LOCUS       NM_001109166            2000 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus T-cell leukemia, homeobox 1 (Tlx1), mRNA.
ACCESSION   NM_001109166 XM_001057997 XM_574674
VERSION     NM_001109166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F,
            Cleary ML and Selleri L.
  TITLE     A Pbx1-dependent genetic and transcriptional network regulates
            spleen ontogeny
  JOURNAL   Development 132 (13), 3113-3126 (2005)
   PUBMED   15944191
  REMARK    Erratum:[Development. 2005 Aug;132(15):3575]
REFERENCE   2  (bases 1 to 2000)
  AUTHORS   Qian Y, Shirasawa S, Chen CL, Cheng L and Ma Q.
  TITLE     Proper development of relay somatic sensory neurons and D2/D4
            interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
  JOURNAL   Genes Dev 16 (10), 1220-1233 (2002)
   PUBMED   12023301
REFERENCE   3  (bases 1 to 2000)
  AUTHORS   Kanzler B and Dear TN.
  TITLE     Hox11 acts cell autonomously in spleen development and its absence
            results in altered cell fate of mesenchymal spleen precursors
  JOURNAL   Dev Biol 234 (1), 231-243 (2001)
   PUBMED   11356032
REFERENCE   4  (bases 1 to 2000)
  AUTHORS   Dube ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC,
            Crist WM, Carroll AJ, Minowada J et al.
  TITLE     A novel human homeobox gene lies at the chromosome 10 breakpoint in
            lymphoid neoplasias with chromosomal translocation t(10;14)
  JOURNAL   Blood 78 (11), 2996-3003 (1991)
   PUBMED   1683261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057997.1, XM_574674.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345331,
                              SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2000
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /note="T-cell leukemia, homeobox 1"
                     /db_xref="GeneID:499361"
                     /db_xref="RGD:1563655"
     exon            1..778
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1203
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 1"
                     /protein_id="NP_001102636.1"
                     /db_xref="GeneID:499361"
                     /db_xref="RGD:1563655"
                     /translation="

MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAGAGAGGTGAYGTGGPGGPGGPAGGGGGACSMGPLAGSYNVNMALAGGPGPGGGGGGAGAGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAVPGVNNLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE"

     misc_feature    order(814..828,832..834,883..885,901..903,940..942,
                     946..951,958..963,967..975,979..984)
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    820..981
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(820..822,829..831,949..951,958..963,970..972)
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            779..980
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2000
                     /gene="Tlx1"
                     /gene_synonym="RGD1563655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggaaggagaagccggagaggggaagaatacagctctccctctctcctccccctcccccctactttggcccttctgcgcacttcgccttcaagtctcaccgcagcctggagcggcgattgcctccgcgcccctactcgctgcccgggtagtccagcgcagcgagcgcccgcgcccgggcccccgcgtggggccggggccagcatggagcacctgggtccgcaccatctccacccgggccacgcggagcccatcagcttcggcatcgaccagatcctcaacagcccggaccagggcggctgcatggggcccgcctcgcgcctccaggacggagaatacggccttggctgtttggtcggaggcgcctacacttatggcggagggggttccgccgctggagcgggggccgggggcacaggcgcttacggcaccggtggcccgggtggtcccggaggcccggcgggcggtggcggaggtgcctgcagcatgggcccactggccggctcctacaacgtgaacatggccttggcgggcggcccgggtccgggaggcggcggcggtggcgcgggtgccggtggcgccggtgcgctgagcgctgcaggggtgatccgggtgcccgcgcacaggccgctagctggagctgtggcccatccccagcccctggccaccggcttgcctactgtgccctctgtgcctgcggtgccgggtgtcaacaacctcaccggcctcaccttcccctggatggagagtaaccgcagatacacaaaggacaggttcacaggtcacccctatcagaaccggacgccccctaagaagaagaagccgcgtacatccttcacacgcctgcagatctgtgagctggaaaagcgcttccaccgccagaagtacttggcttcggcggagcgcgctgctctggccaaagcgctcaaaatgaccgatgcgcaagtcaaaacctggttccagaacaggaggacgaaatggaggcgacagacagcagaggagcgtgaggccgagaggcagcaggcgaaccgcatcctcttgcagctgcagcaggaggccttccagaagagcctggcccagccgctgcctgcagacccactgtgcgtgcacaactcgtcgctctttgccctgcagaacctgcagccgtggtctgacgactccaccaaaatcactagcgtcacgtccgtggcttcggcctgtgagtgaggacccaagcccaattgagggctatccggagaaccagaactctcgataccttttctgagtgcacgcaggaagggaacgggcttctcagcaaggctcccagcaccgcctcacacccctgaggacactgtccggtcttcggtggaagagggtggagatagaggcagaagcctgcgtgatcctgtctcactctggaactgttcagaatctcctctttttctctatttcataaaatttactctgattttaacatgggacagagagacccaagggatgtagggtcctgaaggcttctgggatccccaggcagccatccgtactaaggctggaaacctctctattcctttcctcctacatccacacagaggtgataccactgtccctcctggcgtcaccttagagccacatgcaggggccgatggcagagcatcacagcacatacaggatcacaacaaatgacccttgccgttgggcacagtctagggtgacacttggactcgcccaaacagcacggacctcctcttactcgaacacaaggccatagtcacatagtgacacaccagcccacacacaacagctaaacctggcctgtcaggtccctcgccacacatcccagcggcacccaggtatgcacagacaggctttcacacaaatgcagcccatttctccagatcctgtttggggaggggggtaagttatgcacttataagttatgcacttataaggtgttttctgtgtaaccattttataaagtgcttgtgtaatttatgtggaaaaataataaaaccctcccgatcagg

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