LOCUS       NM_001134983            2908 bp    mRNA    linear   ROD 14-JUL-2024
DEFINITION  Rattus norvegicus TGFB-induced factor homeobox 2 (Tgif2), mRNA.
ACCESSION   NM_001134983 XM_001067005 XM_575274
VERSION     NM_001134983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2908)
  AUTHORS   Icardi,L., Mori,R., Gesellchen,V., Eyckerman,S., De Cauwer,L.,
            Verhelst,J., Vercauteren,K., Saelens,X., Meuleman,P.,
            Leroux-Roels,G., De Bosscher,K., Boutros,M. and Tavernier,J.
  TITLE     The Sin3a repressor complex is a master regulator of STAT
            transcriptional activity
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12058-12063 (2012)
   PUBMED   22783022
REFERENCE   2  (bases 1 to 2908)
  AUTHORS   Powers,S.E., Taniguchi,K., Yen,W., Melhuish,T.A., Shen,J.,
            Walsh,C.A., Sutherland,A.E. and Wotton,D.
  TITLE     Tgif1 and Tgif2 regulate Nodal signaling and are required for
            gastrulation
  JOURNAL   Development 137 (2), 249-259 (2010)
   PUBMED   20040491
REFERENCE   3  (bases 1 to 2908)
  AUTHORS   Satoh,S. and Watanabe,S.
  TITLE     TGIF, a homeodomain transcription factor, regulates retinal
            progenitor cell differentiation
  JOURNAL   Exp Eye Res 87 (6), 571-579 (2008)
   PUBMED   18926818
REFERENCE   4  (bases 1 to 2908)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168719.1.
            
            On or before Sep 16, 2008 this sequence version replaced
            XM_575274.2, XM_001067005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168719.1, FQ235168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132295
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2908
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="TGFB-induced factor homeobox 2"
                     /db_xref="GeneID:499929"
                     /db_xref="RGD:1560115"
     exon            1..184
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..410
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    204..206
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="upstream in-frame stop codon"
     CDS             219..932
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="TGFB-induced factor homeobox 2-like 1"
                     /codon_start=1
                     /product="homeobox protein TGIF2"
                     /protein_id="NP_001128455.1"
                     /db_xref="GeneID:499929"
                     /db_xref="RGD:1560115"
                     /translation="

MSDSDLGEDEGLLSLTGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSLLAVSVPAPTNMLSLSVCSMPLHSGQGEKPAASFPQVELESPKALVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKDDFSSFQLLVEVALQRAAEMELQKQQDPAPPLLHTPLPLVSENAK"

     misc_feature    order(273..287,291..293,351..353,369..371,408..410,
                     414..419,426..431,435..443)
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(279..281,288..290,417..419,426..431,438..440)
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    327..443
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            411..2885
                     /gene="Tgif2"
                     /gene_synonym="RGD1560115; RGD1564927; Tgif2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaggcgggcgcgatgggaggagaggggatctgacgtcaggtcgcgaggtgctttccagccgcgagctgtcaggcgggtgtcagacccggcaggtacccggcgcgttccccctgcgcccccccgtcccggcccggtcgtccctcaccccacagaggccgcgtgggccggaaagccgccggggaaggctgcccagaggtccagcttagtccccaagcaccatgtcggacagcgatctaggcgaggatgaaggtcttctgtcactgactggcaagaggaagcgcagggggaacctgcccaaggagtcagtaaagattctccgagactggctgtatctgcaccgctacaacgcctacccctctgagcaggagaagctaagcctctctggacagaccaacctctccgtgctgcagatatgtaactggttcatcaatgcccgccgccgccttctccctgacatgcttcggaaggatggcaaagaccctaatcagttcaccatctcccggcgcgggggtaaggcctcagatgtggctctccccaggggcagcagcccctctctgctggctgtgtctgttccagcccccaccaacatgctctccttgtctgtgtgttccatgccactccactcaggccaaggtgaaaagccagcagcgtccttcccacaagtggagctggagtcccccaaggccctggtgacccctgggagcacactcaccctgctgactagggcagaggctggaagccccacaggtggactcttcaatacgccaccacccacacccccagagcaggacaaggacgacttcagcagcttccagttgctggtggaggtggcgctgcagagggctgctgagatggagcttcagaagcagcaagatccagcgccacccttactacacactccgctccctctagtctcagaaaatgccaagtaggcactgctcccaggcggcttgaggtccaggccagctgtcccaggtttctggttcacttccctttcatacagagggttatctatgtacggatcactgccgagcatcaggatcatctgtccagcgggcctcagcagaaagaggccactgatgtcgctgcactgcaccggtaacagggcctgtactctgctgagtgccattccttcaagcgtcctctccgaggagaccaaggcaccagagccaggtgtggtgctgctgctgctgcttctccagagagccctgggacacctgcactccagcctgctttctgacgcaggctcaggaaacctgccaagttcagacttgagctgggtccaagccgcccctaagctgtgcctcttggtcgagccaggtgcacacattccagcctattcaaaggacaaaggaaaatgcccagcagatgtcacagaaccgactccagttgaatgtttagatttttgctaaattgttttattttccttttgctgtggtttgtgttaatggcagtaggtagcccagaagcacaggtgtggggagagagcaccttacgtgatggatggggcttgatgaatggggtaatctacggctgctcaggatgactgtataagggaccagcagattctctatagtgctgaattcagactatggtgattgtttaagtcttggtttggtttaccctgttataaaagacagaaggaaaatatccacaggtggtggattatttgcaccagacacaggcggggaataaagccacaaccaagtccaagcaaaccagacagccatttagacacagcagagacagatgataaagtcagagacacacttgtttctattgtagtttggggtggttaagctagactgaaacagttttgtttttctctctgttctgggtagcttgtttcagacttattccagcgtctcctgcttggggaagagtgagccatctgctggtcaggaggcccttcagacatgccgcttgttccttacctaggcagttggagccttcctagaggagaggctagtgcggctacagcctggcccagccgcctgggagctgtgtctgttcacctcccttcaagttgggattgcaaggggcctgcctagatttcccgggaaacagaccacacttggtcttaatcttccttccccctgtttactttgcttagttttcagcagcactgtaccccatctttatatatcctaagaaacactaaccctaggtttttattaatcaaaatatttgtgttctgaataaccagaagatgtgaggagccctgactgtaatttcctggggtctaccaggttgtgcgcacagatggggctcttggatgttgactgacttggagtgcctgtcccagaggaaggcagaagaccactcgctctggcctttctgggagcccctgatgtttaccaggcttccatacctctcctgagtggctgtgccccattcgttgctgtgcaagtggaatgggagatttgctgtttgtagggactgctctcctaggctgtctcgtgcccccctctggcttcctgtactgcaggagacccagcaacctcacctgtgacctggaggcactcctgggaagggcatggtgggttcactgagtttggtttgcccacttctaccccacctgtctgagagctcccatggctgtgtaggatgctccagtaggggtgatactaggatgagggattttccccccacagtgcactgagcagggggaggagggaaggagccatgctgctgacatattctggcaccccctcctggagtgaaacggcgtctgcagggtagagcagtctctgcttgtaagataaatctggagaagcgcagttgtcccattgaacaatatttgagcaaaaaaactactgtaaataactggtttttgtcttttgtcaaataaaattgttttggttttgtttatgtttaaagtcaaaaaaaaaaaaaaaaaaaaaaaaaa

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