaatttaaccttaataccaaaactatctgattaaagtttgactgactttgtcacaagtctaatcaggtacaaaaaaaaaaggaaaagaaaagagaaagaaagaaagaaagctgtctatgatggtgggagcagcctcagcactcagacgctctgctctcaccaagttcaccattggagggtgacaggcagcggagtcacctgtcctgacaagagatctcactgttcgcagttacaggctttggaagcaggcaggggtcacactaggagtcacacagactattcattcatgttgcaggaactttttcttgggagcgagggtgtgtcccttttcttaaaaaaaaacaaaaagcaaaaaaaacaaaaaaaaccccgcaatgcactaaaactattttaagaatgtagttactcctacttcttcatagacggcacctccctgcctgtgtttcaggtgtaagactgacgctctggcttttcctgtttctcacgtgctctcttgtttgttctctctctcttttttttaaaaactaatttttctttatgaatatgtctgtgacatttgtaataaatgtcttgtaataatttgc
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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