LOCUS       NM_001109455            1881 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NK6 homeobox 3 (Nkx6-3), mRNA.
ACCESSION   NM_001109455 XM_001062306
VERSION     NM_001109455.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S,
            Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A,
            Ginno PA, Domcke S, Yan J, Schubeler D, Vinson C and Taipale J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Yoon JH, Choi WS, Kim O, Choi SS, Lee EK, Nam SW, Lee JY and Park
            WS.
  TITLE     NKX6.3 controls gastric differentiation and tumorigenesis
  JOURNAL   Oncotarget 6 (29), 28425-28439 (2015)
   PUBMED   26314965
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB and Shivdasani
            RA.
  TITLE     Requirement of the tissue-restricted homeodomain transcription
            factor Nkx6.3 in differentiation of gastrin-producing G cells in
            the stomach antrum
  JOURNAL   Mol Cell Biol 28 (10), 3208-3218 (2008)
   PUBMED   18347062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001062306.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840120,
                              SAMN13663610 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1881
                     /gene="Nkx6-3"
                     /note="NK6 homeobox 3"
                     /db_xref="GeneID:685102"
                     /db_xref="RGD:1597780"
     exon            1..696
                     /gene="Nkx6-3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    279..281
                     /gene="Nkx6-3"
                     /note="upstream in-frame stop codon"
     CDS             312..1100
                     /gene="Nkx6-3"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.3"
                     /protein_id="NP_001102925.1"
                     /db_xref="GeneID:685102"
                     /db_xref="RGD:1597780"
                     /translation="

MESNLQGTFLLNNTQLAQFSEMKAPMCQYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVATPNSSLLSGYPHVAGFGGLSSQGVYYGPQVGSFSKTGNEYPTRTRNCWADTGQDWRGSTRPCSNTPDPLSDTIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAPGGASGDRAASENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSLGAHSV"

     misc_feature    726..902
                     /gene="Nkx6-3"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            697..866
                     /gene="Nkx6-3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1881
                     /gene="Nkx6-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

taaaacttctgatggagggcccccagactcagaggcagagaaaccgggtgctctgattatggagagcacccctccttaggcccagtaggcagagagggaacgcgcggaaggcctcccaccttctctggacacctgactttccagaaggctgacgtaggtgccccatctctaaggaagggcctagccagagggcagtcggaggctcggggtgggatggggggttctgattctccaaatctgccatgagattctgggccaccatttatagtgctggcctttaagggctcctcgacctcactgacctgaagaccatggagtccaacctgcaggggaccttcctcctgaacaacacacagctggcccagttctccgaaatgaaggctcccatgtgccagtactcggtgcagaactccttctacaagctcagccctccgggacttggcccccagctggcggctgggacaccccacggaatcactgacatcctgagcaggccggtggccactccgaacagcagccttctctccggctacccccacgtggcaggctttggtggactcagctcccagggcgtctactacggcccccaggtggggagtttttccaagactgggaacgagtaccccacccggacccggaactgctgggcagacacaggccaggactggagaggtagcactcggccatgcagcaacaccccagaccccctgagtgacactatccacaagaaaaagcacacccgccctaccttcacaggccaccagatctttgctctggagaaaacctttgagcagaccaagtacttggctggccccgagcgggcgaggctggcttattcactgggcatgacagagtcacaggtcaaggtgtggttccagaaccgccgaaccaagtggaggaagaagagcgctttggagccctcgtcctccacgccccgggccccgggcggtgcgagcggggaccgcgcggcctcggagaacgaggatgatgagtacaacaagcccctggacccagactcggacgacgagaagattcgcctgctgctgcgcaagcaccgggccgccttctccgtgctcagcctgggcgcgcacagcgtgtgacgccgggcctgcggcgcggaccagccttcccctcccctttccgtgcagcccgctgtgggcagggaccagagaagaggagttccggggggagggggtggaaaagaggaaggaagtggaaagaggaggaggaagcgagagggaaggaagggaaggaggagaggaatggcgagtgccccgagagaggagacggcgcatctctctgccattcctccctctgggccccttgcccagtcggccctgctcagcagggaacctggctatggaactctccagatcccctaaggaccagcagattagggagtcacacaaggcactgcgcccagtcgtaggctgggactgcaaagcaaaaggtggaggccgaggtccaggtgtgcttcccagtgatcccactgctggggacaggaggaaatccacctctgcgaggggagcgggtcctgaaaacagcaattcttcaaaccccgagtttcaggaccctgggacccccaactgcactttactgtcaacgcagatcccgctgtatcaaggaagactctgggaaagggaggaggggaagccaggcagagggaaaacaggtacccaccaaggcatcgcggggcacctaagcacaccagagtttgggagcacctcagcaggatggagagaaagtctctgaacgccacactccaccagtaggagcaccagactgagagaacttcaggcaggacaggggggctgggagtgctgttgggcacccaggcttttaaaaccaaactagaataaagatgaaaatcccagaaacctc

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