LOCUS       NM_001398518            1680 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus homeo box C6 (Hoxc6), mRNA.
ACCESSION   NM_001398518 XM_003750415
VERSION     NM_001398518.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1680)
  AUTHORS   Long,X., You,G., Wu,Q., Zhou,Y., Yu,F., Xiao,Y., Deng,S., Song,F.,
            Huang,J. and Tian,M.
  TITLE     Abnormal expression of homeobox c6 in the atherosclerotic aorta and
            its effect on proliferation and migration of rat vascular smooth
            muscle cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (9), 935-943 (2020)
   PUBMED   32785574
  REMARK    GeneRIF: Abnormal expression of homeobox c6 in the atherosclerotic
            aorta and its effect on proliferation and migration of rat vascular
            smooth muscle cells.
REFERENCE   2  (bases 1 to 1680)
  AUTHORS   Hussain,I., Bhan,A., Ansari,K.I., Deb,P., Bobzean,S.A.,
            Perrotti,L.I. and Mandal,S.S.
  TITLE     Bisphenol-A induces expression of HOXC6, an estrogen-regulated
            homeobox-containing gene associated with breast cancer
  JOURNAL   Biochim Biophys Acta 1849 (6), 697-708 (2015)
   PUBMED   25725483
  REMARK    GeneRIF: Our studies demonstrate that HOXC6, which is a critical
            player in mammary gland development, is upregulated in multiple
            cases of breast cancer, and is transcriptionally regulated by E2
            and BPA, in vitro and in vivo.
REFERENCE   3  (bases 1 to 1680)
  AUTHORS   McIntyre,D.C., Rakshit,S., Yallowitz,A.R., Loken,L., Jeannotte,L.,
            Capecchi,M.R. and Wellik,D.M.
  TITLE     Hox patterning of the vertebrate rib cage
  JOURNAL   Development 134 (16), 2981-2989 (2007)
   PUBMED   17626057
REFERENCE   4  (bases 1 to 1680)
  AUTHORS   Iimura,T., Oida,S., Takeda,K., Maruoka,Y. and Sasaki,S.
  TITLE     Changes in homeobox-containing gene expression during ectopic bone
            formation induced by bone morphogenetic protein
  JOURNAL   Biochem Biophys Res Commun 201 (2), 980-987 (1994)
   PUBMED   7911662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 20, 2021 this sequence version replaced XM_003750415.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.28182.1,
                                           SRR26643295.30569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               JAXUCZ010000007.1  136024961-136025487
            528-1680            JAXUCZ010000007.1  136026213-136027365
FEATURES             Location/Qualifiers
     source          1..1680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1680
                     /gene="Hoxc6"
                     /note="homeo box C6"
                     /db_xref="GeneID:252885"
                     /db_xref="RGD:620626"
     exon            1..527
                     /gene="Hoxc6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    47..49
                     /gene="Hoxc6"
                     /note="upstream in-frame stop codon"
     CDS             128..835
                     /gene="Hoxc6"
                     /codon_start=1
                     /product="homeobox protein Hox-C6"
                     /protein_id="NP_001385447.1"
                     /db_xref="GeneID:252885"
                     /db_xref="RGD:620626"
                     /translation="

MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE"

     misc_feature    551..721
                     /gene="Hoxc6"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            528..1680
                     /gene="Hoxc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cagctgactttgtcattttgtctgtcctggattggagccgtccctataaccatctagttccgagtacaaactggagacagaaataaatattaaagaaatcatagcccgaccaggtaaaggcaaagggatgaattcctacttcactaacccttccttatcctgccacctcgccgggggccaggacgtcctccccaacgtcgccctcaattccaccgcctatgatccagtgaggcatttctcgacctatggagcagccgtagctcagaaccggatctactcgactcccttttattcgccacaggagaatgtcgtgttcagttccagccgggggccgtatgactatggatctaattccttttaccaggagaaagacatgctctcaaactgcagacaaaacaccttaggacataacacacagacctcaatcgctcaggattttagttctgagcagggcaggactgcgccccaggaccagaaagccagtatccagatttacccctggatgcagcgaatgaattcgcacagtggggtcggttacggagcggaccggaggcgcggccgccagatctactctcggtaccagaccctggaactggagaaagaatttcacttcaaccgctacctaactcggcgccggcgcatcgagatcgccaatgctctgtgcctgaccgagcgacagatcaaaatctggttccagaaccgccggatgaagtggaaaaaagaatctaatctcacgtccacgctctcagggggtggcggaggggcaactgccgacagcctgggaggaaaagaggaaaagcgagaagagacagaagaagagaaacagaaagagtgaccaggactgcccttgcacccctatctcctcccttgctcatcccagctccccgaatcacacactctgtatttatctctggcacaattgatgtgttgtgacttcctaaaacaaaacagggagtcaaacgtggacctgaaagtcagctctggaccccatccctcactgcacaactcttcactcgcctcttcctctagctccctcgctagttccttcctggcttgtctgcaggcccctttcccttgcctaggcctaggggacctgaacctcgcttcagattccacagatgtccctccaagtgagccctagcctccctccccacctcccgacgcccttcacccccgccctcccgcgcggagagctggctccggggcctggggcctccactccggggcctcagggcccggcctgacagccggagggccggaggcctcaggagggcgcgccttggctccgcaacaacccccagggcctctccccagtccctgaccggcccctctgccccagcacatgcccagaacaggcaaattgtatttaaagattcctgggggtcattatgacatatttcgaactgtgaccgtttctgtgtgaatatttctagctgtatttgtggtctctgtatttatatttatgtttagcaccgtcagtgttccgatctcattttaaaaaaaaggattttaaaaaaagagggaaaataacaaaaaagcgaaaaaagtgaatgacgtttgtttagccagtaggagaaaataaataaaaaaataaacccctacgtgttatcctcctgtataaatccgacctctggatccgttctcgaatatttaataaaactgatattatttttaaaagtt

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