LOCUS       NM_001108472            1859 bp    mRNA    linear   ROD 12-JAN-2022
DEFINITION  Rattus norvegicus Meis homeobox 3 (Meis3), transcript variant 2,
            mRNA.
ACCESSION   NM_001108472 XM_001074213 XM_341796
VERSION     NM_001108472.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Liu J, Wang Y, Birnbaum MJ and Stoffers DA.
  TITLE     Three-amino-acid-loop-extension homeodomain factor Meis3 regulates
            cell survival via PDK1
  JOURNAL   Proc Natl Acad Sci U S A 107 (47), 20494-20499 (2010)
   PUBMED   21059917
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Shim S, Kim Y, Shin J, Kim J and Park S.
  TITLE     Regulation of EphA8 gene expression by TALE homeobox transcription
            factors during development of the mesencephalon
  JOURNAL   Mol Cell Biol 27 (5), 1614-1630 (2007)
   PUBMED   17178831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000033.1.
            
            On Jan 12, 2022 this sequence version replaced NM_001108472.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JACYVU010000033.1  738822-738911
            91-263              JACYVU010000033.1  739122-739294
            264-445             JACYVU010000033.1  741078-741259
            446-605             JACYVU010000033.1  741398-741557
            606-656             JACYVU010000033.1  741651-741701
            657-707             JACYVU010000033.1  742513-742563
            708-857             JACYVU010000033.1  742717-742866
            858-969             JACYVU010000033.1  745410-745521
            970-1118            JACYVU010000033.1  745656-745804
            1119-1195           JACYVU010000033.1  747142-747218
            1196-1254           JACYVU010000033.1  747389-747447
            1255-1338           JACYVU010000033.1  748014-748097
            1339-1408           JACYVU010000033.1  748617-748686
            1409-1859           JACYVU010000033.1  749195-749645
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1859
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="Meis homeobox 3"
                     /db_xref="GeneID:361514"
                     /db_xref="RGD:1308532"
     exon            1..90
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..263
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1388
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Meis1, myeloid ecotropic viral integration site 1 homolog
                     3; myeloid ecotropic viral integration site-related gene
                     2; homeobox protein Meis3"
                     /codon_start=1
                     /product="homeobox protein Meis3 isoform 2"
                     /protein_id="NP_001101942.1"
                     /db_xref="GeneID:361514"
                     /db_xref="RGD:1308532"
                     /translation="

MARRYEEPRHYPGITEHTAALASFPEAAPSVPRAPGPYGPHRPPQPQGPGLDSDSLKREKDDIYGHPLFPLLALVFEKCELATCSPRDGASAGLGSPPGGDVCSSDSFNEDIAAFAKQIRSERPLFSSNPELDNLMVQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRDGGCREDLEDYAASCPSLPDQNTTWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGLDTSVASPSSAGEDEDLDLERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGASFNPEGQSMAGYTETQPHVTVRTPGSMGMNLNLEGEWHYL"

     misc_feature    546..800
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:435375"
     misc_feature    order(1050..1061,1065..1067,1125..1127,1143..1145,
                     1182..1184,1188..1193,1200..1205,1209..1217)
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1053..1055,1062..1064,1191..1193,1200..1205,
                     1212..1214)
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1101..1217
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            264..445
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..605
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..656
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..707
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..857
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..969
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1118
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1195
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1254
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1338
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1408
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1859
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaggagaagcagagaggaccaagagagagggtggggaccgcgggaagctccagacacaagaccccgcgaatctgacatacaaaggccaaagccgggcccgtgtgagcccaggagccgccgccaccctcggccgcgatccgcgggtcttggccactcggagaccccggcacccggcggggacctcggggacctccggccgcgatgagccccaggccgtgacctcccgagcccaggacgcgcggcgccggctcatggcccggaggtatgaggagccgcgccactaccccggcattaccgagcacacggcagccctggccagttttccagaggcagcaccttcagtacctcgagctcctgggccctatggcccacaccggccgccccaaccccaaggtccaggcttggacagcgatagcttgaagagagagaaggatgacatctatggacaccccctcttcccactcttggccctggtctttgagaagtgtgagctggctacatgctcgccccgtgatggggcctcggctgggctgggttcacccccaggtggtgacgtctgctcctctgactccttcaatgaggatattgctgcctttgctaagcagatccgctccgagaggccgctgttctcttccaacccggagctggacaacctgatggtccaggccatccaggtactccggttccacctgctggagctggagaaggtccacgacctgtgcgacaacttctgtcaccgctacatcacctgcctcaaggggaagatgcccatagacctggtgatcgaggatcgggatggtggttgcagggaggaccttgaggactacgcagcctcctgccccagcctcccagaccagaatactacatggatcagagaccatgaggacagtgggtctgtacatttggggaccccaggtccatccagcggaggcctggcctcccagagcggggacaactcaagtgaccaaggagatgggctggacaccagcgtggcctctcccagctccgcaggagaggatgaggacctggacctggagcgcagacggaacaagaagagggggatcttccccaaagtggccaccaacatcatgagggcctggttgttccagcatctctcgcacccgtacccctcagaagagcaaaagaaacagctggcccaggacaccgggctcaccattctgcaggtgaacaactggtttattaatgcccggagacggatagtgcagcccatgattgaccagtctaatcgtacagggcagggtgcatctttcaaccctgagggccagtccatggcaggctacacagagactcaaccacatgtgacagtcaggacgccaggatcaatggggatgaatctgaacttagaaggagaatggcattacctatagaggttggggtcaaaaggagggccccagcctctgactatgaccaccagccttgcacctaattggtccctgctggtccctgggcttcaggacttcacctccaaagctcccaccccattcaacgcctacctccctggggcccccagaggcttgaggacccagagcccacttgagggtttctcaagggcaaagacaaagcctcaaggtcctgcacccttcttctgccctcccctttgcccaggacctgagctgagaactgggccaaggtctgaagaagatggtggctggggccccaatccaggacagagaagagactggggttgggcaaggatgggcaaggaaggagggtcagctggatccaatgtttgggagaatccttcatcttcctgctctctgcctctctcacctcccttctctgacattcttctacctttcctttttttaatgataaagtcttaaaagtgcaaatcaaaa

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