LOCUS       NM_001127373            4263 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ADNP homeobox 2 (Adnp2), mRNA.
ACCESSION   NM_001127373 XM_001057780 XM_225732
VERSION     NM_001127373.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4263)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166606.1.
            
            On or before May 17, 2008 this sequence version replaced
            XM_225732.4, XM_001057780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166606.1, DN936322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..4263
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox 2"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
     exon            1..262
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="upstream in-frame stop codon"
     exon            263..383
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..3686
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="ADNP homeobox protein 2"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /protein_id="NP_001120845.1"
                     /db_xref="GeneID:307236"
                     /db_xref="RGD:1308279"
                     /translation="

MFQIPVQNLDNIRKVRKRVKGILVDIGLDSCKELLKDLKGFDPGEKYFCNTSWGDVSLWEPSGKRAKYRTKPYCCSLCRYSTKVLTSLKNHLHRYHEEEADQELMIPCPNCPFASQPKVVGKHFRMFHAPARKVQSYTVNILGEAKTSRSDVISFTCLKCNFSNTLYYSMKKHVLVAHFNYLINSYFGLRTEETGEQPKASDPVSVDKALPFDKYYCKKCSAIASSQDALMYHILTSDAHRDLENKLRSVISEHIKRTGFLKQMHIAPKPVTHIALPPNSSAPSIAAPPPCFQLALPQNSQSPGTVQSVTVAPGTSGSLTHSPPTTAQSHVALVSSSLPVCQSSLTLQQSAPPPVFLSHSVPLSQPVSTSVLPLTQPLGPVNKSVGTSLLPVNQAMCSVNQAVRPGVLPLPKPMGPINRPVGPGVLPVGPSVNSGVLQATSPGVISVGRAVPSGVLPAGQVTPAGVIPGQTATSGVLPTGQVVQSSVLPVGQTAPSRVLPPGQTVPLRVLPAGQVVPPGLLSPNQTVPSGVVPVNQGVNSGVLQLSQPVTPGVLPVGPPVRPGVLQLSPSVSTSILPVSQPVRAGTSQNTTFLTSGSILRQLIPTGKQVNGIPTYTLAPVSVTLPVPSAGGLAAVGPPPQVPVQFLPSSSGTQMGSSLPSLPSPQVLVSPAPSVFVQATPPVADANQALRQAKQWKTCPVCNELFPANVYQVHMEVAHTQSEAKSSEKPEPERLAACAPFLKWMREKTVRCLSCKCLVSQEELMHHLLMHGLGCLFCPCTFHDVRGLVEHSRTKHLGKKRLSMDYSNRGFQLDLDANGNLLFPHLDFITILPREKLGEREVYLAILAGIHSKSLVPVYVKVRPQPEVAPKIPNRQKLTCPFCFGTFMAADAYELHLKERHHVMPTVHTMLRSPAFKCIHCCGVYTGNMTLGAIAVHLLRCRSAPKDSSSDLQAQPDFIESSELLMVNGEVIPESTFPLKRKLPEGHLGPEEQGDGDEPQLTVDTDASPGSEKGLSAVPLKRQKNESRTEGSGASDDSLQVLALDPSKYGSRSYEEKKQFLRDYFHKRPYPSRKEVELLSSLLWVWKIDVASFFGKRRYICMKAIKSHKPSVLLGFDMSELKNVKHRLNFECESENL"

     misc_feature    276..3269
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    3408..3569
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(3414..3425,3429..3431,3480..3482,3498..3500,
                     3537..3539,3543..3548,3555..3560,3564..3572,3576..3581)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(3417..3419,3426..3428,3546..3548,3555..3560,
                     3567..3569)
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            384..473
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
     exon            474..4252
                     /gene="Adnp2"
                     /gene_synonym="RGD1308279"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcgaggcccgcggggtccaggggcctggaggggcccgtgagatgagcccagggggtccccaggcacactctacacccattggctggcctcgtcggcatgcaaataaggcaacgtcacttcctgaggcagctgagcgccatcttctctttctggcgcgcgggaggagggacgggcgcggggcgggggtcccgccgcgtaggcggaggacgcggcggtgttgcgacggcggcgggacgcggcgctcctcgcgccccgtggtaggaaaatatcaaaaatgtttcaaattcctgtgcagaatcttgacaacatcagaaaggtgcggaagagggtgaaaggcatccttgtggacattggacttgacagctgcaaggagctgctgaaggatcttaaaggctttgatccgggagagaagtacttttgtaatacatcgtggggagatgtttctctttgggaaccttctggaaagagagcgaaatacagaacaaagccctactgctgtagtctctgcaggtactcaacgaaggtgctcacctccctcaaaaatcacctgcaccgataccacgaagaggaggctgaccaggagctcatgatcccctgccccaactgcccgtttgcctctcagcccaaggttgtgggcaagcacttcagaatgttccacgcgcctgcgcggaaagtccagagctacacagtgaacatcctgggtgaggcgaagacttcaaggagtgatgtgataagcttcacatgtttaaaatgtaacttttcaaacactctgtactacagcatgaagaagcatgtgctggtggcccattttaattacttaattaactcctactttggattgcgaactgaggaaacaggagaacaaccgaaagcaagtgatccagtttctgtggataaagccctgccatttgacaagtactactgtaaaaaatgcagcgccatcgccagtagtcaggatgccctgatgtatcacattctgacatcagatgcacatagggacttggagaataagctgaggtctgttatctcagagcacatcaagaggaccgggtttctgaagcaaatgcatattgctccaaagccagtgacccacatagctttaccgccaaacagcagtgctccgagcattgcagcccctcctccttgcttccagcttgctttgccacagaacagtcaaagtcccggcactgtgcagtcagtgactgtggccccaggcacttctgggagccttacacactcaccacctaccacggcccagtctcatgtagctctggtctccagctctttgcctgtgtgccagagtagcctcaccctgcagcagtccgctcccccacctgtctttctctctcacagtgtcccactgagtcagcccgtcagtacttctgtgctgcctctcactcagccacttgggcctgtgaataagtctgttggaacaagcctcctccctgtgaaccaagccatgtgctccgtgaaccaagctgtccgccctggagttttacccctccctaagcccatggggcccataaacagacctgtgggccctggtgtcttgcctgtgggtccctctgttaactcaggggttctccaggctacatctcctggggtgatttctgtaggtcgagcagttccatcaggagtccttcctgcaggtcaggtgacccctgctggtgtgatccctgggcagacagccacttccggggtcttacccactggccaggtggtccagtcgtcagttctccctgttggccagacagcgccatctcgagttctccctcctggccagacagtgcccttgagggttctccctgcaggccaggtggtaccgcctgggctgctttctccaaaccaaactgtcccctcgggagttgtccctgtgaatcaaggtgtgaactctggtgttcttcagctcagtcagccagtaacaccaggagtccttcctgtgggcccacccgtgaggcctggtgttctgcagctcagtccgtctgtcagcaccagcatcctgcccgtgagccagccggtgagagctggaacgtcccaaaacactactttccttacttcaggttctattctcagacagctcattccaactgggaaacaggtgaatggaatccccacctatacgctggccccagtgtccgtcactctgccggtgccctccgctggaggccttgcagctgttggaccgccaccccaggtgccagtgcagttcctgccctcaagctcgggcacacagatgggcagctccttgcccagcctgccctcgccacaggtgctagtgagccctgcccctagcgtgtttgttcaggctaccccgcctgtggcagatgcaaatcaggcactcagacaggccaagcagtggaaaacatgcccagtttgcaacgagctcttccctgccaacgtctaccaggtccacatggaagtggctcacacgcagagcgaggccaagtccagtgagaagcctgagcccgaaaggcttgctgcatgcgccccatttctgaagtggatgagagagaagacagtgcgctgcctctcttgtaagtgcctggtctcgcaggaggagctgatgcaccatttgctcatgcatggcctggggtgcctgttctgtccatgcacttttcatgatgtccggggccttgtggagcacagcaggactaagcacctgggcaagaagagactgtctatggattacagtaacagaggtttccagctggacttggatgctaatgggaacctgctgttccctcatctcgatttcatcaccatactgccacgagagaaacttggagagcgagaagtgtacctggctatccttgctggaatacactccaagtcgttggtccctgtgtacgttaaggtgaggcctcagcctgaggttgcaccaaagatacctaacagacagaagctgacctgcccgttctgttttggcacattcatggctgctgatgcctacgagctgcatctgaaggagaggcaccatgtcatgcccacagtccatacaatgctccggtctccggcctttaagtgcatccactgttgtggggtctacactggaaacatgaccttaggagccatcgctgtccatttgctccgttgtagaagtgctccaaaggacagcagctcagacctgcaagcccagccagattttatcgagagcagtgaactgctgatggtcaatggggaagtgatccccgagtccacctttcctctgaagagaaagctgccagaaggccatttagggccagaagagcagggggacggggacgagccccagctcacagtagacaccgatgcgagcccaggttcagagaaagggctgagtgctgtgcctttgaagagacagaagaatgagagcaggacagaggggtcaggggccagtgatgactccctgcaggtgttggcgttagaccccagtaagtatggaagtcgttcctatgaggaaaagaaacagttcctcagagactattttcacaagagaccatatcctagtcgaaaagaagtggaactactgtcctcgctcttgtgggtgtggaaaatcgacgtggcctcgttctttgggaaaaggaggtatatctgcatgaaagcaataaaatcccacaagccctctgtacttctgggttttgatatgtctgagcttaagaatgtcaaacacaggctgaactttgagtgtgagtcagaaaacctgtaggagagtaagtctgaagtctcctgacttccagcccttcccacctctcgctctgttgtaagtgtccgaggcccttcaaggtgtcccaggtgctcagaaagcctgaaaaggaagcacacactgccacagaggagctgttctccgcagtttgcgttgcggctgtctgttttccttctgtcatgtaaattaaatctttggtattccatgcacgccttgtttccccacgagtgtcagtgtcaatagcaacaacctggagtctgcagatacttggtttttcattttagagaatttctgcttgtttgagaaacttgattaatagaaaattgaagcgttgctccctcttagttcctagctgcagctagtgacagtgtgtgtttagagaagcaagcactctgatgtgtatgactccctaaggacatacttttaagcattaacttctgctgattctgtgaccgacgtttgcttaaggctacaaatttgatttacaccttttcaagtgtcccctgacagctatttttttaatatcattattcattaaaaaaatcccagatgttttccatttattaaaaaaaaaaaaaaa

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