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Previous release (v1)
2025-03-04 02:09:26, GGRNA.v2 : RefSeq release 228 (Jan, 2025)
LOCUS NM_001399505 5279 bp mRNA linear ROD 12-NOV-2024
DEFINITION Rattus norvegicus BRF1 general transcription factor IIIB subunit
(Brf1), mRNA.
ACCESSION NM_001399505 XM_006240658
VERSION NM_001399505.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 5279)
AUTHORS Vannini,A.
TITLE A structural perspective on RNA polymerase I and RNA polymerase III
transcription machineries
JOURNAL Biochim Biophys Acta 1829 (3-4), 258-264 (2013)
PUBMED 23031840
REMARK Review article
REFERENCE 2 (bases 1 to 5279)
AUTHORS Patel,D.J. and Wang,Z.
TITLE Readout of epigenetic modifications
JOURNAL Annu Rev Biochem 82, 81-118 (2013)
PUBMED 23642229
REMARK Review article
REFERENCE 3 (bases 1 to 5279)
AUTHORS Dumay-Odelot,H., Durrieu-Gaillard,S., Da Silva,D., Roeder,R.G. and
Teichmann,M.
TITLE Cell growth- and differentiation-dependent regulation of RNA
polymerase III transcription
JOURNAL Cell Cycle 9 (18), 3687-3699 (2010)
PUBMED 20890107
REMARK Review article
REFERENCE 4 (bases 1 to 5279)
AUTHORS Johnson,S.A., Dubeau,L. and Johnson,D.L.
TITLE Enhanced RNA polymerase III-dependent transcription is required for
oncogenic transformation
JOURNAL J Biol Chem 283 (28), 19184-19191 (2008)
PUBMED 18456653
REFERENCE 5 (bases 1 to 5279)
AUTHORS Angelis,E., Garcia,A., Chan,S.S., Schenke-Layland,K., Ren,S.,
Goodfellow,S.J., Jordan,M.C., Roos,K.P., White,R.J. and
MacLellan,W.R.
TITLE A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA
polymerase III after biomechanical stress in adult myocardium
JOURNAL Circ Res 102 (10), 1222-1229 (2008)
PUBMED 18420946
REFERENCE 6 (bases 1 to 5279)
AUTHORS Ernens,I., Goodfellow,S.J., Innes,F., Kenneth,N.S., Derblay,L.E.,
White,R.J. and Scott,P.H.
TITLE Hypoxic stress suppresses RNA polymerase III recruitment and tRNA
gene transcription in cardiomyocytes
JOURNAL Nucleic Acids Res 34 (1), 286-294 (2006)
PUBMED 16407335
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 5279)
AUTHORS Raineri,I., Wegmueller,D., Gross,B., Certa,U. and Moroni,C.
TITLE Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover
studied by RNA interference
JOURNAL Nucleic Acids Res 32 (4), 1279-1288 (2004)
PUBMED 14976220
REMARK Publication Status: Online-Only
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000006.1.
On Jan 10, 2022 this sequence version replaced XM_006240658.4.
##Evidence-Data-START##
Transcript exon combination :: SRR26360186.197867.1,
SRR26360181.2450058.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-263 JAXUCZ010000006.1 137902124-137902386 c
264-344 JAXUCZ010000006.1 137896218-137896298 c
345-518 JAXUCZ010000006.1 137891218-137891391 c
519-550 JAXUCZ010000006.1 137885944-137885975 c
551-623 JAXUCZ010000006.1 137882560-137882632 c
624-773 JAXUCZ010000006.1 137875497-137875646 c
774-867 JAXUCZ010000006.1 137874208-137874301 c
868-994 JAXUCZ010000006.1 137872166-137872292 c
995-1034 JAXUCZ010000006.1 137871544-137871583 c
1035-1127 JAXUCZ010000006.1 137871367-137871459 c
1128-1391 JAXUCZ010000006.1 137867190-137867453 c
1392-1453 JAXUCZ010000006.1 137865841-137865902 c
1454-1535 JAXUCZ010000006.1 137865136-137865217 c
1536-1591 JAXUCZ010000006.1 137865003-137865058 c
1592-1848 JAXUCZ010000006.1 137863986-137864242 c
1849-1900 JAXUCZ010000006.1 137859783-137859834 c
1901-2072 JAXUCZ010000006.1 137859176-137859347 c
2073-5279 JAXUCZ010000006.1 137855449-137858655 c
FEATURES Location/Qualifiers
source 1..5279
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="6"
/map="6q32"
gene 1..5279
/gene="Brf1"
/note="BRF1 general transcription factor IIIB subunit"
/db_xref="GeneID:299347"
/db_xref="RGD:1311158"
exon 1..263
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
misc_feature 14..16
/gene="Brf1"
/note="upstream in-frame stop codon"
CDS 80..2110
/gene="Brf1"
/note="BRF1 homolog, subunit of RNA polymerase III
transcription initiation factor IIIB; BRF1, RNA polymerase
III transcription initiation factor 90 subunit; BRF1, RNA
polymerase III transcription initiation factor subunit"
/codon_start=1
/product="transcription factor IIIB 90 kDa subunit"
/protein_id="NP_001386434.1"
/db_xref="GeneID:299347"
/db_xref="RGD:1311158"
/translation="
MTGRVCRGCGGTDIELDAARGDAVCTGCGSVLEDNIIVSEVQFVENSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGSQLQLNQHCLDTAFNFFKMAVSKHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISTYQDAIEIELENSRPKAKGALANLSKDGSGEDATSSPFCEEDTEDEELEAAASHMNKDFYRELLGADGGSEAAEDADGGSRPLALESLLGPLPTAASLGISDSIRECISSPSGDPKDSSGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQKEKEARIAKEKELGIYKEHKPKKSCKRREPILASTAGEAIEKMLEQKKISSKINYSVLRDLNSKGGGSPPRDDSQPPEHTSTKKLSRRKRAATRNSADPGTSMGKRLRPLVSAQPAKKAAVGEALLLNSPALGAEPVKPSAVLVESGPVSYHPEEDADEEDAEEEDGEPCVSALQMMGGNDYGCDGDEDDGY"
misc_feature 89..217
/gene="Brf1"
/note="TFIIB zinc-binding; Region: TF_Zn_Ribbon;
pfam08271"
/db_xref="CDD:400527"
misc_feature 329..601
/gene="Brf1"
/note="first cyclin box found in transcription factor IIIB
90 kDa subunit (TFIIIB90) and similar proteins; Region:
CYCLIN_TFIIIB90_rpt1; cd20553"
/db_xref="CDD:410256"
misc_feature order(332..334,449..460,560..562,572..574,581..586)
/gene="Brf1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:410256"
misc_feature 614..889
/gene="Brf1"
/note="second cyclin box found in transcription factor
IIIB 90 kDa subunit (TFIIIB90) and similar proteins;
Region: CYCLIN_TFIIIB90_rpt2; cd20554"
/db_xref="CDD:410257"
misc_feature order(743..751,842..847,851..856)
/gene="Brf1"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:410257"
misc_feature 1424..1717
/gene="Brf1"
/note="Brf1-like TBP-binding domain; Region: BRF1;
pfam07741"
/db_xref="CDD:462250"
exon 264..344
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 345..518
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 519..550
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 551..623
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 624..773
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 774..867
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 868..994
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 995..1034
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1035..1127
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1128..1391
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1392..1453
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1454..1535
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1536..1591
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1592..1848
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1849..1900
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 1901..2072
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
exon 2073..5279
/gene="Brf1"
/inference="alignment:Splign:2.1.0"
ORIGIN
gggccttgcgggctgagggccgcgggcggagagcgggttggtgagcggcagggggccggtggggccccgcggctccaacatgacgggccgcgtctgccgcggttgcggcggcacggacatcgagttggatgcggcgcgcggcgacgcggtgtgcacgggctgcggttcggtgctcgaggacaacatcatcgtgtccgaggtgcagttcgtggagaacagcggcggcggctcgtcggcagtcggccagttcgtgtcgctggacggtgcggggaaaaccccaaccctaggcggcggctttcatgtgaacttgggaaaggaatcaagagcacagaccctacagaatgggcggcgccacatccaccacctggggagccagttgcaactgaaccagcactgcctggacacagccttcaacttcttcaagatggctgtaagcaagcatcttacccgaggacggaaaatggcccatgtgattgctgcctgcctctacttggtttgccgaacggaaggcacacctcacatgctcctcgacctcagcgacctgctccaggttaacgtgtatgtgctgggaaagaccttcctgctcttggcgagggagctttgcatcaacgcaccagctatagacccatgcttgtacattccacgatttgcgcatctactggaatttggggagaagaaccatgaggtatccatgacggccctgaggcttctgcagaggatgaaaagggattggatgcacacaggccggcgcccctctggcctctgtggagcagcacttctggttgcagccagaatgcatgacttccggagaaccgtcaaagaagtcatcagcgtggtcaaagtatgtgagtccacattgcggaagaggctcacagaatttgaagacactccaaccagtcagctcactattgacgagtttatgaagattgacctggaggaggagtgtgacccgccctcatacaccgctggacagaggaagctgcgcatgaagcagctggaacaggtcctgtccaaaaagctagaagaagttgaaggtgagatatccacttaccaagatgccattgaaattgagctagaaaacagtcggccaaaggctaaaggggctctcgccaacttgtcaaaggatggctccggtgaggacgccacatccagcccgttctgtgaggaagacactgaggatgaggagctcgaggctgctgccagccacatgaacaaggacttttaccgagagctcctgggggctgatggcggctcggaggcagcagaagacgctgatgggggcagcagacccctcgccctggagtccctgcttggtcccctgcccacagcagccagcctgggtatctcagactccatccgagagtgcatctcctcccccagtggagaccccaaagactcttcaggggatggggagctggacctcagcggcatcgatgaccttgagattgacagatacatcctgaacgagtcagaagcccgggtaaaggctgagttgtggatgcgggagaatgctgagtacctgcgggaacagaaagagaaagaagcaagaatagcgaaggagaaggagcttggcatctataaggagcacaagcccaagaagtcttgcaaacgccgggagccaatcctagccagcacagccggggaggccattgagaagatgctggaacagaagaaaatctccagcaagatcaactacagtgtgctgcgggaccttaacagcaagggtgggggcagcccgcccagggacgactcacagcctccagagcacaccagcaccaagaagctgtcacggaggaaaagagcagctaccaggaacagtgctgatcctgggacaagcatggggaagaggttgaggcctttggtgtctgctcagcccgctaagaaggcagctgtgggagaggccttgctcttaaattcccctgccttgggagctgagcctgtcaagccatcggcagtcttggtggagagtggccctgtgtcataccatcctgaggaggatgcagatgaggaggacgccgaggaagaggatggagagccctgcgtcagtgctctgcagatgatgggaggcaatgattatggctgtgatggtgacgaggatgatggctactgagtggaactcaagaccaggcagcatcccggtgctggactccaagtgtatctgtttataggtgtcagatgggccttgggccacggctcacaggcatgatttctgagactcgaccagtcaagcactgccccacttatttgaagctctcttcccatggccgcactgtggaccattgtacttactattgggaatcatgttttgagcaatgcaagggatattttttgccctgcaagggaaacgagctgtgtgttatgtgtaatgaaacatggtcagagagtagccgggtctggaaccacgtcatgcctcacctactagtcactgtttaccagggatcctcaggcagaccctgtgccctctagtcatagggagattgaagcacaagagcctcagtgtagaagagccctgctctgaacctgctgtttgttctctgccctgtccttgcctgagacgtgtcagtcattgctctatactaggccaccacagtctgcagtctctgcctttaacctcaacaccagcttcctgcgggcaggatgctccccaccattccagtgtccactccctgtcttggaccaccaggagcatcgtaggcctcagcctcctgcctaggactcgtccttgaggcacccagtagcttgttagtcagatttatctgcagcacccagaaagcgaagaccagcagaccatgtgctccatcacttaaaatggacctttcgtactcctgaacagaaccctctgcaaagaagcctgcaagctatctcctggcctcttcatgagagggcccacagagttccctccgttcatttaactccagcctccctggatgcaaccctggatgcagactacttggctttcagatcaagaggtgggggccaggcttggggtgatgagttggggcagctacagatgagggaatgagtcggacaggtaggaagtgatttgatgaaagactgcaagatgctttgggactctatgtcccaaaggggagtgtggaaccatggtcagagcatggaagggaaagtattttaggatgtttttatacagcaagacttgcctgtgtcgtggagagagtacagagtgaagggtgagaagaggaggactgtgacctgctccctagctgtgtgtcttgtctgcccaggaggagagcccagtgctgggaaatgagcaggggccaggaaggctggagtgctcctgtgaggtaattgagttagttgctcactaccgtggatagcaggtagcggataggaaagcaggataggatggctgtagaaagctgaggtggagggcggtggacagtactgagtgaggatgatccctagaagatagggaagtagccaagtcagggtgaggggttgtcttgaaatgtgggtcacatggttggagacccaggtgctgaggaggatggtcccagtagggggcagccgtgaagtgggcaagatgcttctgagctgagctcacagccttgtgtctgagctaccagcagcactagtgtgaggctcaaagaggcactgggtctgtatgaccccgctgtgcttgtaattagtccgtttctatgcgcttttttctgactgggattatcacagcagaatctgcctgcctggggtcttctcagagggtagagcagcagaaccagccctcaccacactggaccttaggaaagggaaggaggggacgagggagtccactggatcctgcattttagactgagaccctgtgtggtatgcacacttgcatgctgagcagacaggatagcacacttcagtctcctctgccttctgtcttcctgccagggagagggaggtccagggacactacatgcaggatgcaccatccaagtttcttgccagccatctaaactgaggaacctaatacttagtggttgccaccatcctctgcaaactgggtgatcactggggaatacagtagcagtcagcaaggttcctgataaacctagacatttgaggcttggcagagtgtgtgcctggctttagaggtaaccaggggatgctttcaggagctggaccacagaatgaggttatagccatgcaaggctgtcaggcactgtttccgctttagctgttcctcctgagcaattgtgcccattgagaagcttctccagccaaccctgggccccggttttctgattcaggtgctctctcctgccatatactacgggtgaagtaagcccttccctatgcctagttagactgcggagaccaaggtttggccatgtccttcgctcagtacctgtcgaggacccaggggacggatacaccttggcagtgggagaggatacatgggatgggtatgggtccagctgggtagatgtttgcctgtttgaagtacctgtcaccacgtttagctagatggcaggtaccctacaagaaactccagagaccaaagaagcagggcctccatgggtgttaatgagggagtagagtagtggggtatgtgcatcttagaatacctgttagacccagcgtttctctctggcctcccttctaagaggtatagaacaggagttaagtaaagaacggggattggaggagactggtgggtaccccctggaggttgcttctgcatgatggataacctgggttctgattgctctcttctcagcagagagcagtagatctctgagtgctcaggtgtgcacgccagacagggtgccagcctagaatgcaggatccaagggtttgagacagtagctggacctgggtctagggtggttttgtgggagtccttccagtctagggagccaagcctgggccagcccctggaaagcctgacttcagtgaagagatgcatcagctcctagaccccactggattgctgcggtcagaacttgctgcaggctaccaccctgcaggcccgcagcccctccacaatccttataagctctgggcctaccccagcatcttatctcagtcagtgtagaggggagtttctgacttcatttgcccaagccttgaggtggaacccaaatcttgggccttttttgggcacagaggaagctttatgattcctggcaccaaacccctgcctggctttccccagcccagccagtttctgtggctgctggggtggatggcaccaaggaagtctgtaccccatgagtgagggtggctgcaccggagtgtggcggcatacatgcagtacaggttagtgttgcata
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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