LOCUS       NM_001401000            2203 bp    mRNA    linear   ROD 01-FEB-2022
DEFINITION  Rattus norvegicus intestine-specific homeobox (Isx), transcript
            variant 1, mRNA.
ACCESSION   NM_001401000 XM_008772332
VERSION     NM_001401000.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Widjaja-Adhi MA, Lobo GP, Golczak M and Von Lintig J.
  TITLE     A genetic dissection of intestinal fat-soluble vitamin and
            carotenoid absorption
  JOURNAL   Hum Mol Genet 24 (11), 3206-3219 (2015)
   PUBMED   25701869
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi
            A, Takahashi Y, Oiso Y, Iwanaga T and Seino S.
  TITLE     Isx participates in the maintenance of vitamin A metabolism by
            regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
  JOURNAL   J Biol Chem 283 (8), 4905-4911 (2008)
   PUBMED   18093975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000303.1.
            
            On Feb 1, 2022 this sequence version replaced XM_008772332.2.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              JACYVU010000303.1  13217637-13218768
            1133-1284           JACYVU010000303.1  13236146-13236297
            1285-1360           JACYVU010000303.1  13238046-13238121
            1361-2203           JACYVU010000303.1  13238912-13239754
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2203
                     /gene="Isx"
                     /note="intestine-specific homeobox"
                     /db_xref="GeneID:682968"
                     /db_xref="RGD:1592776"
     exon            1..1132
                     /gene="Isx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    700..702
                     /gene="Isx"
                     /note="upstream in-frame stop codon"
     CDS             916..1644
                     /gene="Isx"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="intestine-specific homeobox isoform 1"
                     /protein_id="NP_001387929.1"
                     /db_xref="GeneID:682968"
                     /db_xref="RGD:1592776"
                     /translation="

MAGPTIQRDIEKSSGYCEAPEKLGLSFSIEAILKRPTERRNLPRPQSIGGGDSRQTTTSGSKLEKPTQDQPQEERKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGSLSAPQQPGSCTDAHCSAHIGATHRMLPPLSDSARFKLVPCPDSPCPMAPMGPAAPAWPSHPAALCPYLHPPTPKPQVGQHLCNANIRTGFSLPKQATLLPQ"

     misc_feature    order(1150..1164,1168..1170,1219..1221,1237..1239,
                     1276..1278,1282..1287,1294..1299,1303..1311,1315..1320)
                     /gene="Isx"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1156..1158,1165..1167,1285..1287,1294..1299,
                     1306..1308)
                     /gene="Isx"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1159..1317
                     /gene="Isx"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     exon            1133..1284
                     /gene="Isx"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1360
                     /gene="Isx"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2203
                     /gene="Isx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acacatttctttgaacggaattcctggcaagatagagcagtgactgtcagctccgagcctggagtttattggacagggcgtcttcggggctgtctcagagacaggtaaagggcaatcaagcaggaaaaaagtagaaaggaccccaaaagaaggagaaacgggtgactaaagaatttagtatgtgactgaaagttgggaagaggagaacagcataaagaccagtggagaagagtcagaccacaggcctgaggtgaaagcaagcacagacctggcagtgacccagaatcgtccttaacctctgctgaagatctgcagaggtacaggagccctggaagtctgactcttgagactggaagctgaattgaggaagtccagaagggcctctgagaagaggctcagggctcacttggccacgaagaacccataggtggcaccctagcttcccagggactgcctgaggccagcaggaaggggacacgagtcagagagaggacaaaggtggatgctggctccaaatctctaggcagtgatatcatcccaccaactccgctgttttttttttctttctttgttttctggtatccttgagctcaggatctttgcctaggctggtgactgtgaaagcctccacctccaagaagaccctctctggaaaacttgacctgtggagacaggacaagtacccaccagctcttctgctaaaagccactttctaatcttggaggtgttcgaggtccatggaagtccctgtgttcaaggaattgtgccagagtcccccagcatcaggatctccaatcaccacctctgtgtgccctctgggtccccagaaactccagaaagaaaatataccaccttctgctggcatcgccccaggcacacacagagtgttcctcccagcagccttcagatcaggctatggcaggtcctaccatccagagggacatagagaagagttcaggatactgtgaggccccagagaagctgggcctgtctttctccattgaggcaattctgaagagacccacagaaagaagaaatttgcccagaccacaaagcattggtggtggggactccaggcagacaactacctcaggttctaagttggagaagcccacacaggatcagccccaagaggaaagaaagaacaagcggagagttcggactaccttcaccacagagcagctacaggagctggagaagctcttccacttcacccactaccccgacatccatgtccggtcccagctggcttccaggattaacctgcccgaagctcgagtacagatctggttccagaatcagagggccaagtggaggaagcaggagaagagtgggagcctcagtgccccacagcagcctgggtcctgtactgacgcccactgctctgcccacattggtgccacccacagaatgctacctcctctctcagactcagctcgcttcaagctggttccctgcccagattccccttgtcccatggcacccatgggacctgcagcccctgcctggccctctcacccagcagccttgtgtccctaccttcatcctcccacccccaaaccccaagtggggcagcatctgtgcaatgccaacataaggactggtttctctcttcccaagcaagcaactctcctccctcagtgatggccgacagccctggacctcagagaaaatcacttccacagtccatcaatggcccccagctgaggaagctacccagagcttgccattaaagactgtaccagccatggatgacagccaaggacagcacacatctcaccaagtcagtctcctagtgcaaaatcctggctgactaagggctgggatgaagctcagaataagctgctctcttctcacccctcatctataactaagcagccatttctatggacccctttgccccttatttaagagagccttgggaaatacaaggcatggggggagggctgcacattcatgaacccatccgtatactcgttcacaatgtccacactgaacgctgagcactgtgcacttgcaaacagatgttgggctacacaggtcagattctgcccaggttagctgaaaggtgatcctaacctctgcctgcaaatggatgttggtgacattggactcagctagtgtctagcacattcctaatgactttgatatgaaaaaaaaatctcagaatgggagagaaatagaagaaattgttcttaattta

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