LOCUS       NM_001191771            3584 bp    mRNA    linear   ROD 28-SEP-2022
DEFINITION  Rattus norvegicus prospero homeobox 2 (Prox2), transcript variant
            1, mRNA.
ACCESSION   NM_001191771 XM_234418
VERSION     NM_001191771.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3584)
  AUTHORS   Galeeva A, Treuter E, Tomarev S and Pelto-Huikko M.
  TITLE     A prospero-related homeobox gene Prox-1 is expressed during
            postnatal brain development as well as in the adult rodent brain
  JOURNAL   Neuroscience 146 (2), 604-616 (2007)
   PUBMED   17368742
  REMARK    GeneRIF: The prominent but limited distribution of Prox-1 in the
            brain suggests its potentially important role during postnatal
            brain development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000166.1.
            
            On Sep 28, 2022 this sequence version replaced NM_001191771.1.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JACYVU010000166.1  4757940-4758084     c
            146-845             JACYVU010000166.1  4752847-4753546     c
            846-2313            JACYVU010000166.1  4740266-4741733     c
            2314-2421           JACYVU010000166.1  4734889-4734996     c
            2422-2616           JACYVU010000166.1  4733086-4733280     c
            2617-2818           JACYVU010000166.1  4732477-4732678     c
            2819-3584           JACYVU010000166.1  4730850-4731615     c
FEATURES             Location/Qualifiers
     source          1..3584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3584
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /note="prospero homeobox 2"
                     /db_xref="GeneID:314319"
                     /db_xref="RGD:1310315"
     exon            1..145
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     exon            146..845
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    772..774
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /note="upstream in-frame stop codon"
     exon            846..2313
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     CDS             1021..2802
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /codon_start=1
                     /product="prospero homeobox protein 2"
                     /protein_id="NP_001178700.1"
                     /db_xref="GeneID:314319"
                     /db_xref="RGD:1310315"
                     /translation="

MDPPAVLLSPQSQTCTHLAETCMGQERSPPTAEVGSDSFFPSGQLPSSSLTDADWFWDEHIQAKRARVETIVRGMCLSPSSLVSGRARESSRCPEKVRERKRKQSLPMHQGPLKSSPAWDRGPKKGGTRVKEQLHLLKQQLRHLQEHVLQATEPRAPAQSPGGTESRSSLGAKARNTFPYSAWAVESKPHQSSSKDIGGAVKPGAAEVLQQSEEPVFCPSGPRALVETLRKELSRAVSQAVDSVLQQVLLDPQSLLPRQDGSCQGLASEGRSQPSPPGRSAYKDPLALATLPRKVQPQAGVPLGNSTLARPLDSPICPVSPRGVPRSYQSPLSNCPLTTVPSHIWENQILSQLLGRGPDGHWSGSPSQDASHQSHTSPESAQQPWGLSQQRLPLSFTPVHLESRPLLPAAVKMEQSALQGVADSLPFSSVHIQEGLSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKYARQAVSDGVTNAQALAVLRDSELFRVLNTHYNKGNDFEVPECFLQIATLTLQEFFRAVSTGKDSDPSWKKPIYKIISKLDSDIPEILKSSSYSQGLFPS"

     misc_feature    2323..2778
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /note="Homeo-prospero domain; Region: HPD; pfam05044"
                     /db_xref="CDD:428277"
     exon            2314..2421
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2616
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2818
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..3584
                     /gene="Prox2"
                     /gene_synonym="RGD1310315"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaggccggccgcagcaccagccaagcagcgaggggtgttcggagtgaaccactaaccgtgttgggtggcgggtggtgagccgggctagtatcattagcggtcccagcgctggggaatctgtggctctaagagcgggctagcttggggtgaagtggagaagacggaaaattctggggtgatggtctgggtgtaggccagttctcctcagctctatcagacataggcctatcagcaagcatccagtatcctctactgctggggcaggcctcacggactgttcttcctgagatctgaggagattttggtgcaagatagaattcagacccctgagattgctggaggggtctgaagaaaggtgatcactttggaggcgtctcacaacggaacttggaggcagaggtcaggagctgacagagcagtgggggaagctgagcaatcccggctccaaaccttcaaagggctctgaaaattcttagcaaggacagggaagatggcatcttgagaaaccctctgagctgggctttcagagaacctgatttgccacggagggaggtgggaaatgacaggggtcagccaaccagcttgggggctccaatttgcatattcataagccccccttgctggttggctgtgcttagcagcccactgggccccagtagggttgggtctgtcagatagtgacttgtattgagaagagacaggaggctcccctcacccagccacagcacctggctgacttggggagggagaaaggaaaccaaaatcacttcctgaccctcgctctgtttgcccaaggctggtgaagacactaatggagaacagacctccctgagaacttcttctcagagtctgaccgagagagtcctttggcctggccctcttgaatcccagaagcagctgattctcacccttctgtgtgtgaagaagacccttcagcatggtctagcccacctcccgctgctcgatttagcagggctctcctttctgggagctctccacaggcacccggagaggcaggtcatggatccacctgctgtcttgctttctcctcagtctcagacctgcacccacctggcagaaacatgcatgggacaggagaggagcccacccaccgcagaagtgggcagtgactccttctttcccagtggtcagttgcccagctccagcctcactgatgccgattggttttgggatgaacacatccaggcaaagagggccagagtagagaccattgtccgaggcatgtgtctctctccgagttcgttggtgtcaggcagagccagggagagctcacgctgtccagaaaaggtccgggagaggaagagaaagcagagtcttccaatgcaccaaggtcccctgaaatctagccctgcctgggatcgagggcccaagaagggggggacccgggtgaaagaacagcttcatctactgaagcaacagctaagacatttgcaggagcatgtcctacaggccactgagcccagagcaccagcacagagcccaggaggtactgagtcaagaagctctctgggagccaaggcgaggaacaccttcccatatagcgcctgggccgtggagagcaaacctcaccagagttctagcaaggacattggtggagcagtcaagcccggagccgctgaagttctacagcagtcagaggagcctgtgttctgtccttccggcccacgggctctagtggagactctgaggaaagaactcagcagggctgtatcccaggctgtggactcagtattacaacaggtgctacttgacccacagagcctgctcccgcggcaggacgggagctgccaggggctggcatcagagggcagaagccagccttcacctccagggagaagtgcctataaggacccacttgctcttgccaccctgcccaggaaggtccagccacaagccggggttcccttgggcaattcaacactggctaggcctctagattctcctatatgtcctgtctctccaagaggagttcccagatcatatcagagtcccctatcaaattgtcccttgacaactgtaccttcccacatctgggaaaaccagattcttagccagcttctgggtcgtgggcctgatggccattggagtggcagtccttcccaggatgcatctcaccaaagtcatacctccccagagtctgcccagcaaccctgggggttgagccagcagcgcctccccctgtctttcacccctgtgcacctggaaagccgtcctctcctgccggcggcggtgaagatggagcagagcgcgctgcagggcgtggccgactcacttcctttctcttccgtccacatccaggaaggcctgagccctggtcacctgaagaaggccaagctaatgtttttcttcacgcggtatcccagctccagcctcctgaaagcttacttccctgatgttcagttcaatcgatgcatcacctcccagatgatcaagtggtttagcaatttccgtgagttttactacatccagatggagaagtatgcccggcaagcggtttcagacggtgtcacgaatgcccaagcgctagcagtcctccgagactcagagctttttcgagttctcaatacacactataacaaagggaatgactttgaggtcccagaatgcttcttgcaaattgccaccttgacattacaggagttcttcagggctgtctccacagggaaagattcagatccttcctggaagaaacccatttacaaaattatttcaaaactggacagtgacatcccggagatactcaaatcttccagctattcccaaggactgtttccaagttaagatccaacaaaatgagggaaaatccataccaacaggacacccacagagtggcactgccattcgaccaggtttgcactctggagtgcgtcaccatccaccgctgttgcttgcatctgtctgctggcacactgtgtcagctgacagttctacatcctacttgacctatgtgctgatgccccaactgcctatacgcacaaaatatatataaataaaaatggaacttcatgatgaggaggccagaaggggccctggagaccatctgatccaccttgtgtaacctgtggaggaaacaggctagcatacactttgtagggcctcacattccatgaatggcagggctgggacaaaggcaaaaatggagattttcctactttgaaatgattacagtctatgattgaactcgcacggatgagcaaatgacattcatattccccccatgggtccgacacaattgtgacagactctgagcaccaggcaaggcacacataaactggaacaactgtgtcttccagtcagaaccaagccggtaacactgctggaggagagcaggatggagtagccttcaggattcccagtgctaagtgagtgcaactgtgcctgcaatagctcccctccctgccctcagcccagaacgattttcacatcgagctcctctgccttcaggacttgatgggtcgtggctgtggctactgctagatatgtcagactacaccaatatgaacaaggcctttcctctgaatcttctgttcaaatagtggagagaagaaacaacacatacttaa

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