LOCUS       NM_001108426            2949 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus kinesin family member 20A (Kif20a), mRNA.
ACCESSION   NM_001108426 XM_001061764 XM_341592
VERSION     NM_001108426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2949)
  AUTHORS   Miserey-Lenkei S, Bousquet H, Pylypenko O, Bardin S, Dimitrov A,
            Bressanelli G, Bonifay R, Fraisier V, Guillou C, Bougeret C,
            Houdusse A, Echard A and Goud B.
  TITLE     Coupling fission and exit of RAB6 vesicles at Golgi hotspots
            through kinesin-myosin interactions
  JOURNAL   Nat Commun 8 (1), 1254 (2017)
   PUBMED   29093437
  REMARK    GeneRIF: Results suggest that coupling between actin and
            microtubule cytoskeletons driven by Myosin II and KIF20A ensures
            the spatial coordination between RAB6-positive vesicles fission
            from Golgi/trans-Golgi network membranes and their exit along
            microtubules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2949)
  AUTHORS   Zhang Y, Liu J, Peng X, Zhu CC, Han J, Luo J and Rui R.
  TITLE     KIF20A regulates porcine oocyte maturation and early embryo
            development
  JOURNAL   PLoS One 9 (7), e102898 (2014)
   PUBMED   25036038
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2949)
  AUTHORS   Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB,
            Abraham RT and Jiang W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   4  (bases 1 to 2949)
  AUTHORS   Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU
            and Barr FA.
  TITLE     Phosphorylation of mitotic kinesin-like protein 2 by polo-like
            kinase 1 is required for cytokinesis
  JOURNAL   J Cell Biol 162 (5), 863-875 (2003)
   PUBMED   12939256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161953.1.
            
            On Apr 6, 2008 this sequence version replaced NM_001108426.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161953.1, SRR8487230.90917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2949
                     /gene="Kif20a"
                     /note="kinesin family member 20A"
                     /db_xref="GeneID:361308"
                     /db_xref="RGD:1307695"
     exon            1..56
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    13..15
                     /gene="Kif20a"
                     /note="upstream in-frame stop codon"
     exon            57..240
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2745
                     /gene="Kif20a"
                     /codon_start=1
                     /product="kinesin-like protein KIF20A"
                     /protein_id="NP_001101896.1"
                     /db_xref="GeneID:361308"
                     /db_xref="RGD:1307695"
                     /translation="

MSHGILSPPVGLLSDEDVADSPVLESTAADLRSVVRKDLLSDCSVISASLEDKQAPMEDTAEKMKVYLRIRPFLTSELERQEDQGCVCIENTETLLLQAPKDSFALKSNERGIGQATHKFTFSQIFGPEVGQVSFFNLTMKEMVKDVLRGQNWLIYTYGVTNSGKTYTIQGTSKDVGILPQSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEIKKLSLLIGGLQEEELSTSLKKRVHAESRIGASNSFDSGIAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPADIRFSIWISFFEIYNELLYDLLEPPSHQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKNQSFASTHMNQHSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKHQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHAAKFSALASQLVHAPPVHLGIPSLHSFIKEHSLQVSPGLKKEGKADSDLEDSPEDEADISMYGKEELLQVVEAMKALLLKERQEKLQLEIQLREEICNEMVEQMQQREQWCSERLDTQKDLLEELYEDKLKILKESLTTFYQEQIQERDEKIEELETLLQEAKQQPVAQQSGGCELSLRRSQRLAASASSQQLQEVKAELEQCKTELGSTTAELQKYQQMLKPPPTAKPFTIDVDKKLEEGQKNIRLLRTELQELGQSLQSAERACCHSTGAGKLRQALTNCDDILIKQNQTLAELQNNMMLVKLDLQKKAACIAEQYQTVLKLQGQASAKKRLGANQENQQPNHQPPGKKPFLRHLLPRTPTCQSSTDSSPYARILRSRHSPLLKSPFGKKY"

     misc_feature    262..1590
                     /gene="Kif20a"
                     /note="Kinesin motor domain, KIF23-like subgroup; Region:
                     KISc_KIF23_like; cd01368"
                     /db_xref="CDD:276819"
     misc_feature    order(289..291,553..555,562..564,568..579,1297..1299)
                     /gene="Kif20a"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:276819"
     misc_feature    order(1453..1455,1462..1464,1471..1473)
                     /gene="Kif20a"
                     /note="microtubule interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:276819"
     misc_feature    <1756..2529
                     /gene="Kif20a"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    1879..2046
                     /gene="Kif20a"
                     /note="RAB6 binding domain (RBD) found in kinesin-like
                     protein KIF20A, and similar proteins; Region: RBD_KIF20A;
                     cd21787"
                     /db_xref="CDD:409645"
     misc_feature    order(1882..1887,1891..1896,1903..1911,1915..1920,
                     1927..1932,1939..1944,1948..1953,1960..1965,1972..1977,
                     1984..1989,1993..1998,2005..2010)
                     /gene="Kif20a"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409645"
     misc_feature    order(1942..1944,1948..1953,1957..1965,1969..1974,
                     1978..1986,1990..1992)
                     /gene="Kif20a"
                     /note="RAB6 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409645"
     exon            241..330
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            331..450
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            451..589
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            590..777
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            778..907
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1102
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1214
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1283
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1427
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1593
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1758
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1898
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2001
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2200
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2292
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2430
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2921
                     /gene="Kif20a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtctcagctgggtagaagctgggaatcagagaagcagcgaagcaggctgtcttcagacatagactgaccctgcttgtcatgtctcacgggatcctttctccgccagtgggcttactctctgatgaggatgttgcagactcccccgtgttagagtccacagctgcagatctgaggtctgtggtccgaaaggacctgttgtcagattgctctgtcatctcggcctctctggaggacaaacaggctccaatggaggacactgcagagaagatgaaagtttatcttcgaatcagaccgttcttaacttctgagctggagagacaggaagatcagggctgtgtctgtattgagaatacagagacccttctgctacaggcacccaaagactcctttgccttgaagagtaatgagaggggaattggtcaagccactcacaaattcaccttttcccagatatttgggccagaagtgggccaggtgtccttcttcaacctgaccatgaaggagatggtaaaggatgtgctcagagggcagaactggctcatatacacctacggagtcaccaactctgggaagacctacacgatccaaggtactagtaaggatgtggggatcctgccccagtcccttgctctcatctttaatagtctccaaggccagcttcatccaacacctgatctgaagcccttgctgtccaatgaggtaatctggctagacagcaagcagattcgacaagaggaaataaagaagctgtccttgctaattggaggcctccaagaggaggagctatccacctccttgaagaaacgtgtccacgccgaaagtcggataggtgccagcaacagctttgacagtggcattgctgggctgtcttccaccagtcaattcaccagcagcagccagctagatgaaacaagtcagttatgggcacagccagacactgtcccagtaagtgttccagcagacattcgcttctctatctggatctccttctttgagatctacaatgagttgctttatgacctgttagaaccacctagccatcagcataagagacagacactgcggctgtgtgaggatcagaacggcaatccttacgtgaaagacctcaactggattcatgttcgtgatgttgaggaagcctggaaacttttgaaagtgggtcgtaagaaccagagctttgccagcacccacatgaaccagcactctagtcgcagtcacagtatattctcaatcagaatcttgcaccttcagggagaaggagatatagtgcccaagatcagtgaactgtcactctgtgatctggctggctcagagcgctgcaaacatcaaaaaagtggtgaacggctaaaggaggcaggaaacattaacacttccctgcacaccctgggccgctgtattgctgccctgcgacagaatcagcagaaccggtcaaagcagaacctgattcccttccgggacagcaagttgactcgtgtgttccaaggcttcttcacaggtcgaggtcgttcctgtatgattgtcaatgtgaatccctgtgcatctacatatgacgaaactctccatgcagccaaattctcagccttagccagccagcttgtgcatgccccacctgtgcatctgggaatcccatccctgcattcattcatcaaggagcacagtcttcaggtgtcccctggcttaaagaaagagggcaaggccgactcggaccttgaggacagtcctgaagacgaagctgacatctccatgtatggcaaggaggagctactccaggtggtggaagccatgaaagcgctgcttttaaaagaacgacaagaaaagctgcagttggagatacagctccgggaggaaatttgcaacgagatggtggaacagatgcagcaaagggagcagtggtgcagcgagcgtttggacacccaaaaggatctgttggaggaactgtatgaggacaaactaaagatcctgaaggagtctctaacaactttctaccaagaacagatccaggagcgggatgaaaaaattgaagagctagaaactctcttgcaggaagccaaacagcagccagtggcacaacagtcaggggggtgtgaactgtccctccggcggtcacaaaggttggcagcctctgcctcctctcagcagctccaggaagttaaagctgaactagagcaatgcaaaacagagttaggctctaccaccgcagagctgcagaagtaccagcagatgttaaaaccaccacccacagccaaacctttcaccatcgatgtggataagaagttagaggagggccagaagaatataaggctgctacggacagagctccaggagctaggacagtctctgcagtcagcagagagagcctgttgccacagcacaggagcaggaaaacttcgtcaagcattaactaactgcgatgacatcttaatcaaacagaaccagaccctggccgagctacagaataacatgatgctagtgaaactggaccttcagaaaaaggcagcctgcattgccgagcagtatcagactgtgctgaagctccaaggccaagcctctgccaaaaagcgactgggagcaaaccaggaaaaccagcaaccgaatcatcaacccccagggaagaaaccattcctacgacacttacttccccggacacctacctgccaaagctcgacagacagcagcccttacgcacggatcttgcgctcacggcattctcctttactcaaatctccctttggcaaaaaatactaaagttgtggggatgaagatgcatggttgttgccctgcggttgctcagctgctaggtcggtctcttaggcttgagcatgtactcagactgtattcagaatgactgtattatattcacctatgcaatcttgttcttaatgcacaaatattatatggaataaagacattgtttatgctttaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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